Roberts AE, Allanson JE, Tartaglia M, Gelb BD (2013) Noonan syndrome. Lancet 381:333–342. https://doi.org/10.1016/S0140-6736(12)61023-X

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mendez HM, Opitz JM (1985) Noonan syndrome: a review. Am J Med Genet 21:493–506. https://doi.org/10.1002/ajmg.1320210312

Article  CAS  PubMed  Google Scholar 

El Bouchikhi I, Belhassan K, Moufid FZ et al (2016) Noonan syndrome-causing genes: molecular update and an assessment of the mutation rate. Int J Pediatr Adolesc Med 3:133–142. https://doi.org/10.1016/j.ijpam.2016.06.003

Article  PubMed  PubMed Central  Google Scholar 

Tafazoli A, Eshraghi P, Pantaleoni F et al (2018) Novel mutations and their genotype-phenotype correlations in patients with Noonan syndrome, using next-generation sequencing. Adv Med Sci 63:87–93. https://doi.org/10.1016/j.advms.2017.07.001

Article  PubMed  Google Scholar 

Breilyn MS, Mehta L (2019) Clinical manifestations of Noonan syndrome and related disorders. Pediatr Endocrinol Rev 16:428–434. https://doi.org/10.17458/per.vol16.2019.bm.clinicalnoonan

Article  PubMed  Google Scholar 

Romano AA, Allanson JE, Dahlgren J et al (2010) Noonan syndrome: clinical features, diagnosis, and management guidelines. Pediatrics 126:746–759. https://doi.org/10.1542/peds.2009-3207

Article  PubMed  Google Scholar 

Carcavilla A, Suárez-Ortega L, Rodríguez Sánchez A et al (2020) Noonan syndrome: genetic and clinical update and treatment options. An Pediatr (Engl Ed) 93:61.e1-61.e14. https://doi.org/10.1016/j.anpedi.2020.04.008

Article  PubMed  Google Scholar 

Wolf CM, Zenker M, Burkitt-Wright E et al (2022) Management of cardiac aspects in children with Noonan syndrome - results from a European clinical practice survey among paediatric cardiologists. Eur J Med Genet 65:104372. https://doi.org/10.1016/j.ejmg.2021.104372

Article  PubMed  Google Scholar 

Romano AA (2019) Growth and growth hormone treatment in Noonan syndrome. Pediatr Endocrinol Rev 16:459–464. https://doi.org/10.17458/per.vol16.2019.r.growthhormonenoonan

Article  PubMed  Google Scholar 

Saint-Laurent C, Mazeyrie L, Yart A, Edouard T (2024) Novel therapeutic perspectives in Noonan syndrome and RASopathies. Eur J Pediatr 183:1011–1019. https://doi.org/10.1007/s00431-023-05263-y

Article  PubMed  Google Scholar 

Draaisma F, Erasmus CE, Braakman HMH et al (2023) Hypertrophic neuropathy: a possible cause of pain in children with Noonan syndrome and related disorders. Eur J Pediatr 182:3789–3793. https://doi.org/10.1007/s00431-023-05045-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pierpont EI, Tworog-Dube E, Roberts AE (2013) Learning and memory in children with Noonan syndrome. Am J Med Genet A 161A:2250–2257. https://doi.org/10.1002/ajmg.a.36075

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rauen KA (2013) The RASopathies. Annu Rev Genomics Hum Genet 14:355–369. https://doi.org/10.1146/annurev-genom-091212-153523

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stroup DF, Berlin JA, Morton SC et al (2000) Meta-analysis of observational studies in epidemiology: A proposal for reporting. J Am Med Assoc 283:2008–2012. https://doi.org/10.1001/jama.283.15.2008

Article  CAS  Google Scholar 

Page MJ, McKenzie JE, Bossuyt PM et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71. https://doi.org/10.1136/bmj.n71

Article  PubMed  PubMed Central  Google Scholar 

Higgins JPT, Thomas J, Chandler J, et al (2019) Cochrane handbook for systematic reviews of interventions. Cochrane Handbook for Systematic Reviews of Interventions 1–694. https://doi.org/10.1002/9781119536604

