Effects of alpha-lipoic acid in non-alcoholic fatty liver disease (NAFLD): a systematic review of literature

Karimi A, Vajdi M, Sanaie S, Akhlaghi S, Negari A, Dashti F, et al. A comprehensive insight into the effect of berberine on nonalcoholic fatty liver disease (NAFLD): a systematic review. J Food Biochem. 2023;2023(1):7277060.

Google Scholar 

Kooshki F, Moradi F, Karimi A, Niazkar HR, Khoshbaten M, Maleki V, et al. Chromium picolinate balances the metabolic and clinical markers in nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled trial. Eur J Gastroenterol Hepatol. 2021;33(10):1298–306.

Article  CAS  PubMed  Google Scholar 

Moradzad M, Ghaderi D, Abdi M, Sheikh Esmaili F, Rahmani K, Vahabzadeh Z. Gut microbiota dysbiosis contributes to choline unavailability and NAFLD development. J Diabetes Metabolic Disorders. 2025;24(1):37.

Article  CAS  Google Scholar 

Rafizadeh M, Khazaei-Poul Y, Mohammadi H, Khorramizadeh M, Amoli M, Larijani M. Applications of Danio rerio as a model for studying NAFLD and NASH. J Diabetes Metabolic Disorders. 2025;25(1):8.

Article  Google Scholar 

Benedict M, Zhang X. Non-alcoholic fatty liver disease: An expanded review. World J Hepatol. 2017;9(16):715–32. https://doi.org/10.4254/wjh.v9.i16.715.

Article  PubMed  PubMed Central  Google Scholar 

Engel B, Manns MP. Epidemiology of chronic liver diseases. Textbook of Liver Transplantation: A Multidisciplinary Approach. Springer. 2022;3–17.

Huh Y, Cho YJ, Nam GE. Recent epidemiology and risk factors of nonalcoholic fatty liver disease. J Obes metabolic syndrome. 2022;31(1):17.

Article  Google Scholar 

Meroni M, Longo M, Rustichelli A, Dongiovanni P. Nutrition and genetics in NAFLD: the perfect binomium. Int J Mol Sci. 2020;21(8):2986.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rehman K, Haider K, Jabeen K, Akash MSH. Current perspectives of oleic acid: Regulation of molecular pathways in mitochondrial and endothelial functioning against insulin resistance and diabetes. Reviews Endocr Metabolic Disorders. 2020;21:631–43.

Article  CAS  Google Scholar 

Ayala A, Muñoz MF, Argüelles S. Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy‐2‐nonenal. Oxidative Med Cell Longev. 2014;2014(1):360438.

Google Scholar 

Liu W, Baker SS, Baker D, Zhu R. Antioxidant mechanisms in nonalcoholic fatty liver disease. Curr Drug Targets. 2015;16(12):1301–14.

Article  CAS  PubMed  Google Scholar 

Malakouti M, Kataria A, Ali SK, Schenker S. Elevated liver enzymes in asymptomatic patients–what should I do? J Clin translational Hepatol. 2017;5(4):394.

Article  Google Scholar 

Brunner KT, Henneberg CJ, Wilechansky RM, Long MT. Nonalcoholic fatty liver disease and obesity treatment. Curr Obes Rep. 2019;8(3):220–8. https://doi.org/10.1007/s13679-019-00345-1.

Article  PubMed  PubMed Central  Google Scholar 

Fernandez-Galilea M. Effects of α-lipoic acid on lipid metabolism and mitochondrial biogenesis in adipocytes: study of the molecular mechanisms involved. 2016. https://hdl.handle.net/10171/39790

Tripathi AK, Ray AK, Mishra SK, Bishen SM, Mishra H, Khurana A. Molecular and therapeutic insights of alpha-lipoic acid as a potential molecule for disease prevention. Revista Brasileira de Farmacognosia. 2023;33(2):272–87.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fougerat A, Bruse J, Polizzi A, Montagner A, Guillou H, Wahli W. Lipid sensing by PPARα: Role in controlling hepatocyte gene regulatory networks and the metabolic response to fasting. Prog Lipid Res. 2024;96:101303. https://doi.org/10.1016/j.plipres.2024.101303.

Article  CAS  PubMed  Google Scholar 

Chua D, Low ZS, Cheam GX, Ng AS, Tan NS. Utility of human relevant preclinical animal models in navigating NAFLD to MAFLD paradigm. Int J Mol Sci. 2022;23(23):14762.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jung UJ, Choi M-S. Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease. Int J Mol Sci. 2014;15(4):6184–223.

