Performance of Staging Systems for Non-head and Neck Cutaneous Squamous Cell Carcinoma

Kim JYS, Kozlow JH, Mittal B, Moyer J, Olenecki T, Rodgers P, et al. Guidelines of care for the management of cutaneous squamous cell carcinoma. J Am Acad Dermatol. 2018;78:560–78.

Article  PubMed  PubMed Central  Google Scholar 

Manyam BV, Garsa AA, Chin R, Reddy CA, Gastman B, Thorstad W, et al. A multi-institutional comparison of outcomes of immunosuppressed and immunocompetent patients treated with surgery and radiation therapy for cutaneous squamous cell carcinoma of the head and neck. Cancer. 2017;123:2054–60.

Article  CAS  PubMed  Google Scholar 

Lopez A, Babadzhanov M, Cheraghlou S, Canavan T, Doudican N, Stevenson M, et al. Immunosuppressed patients are at increased risk of local recurrence, metastasis, and disease specific death from cutaneous squamous cell carcinoma. Arch Dermatol Res. 2023;315:1429–33.

CAS  PubMed  Google Scholar 

Ruiz ES, Karia PS, Besaw R, Schmults CD. Performance of the American Joint Committee on Cancer staging manual, 8th edition vs the Brigham and Women’s Hospital tumor classification system for cutaneous squamous cell carcinoma. JAMA Dermatol. 2019;155:819.

Article  PubMed  PubMed Central  Google Scholar 

Eigentler TK, Leiter U, Häfner H-M, Garbe C, Röcken M, Breuninger H. Survival of patients with cutaneous squamous cell carcinoma: results of a prospective cohort study. J Investig Dermatol. 2017;137:2309–15.

Article  CAS  PubMed  Google Scholar 

Skulsky SL, O’Sullivan B, McArdle O, Leader M, Roche M, Conlon PJ, et al. Review of high-risk features of cutaneous squamous cell carcinoma and discrepancies between the American Joint Committee on Cancer and NCCN clinical practice guidelines in oncology. Head Neck. 2017;39:578–94.

Article  PubMed  Google Scholar 

McIlwee BE, Abidi NY, Ravi M, Carr DR. Utility of debulk specimens during Mohs micrographic surgery for cutaneous squamous cell carcinoma. Dermatol Surg. 2021;47:599–604.

Article  CAS  PubMed  Google Scholar 

Cañueto J, Burguillo J, Moyano-Bueno D, Viñolas-Cuadros A, Conde-Ferreirós A, Corchete-Sánchez LA, et al. Comparing the eighth and the seventh editions of the American Joint Committee on Cancer staging system and the Brigham and Women’s Hospital alternative staging system for cutaneous squamous cell carcinoma: implications for clinical practice. J Am Acad Dermatol. 2019;80:106-113.e2.

Article  PubMed  Google Scholar 

Venables ZC, Tokez S, Hollestein LM, Mooyaart AL, Van Den Bos RR, Rous B, et al. Validation of four cutaneous squamous cell carcinoma staging systems using nationwide data. Br J Dermatol. 2022;186:835–42.

Article  PubMed  PubMed Central  Google Scholar 

Guerra R, Shahwan KT, Nikahd M, Hyer M, Carr DR. Performance of staging systems for non-head and neck cutaneous squamous cell carcinoma. Dermatol Surg. 2024;50:121–4.

Article  CAS  PubMed  Google Scholar 

Puebla-Tornero L, Corchete-Sánchez LA, Conde-Ferreirós A, García-Sancha N, Corchado-Cobos R, Román-Curto C, et al. Performance of Salamanca refinement of the T3-AJCC8 versus the Brigham and Women’s Hospital and Tübingen alternative staging systems for high-risk cutaneous squamous cell carcinoma. J Am Acad Dermatol. 2021;84:938–45.

Article  PubMed  Google Scholar 

Karia PS, Han J, Schmults CD. Cutaneous squamous cell carcinoma: estimated incidence of disease, nodal metastasis, and deaths from disease in the United States, 2012. J Am Acad Dermatol. 2013;68:957–66.

Article  PubMed  Google Scholar 

Lydiatt WM, Patel SG, O’Sullivan B, Brandwein MS, Ridge JA, Migliacci JC, et al. Head and neck cancers—major changes in the American Joint Committee on cancer eighth edition cancer staging manual. CA Cancer J Clinicians. 2017;67:122–37.

