Evaluation of Ornithine Decarboxylase and Ferric Reducing Capacity Levels as Potential Biomarkers for Polycystic Ovary Syndrome

Fahs, D., Salloum, D., Nasrallah, M., and Ghazeeri, G., Polycystic ovary syndrome: Pathophysiology and controversies in diagnosis, Diagnostics, 2023, vol. 13, no. 9, p. 1559.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Marques, P., Skorupskaite, K., Rozario, K.S., Anderson, R.A., and George, J.T., Physiology of GNRH and gonadotropin secretion, Endotext , 2022.

Google Scholar 

Karkera, S., Agard, E., and Sankova, L., The clinical manifestations of polycystic ovary syndrome (PCOS) and the treatment options, Eur. J. Biol. Med. Sci. Res., 2023, vol. 11, no. 1, pp. 57–91.

Article  Google Scholar 

Rao, P. and Bhide, P., Controversies in the diagnosis of polycystic ovary syndrome, Ther. Adv. Reprod. Health, 2020, vol. 14, p. 2633494120913032.

Article  PubMed  PubMed Central  Google Scholar 

Liew, F.F., Dutta, S., and Sengupta, P., Fertility treatment-induced oxidative stress and reproductive disorders, J. Integr. Sci. Technol., 2024, vol. 12, no. 3, р. 756.

Piri-Gharaghie, T., Polycystic ovary syndrome and genetic factors influencing its development: A review article, Pers. Med. J., 2021, vol. 6, no. 23, pp. 25–29.

Google Scholar 

Parker, J., O’brien, C., Hawrelak, J., and Gersh, F.L., Polycystic ovary syndrome: An evolutionary adaptation to lifestyle and the environment, Int. J. Environ. Res. Public Health, 2022, vol. 19, no. 3, p. 1336.

Article  CAS  PubMed  PubMed Central  Google Scholar 

AlHussain, F., AlRuthia, Y., Al-Mandeel, H., Bellahwal, A., Alharbi, F., Almogbel, Y., et al., Metformin improves the depression symptoms of women with polycystic ovary syndrome in a lifestyle modification program, Patient Prefer. Adherence, 2020, pp. 737–746.

Ee, C., Pirotta, S., Mousa, A., Moran, L., and Lim, S., Providing lifestyle advice to women with PCOS: An overview of practical issues affecting success, BMC Endocr. Disord., 2021, vol. 21, p. 234.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Russell, D.H., The physiological significance of ornithine decarboxylase, in The Physiology of Polyamines, CRC Press, 2021, vol. 1, pp. 255–279.

Google Scholar 

Kang, B., Wang, X., An, X., Ji, C., Ling, W., Qi, Y., et al., Polyamines in ovarian aging and disease, Int. J. Mol. Sci., 2023, vol. 24, no. 20, p. 15330.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yurdagul, A., Jr., Kong, N., Gerlach, B.D., Wang, X., Ampomah, P., Kuriakose, G., et al., ODC (ornithine decarboxylase)-dependent putrescine synthesis maintains MerTK (MER tyrosine-protein kinase) expression to drive resolution, Arterioscler., Thromb., Vasc. Bi-ol., 2021, vol. 41, no. 3, pp. e144–e159.

Google Scholar 

Mate, N.A., Wadhwa, G., Taliyan, R., and Banerjee, A., Impact of polyamine supplementation on GnRH expression, folliculogenesis, and puberty onset in young mice, Theriogenology, 2024, vol. 229, pp. 202–213.

Article  CAS  PubMed  Google Scholar 

Ramil, R.J.D., Assessment on the physicochemical and phytochemical properties, nutritional and heavy metal contents, and antioxidant activities of Hylocereus polyrhizus peel from Northern Philippines, Indian J. Sci. Technol., 2021, vol. 14, p. 2286.

Article  Google Scholar 

Niepsuj, J., Franik, G., Madej, P., Piwowar, A., and Bizoń, A., Evaluation of pro/antioxidant imbalance in blood of women with polycystic ovary syndrome based on determination of oxidized low-density lipoproteins and ferric reducing ability of plasma values, Biomedicines, 2022, vol. 10, no. 7, p. 1564.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Benzie, I.F. and Strain, J.J., The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: The FRAP assay, Anal. Biochem., 1996, vol. 239, no. 1, pp. 70–76.

Article  CAS  PubMed  Google Scholar 

Bhattacharya, K., Saha, I., Sen, D., Bose, C., Chaudhuri, G.R., Dutta, S., et al., Role of anti-Mullerian hormone in polycystic ovary syndrome, Middle East Fertil. Soc. J., 2022, vol. 27, no. 1, p. 32.

Article  Google Scholar 

Shrikhande, L., Shrikhande, B., and Shrikhande, A., AMH and its clinical implications, J. Obstet. Gynecol. India, 2020, vol. 70, no. 5, pp. 337–341.

Article  Google Scholar 

Dewailly, D., Barbotin, A.-L., Dumont, A., Catteau-Jonard, S., and Robin, G., Role of anti-Müllerian hormone in the pathogenesis of polycystic ovary syndrome, Front. Endocrinol., 2020, vol. 11, p. 641.

Article  Google Scholar 

Palmerola, K.L., Montenegro, M., Bustillo, M., Collazo, I., Valdes, Y., and Arora, H., Subclinical inflammation linked to elevated AMH levels and decreased IVF pregnancy rates, Fertil. Steril., 2023, vol. 120, no. 4, p. e246.

