Warsame HA, Theuri C, Abdullahi NM, Ahmed Keynan AM, Ahmed MAM (2025) Prevalence and risk factors for neonatal jaundice: a multicentre analytical cross-sectional study at neonatal intensive care units, Mogadishu, Somalia. BMJ Open 15(3):e096692. https://doi.org/10.1136/bmjopen-2024-096692
Article PubMed PubMed Central Google Scholar
Kliegman RM, St Geme JW, Blum NJ (2023) Nelson textbook of pediatrics, 22nd ed. Elsevier
Le Pichon JB, Riordan SM, Watchko J, Shapiro SM (2017) The neurological sequelae of neonatal hyperbilirubinemia: definitions, diagnosis and treatment of the kernicterus spectrum disorders. Curr Pediatr Rev 13(3):199–209. https://doi.org/10.2174/1573396313666170815100214
Article PubMed CAS Google Scholar
Maisels MJ, McDonagh AF (2008) Phototherapy for neonatal jaundice. N Engl J Med 358:920–928. https://doi.org/10.1056/NEJMct0708376
Article PubMed CAS Google Scholar
Stokowski LA (2006) Fundamentals of phototherapy for neonatal jaundice. Adv Neonatal Care 6:303–312. https://doi.org/10.1016/j.adnc.2006.08.003
Lindqvist D, Hansson M, Thomas M et al (2025) Bilirubin photoisomers in neonatal jaundice. Int J Mol Sci 26(21):10791. https://doi.org/10.3390/ijms262110791
Article PubMed PubMed Central CAS Google Scholar
Maurer HM, Shumway CN, Draper DA, Hossaini AA (1973) Controlled trial comparing agar, intermittent phototherapy, and continuous phototherapy for reducing neonatal hyperbilirubinemia. J Pediatr 82(1):73–76. https://doi.org/10.1016/s0022-3476(73)80014-9
Article PubMed CAS Google Scholar
Patel A, Vagha JD, Meshram RJ et al (2024) Illuminating progress: evolution of phototherapy for neonatal hyperbilirubinemia. Cureus 16(3):e55608. https://doi.org/10.7759/cureus.55608
Article PubMed PubMed Central Google Scholar
Mendelson S (2023) Neonatal phototherapy adverse effects: a scoping review. Med Res Arch 11(7.1). https://doi.org/10.18103/mra.v11i7.1.4099
Tan KL (2014) Postnatal management of neonatal jaundice. Acta Paediatr 103:e127–e132. https://doi.org/10.1111/apa.12490
Zhou S, Wu X, Ma A, Zhang M, Liu Y (2019) Therapeutic effect of intermittent vs continuous phototherapy in neonatal hemolytic jaundice. Exp Ther Med. https://doi.org/10.3892/etm.2019.7432
Article PubMed PubMed Central Google Scholar
Chu L, Xue X, Qiao J (2021) Efficacy of intermittent phototherapy versus continuous phototherapy for treatment of neonatal hyperbilirubinaemia: a systematic review and meta-analysis. J Adv Nurs 77(1):12–22. https://doi.org/10.1111/jan.14535
Higgins JPT, Thomas J, Chandler J (2019) Cochrane handbook for systematic reviews of interventions, 2nd ed. Wiley. https://doi.org/10.1002/9781119536604
Page MJ, McKenzie JE, Bossuyt PM et al (2021) The PRISMA 2020 statement: updated guideline for reporting systematic reviews. BMJ 372:n71. https://doi.org/10.1136/bmj.n71
Article PubMed PubMed Central Google Scholar
Wan X, Wang W, Liu J, Tong T (2014) Estimating mean and SD from median and range/IQR. BMC Med Res Methodol 14:135. https://doi.org/10.1186/1471-2288-14-135
Article PubMed PubMed Central Google Scholar
Sterne JAC, Savović J, Page MJ et al (2019) RoB 2: revised tool for risk of bias in randomized trials. BMJ 366:l4898. https://doi.org/10.1136/bmj.l4898
Thorlund K, Engstrøm J, Wetterslev J, Brok J, Imberger G, Gluud C (2011) User manual for trial sequential analysis (TSA). Copenhagen trial unit. Available at: www.ctu.dk/tsa
Wetterslev J, Thorlund K, Brok J, Gluud C (2008) Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis. J Clin Epidemiol 61(1):64–75. https://doi.org/10.1016/j.jclinepi.2007.03.013
Guyatt GH, Oxman AD, Vist GE et al (2008) GRADE: rating quality of evidence and strength of recommendations. BMJ 336:924–926. https://doi.org/10.1136/bmj.39489.470347.AD
Article PubMed PubMed Central Google Scholar
