Dacarbazine Increases Melanoma BRO Cell Adhesion to the Extracellular Matrix Components

Pourjamal, N., Yazdi, N., Halme, A., Joncour, V.L., Laakkonen, P., et al., Comparison of trastuzumab emtansine, trastuzumab deruxtecan, and disitamab vedotin in a multiresistant HER2-positive breast cancer lung metastasis model, Clin. Exp. Metastasis, 2024, vol. 41, pp. 91–102. https://doi.org/10.1007/s10585-024-10278-2

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fares, J., Fares, M.Y., Khachfe, H.H., Salhab, H.A., and Fares, Y., Molecular principles of metastasis: A hallmark of cancer revisited, Signal Transduction Targeted Ther., 2020, vol. 5, p. 28. https://doi.org/10.1038/s41392-020-0134-x

Article  Google Scholar 

Sergeeva, E., Ruksha, T., and Fefelova, Y., Effects of obesity and calorie restriction on cancer development, Int. J. Mol. Sci., 2023, vol. 24, p. 9601. https://doi.org/10.3390/ijms24119601

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sleeboom, J.J.F., van Tienderen, G.S., Schenke-Layland, K., van der Laan, L.J.W., et al., The extracellular matrix as hallmark of cancer and metastasis: From Biomechanics to therapeutic targets, Sci. Transl. Med., 2024, vol. 16, p. eadg3840. https://doi.org/10.1126/scitranslmed.adg3840

Esimbekova, A.R., Palkina, N.V., Zinchenko, I.S., Belenyuk, V.D., Savchenko, A.A., et al., Focal adhesion alterations in G0-positive melanoma cells, Cancer Med., 2023, vol. 12, pp. 7294–7308. https://doi.org/10.1002/cam4.5510

Article  CAS  PubMed  Google Scholar 

Jiang, G., Li, R.H., Sun, C., Liu, Y.Q., and Zheng, J.N., Dacarbazine combined targeted therapy versus dacarbazine alone in patients with malignant melanoma: A meta-analysis, PLoS One, 2014, vol. 9, p. e111920. https://doi.org/10.1371/journal.pone.0111920

Article  CAS  PubMed  Google Scholar 

Roy, A. and Gauld, J.W., Sulfilimine bond formation in collagen IV, Chem. Commun. (Cambridge, U. K.), 2024, vol. 60, pp. 646–657. https://doi.org/10.1039/D3CC05715A

Article  CAS  Google Scholar 

Qu, J., Cheng, X., Liu, M., and Zhang, Q., CTNND2 gene expression in melanoma tissues and its effects on the malignant biological functions of melanoma cells, Transl. Cancer Res., 2024, vol. 13, pp. 6347–6363. https://doi.org/10.21037/tcr-24-2159

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dalton, C.J. and Lemmon, C.A., Fibronectin: Molecular structure, fibrillar structure and mechanochemical signaling, Cells, 2021, vol. 10, p. 2443. https://doi.org/10.3390/cells10092443

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li, M., Chen, L., Wang, M., Huang, X., Ke, Q., et al., Curcumin alleviates the aggressiveness of breast cancer through inhibiting cell adhesion mediated by TEAD4-fibronectin axis, Biochem. Pharmacol., 2025, vol. 232, p. 116690. https://doi.org/10.1016/j.bcp.2024.116690

Article  CAS  PubMed  Google Scholar 

Ando, T., Tai-Nagara, I., Sugiura, Y., Kusumoto, D., Okabayashi, K., et al., Tumor-specific interendothelial adhesion mediated by FLRT2 facilitates cancer aggressiveness, J. Clin. Invest., 2022, vol. 132, p. e153626. https://doi.org/10.1172/JCI153626

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hao, N., Yang, D., Liu, T., Liu, S., Lu, X., et al., Laminin-integrin a6b4 interaction activates notch signaling to facilitate bladder cancer development, BMC Cancer, 2022, vol. 22, p. 558. https://doi.org/10.1186/s12885-022-09645-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ruzha, Y., Ni, J., Quan, Z., Li, H., and Qing, H., Role of vitronectin and its receptors in neuronal function and neurodegenerative diseases, Int. J. Mol. Sci., 2022, vol. 23, p. 12387. https://doi.org/10.3390/ijms232012387

