Osteoporotic Fractures of the Proximal Humerus: an In-Depth Review of Current Management Options

Porter JL, Varacallo M, Castano M. Osteoporosis (Nursing). StatPearls [Internet]: StatPearls Publishing; 2023.

Google Scholar 

Rosen CJ et al. The epidemiology and pathogenesis of osteoporosis. In: Feingold KR, Ahmed SF, Anawalt B, Blackman MR, Boyce A, Chrousos G, editors. Endotext2000.

Varacallo MA, Fox EJ. Osteoporosis and its complications. Med Clin North Am. 2014;98(4):817–31. https://doi.org/10.1016/j.mcna.2014.03.007.

Article  PubMed  Google Scholar 

Lee SH, Dargent-Molina P, Bréart G. Risk factors for fractures of the proximal humerus: results from the EPIDOS prospective study. J Bone Miner Res. 2002;17(5):817–25.

Article  PubMed  Google Scholar 

Olsson C, Nordquist A, Petersson CJ. Long-term outcome of a proximal humerus fracture predicted after 1 year: a 13-year prospective population-based follow-up study of 47 patients. Acta Orthop. 2005;76(3):397–402.

Article  PubMed  Google Scholar 

Court-Brown CM, Caesar B. Epidemiology of adult fractures: A review. Injury. 2006;37(8):691–7. https://doi.org/10.1016/j.injury.2006.

Article  PubMed  Google Scholar 

Palvanen M, Kannus P, Niemi S, Parkkari J. Update in the epidemiology of proximal humeral fractures. Clin Orthop Relat Res. 2006;442:87–92. https://doi.org/10.1097/01.blo.0000194672.79634.78.

Article  PubMed  Google Scholar 

Clarke B. Normal bone anatomy and physiology. Clin J Am Soc Nephrol. 2008;3(Supplement3):S131–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu L, Tang Y, Li X-Y, Keller ET, Yang J, Cho J-S, et al. Osteoclast-mediated bone resorption is controlled by a compensatory network of secreted and membrane-tethered metalloproteinases. Sci Transl Med. 2020;12(529):eaaw6143.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Long F. Building strong bones: molecular regulation of the osteoblast lineage. Nat Rev Mol Cell Biol. 2012;13(1):27–38.

Article  CAS  Google Scholar 

Feng X, McDonald JM. Disorders of bone remodeling. Annu Rev Pathol. 2011;6(1):121–45.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Parfitt AM. The coupling of bone formation to bone resorption: a critical analysis of the concept and of its relevance to the pathogenesis of osteoporosis. Elsevier; 1982. pp. 1–6.

Adejuyigbe B, Kallini J, Chiou D, Kallini JR. Osteoporosis: molecular pathology, diagnostics, and therapeutics. Int J Mol Sci. 2023;24(19):14583.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cummings SR, Browner W, Black D, Nevitt M, Genant H, Cauley J, et al. Bone density at various sites for prediction of hip fractures. Lancet. 1993;341(8837):72–5.

Article  CAS  PubMed  Google Scholar 

Kalpakcioglu BB, Morshed S, Engelke K, Genant HK. Advanced imaging of bone macrostructure and microstructure in bone fragility and fracture repair. J Bone Joint Surg. 2008;90(Supplement1):68–78.

Article  PubMed  Google Scholar 

Ciarelli T, Fyhrie D, Schaffler M, Goldstein S. Variations in three-dimensional cancellous bone architecture of the proximal femur in female hip fractures and in controls. J Bone Miner Res. 2000;15(1):32–40.

Article  CAS  PubMed  Google Scholar 

He Z, Chu L, Liu X, Han X, Zhang K, Yan M, et al. Differences in subchondral trabecular bone microstructure and finite element analysis-based biomechanical properties between osteoporosis and osteoarthritis. J Orthop Translat. 2020;24:39–45.

Article  PubMed  PubMed Central  Google Scholar 

Legrand E, Chappard D, Pascaretti C, Duquenne M, Krebs S, Rohmer V, et al. Trabecular bone microarchitecture, bone mineral density, and vertebral fractures in male osteoporosis. J Bone Miner Res. 2000;15(1):13–9.

