Wang S, Liu J, Zhang X, Liu Y, Li J, Wang H et al (2024) Global, regional and national burden of retinopathy of prematurity among childhood and adolescent: a spatiotemporal analysis based on the Global Burden of Disease Study 2019. BMJ Paediatr Open 8:8. https://doi.org/10.1136/bmjpo-2023-002267

Article  CAS  Google Scholar 

Ying G-S, Quinn GE (2023) Nationwide increase in the incidence of retinopathy of prematurity in the US-a growing problem? JAMA Ophthalmol 141:486–487. https://doi.org/10.1001/jamaophthalmol.2023.0926

Article  PubMed  PubMed Central  Google Scholar 

Agarwal K, Balakrishnan D, Rani PK, Jalali S (2019) Changing patterns of early childhood blinding conditions presenting to a tertiary eye center: the epidemic of retinopathy of prematurity in India. Indian J Ophthalmol 67:816–818. https://doi.org/10.4103/ijo.IJO_709_18

Article  PubMed  PubMed Central  Google Scholar 

Jalali S, Azad R, Trehan HS, Dogra MR, Gopal L, Narendran V (2010) Technical aspects of laser treatment for acute retinopathy of prematurity under topical anesthesia. Indian J Ophthalmol 58:509–515. https://doi.org/10.4103/0301-4738.71689

Article  PubMed  PubMed Central  Google Scholar 

Gavriilidou A, Seliniotaki AK, Arvanitaki Z, Ziakas N, Haidich A-B, Mataftsi A (2023) Safety profile of anesthetic modalities during laser treatment for retinopathy of prematurity: a systematic review. J Perinatol 43:685–693. https://doi.org/10.1038/s41372-023-01622-7

Article  PubMed  Google Scholar 

Giordano V, Deindl P, Gal E, Unterasinger L, Fuiko R, Steinbauer P et al (2023) Pain and neurodevelopmental outcomes of infants born very preterm. Dev Med Child Neurol 65:1043–1052. https://doi.org/10.1111/dmcn.15505

Article  PubMed  Google Scholar 

Chen SDM, Sundaram V, Wilkinson A, Patel CK (2007) Variation in anaesthesia for the laser treatment of retinopathy of prematurity--a survey of ophthalmologists in the UK. Eye (Lond) 21:1033–1036. https://doi.org/10.1038/sj.eye.6702499

Article  CAS  PubMed  Google Scholar 

Sekeroglu MA, Hekimoglu E, Sekeroglu HT, Arslan U (2013) Retinopathy of prematurity: a nationwide survey to evaluate current practices and preferences of ophthalmologists. Eur J Ophthalmol 23:546–552. https://doi.org/10.5301/ejo.5000272

Article  PubMed  Google Scholar 

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71. https://doi.org/10.1136/bmj.n71

Article  PubMed  PubMed Central  Google Scholar 

Guyatt G, Agoritsas T, Brignardello-Petersen R, Mustafa RA, Rylance J, Foroutan F et al (2025) Core GRADE 1: overview of the Core GRADE approach. BMJ 389:e081903. https://doi.org/10.1136/bmj-2024-081903

Article  PubMed  Google Scholar 

Ulgey A, Güneş I, Bayram A, Aksu R, Biçer C, Uğur F et al (2015) Decreasing the need for mechanical ventilation after surgery for retinopathy of prematurity: sedoanalgesia vs. general anesthesia. Turk J Med Sci 45:1292–1299. https://doi.org/10.3906/sag-1401-24

Article  CAS  PubMed  Google Scholar 

Kataria M, Narang S, Chawla D, Sood S, Gupta PC (2015) Oral dextrose for pain management during laser treatment of retinopathy of prematurity under topical anesthesia. Indian J Pediatr 82:694–697. https://doi.org/10.1007/s12098-015-1718-2

Article  PubMed  Google Scholar 

Sethi A, Sankar MJ, Kulkarni S, Thukral A, Chandra P, Agarwal R (2020) Low dose fentanyl infusion versus 24% oral sucrose for pain management during laser treatment for retinopathy of prematurity-an open label randomized clinical trial. Eur J Pediatr 179:285–292. https://doi.org/10.1007/s00431-019-03514-5