Boat TF, Wu JT, Disorders C to E the SSIDP for C with M, et al (2015) Mental Disorders and Disabilities Among Low-Income Children. Washington (DC): National Academies Press (US). https://www.ncbi.nlm.nih.gov/books/NBK332877/

Salvador-Carulla L, Reed GM, Vaez-Azizi LM et al (2011) Intellectual developmental disorders: towards a new name, definition and framework for “mental retardation/intellectual disability” in ICD-11. World Psychiatry 10:175–180. https://doi.org/10.1002/j.2051-5545.2011.tb00045.x

Article  PubMed  Google Scholar 

Ma L-L, Wang Y-Y, Yang Z-H et al (2020) Methodological quality (risk of bias) assessment tools for primary and secondary medical studies: what are they and which is better? Mil Med Res 7:7. https://doi.org/10.1186/s40779-020-00238-8

Article  PubMed  PubMed Central  Google Scholar 

Atkins D, Best D, Briss PA et al (2004) Grading quality of evidence and strength of recommendations. BMJ 328:1490. https://doi.org/10.1136/bmj.328.7454.1490

Article  PubMed  Google Scholar 

DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177–188. https://doi.org/10.1016/0197-2456(86)90046-2

Article  CAS  PubMed  Google Scholar 

Higgins JPT, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21:1539–1558. https://doi.org/10.1002/sim.1186

Article  PubMed  Google Scholar 

Egger M, Smith GD, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629–634. https://doi.org/10.1136/bmj.315.7109.629

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mavridis D, Salanti G (2014) How to assess publication bias: funnel plot, trim-and-fill method and selection models. Evid Based Ment Health 17:30. https://doi.org/10.1136/eb-2013-101699

Article  PubMed  Google Scholar 

Kiran A, Crespillo AP, Rahimi K (2017) Graphics and Statistics for Cardiology: Data visualisation for meta-analysis. Heart 103:19–23. https://doi.org/10.1136/heartjnl-2016-309685

Article  PubMed  Google Scholar 

Adviento B, Corbin IL, Widjaja F et al (2014) Autism traits in the RASopathies. J Med Genet 51:10–20. https://doi.org/10.1136/jmedgenet-2013-101951

Article  CAS  PubMed  Google Scholar 

Alfieri P, Piccini G, Caciolo C et al (2014) Behavioral profile in RASopathies. Am J Med Genet A. https://doi.org/10.1002/ajmg.a.36374

Article  PubMed  Google Scholar 

Alfieri P, Cumbo F, Serra G et al (2021) Manic and depressive symptoms in children diagnosed with Noonan syndrome. Brain Sci 11:233. https://doi.org/10.3390/brainsci11020233

Article  CAS  PubMed  PubMed Central  Google Scholar 

Davico C, Borgogno M, Campagna F et al (2022) Psychopathology and adaptive functioning in children, adolescents, and young adults with Noonan syndrome. J Dev Behav Pediatr 43:e87–e93. https://doi.org/10.1097/DBP.0000000000000991

Article  PubMed  Google Scholar 

Davico C, D’Alessandro R, Borgogno M et al (2022) Epilepsy in a cohort of children with Noonan syndrome and related disorders. Eur J Pediatr 181:2919–2926. https://doi.org/10.1007/s00431-022-04497-6

Article  PubMed  Google Scholar 

Dumont E, Tiemens DK, Draaisma JMT et al (2024) Do children with a Noonan syndrome-like RASopathy and avoidant/restrictive food intake disorder benefit from behavioral therapy? Eur J Pediatr 184:100. https://doi.org/10.1007/s00431-024-05933-5

Article  PubMed  Google Scholar 

Foy AMH, Hudock RL, Shanley R, Pierpont EI (2022) Social behavior in RASopathies and idiopathic autism. J Neurodev Disord 14:5. https://doi.org/10.1186/s11689-021-09414-w