Google Scholar 

Hallak D, Ruiz E, Ran N, Granger EE, Jambusaria-Pahlajani A, Koyfman S, et al. Protocol for establishing a large, international, multicenter cutaneous squamous cell carcinoma database. Arch Dermatol Res. 2025;317:829.

Article  Google Scholar 

Harrell FE, Califf RM, Pryor DB, Lee KL, Rosati RA. Evaluating the yield of medical tests. JAMA. 1982;247:2543–6.

Article  PubMed  Google Scholar 

Jambusaria-Pahlajani A, Kanetsky PA, Karia PS, Hwang W-T, Gelfand JM, Whalen FM, et al. Evaluation of AJCC tumor staging for cutaneous squamous cell carcinoma and a proposed alternative tumor staging system. JAMA Dermatol. 2013;149:402.

Article  CAS  PubMed  Google Scholar 

Shahwan KT, Walker TD, Tan A, Ruiz E, Ran N, Granger EE, et al. Identifying the impact of minor risk factors in Brigham and Women’s Hospital stage T1 cutaneous squamous cell carcinomas on risk of poor outcomes: a retrospective cohort study. J Am Acad Dermatol. 2025;92:1319–26.

Article  PubMed  Google Scholar 

Jambusaria-Pahlajani A, Jeanselme V, Wang DM, Ran NA, Granger EE, Cañueto J, et al. riSCC: a personalized risk model for the development of poor outcomes in cutaneous squamous cell carcinoma. J Am Acad Dermatol. 2025;93:73–81.

Article  CAS  PubMed  Google Scholar 

Wang DM, Vestita M, Murad FG, Morgan FC, Rowley R, Rettig EM, et al. Mohs surgery vs wide local excision in primary high-stage cutaneous squamous cell carcinoma. JAMA Dermatol. 2025;161:508–14.

Article  PubMed  Google Scholar 

Granger EE, Ran NA, Groover MK, Koyfman SA, Vidimos AT, Wysong A, et al. Most cutaneous squamous cell carcinoma recurrences occur in the first 3 years after diagnosis: a multicenter retrospective cohort study. J Am Acad Dermatol. 2024;91:957–60.

Article  PubMed  Google Scholar 

Brantsch KD, Meisner C, Schönfisch B, Trilling B, Wehner-Caroli J, Röcken M, et al. Analysis of risk factors determining prognosis of cutaneous squamous-cell carcinoma: a prospective study. Lancet Oncol. 2008;9:713–20.

Article  PubMed  Google Scholar 

Mourouzis C, Boynton A, Grant J, Umar T, Wilson A, Macpheson D, et al. Cutaneous head and neck SCCs and risk of nodal metastasis—UK experience. J Cranio-Maxillofac Surg. 2009;37:443–7.

Article  Google Scholar 

Schmults CD, Karia PS, Carter JB, Han J, Qureshi AA. Factors predictive of recurrence and death from cutaneous squamous cell carcinoma: a 10-year, single-institution cohort study. JAMA Dermatol. 2013;149:541.

Article  PubMed  Google Scholar 

van Lee CB, Roorda BM, Wakkee M, Voorham Q, Mooyaart AL, de Vijlder HC, et al. Recurrence rates of cutaneous squamous cell carcinoma of the head and neck after Mohs micrographic surgery vs. standard excision: a retrospective cohort study. Br J Dermatol. 2019;181:338–43.

Article  PubMed  Google Scholar 

Zakhem GA, Pulavarty AN, Carucci J, Stevenson ML. Association of patient risk factors, tumor characteristics, and treatment modality with poor outcomes in primary cutaneous squamous cell carcinoma: a systematic review and meta-analysis. JAMA Dermatol. 2023;159:160–71.

Article  PubMed  Google Scholar 

Campoli M, Brodland DG, Zitelli J. A prospective evaluation of the clinical, histologic, and therapeutic variables associated with incidental perineural invasion in cutaneous squamous cell carcinoma. J Am Acad Dermatol. 2014;70:630–6.

Article  PubMed  Google Scholar 

Thai AA, Young RJ, Bressel M, Angel C, McDowell L, Tiong A, et al. Comprehensive profiling identifies tumour and immune microenvironmental differences in clinical subsets of cutaneous squamous cell carcinoma. Br J Dermatol. 2023;189:588–602.

Article  CAS  PubMed  Google Scholar 

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