Article  PubMed  PubMed Central  Google Scholar 

Genazzani AD, Battipaglia C, Rusce L, Prampolini G, Aio C, Ricciardiello F, et al. Alpha lipoic acid administration improved both peripheral sensitivity to insulin and liver clearance of insulin reducing potential risk of diabetes and nonalcoholic fatty liver disease in overweight/obese PCOS patients. Gynecol Endocrinol. 2024;40(1):2341701.

Article  PubMed  Google Scholar 

Ko CY, Lo YM, Xu JH, Chang WC, Huang DW, Wu JS, Yang CH, Huang WC, Shen SC. Alpha‐lipoic acid alleviates NAFLD and triglyceride accumulation in liver via modulating hepatic NLRP3 inflammasome activation pathway in type 2 diabetic rats. Food science & nutrition. 2021;9(5):2733-42.

Dugbartey GJ, Alornyo KK, Adams I, Atule S, Obeng-Kyeremeh R, Amoah D, et al. Targeting hepatic sulfane sulfur/hydrogen sulfide signaling pathway with α-lipoic acid to prevent diabetes-induced liver injury via upregulating hepatic CSE/3-MST expression. Diabetol Metab Syndr. 2022;14(1):148.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Castro MC, Francini F, Gagliardino JJ, Massa ML. Lipoic acid prevents fructose-induced changes in liver carbohydrate metabolism: role of oxidative stress. Biochimica et Biophysica Acta (BBA)-General Subjects. 2014;1840(3):1145-51

Kravchenko LV, Aksenov IV, Nikitin NS, Guseva GV, Avrenyeva LI, Trusov NV, et al. Lipoic acid exacerbates oxidative stress and lipid accumulation in the liver of Wistar rats fed a hypercaloric choline-deficient diet. Nutrients. 2021;13(6):1999

Yang Y, Li W, Liu Y, Li Y, Gao L, Zhao J-j. Alpha-lipoic acid attenuates insulin resistance and improves glucose metabolism in high fat diet-fedmice. Acta Pharmacologica Sinica. 2014;35(10):1285-92.

Stanković MN, Mladenović D, Ninković M, Ðuričić I, Šobajić S, Jorgačević B, de Luka S, Vukicevic RJ, Radosavljević TS. The effects of α-lipoic acid on liver oxidative stress and free fatty acid composition in methionine–choline deficient diet-induced NAFLD. Journal of medicinal food. 2014;17(2):254-61.

Valdecantos MP, Pérez-Matute P, González‐Muniesa P, Prieto‐Hontoria PL, Moreno‐Aliaga MJ, Martínez JA. Lipoic acid improves mitochondrial function in nonalcoholic steatosis through the stimulation of sirtuin 1 and sirtuin 3. Obesity. 2012;20(10):1974–83.

Article  CAS  PubMed  Google Scholar 

Kaya-Dagistanli F, Tanriverdi G, Altinok A, Ozyazgan S, Ozturk M. The effects of alpha lipoic acid on liver cells damages and apoptosis induced by polyunsaturated fatty acids. Food and chemical toxicology. 2013;53:84-93.

Yang Y, Li W, Liu Y, Sun Y, Li Y, Yao Q, et al. Alpha-lipoic acid improves high-fat diet-induced hepatic steatosis by modulating the transcription factors SREBP-1, FoxO1 and Nrf2 via the SIRT1/LKB1/AMPK pathway. J Nutr Biochem. 2014;25(11):1207–17.

Article  CAS  PubMed  Google Scholar 

Stanković MN, Mladenović D, Ninković M, Ðuričić I, Šobajić S, Jorgačević B, et al. The Effects of α-Lipoic Acid on Liver Oxidative Stress andFree Fatty Acid Composition in Methionine–Choline Deficient Diet-Induced NAFLD. Journal of Medicinal Food. 2013;17(2):254-61. doi:10.1089/jmf.2013.0111.

Zwierz M, Chabowski A, Sztolsztener K. α-Lipoic acid – a promising agent for attenuating inflammation and preventing steatohepatitis in rats fed a high-fat diet. Archives of Biochemistry and Biophysics. 2023;750:109811. https://doi.org/10.1016/j.abb.2023.109811

Sztolsztener K, Chabowski A. Hepatic-Metabolic Activity of α-Lipoic Acid—Its Influence on Sphingolipid Metabolism and PI3K/Akt/mTORPathway in a Rat Model of Metabolic Dysfunction-Associated Steatotic Liver Disease. Nutrients. 2024;16(10):1501.