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bera, A., Subramanian, M., Karaian, J., Eklund, M., Radhakrishnan, S., et al., Functional role of vitronectin in breast cancer, PLoS One, 2020, vol. 15, p. e0242141. https://doi.org/10.1371/journal.pone.0242141

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee, Y.C., Lin, S.C., Yu, G., Zhu, M., Song, J.H., et al., Prostate tumor-induced stromal reprogramming generates Tenascin C that promotes prostate cancer metastasis through YAP/TAZ inhibition, Oncogene, 2022, vol. 41, pp. 757–769. https://doi.org/10.1038/s41388-021-02131-7

Article  CAS  PubMed  Google Scholar 

Pobbati, A.V. and Hong, W. A combat with the YAP/TAZ-TEAD oncoproteins for cancer therapy, Theranostics, 2020, vol. 10, pp. 3622–3635. https://doi.org/10.7150/thno.40889

Article  CAS  PubMed  PubMed Central  Google Scholar 

Isono, K., Nemoto, K., Li, Y., Takada, Y., Suzuki, R., et al., Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals, Mol. Cell Biol., 2006, vol. 26, pp. 2758–2771. https://doi.org/10.1128/MCB.26.7.2758-2771.2006

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ventura, E., Iannuzzi, C.A., Pentimalli, F., Giordano, A., and Morrione, A., RBL1/p107 expression levels are modulated by multiple signaling pathways, Cancers, 2021, vol. 13, p. 5025. https://doi.org/10.3390/cancers13195025

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ng, S.R., Rideout, W.M. III, Akama-Garren, E.H., Bhutkar, A., Mercer, K.L., et al., CRISPR-mediated modeling and functional validation of candidate tumor suppressor genes in small cell lung cancer, Proc. Natl. Acad. Sci. U. S. A., 2020, vol. 117, pp. 513–521. https://doi.org/10.1073/pnas.1821893117

Article  CAS  PubMed  Google Scholar 

Pang, X., He, X., Qiu, Z., Zhang, H., Xie, R., et al., Targeting integrin pathways: Mechanisms and advances in therapy, Signal Transduction Targeted Ther., 2023, vol. 8, p. 1. https://doi.org/10.1038/s41392-022-01259-6

Article  CAS  Google Scholar 

Katkat, E., Demirci, Y., Heger, G., Karagulle, D., Papatheodorou, I., et al., Canonical Wnt and TGF-β/BMP signaling enhance melanocyte regeneration but suppress invasiveness, migration, and proliferation of melanoma cells, Front. Cell Dev. Biol., 2023, vol. 11, p. 1297910. https://doi.org/10.3389/fcell.2023.1297910

Article  PubMed  PubMed Central  Google Scholar 

Maia, A., Gu, Z., Koch, A., Berdiel-Acer, M., Will, R., Schlesner, M., and Wiemann, S., IFNβ1 secreted by breast cancer cells undergoing chemotherapy reprograms stromal fibroblasts to support tumour growth after treatment, Mol. Oncol., 2021, vol. 15, pp. 1308–1329. https://doi.org/10.1002/1878-0261.12905

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cui, Q., Wang, B., Li, K., Sun, H., Hai, T., et al., Upregulating MMP-1 in carcinoma-associated fibroblasts reduces the efficacy of Taxotere on breast cancer synergized by Collagen IV, Oncol. Lett., 2018, vol. 16, pp. 3537–3544. https://doi.org/10.3892/ol.2018.9092

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yeh, Y.W., Hsu, T.W., Su, Y.H., Wang, C.H., Liao, P.H., et al., Silencing of Dicer enhances dacarbazine resistance in melanoma cells by inhibiting ADSL expression, Aging, 2023, vol. 15, pp. 12873–12889. https://doi.org/10.18632/aging.205207

Article  CAS  PubMed  PubMed Central  Google Scholar 

Comments (0)

No login
gif