Abedini A and Raleigh DP 2006 Destabilization of human IAPP amyloid fibrils by proline mutations outside of the putative amyloidogenic domain: Is there a critical amyloidogenic domain in human IAPP? J. Mol. Biol. 355 274–281

Article  CAS  PubMed  Google Scholar 

Cooper GJS, Willis AC, Clark A, et al. 1987 Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients. Proc. Natl. Acad. Sci. USA 84 8628–8632

Article  PubMed Central  CAS  PubMed  Google Scholar 

Gandasi N 2024 Secretion of multivesicular bodies maintains the pancreatic islet environment in pancreatic β cells—does dysregulation lead to type 2-diabetes? Biophys. J. 123 7a

Article  Google Scholar 

Gandasi NR and Barg S 2014 Contact-induced clustering of syntaxin and munc18 docks secretory granules at the exocytosis site. Nat. Commun. 5 3914

Article  CAS  PubMed  Google Scholar 

Gandasi NR, Yin P, Riz M, et al. 2017 Ca2+ channel clustering with insulin-containing granules is disturbed in type 2 diabetes. J. Clin. Invest. 127 2353–2364

Article  PubMed Central  PubMed  Google Scholar 

Gandasi NR, Yin P, Omar-Hmeadi M, et al. 2018 Glucose-dependent granule docking limits insulin secretion and is decreased in human type 2 diabetes. Cell Metab. 27 470–478

Article  CAS  PubMed  Google Scholar 

Gurlo T, Ryazantsev S, Huang CJ, et al. 2010 Evidence for proteotoxicity in β cells in type 2 diabetes: Toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway. Am. J. Pathol. 176 861–869

Article  PubMed Central  CAS  PubMed  Google Scholar 

Hazari MA, Kannan G, Dasgupta S, et al. 2025 Faster amylin aggregation on fibrillar collagen I hastens diabetic progression through β-cell death and loss of function. J. Am. Chem. Soc. 147 15985–16006

Article  CAS  PubMed  Google Scholar 

Iglesias-Fortes S, González-Blanco C, García-Carrasco A, et al. 2024 The overexpression of human amylin in pancreatic β cells facilitate the appearance of amylin aggregates in the kidney contributing to diabetic nephropathy. Sci. Rep. 14 24729

Article  PubMed Central  CAS  PubMed  Google Scholar 

Janson J, Soeller WC, Roche PC, et al. 1996 Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide. Proc. Natl. Acad. Sci. USA 93 7283–7288

Article  PubMed Central  CAS  PubMed  Google Scholar 

McLaurin J, Franklin T, Zhang X, et al. 1999 Alzheimer amyloid-β peptides with glycosaminoglycans. Eur. J. Biochem. 266 1101–1110

Article  CAS  PubMed  Google Scholar 

Meng F, Abedini A, Plesner A, et al. 2010 The flavanol (-)-epigallocatechin 3-gallate inhibits amyloid formation by islet amyloid polypeptide, disaggregates amyloid fibrils, and protects cultured cells against IAPP-induced toxicity. Biochemistry 49 8127–8133

Article  CAS  PubMed  Google Scholar 

Omar-Hmeadi M and Idevall-Hagren O 2021 Insulin granule biogenesis and exocytosis. Cell. Mol. Life Sci. 78 1957–1970

Article  CAS  PubMed  Google Scholar 

Relini A, Canale C, De Stefano S, et al. 2006 Collagen plays an active role in the aggregation of β2- microglobulin under physiopathological conditions of dialysis-related amyloidosis. J. Biol. Chem. 281 16521–16529

Article  CAS  PubMed  Google Scholar 

Ribeiro D, Horvath I, Heath N, et al. 2017 Extracellular vesicles from human pancreatic islets suppress human islet amyloid polypeptide amyloid formation. Proc. Natl. Acad. Sci. USA 114 11127–11132

Article  PubMed Central  CAS  PubMed  Google Scholar 

Rorsman P and Renström E 2003 Insulin granule dynamics in pancreatic beta cells. Diabetologia 46 1029–1045

Article  CAS  PubMed  Google Scholar 

Veerabhadraswamy P, Lata K, Dey S, et al. 2024 Comparison of localization and release of multivesicular bodies and secretory granules in islet cells: Dysregulation during type-2 diabetes. J. Extracell. Biol. 3 e70014

Article  PubMed Central  CAS  PubMed  Google Scholar 

Westermark P, Engström U, Johnson KH, et al. 1990 Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation. Proc. Natl. Acad. Sci. USA 87 5036–5040

Article  PubMed Central  CAS  PubMed  Google Scholar 

Westermark P, Wernstedt C, Wilander E, et al. 1987 Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells. Proc. Natl. Acad. Sci. USA 84 3881–3885

Article  PubMed Central  CAS  PubMed  Google Scholar 

Westermark GT and Westermark P 2000 Endocrine amyloid - A subject of increasing interest for the next century. Amyloid 7 19–22

Article  CAS  PubMed  Google Scholar 

Wirth F, Heitz FD, Seeger C, et al. 2023 A human antibody against pathologic IAPP aggregates protects beta cells in type 2 diabetes models. Nat. Commun. 14 6294

Article  PubMed Central  CAS  PubMed  Google Scholar 

Zechner D, Knapp N, Bobrowski A, et al. 2014 Diabetes increases pancreatic fibrosis during chronic inflammation. Exp. Biol. Med. 239 670–676

Article  Google Scholar