Ahmad M, Anwar M, Hussain A, Javeed A (2023) Intermittent versus continuous phototherapy among term infants presenting with non-hemolytic moderate hyperbilirubinemia at a tertiary care hospital: a randomized controlled trial. Prof Med J 30(6):695–699. https://doi.org/10.29309/TPMJ/2023.30.06.7479
Arnold C et al (2020) Intermittent phototherapy in extremely preterm infants: a randomized clinical trial. JAMA Pediatr. https://doi.org/10.1001/jamapediatrics.2020.0559
Article PubMed PubMed Central Google Scholar
Asharab M et al (2025) Comparison of intermittent versus continuous phototherapy in neonatal hyperbilirubinemia. Int J Biol Res 3(4). https://doi.org/10.70749/ijbr.v3i4.2049
Demirel HN, SevukOzumut S, Ovalı HF (2024) Continuous versus intermittent phototherapy in treatment of neonatal jaundice: a randomized controlled trial. Eur J Pediatr 183(8):3389–3396. https://doi.org/10.1007/s00431-024-05610-7
Article PubMed CAS Google Scholar
Girija G, Reddy KR, Ravichander B (2021) The efficacy of intermittent versus continuous phototherapy in the duration of phototherapy required in the given bilirubin level. Int J Paediatr Geriatr 4(1):18–21. https://doi.org/10.33545/26643685.2021.v4.i1a.119
Gottimukkala SB, Sethuraman G, Kitchanan S, Pathak S (2021) Comparison of efficacy, safety & satisfaction of intermittent versus continuous phototherapy in hyperbilirubinaemic newborns ≥35 week gestation: a randomized controlled trial. Indian J Med Res 153(4):446–452. https://doi.org/10.4103/IJMR.IJMR_2156_18
Article PubMed PubMed Central CAS Google Scholar
Gowtami GS (2019) Continuous and intermittent phototherapy in the management of neonatal hyperbilirubinemia: a randomised intervention study. MD Dissertation. BLDE (Deemed to be University), Shri B. M. Patil Medical College, Hospital & Research Centre, Vijayapura, India
Hamidi M et al (2021) Intermittent versus continuous phototherapy in neonatal hyperbilirubinemia. J Chem Health Risks. https://doi.org/10.22034/jchr.2021.1910275.1188
Kareem HM et al (2011) Comparison between continuous and intermittent phototherapy in the management of neonatal jaundice. Zanco J Med Sci 15(2):40–44
Khalid MA, Bakhtawar A, Akbar N (2017) Comparison of continuous with intermittent phototherapy technique for the management of neonatal jaundice. Med Forum 28(9):71–74
Khaliq A (2016) Comparison of continuous with intermittent phototherapy in the treatment of neonatal jaundice. J Postgrad Med Inst 30(2):173–176
Khandwal O et al (2024) Comparison between the efficacy of continuous phototherapy and intermittent phototherapy in the treatment of neonatal jaundice. Perinatology 25(2):114–122
Lau SP, Fung KP (1984) Serum bilirubin kinetics in intermittent phototherapy of physiological jaundice. Arch Dis Child. https://doi.org/10.1136/adc.59.9.892
Article PubMed PubMed Central Google Scholar
Mari A et al (2021) Comparison of intermittent versus continuous phototherapy in neonatal hyperbilirubinemia. J Pharm Res Int 33(52A):26–31. https://doi.org/10.9734/JPRI/2021/v33i52A33554
Niknafs P et al (2008) Intermittent versus continuous phototherapy in neonatal hyperbilirubinemia. Iran J Pediatr 18(3):251–256
Ong SH et al (2026) Continuous versus intermittent phototherapy in neonatal jaundice: a randomized controlled trial. Eur J Pediatr 185:67. https://doi.org/10.1007/s00431-025-06727-z
Article PubMed PubMed Central Google Scholar
Patil MM, Gowthami GS, Bijapure HR, Sajjan AK (2020) Continuous versus intermittent phototherapy in the management of non-hemolytic neonatal hyperbilirubinemia: a randomized non-inferiority study. J Nepal Paediatr Soc 40(3):185–189
Sachdeva M, Murki S, Oleti TP, Kandraju H (2015) Intermittent versus continuous phototherapy in infants >34 weeks gestation: a randomized controlled trial. Eur J Pediatr 174:177–181. https://doi.org/10.1007/s00431-014-2373-8
Comments (0)