Article  CAS  PubMed  Google Scholar 

Madathil S, Thomas D, Chandra P, Agarwal R, Sankar MJ, Thukral A et al (2021) “NOPAIN-ROP” trial: intravenous fentanyl and intravenous ketamine for pain relief during laser photocoagulation for retinopathy of prematurity (ROP) in preterm infants: a randomised trial. BMJ Open 11:e046235. https://doi.org/10.1136/bmjopen-2020-046235

Article  PubMed  PubMed Central  Google Scholar 

Clinical Trials Registry - India [Internet] (n.d.) New Delhi: ICMR-National Institute of Medical Statistics; 2007 [cited 2026 Jan 12]. Identifier CTRI/2025/06/089808, Opioid free analgesia using Dexmedetomidine vs Ketamine in infants with retinopathy of prematurity undergoing laser photocoagulation surgeries. Registered 2025 Jun 30. Available from: https://ctri.nic.in/Clinicaltrials/pmaindet2.php?EncHid=MTM1MTM0. Accessed 12 Jan 2026

Clinical Trials Registry - India [Internet] (n.d.) New Delhi: ICMR-National Institute of Medical Statistics; 2007 [cited 2026 Jan 12]. Identifier CTRI/2024/04/066305, Combination of intravenous fentanyl and ketamine vs intravenous fentanyl for analgesia during laser photocoagulation in retinopathy of prematurity in preterm neonates: a randomized control trial. Registered 2024 Apr 25. Available from: https://ctri.nic.in/Clinicaltrials/pmaindet2.php?EncHid=MTAzNDAz. Accessed 12 Jan 2026

Chandra P, Chawla (Chairperson) D, Deorari AK, Dogra MR, Jalali S, Kumar P et al (2020) Screening and management of retinopathy of prematurity. J Neonatol 34:63–82. https://doi.org/10.1177/0973217920934397

Pirelli A, Savant Levet P, Garetti E, Ancora G, Merazzi D, Bellieni CV et al (2019) Literature review informs clinical guidelines for pain management during screening and laser photocoagulation for retinopathy of prematurity. Acta Paediatr 108:593–599. https://doi.org/10.1111/apa.14523

Article  PubMed  Google Scholar 

Klein KS, Aucott S, Donohue P, Repka M (2013) Anesthetic and airway management during laser treatment for retinopathy of prematurity: a survey of US ophthalmologists and neonatologists. J AAPOS 17:221–222. https://doi.org/10.1016/j.jaapos.2012.11.007

Article  PubMed  Google Scholar 

Maxwell LG, Fraga MV, Malavolta CP (2019) Assessment of pain in the newborn: an update. Clin Perinatol 46:693–707. https://doi.org/10.1016/j.clp.2019.08.005

Article  PubMed  Google Scholar 

Stevens BJ, Gibbins S, Yamada J, Dionne K, Lee G, Johnston C et al (2014) The premature infant pain profile-revised (PIPP-R): initial validation and feasibility. Clin J Pain 30:238–243. https://doi.org/10.1097/AJP.0b013e3182906aed

Article  PubMed  Google Scholar 

Slater R, Cantarella A, Franck L, Meek J, Fitzgerald M (2008) How well do clinical pain assessment tools reflect pain in infants? PLoS Med 5:e129. https://doi.org/10.1371/journal.pmed.0050129

Article  PubMed  PubMed Central  Google Scholar 

Blencowe H, Moxon S, Gilbert C (2016) Update on blindness due to retinopathy of prematurity globally and in India. Indian Pediatr 53(Suppl 2):S89-92

PubMed  Google Scholar 

Sivanandan S, Chandra P, Deorari AK, Agarwal R (2016) Retinopathy of prematurity: AIIMS, New Delhi experience. Indian Pediatr 53(Suppl 2):S123–S128

PubMed  Google Scholar