Article  CAS  PubMed  Google Scholar 

Liu XS, Sajda P, Saha PK, Wehrli FW, Guo XE. Quantification of the roles of trabecular microarchitecture and trabecular type in determining the elastic modulus of human trabecular bone. J Bone Miner Res. 2006;21(10):1608–17.

Article  PubMed  Google Scholar 

Parfitt A, Mathews C, Villanueva A, Kleerekoper M, Frame B, Rao D. Relationships between surface, volume, and thickness of Iliac trabecular bone in aging and in osteoporosis. Implications for the microanatomic and cellular mechanisms of bone loss. J Clin Invest. 1983;72(4):1396–409.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Calvo E, Morcillo D, Foruria AM, Redondo-Santamaría E, Osorio-Picorne F, Caeiro JR. Nondisplaced proximal humeral fractures: high incidence among outpatient-treated osteoporotic fractures and severe impact on upper extremity function and patient subjective health perception. J Shoulder Elb Surg. 2011;20(5):795–801.

Article  Google Scholar 

Prince RL, Lewis JR, Lim WH, Wong G, Wilson KE, Khoo BC, et al. Adding lateral spine imaging for vertebral fractures to densitometric screening: improving ascertainment of patients at high risk of incident osteoporotic fractures. J Bone Miner Res. 2019;34(2):282–9. https://doi.org/10.1002/jbmr.3595.

Article  PubMed  Google Scholar 

Rachner TD, Hofbauer LC, Göbel A, Tsourdi E. Novel therapies in osteoporosis: PTH-related peptide analogs and inhibitors of sclerostin. J Mol Endocrinol. 2019;62(2):R145–54. https://doi.org/10.1530/jme-18-0173.

Article  CAS  PubMed  Google Scholar 

Johnell O, Kanis J. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int. 2006;17(12):1726–33.

Article  CAS  PubMed  Google Scholar 

Hsu SH, Chen LR, Chen KH. Primary osteoporosis induced by androgen and estrogen deficiency: the molecular and cellular perspective on pathophysiological mechanisms and treatments. Int J Mol Sci. 2024. https://doi.org/10.3390/ijms252212139.

Article  PubMed  PubMed Central  Google Scholar 

Panday K, Gona A, Humphrey MB. Medication-induced osteoporosis: screening and treatment strategies. Ther Adv Musculoskelet Dis. 2014;6(5):185–202. https://doi.org/10.1177/1759720x14546350.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sobh MM, Abdalbary M, Elnagar S, Nagy E, Elshabrawy N, Abdelsalam M, et al. Secondary osteoporosis and metabolic bone diseases. J Clin Med. 2022;11(9):2382. https://doi.org/10.3390/jcm11092382.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pouresmaeili F, Kamalidehghan B, Kamarehei M, Goh YM. A comprehensive overview on osteoporosis and its risk factors. Ther Clin Risk Manag. 2018;14:2029–49. https://doi.org/10.2147/tcrm.S138000.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schumaier A, Grawe B. Proximal humerus fractures: evaluation and management in the elderly patient. Geriatr Orthop Surg Rehabil. 2018;9:2151458517750516. https://doi.org/10.1177/2151458517750516.

Article  PubMed  PubMed Central  Google Scholar 

Court-Brown CM, Garg A, McQueen MM. The epidemiology of proximal humeral fractures. Acta Orthop Scand. 2001;72(4):365–71.

Article  CAS  PubMed  Google Scholar 

Karl JW, Olson PR, Rosenwasser MP. The epidemiology of upper extremity fractures in the united States, 2009. J Orthop Trauma. 2015;29(8):e242-4.

Article  PubMed  Google Scholar 

Launonen AP, Lepola V, Saranko A, Flinkkilä T, Laitinen M, Mattila VM. Epidemiology of proximal humerus fractures. Arch Osteoporos. 2015;10(1):2.

Article  Google Scholar 

Sumrein B, Huttunen T, Launonen A, Berg H, Felländer-Tsai L, Mattila V. Proximal humeral fractures in Sweden—a registry-based study. Osteoporos Int. 2017;28(3):901–7.

Article  CAS  PubMed 

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