Article  Google Scholar 

Bongrani, A., Plotton, I., Mellouk, N., Ramé, C., Guerif, F., Froment, P., et al., High androgen concentrations in follicular fluid of polycystic ovary syndrome women, Reprod. Biol. Endocrinol., 2022, vol. 20, no. 1, p. 88.

Article  CAS  PubMed  PubMed Central  Google Scholar 

de las Heras, M. and Calandra, R., Androgen-dependence of ornithine decarboxylase in the rat, J. Reprod. Fertil., 1987, vol. 79, pp. 9–14.

Article  CAS  PubMed  Google Scholar 

Rui, H., Brekke, I., Mørkås, L., and Purvis, K., Androgen interaction with the polyamine system of the rat prostate, Andrologia, 1987, vol. 19, no. 2, pp. 134–142.

Article  CAS  PubMed  Google Scholar 

Zhou, Z., Chen, H., Chu, L., Zou, Q., Chen, Q., Yang, J., et al., The effects of metformin on anti-Müllerian hormone levels in patients with polycystic ovary syndrome: A systematic review and meta-analysis, J. Ovarian Res., 2023, vol. 16, no. 1, p. 123.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mehdinezhad Roshan, M., Sohouli, M.H., Izze da Silva Magalhães, E., and Hekmatdoost, A., Effect of metformin on anti-mullerian hormone levels in women with polycystic ovarian syndrome: A systematic review and meta-regression analysis of randomized controlled trials with, BMC Endocr. Disord., 2024, vol. 24, no. 1, p. 43.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ohara, M., Yoshida-Komiya, H., Ono-Okutsu, M., Yamaguchi-Ito, A., Takahashi, T., and Fujimori, K., Metformin reduces androgen receptor and upregulates homeobox A10 expression in uterine endometrium in women with polycystic ovary syndrome, Reprod. Biol. Endocrinol., 2021, vol. 19,pp. 77.

Mastnak, L., Herman, R., Ferjan, S., Janež, A., and Jensterle, M., Prolactin in polycystic ovary syndrome: Metabolic effects and therapeutic prospects, Life, 2023, vol. 13, no. 11, p. 2124.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Davoudi, Z., Araghi, F., Vahedi, M., Mokhtari, N., and Gheisari, M., Prolactin level in polycystic ovary syndrome (PCOS): An approach to the diagnosis and management, Acta Bio Med. Atenei Parmensis, 2021, vol. 92, no. 5.

Goyal, A. and Ganie, M.A., Idiopathic hyperprolactinemia presenting as polycystic ovary syndrome in identical twin sisters: A case report and literature review, Cureus, 2018, vol. 10, no. 7, p. e3004.

Krysiak, R., Kowalcze, K., and Okopień, B., The impact of metformin on prolactin levels in postmenopausal women, J. Clin. Pharm. Ther., 2021, vol. 46, no. 5, pp. 1433–1440.

Article  CAS  PubMed  Google Scholar 

Krysiak, R., Kowalcze, K., Szkróbka, W., and Okopień, B., Impaired prolactin-lowering effects of metformin in women with polycystic ovary syndrome, J. Clin. Med., 2023, vol. 12, no. 17, p. 5474.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee, H.J., Jo, H.N., Noh, H.K., Kim, S.H., and Joo, J.K., Is there association between thyroid stimulating hormone levels and the four phenotypes in polycystic ovary syndrome?, Ginekol. Pol., 2023, vol. 94, no. 3, pp. 203–210.

Article  Google Scholar 

Khan, A.A., Sharma, R., Ata, F., Khalil, S.K., Aldien, A.S., Hasnain, M., et al., Systematic review of the association between thyroid disorders and hyperprolactinemia, Thyroid Res., 2025, vol. 18, no. 1, p. 1.

Article  PubMed  PubMed Central  Google Scholar 

Cai, J., Zhang, Y., Wang, Y., Li, S., Wang, L., Zheng, J., et al., High thyroid stimulating hormone level is associated with hyperandrogenism in euthyroid polycystic ovary syndrome (PCOS) women, independent of age, BMI, and thyroid autoimmunity: A cross-sectional analysis, Front. Endocrinol., 2019, vol. 10, p. 222.

Article  CAS  Google Scholar 

Cannarella, R., Condorelli, R., Barbagallo, F., Aversa, A., Calogero, A., and La Vignera, S., TSH lowering effects of metformin: A possible mechanism of action, J. Endocrinol. Invest., 2021, vol. 44, pp. 1547–1550.

Article  CAS  PubMed  Google Scholar 

Amirabadizadeh, A., Amouzegar, A., Mehran, L., and Azizi, F., The effect of metformin therapy on serum thyrotropin and free thyroxine concentrations in patients with type 2 diabetes: A meta-analysis, Sci. Rep., 2023, vol. 13, no. 1, p. 18757.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ali, S.E. and Khaleel, F.M., Assessing the activity of renin and GST in the serum of ladies suffering from polycystic ovary syndrome and COVID-19 to predict the danger of cardiac disease, Baghdad Sci. J., 2023, vol. 20, no. 3, pp. 0986–0993.

Silander, K.M., Pihlajamaa, P., Sahu, B., Jänne, O.A., and Andersson, L.C., Characterization of an androgen-responsive, ornithine decarboxylase-related protein in mouse kidney, Biosci. Rep., 2017, vol. 37, no. 4, p. BSR20170163.

Article  CAS 

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