Sprinzak, D. & Blacklow, S. C. Biophysics of Notch signaling. Annu. Rev. Biophys. 50, 157–189 (2021).
Article CAS PubMed PubMed Central Google Scholar
Zhou, B. et al. Notch signaling pathway: architecture, disease, and therapeutics. Signal. Transduct. Target. Ther. 7, 1–33 (2022).
CAS PubMed PubMed Central Google Scholar
Garg, V. et al. Mutations in NOTCH1 cause aortic valve disease. Nature 437, 270–274 (2005).
Article CAS PubMed Google Scholar
Li, L. et al. Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1. Nat. Genet. 16, 243–251 (1997).
Article CAS PubMed Google Scholar
Joutel, A. et al. Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia. Nature 383, 707–710 (1996).
Article CAS PubMed Google Scholar
Bulman, M. P. et al. Mutations in the human Delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis. Nat. Genet. 24, 438–441 (2000).
Article CAS PubMed Google Scholar
Radtke, F. & Raj, K. The role of Notch in tumorigenesis: oncogene or tumour suppressor? Nat. Rev. Cancer 3, 756–767 (2003).
Article CAS PubMed Google Scholar
Hori, K., Sen, A. & Artavanis-Tsakonas, S. Notch signaling at a glance. J. Cell Sci. 126, 2135–2140 (2013).
CAS PubMed PubMed Central Google Scholar
Andersson, E. R. & Lendahl, U. Therapeutic modulation of Notch signalling—are we there yet? Nat. Rev. Drug Discov. 13, 357–378 (2014).
Article CAS PubMed Google Scholar
Brandstadter, J. D. & Maillard, I. Notch signalling in T cell homeostasis and differentiation. Open Biol. 9, 190187 (2019).
Article CAS PubMed PubMed Central Google Scholar
Schmitt, T. M. & Zúñiga-Pflücker, J. C. Induction of T cell development from hematopoietic progenitor cells by Delta-like-1 in vitro. Immunity 17, 749–756 (2002).
Article CAS PubMed Google Scholar
Kelliher, M. A. & Roderick, J. E. NOTCH signaling in T-cell-mediated anti-tumor immunity and T-cell-based immunotherapies. Front. Immunol. 9, 1718 (2018).
Article CAS PubMed PubMed Central Google Scholar
Sierra, R. A. et al. Rescue of Notch-1 signaling in antigen-specific CD8+ T cells overcomes tumor-induced T-cell suppression and enhances immunotherapy in cancer. Cancer Immunol. Res 2, 800–811 (2014).
Article CAS PubMed PubMed Central Google Scholar
Wilkens, A. B. et al. Notch1 signaling during CD4+ T-cell activation alters transcription factor networks and enhances antigen responsiveness. Blood 140, 2261–2275 (2022).
Article CAS PubMed PubMed Central Google Scholar
Kondo, T. et al. Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy. Nat. Commun. 8, 15338 (2017).
Article CAS PubMed PubMed Central Google Scholar
Meloty-Kapella, L., Shergill, B., Kuon, J., Botvinick, E. & Weinmaster, G. Notch ligand endocytosis generates mechanical pulling force dependent on dynamin, epsins, and actin. Dev. Cell 22, 1299–1312 (2012).
Article CAS PubMed PubMed Central Google Scholar
Wang, X. & Ha, T. Defining single molecular forces required to activate Integrin and Notch signaling. Science 340, 991–994 (2013).
Article CAS PubMed PubMed Central Google Scholar
Gordon, W. R. et al. Mechanical allostery: evidence for a force requirement in the proteolytic activation of Notch. Dev. Cell 33, 729–736 (2015).
Article CAS PubMed PubMed Central Google Scholar
Rebay, I. et al. Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor. Cell 67, 687–699 (1991).
Article CAS PubMed Google Scholar
Luca, V. C. et al.Structural basis for Notch1 engagement of Delta-like 4. Science 347, 847–853 (2015).
Article CAS PubMed PubMed Central Google Scholar
Luca, V. C. et al. Notch–Jagged complex structure implicates a catch bond in tuning ligand sensitivity. Science 355, 1320–1324 (2017).
Article CAS PubMed PubMed Central Google Scholar
Gordon, W. R. et al. Structural basis for autoinhibition of Notch. Nat. Struct. Mol. Biol. 14, 295–300 (2007).
Article CAS PubMed Google Scholar
De Strooper, B. et al. A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain. Nature 398, 518–522 (1999).
Brou, C. et al. A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE. Mol. Cell 5, 207–216 (2000).
Article CAS PubMed Google Scholar
Schroeter, E. H., Kisslinger, J. A. & Kopan, R. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature 393, 382–386 (1998).
Article CAS PubMed Google Scholar
Varnum-Finney, B. et al. Immobilization of Notch ligand, Delta-1, is required for induction of notch signaling. J. Cell Sci. 113, 4313–4318 (2000).
Article CAS PubMed Google Scholar
Trotman-Grant, A. C. et al. DL4-μbeads induce T cell lineage differentiation from stem cells in a stromal cell-free system. Nat. Commun. 12, 5023 (2021).
Article CAS PubMed PubMed Central Google Scholar
Li, K. et al. Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of Notch3. J. Biol. Chem. 283, 8046–8054 (2008).
Article CAS PubMed Google Scholar
Tiyanont, K., Wales, T. E., Siebel, C. W., Engen, J. R. & Blacklow, S. C. Insights into Notch3 activation and inhibition mediated by antibodies directed against its negative regulatory region. J. Mol. Biol. 425, 3192–3204 (2013).
Article CAS PubMed PubMed Central Google Scholar
Xu, X. et al. Insights into autoregulation of Notch3 from structural and functional studies of its negative regulatory region. Structure 23, 1227–1235 (2015).
Article CAS PubMed PubMed Central Google Scholar
Ilagan, M. X. G., Lim, S., Fulbright, M., Piwnica-Worms, D. & Kopan, R. Real-time imaging of Notch activation with a luciferase complementation-based reporter. Sci. Signal. 4, rs7(2011).
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