Selby NM, Taal MW. An updated overview of diabetic nephropathy: diagnosis, prognosis, treatment goals and latest guidelines. Diabetes Obes Metab. 2020;22:3–15.
Li S, Xie H, Shi Y, Liu H. Prevalence of diabetic nephropathy in the diabetes mellitus population: a protocol for systematic review and meta-analysis. Medicine. 2022;101(42):e31232.
Article PubMed PubMed Central Google Scholar
Samsu N. Diabetic nephropathy: challenges in pathogenesis, diagnosis, and treatment. BioMed Res Int. 2021;2021(1):1497449.
Article PubMed PubMed Central Google Scholar
Pour-Reza-Gholi F, Assadiasl S. Immunological approaches in the treatment of diabetic nephropathy. Curr Diabetes Rev. 2025;21(1):E061123223172.
Yang M, Zhang C. The role of innate immunity in diabetic nephropathy and their therapeutic consequences. J Pharm Anal. 2024;14(1):39–51.
Assadiasl S, Ahmadpoor P, Nafar M, Lessan Pezeshki M, Pourrezagholi F, Parvin M, et al. Regulatory T cell subtypes and TGF-β1 gene expression in chronic allograft dysfunction. Iran J Immunol. 2014;11(3):139–52.
Sameir M, Soleimanifar N, Selman N, Assadiasl S, Sadr M, Mojtahedi H, et al. Regulatory T cells and type 1 regulatory T cells as immuno-cell therapy in type 1 diabetes. Hammurabi J Med Sci. 2024;1(2):36–42.
Wang L, Wang H-l, Lan H-y. TGF-β signaling in diabetic nephropathy: an update. Diabet Nephrop. 2022;2(1):7–16.
Campbell KN, Raij L, Mundel P. Role of angiotensin II in the development of nephropathy and podocytopathy of diabetes. Curr Diabetes Rev. 2011;7(1):3–7. https://doi.org/10.2174/157339911794273973.
Article PubMed PubMed Central Google Scholar
Zhang L, Miao R, Yu T, Wei R, Tian F, Huang Y, et al. Comparative effectiveness of traditional Chinese medicine and angiotensin converting enzyme inhibitors, angiotensin receptor blockers, and sodium glucose cotransporter inhibitors in patients with diabetic kidney disease: a systematic review and network meta-analysis. Pharmacol Res. 2022;177:106111.
Biancardi VC, Bomfim GF, Reis WL, Al-Gassimi S, Nunes KP. The interplay between angiotensin II, TLR4 and hypertension. Pharmacol Res. 2017;120:88–96.
Singh MV, Cicha MZ, Nunez S, Meyerholz DK, Chapleau MW, Abboud FM. Angiotensin II-induced hypertension and cardiac hypertrophy are differentially mediated by TLR3-and TLR4-dependent pathways. Am J Physiol Heart Circ Physiol. 2019;316(5):H1027-38.
Article PubMed PubMed Central Google Scholar
Assadiasl S, Mousavi MJ, Amirzargar A. Toll-like receptor 4 in renal transplant. Exp Clin Transpl. 2018;16(3):245–52.
De Batista PR, Palacios R, Martin A, Hernanz R, Medici CT, Silva MA, et al. Toll-like receptor 4 upregulation by angiotensin II contributes to hypertension and vascular dysfunction through reactive oxygen species production. PLoS ONE. 2014;9(8):e104020.
Article PubMed PubMed Central Google Scholar
Mattorre B, Tedeschi V, Paldino G, Fiorillo MT, Paladini F, Sorrentino R. The emerging multifunctional roles of ERAP1, ERAP2 and IRAP between antigen processing and renin-angiotensin system modulation. Front Immunol. 2022;13:1002375.
Article PubMed PubMed Central Google Scholar
Zee RY, Rivera A, Inostroza Y, Ridker PM, Chasman DI, Romero JR. Gene variation of endoplasmic reticulum aminopeptidases 1 and 2, and risk of blood pressure progression and incident hypertension among 17,255 initially healthy women. Int J Genomics. 2018;2018(1):2308585.
PubMed PubMed Central Google Scholar
Hovind P, Rossing P, Tarnow L, Smidt UM, Parving H-H. Progression of diabetic nephropathy. Kidney Int. 2001;59(2):702–9. https://doi.org/10.1046/j.1523-1755.2001.059002702.x.
Naaman SC, Bakris GL. Diabetic nephropathy: update on pillars of therapy slowing progression. Diabetes Care. 2023;46(9):1574–86.
Article PubMed PubMed Central Google Scholar
Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative CT method. Nat Protoc. 2008;3(6):1101–8. https://doi.org/10.1038/nprot.2008.73.
Dargahi H, Nicknam MH, Mirahmadian M, Mahmoudi M, Aslani S, Sadrosadat M, et al. Association study of single nucleotide polymorphisms of Endoplasmic reticulum aminopeptidase 1 and 2 genes in Iranian women with preeclampsia. Iran J Public Health. 2019;48(3):531–40.
