Siegel, R.L., Miller, K.D., Fuchs, H.E., and Jemal, A., Cancer statistics, Ca-Cancer J. Clin., 2022, vol. 72, pp. 7–33. https://doi.org/10.3322/caac.21708

Article  PubMed  Google Scholar 

Ansari, D., Gustafsson, A., and Andersson, R., Update on the management of pancreatic cancer: Surgery is not enough, World J. Gastroenterol., 2015, vol. 21, pp. 3157–3165. https://doi.org/10.3748/wjg.v21.i11.3157

Article  PubMed  PubMed Central  Google Scholar 

Garin, A.M. and Bazin, I.S., Morbidity, mortality, long-term outcomes and sequelae of the treatment of cancer patients in different countries of the world, Russ. J. Oncol., 2016, vol. 21, pp. 11–17. https://doi.org/10.18821/1028-9984-2016-21-1-11-17

Article  Google Scholar 

Goral, V., Cholangiocarcinoma: New insights, Asian Pac. J. Cancer Prev., 2017, vol. 18, pp. 1469–1473. https://doi.org/10.22034/APJCP.2017.18.6.1469

Article  PubMed  PubMed Central  Google Scholar 

Ballehaninna, U.K. and Chamberlain, R.S., Serum CA 19-9 as a biomarker for pancreatic cancer—A comprehensive review, Indian J. Surg. Oncol., 2011, vol. 2, pp. 88–100. https://doi.org/10.1007/s13193-011-0042-1

Article  PubMed  PubMed Central  Google Scholar 

Chzhao, A.V., Shevchenko, T.V., and Zharikov, Yu.O., A look at the Klatskin tumor problem, Khirurgiya (Moscow), 2015, vol. 4, pp. 62–67. https://doi.org/10.17116/hirurgia2015462-67

Article  Google Scholar 

Wood, L.D., Canto, M.I., Jaffee, E.M., and Simeone, D.M., Pancreatic cancer: Pathogenesis, screening, diagnosis, and treatment, Gastroenterology, 2022, vol. 163, pp. 386–402. https://doi.org/10.1053/j.gastro.2022.03.056

Article  PubMed  Google Scholar 

Satriano, L., Lewinska, M., Rodrigues, P.M., et al., Metabolic rearrangements in primary liver cancers: Cause and consequences, Nat. Rev. Gastroenterol. Hepatol., 2019, vol. 16, pp. 748–766. https://doi.org/10.1038/s41575-019-0217-8

Article  CAS  PubMed  Google Scholar 

Dolbnya, A.D., Popov, I.A., and Pekov, S.I., Molecular biomarkers in cholangiocarcinoma: Focus on bile, Curr. Top. Med. Chem., 2024, vol. 24, pp. 722–736. https://doi.org/10.2174/0115680266290367240130054142

Article  CAS  PubMed  Google Scholar 

Bernstein, H., Bernstein, C., Payne, C.M., Dvorakova, K., and Garewal, H., Bile acids as carcinogens in human gastrointestinal cancers, Mutat. Res., 2005, vol. 589, pp. 47–65. https://doi.org/10.1016/j.mrrev.2004.08.001

Article  CAS  PubMed  Google Scholar 

Chiang, J.Y., Regulation of bile acid synthesis: Pathways, nuclear receptors, and mechanisms, J. Hepatol., 2004, vol. 40, pp. 539–551. https://doi.org/10.1016/j.jhep.2003.11.006

Article  CAS  PubMed  Google Scholar 

Russell, D.W., The enzymes, regulation, and genetics of bile acid synthesis, Annu. Rev. Biochem., 2003, vol. 72, pp. 137–174. https://doi.org/10.1146/annurev.biochem.72.121801.161712

Article  CAS  PubMed  Google Scholar 

Keppler, D., Progress in the molecular characterization of hepatobiliary transporters, Dig. Dis., 2017, vol. 35, pp. 197–202. https://doi.org/10.1159/000450911

Article  PubMed  Google Scholar 

Dawson, P.A., Lan, T., and Rao, A., Bile acid transporters, J. Lipid Res., 2009, vol. 50, pp. 2340–2357. https://doi.org/10.1194/jlr.R900012-JLR200

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li, T. and Apte, U., Bile acid metabolism and signaling in cholestasis, inflammation, and cancer, Adv. Pharmacol., 2015, vol. 74, pp. 263–302. https://doi.org/10.1016/bs.apha.2015.04.003

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nguyen, J.T., Shaw, R.P.H., and Anakk, S., Bile acids-a peek into their history and signaling, Endocrinology, 2022, vol. 163, p. bqac155. https://doi.org/10.1210/endocr/bqac155

Režen, T., Rozman, D., Kovács, T., Kovács, P., Sipos, A., Bai, P., and Mikó, E., The role of bile acids in carcinogenesis, Cell Mol. Life Sci., 2022, vol. 79, p. 243. https://doi.org/10.1007/s00018-022-04278-2

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chiang, J.Y., Bile acid metabolism and signaling, Comp-r. Physiol., 2013, vol. 3, pp. 1191–1212. https://doi.org/10.1002/cphy.c120023

