Zimmet PZ, Magliano DJ, Herman WH, Shaw JE. Diabetes. A 21st century challenge. Lancet Diabetes Endocrinol. 2014;2(1):56.

Article  PubMed  Google Scholar 

Xu Y, Wang L, He J, Bi Y, Li M, Wang T, Wang L, Jiang Y, Dai M, Lu J, Xu M, Li Y, Hu N, Li J, Mi S, Chen CS, Li G, Mu Y, Zhao J, Kong L, Chen J, Lai S, Wang W, Zhao W, Ning G. 2010 China noncommunicable disease surveillance group. Prevalence and control of diabetes in Chinese adults. JAMA. 2013;310(9):948–59.

Article  CAS  PubMed  Google Scholar 

Li Y, Teng D, Shi X, Qin G, Qin Y, Quan H, Shi B, Sun H, Ba J, Chen B, Du J, He L, Lai X, Li Y, Chi H, Liao E, Liu C, Liu L, Tang X, Tong N, Wang G, Zhang JA, Wang Y, Xue Y, Yan L, Yang J, Yang L, Yao Y, Ye Z, Zhang Q, Zhang L, Zhu J, Zhu M, Ning G, Mu Y, Zhao J, Teng W, Shan Z. Prevalence of diabetes recorded in Mainland China using 2018 diagnostic criteria from the American diabetes association: National cross sectional study. BMJ. 2020;369:m997.

Article  PubMed  PubMed Central  Google Scholar 

Singh A, Gupta A, DeFilippis EM, Qamar A, Biery DW, Almarzooq Z, et al. Cardiovascular mortality after type 1 and type 2 myocardial infarction in young adults. J Am Coll Cardiol. 2020;75(9):1003–13.

Article  PubMed  PubMed Central  Google Scholar 

De Bruijn KM, Arends LR, Hansen BE, Leeflang S, Ruiter R, van Eijck CH. Systematic review and meta-analysis of the association between diabetes mellitus and incidence and mortality in breast and colorectal cancer. Brit J Surg. 2012;100(11):1421–9.

Article  Google Scholar 

Mills KT, Bellows CF, Hoffman AE, Kelly TN, Gagliardi G. Diabetes mellitus and colorectal cancer prognosis: a meta-analysis. Dis Colon Rectum. 2013;56(11):1304–19.

Article  PubMed  PubMed Central  Google Scholar 

Peng WF, Bai F, Shao K, Shen LS, Li HH, Huang S. The key genes underlying pathophysiology association between the type 2-diabetic and colorectal cancer. J Cell Physiol. 2018;233(11):8551–7.

Article  CAS  PubMed  Google Scholar 

Sun Y, Chen P, Zhai B, Zhang M, Xiang Y, Fang J, et al. The emerging role of ferroptosis in inflammation. Biomed Pharmacother. 2020;127:110108.

Article  CAS  PubMed  Google Scholar 

Zheng J, Conrad M. The metabolic underpinnings of ferroptosis. Cell Metab. 2020;32(6):920–37.

Article  CAS  PubMed  Google Scholar 

Hirschhorn T, Stockwell BR. The development of the concept of ferroptosis. Free Radic Biol Med. 2019;133:130–43.

Article  CAS  PubMed  Google Scholar 

Stockwell BR, Jiang X, Gu W. Emerging mechanisms and disease relevance of ferroptosis. Trends Cell Biol. 2020;30(6):478–90.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, et al. Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014;156(1–2):317–31.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Miller JL, Blaszkiewicz M, Beaton C, Johnson CP, Waible S 2nd, Dubois AL, et al. A peroxidized omega-3-enriched polyunsaturated diet leads to adipose and metabolic dysfunction. J Nutr Biochem. 2019;64:50–60.

Article  CAS  PubMed  Google Scholar 

Zhang Q, Yuan X, Luan X, Lei T, Li Y, Chu W, et al. GLUT1 exacerbates trophoblast ferroptosis by modulating AMPK/ACC mediated lipid metabolism and promotes gestational diabetes mellitus associated fetal growth restriction. Mol Med. 2024;30(1):257.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, Gao P, Wu Z, Jiang B, Wang Y, He Z, et al. Exploring the therapeutic potential of Chinese herbs on comorbid type 2 diabetes mellitus and parkinson’s disease: A mechanistic study. J Ethnopharmacol. 2025;338(Pt 3):119095.

Article  CAS  PubMed  Google Scholar 

Niu ZC, Jin Q, Shen QY, Shi HH, Shang Y, Guo XT, et al. Schisandrol B alleviated diabetic cardiac injury by inhibiting ferroptosis and improving lipid metabolism in mice. Phytomedicine. 2025;143:156902.

Article  CAS  PubMed  Google Scholar 

Luo L, Zhou WH, Cai JJ, Feng M, Zhou M, Hu SP, Xu J, Ji LD. Gene expression profiling identifies downregulation of the Neurotrophin-MAPK signaling pathway in female diabetic peripheral neuropathy patients. J Diabetes Res. 2017;2017:8103904.

Article  PubMed  PubMed Central  Google Scholar 

Liu F, Zhao X, Perna F, Wang L, Koppikar P, Abdel-Wahab O, Harr MW, Levine RL, Xu H, Tefferi A, Deblasio A, Hatlen M, Menendez S, Nimer SD. JAK2V617F-mediated phosphorylation of PRMT5 downregulates its methyltransferase activity and promotes myeloproliferation. Cancer Cell. 2011;19(2):283–94.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Smyth GK. Limma: linear models for microarray data, in Bioinformatics and computational biology solutions using R and Bioconductor. Springer. 2005: pp. 397–420.

Zhou N, Bao J. FerrDb: a manually curated resource for regulators and markers of ferroptosis and ferroptosis-disease associations. Database (Oxford). 2020;2020:baaa021.

Article  CAS  PubMed  Google Scholar 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, et al. Gene ontology: tool for the unification of biology. Nat Genet. 2000;25(1):25–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kanehisa M, Goto S. KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 2000;28(1):27–30.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 2005;102(43):15545–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu GC, Wang LG, Han YY, He QY. Clusterprofiler: an R package for comparing biological themes among gene clusters. OMICS. 2012;16(5):284–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Szklarczyk D, Gable AL, Lyon D, Junge A, Wyder S, Huerta-Cepas J, et al. STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 2019;47(D1):D607–13.

Article  CAS  PubMed  Google Scholar 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B, Ideker T. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13(11):2498–504.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chin CH, Chen SH, Wu HH, Ho CW, Ko MT, Lin CY. CytoHubba: identifying hub objects and sub-networks from complex interactome. BMC Syst Biol. 2014;8(Suppl 4):S11.

Article  PubMed  PubMed Central  Google Scholar 

Han H, Cho JW, Lee S, Yun A, Kim H, Bae D, et al. TRRUST v2: an expanded reference database of human and mouse transcriptional regulatory interactions. Nucleic Acids Res. 2018;46(D1):D380–6.

Article  CAS  PubMed  Google Scholar 

Sticht C, De La Torre C, Parveen A, Gretz N. MiRWalk: an online resource for prediction of MicroRNA binding sites. PLoS ONE. 2018;13(10):e0206239.

Article  PubMed  PubMed Central  Google Scholar 

Freshour SL, Kiwala S, Cotto KC, Coffman AC, McMichael JF, Song JJ, et al. Integration of the drug-gene interaction database (DGIdb 4.0) with open crowdsource efforts. Nucleic Acids Res. 2021;49(D1):D1144–51.