PubMed PubMed Central Google Scholar
Mahmoudi M, Jamshidi AR, Amirzargar AA, Farhadi E, Nourijelyani K, Fallahi S et al. Association between Endoplasmic reticulum aminopeptidase-1 (ERAP-1) and susceptibility to ankylosing spondylitis in Iran. Iran J Allergy Asthma Immunol. 2012:294–300.
Harvey D, Pointon JJ, Evans DM, Karaderi T, Farrar C, Appleton LH, et al. Investigating the genetic association between ERAP1 and ankylosing spondylitis. Hum Mol Genet. 2009;18(21):4204–12. https://doi.org/10.1093/hmg/ddp371.
Article PubMed PubMed Central Google Scholar
Akbulut E, Yıldırım T, Öztürk O. Endoplasmic reticulum aminopeptidase-1 polymorphism increases the risk of rheumatoid arthritis. Turk J Biochem. 2022;47(4):465–73.
Gianchecchi E, Crinò A, Palma A, Luciano R, Perri V, Fruci D, et al. Case-control analysis of the ERAP1 polymorphism rs30187 in Italian type 1 diabetes mellitus patients. Health. 2013;5(12):2150–5.
Alamdari A, Minoo FS, Assadiasl S, Freidoon M, Pour-Reza-Gholi F, Soleimanifar N, et al. Expression of programmed cell death 1 and helios genes correlates with rs872071A > G and rs12203592C > T Single-Nucleotide polymorphisms of interferonregulatory factor 4 in patients with T-Cell-Mediated rejection of renal Allograft. Experimental and clinical transplantation. official journal of the Middle East Society for Organ Transplantation; 2021.
Lim AK. Diabetic nephropathy–complications and treatment. Int J Nephrol Renovascular Disease. 2014:361–81.
Ameh OI, Okpechi IG, Agyemang C, Kengne AP. Global, regional, and ethnic differences in diabetic nephropathy. Diabetic nephropathy: pathophysiology and clinical aspects. Springer; 2018. pp. 33–44.
Karimi F, Maleki M, Movahedpour A, Alizadeh M, Kharazinejad E, Sabaghan M. Overview of the renin-angiotensin system in diabetic nephropathy. J Renin-Angiotensin-Aldosterone Syst. 2024;25:14703203241302966.
Sanglard A, Miranda BCB, Vieira ALF, Macedo MVM, Santos RL, Campos ASRR, et al. The role of Renin-Angiotensin system in diabetic nephropathy: an update. Mini-Rev Med Chem. 2025;25(8):591–600.
Amann B, Tinzmann R, Angelkort B. ACE inhibitors improve diabetic nephropathy through suppression of renal MCP-1. Diabetes Care. 2003;26(8):2421–5.
Chawla T, Sharma D, Singh A. Role of the renin angiotensin system in diabetic nephropathy. World J Diabetes. 2010;1(5):141.
Article PubMed PubMed Central Google Scholar
Bhandari S, Mehta S, Khwaja A, Cleland JG, Ives N, Brettell E, et al. Renin–angiotensin system inhibition in advanced chronic kidney disease. N Engl J Med. 2022;387(22):2021–32.
Cui X, Rouhani FN, Hawari F, Levine SJ. An aminopeptidase, ARTS-1, is required for interleukin-6 receptor shedding. J Biol Chem. 2003;278(31):28677–85.
Watanabe Y, Shibata K, Kikkawa F, Kajiyama H, Ino K, Hattori A, et al. Adipocyte-derived leucine aminopeptidase suppresses angiogenesis in human endometrial carcinoma via renin-angiotensin system. Clin Cancer Res. 2003;9(17):6497–503.
Goto Y, Ogawa K, Hattori A, Tsujimoto M. Secretion of endoplasmic reticulum aminopeptidase 1 is involved in the activation of macrophages induced by lipopolysaccharide and interferon-γ. J Biol Chem. 2011;286(24):21906–14.
Article PubMed PubMed Central Google Scholar
Garibotto G, Carta A, Picciotto D, Viazzi F, Verzola D. Toll-like receptor-4 signaling mediates inflammation and tissue injury in diabetic nephropathy. J Nephrol. 2017;30(6):719–27.
Pan Y, Huang Y, Wang Z, Fang Q, Sun Y, Tong C, et al. Inhibition of MAPK-mediated ACE expression by compound C66 prevents STZ‐induced diabetic nephropathy. J Cell Mol Med. 2014;18(2):231–41.
Wang Y, Fang Q, Jin Y, Liu Z, Zou C, Yu W, et al. Blockade of myeloid differentiation 2 attenuates diabetic nephropathy by reducing activation of the renin-angiotensin system in mouse kidneys. Br J Pharmacol. 2019;176(14):2642–57.
Article PubMed PubMed Central Google Scholar
Feng Q, Liu D, Lu Y, Liu Z. The interplay of renin-angiotensin system and toll‐like receptor 4 in the inflammation of diabetic nephropathy. J Immunol Res. 2020;2020(1):6193407.
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