Trushina EN, Riger NA, Mustafina O, Timonin AN, Aksenov IV, Guseva GV, et al. Effect of carnosine and α-lipoic acid on hepatocyte apoptosis and the cytokine profile in induced fatty liver disease in Wistar rats. Vopr Pitan. 2020;89(5):6-16.

Liu G, Liu J, Pian L, Gui S, Lu B. α–lipoic acid protects against carbon tetrachloride–induced liver cirrhosis through the suppression of the TGF–β/Smad3 pathway and autophagy. Mol Med Rep. 2019;19(2):841–50.

CAS  PubMed  Google Scholar 

Kuo Y-T, Lin T-H, Chen W-L, Lee H-M. Alpha-lipoic acid induces adipose triglyceride lipase expression and decreases intracellular lipid accumulation in HepG2 cells. European Journal of Pharmacology. 2012;692(1-3):10-8.

Longhitano L, Tibullo D, Zuppelli T, Ronsisvalle S, La Spina E, Nicolosi A, et al. (+) Alpha-lipoic acid regulates lipid metabolism gene expression and lipidic profile in a cellular model of fatty acid overload. Front Bioscience-Landmark. 2024;29(6):209.

Article  CAS  Google Scholar 

Longhitano L, Distefano A, Musso N, Bonacci P, Orlando L, Giallongo S, et al. (+)-Lipoic acid reduces mitochondrial unfolded protein response and attenuates oxidative stress and aging in an in vitro model of non-alcoholic fatty liver disease. Journal of Translational Medicine. 2024;22(1):82.

Reis R, Kolci K, Bahcivan İ, Coskun GP, Sipahi H. Alpha-lipoic acid modulates the oxidative and inflammatory responses induced by traditional and novel tobacco products in human liver epithelial cells. Chem Biodivers. 2023;20(3):e202200928.

Article  CAS  PubMed  Google Scholar 

Longhitano L, Distefano A, Amorini AM, Orlando L, Giallongo S, Tibullo D, et al. (+)-Lipoic acid reduces lipotoxicity and regulates mitochondrial homeostasis and energy balance in an in vitro model of liver steatosis. Int J Mol Sci. 2023;24(19):14491.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rahmanabadi A, Mahboob S, Amirkhizi F, Hosseinpour-Arjmand S, Ebrahimi-Mameghani M. Oral α-lipoic acid supplementation in patients with non-alcoholic fatty liver disease: effects on adipokines and liver histology features. Food & function. 2019;10(8):4941-52.

Hosseinpour-Arjmand S, Amirkhizi F, Ebrahimi‐Mameghani M. The effect of alpha‐lipoic acid on inflammatory markers and body composition in obese patients with non‐alcoholic fatty liver disease: A randomized, double‐blind, placebo‐controlled trial. J Clin Pharm Ther. 2019;44(2):258–67.

Article  CAS  PubMed  Google Scholar 

Gianturco V, Troisi G, Bellomo A, Bernardini S, D’Ottavio E, Formosa V, et al. Impact of combined therapy with alpha-lipoic and ursodeoxycolic acid on nonalcoholic fatty liver disease: double-blind, randomized clinical trial of efficacy and safety. Hep Intl. 2013;7:570–6.

Article  Google Scholar 

Tutunchi H, Arefhosseini S, Ebrahimi-Mameghani M. Clinical effectiveness of α-lipoic acid, myo-inositol and propolis supplementation on metabolic profiles and liver function in obese patients with NAFLD: A randomized controlled clinical trial. Clin Nutr ESPEN. 2023;54:412–20.

Article  PubMed  Google Scholar 

Amirkhizi F, Hamedi-Shahraki S, Hosseinpour-Arjmand S, Ebrahimi-Mameghani M. The effect of alpha-lipoic acid on liver function and metabolic markers in obese patients with non-alcoholic fatty liver disease: a double-blind randomized controlled trial. Iran Red Crescent Med J. 2018;20(3):1-11.

Higgins J, Altman D, Sterne J, Cochrane statistical methods group and the cochrane bias methods group. Chapter 8: assessing risk of bias in included studies. C ochrane Handb systemic reviews interventions version. 2011;5(0). https://doi.org/10.1002/9780470712184.ch8

Hooijmans CR, Rovers MM, De Vries RB, Leenaars M, Ritskes-Hoitinga M, Langendam MW. SYRCLE’s risk of bias tool for animal studies. BMC Med Res Methodol. 2014;14(1):43.

Article  PubMed  PubMed Central 

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