Article  Google Scholar 

Park, J.Y., Park, B.K., Ko, J.S., et al., Bile acid analysis in biliary tract cancer, Yonsei Med. J., 2006, vol. 6, pp. 817–825. https://doi.org/10.3349/ymj.2006.47.6.817

Article  Google Scholar 

Vitale, G.C., Siow, Y., Baker, P.R., and Cuschieri, A., Reversible bile acid changes in bile duct obstruction and its potential for hepatocellular injury, J. Hepatol., vol. 14, pp. 151–156. https://doi.org/10.1016/0168-8278(92)90151-e

Albiin, N., Smith, I.C.P., Arnelo, U., et al., Detection of cholangiocarcinoma with magnetic resonance spectroscopy of bile in patients with and without primary sclerosing cholangitis, Acta Radiol., 2008, vol. 8, pp. 855–862. https://doi.org/10.1080/02841850802220092

Article  Google Scholar 

Rees, D.O., Crick, P.J., Jenkins, G.J., et al., Comparison of the composition of bile acids in bile of patients with adenocarcinoma of the pancreas and benign disease, J. Steroid Biochem. Mol. Biol., 2017, vol. 174, pp. 290–295. https://doi.org/10.1016/j.jsbmb.2017.10.011

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Aguiar Vallim, T.Q., Tarling, E.J., and Edwards, P.A., Pleiotropic roles of bile acids in metabolism, Cell Metab., 2013, vol. 17, pp. 657–669. https://doi.org/10.1016/j.cmet.2013.03.013

Article  CAS  PubMed  PubMed Central  Google Scholar 

Humbert, L., Maubert, M.A., Wolf, C., Duboc, H., Mahé, M., Farabos, D., Seksik, P., Mallet, J.M., Trugnan, G., Masliah, J., and Rainteau, D., Bile acid profiling in human biological samples: Comparison of extraction procedures and application to normal and cholestatic patients, J. Chromatogr. B: Anal. Technol. Biomed. Life Sci., 2012, vol. 899, pp. 135–145. https://doi.org/10.1016/j.jchromb.2012.05.015

Article  CAS  Google Scholar 

Rappsilber, J., Mann, M., and Ishihama, Y., Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips, Nat. Protoc., 2007, vol. 8, pp. 1896–1906. https://doi.org/10.1038/nprot.2007.261

Article  CAS  Google Scholar 

Sarafian, M.H., Lewis, M.R., Pechlivanis, A., et al., Bile acid profiling and quantification in biofluids using ultra-performance liquid chromatography tandem mass spectrometry, Anal. Chem., 2015, vol. 19, pp. 9662–9670. https://doi.org/10.1021/acs.analchem.5b01556

Article  CAS  Google Scholar 

Jia, Y., et al., Rapid determination of 20 bile acids in human serum by ultra performance liquid chromatography–tandem mass spectrometry, Biomed. Chr-omatogr., 2021, vol. 5, p. e5063. https://doi.org/10.1002/bmc.5063

Article  CAS  Google Scholar 

Bobeldijk, I., Hekman, M., de Vries-van der Weij, J., et al., Quantitative profiling of bile acids in biofluids and tissues based on accurate mass high resolution LC-FT-MS: Compound class targeting in a metabolomics workflow, J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2008, vol. 2, pp. 306–313. https://doi.org/10.1016/j.jchromb.2008.05.008

Alpini, G., Glaser, S., Robertson, W., Phinizy, J.L., Rodgers, R.E., Caligiuri, A., and LeSage, G., Bile acids stimulate proliferative and secretory events in large but not small cholangiocytes, Am. J. Physiol., 1997, vol. 273, pp. 518–529. https://doi.org/10.1152/ajpgi.1997.273.2.G518

Article  Google Scholar 

Liu, R., Zhao, R., Zhou, X., Liang, X., Campbell, D.J., Zhang, X., Zhang, L., Shi, R., Wang, G., Pandak, W.M., Sirica, A.E., Hylemon, P.B., and Zhou, H., Conjugated bile acids promote cholangiocarcinoma cell invasive growth through activation of sphingosine 1-phosphate receptor 2, Hepatology, 2014, vol. 60, pp. 908–918. https://doi.org/10.1002/hep.27085

Article  CAS  PubMed  Google Scholar 

Studer, E., Zhou, X., Zhao, R., Wang, Y., Takabe, K., Nagahashi, M., Pandak, W.M., Dent, P., Spiegel, S., Shi, R., Xu, W., Liu, X., Bohdan, P., Zhang, L., Zhou, H., and Hylemon, P.B., Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes, Hepatology, 2012, vol. 55, pp. 267–276. https://doi.org/10.1002/hep.24681

Article  CAS  PubMed  Google Scholar 

Luo, X., Liu, J., Wang, H., and Lu, H., Metabolomics identified new biomarkers for the precise diagnosis of pancreatic cancer and associated tissue metastasis, Pharmacol. Res., 2020, vol. 156, p. 104805. https://doi.org/10.1016/j.phrs.2020.104805

Article  CAS  PubMed