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A Fragile Phosphate/Pyrophosphate Balance: From Essential Mineralization to Rare Calcifying Diseases
A Fragile Phosphate/Pyrophosphate Balance: From Essential Mineralization to Rare Calcifying Diseases
Calcification, the deposition of phosphate-calcium crystals, is essential for the development and function of mineralized ...
Ageing-Related Changes in Ultrastructural Bone Matrix Composition and Osteocyte Mechanosensitivity
Ageing-Related Changes in Ultrastructural Bone Matrix Composition and Osteocyte Mechanosensitivity
Bone matrix is a multiscale composite material mainly composed of collagen, crystalline apatite mineral, water, and a smal...
Pathophysiology of Femoral Fractures in Hypophosphatasia
Pathophysiology of Femoral Fractures in Hypophosphatasia
In this review, we will examine the pathophysiology, anatomy, biochemistry, and genotype-phenotype correlation of femoral ...
Bone Marrow Adipoq-lineage Progenitors: an Emerging Osteoclast Niche Cell Population
Bone Marrow Adipoq-lineage Progenitors: an Emerging Osteoclast Niche Cell Population
The purpose of this review is to summarize and highlight the recent findings of a novel osteoclastic niche centered on the...
Pathophysiology of Bone Fragility in Type 2 Diabetes Mellitus
Pathophysiology of Bone Fragility in Type 2 Diabetes Mellitus
Individuals with type 2 diabetes mellitus (T2DM) are at greater risk of fragility fractures compared to those without diab...
Fracture Risk in Type 2 Diabetes: Systematic Review of Cardiovascular Outcome Trials with Glucagon Like Peptide Receptor Agonists
Fracture Risk in Type 2 Diabetes: Systematic Review of Cardiovascular Outcome Trials with Glucagon Like Peptide Receptor Agonists
This systematic review examined the available evidence on fracture risk in people with type 2 diabetes (T2D) using cardiov...
Epidemiology, Pathophysiology and Management of Atypical Femur Fractures: an Update
Epidemiology, Pathophysiology and Management of Atypical Femur Fractures: an Update
To summarise recent publications addressing the epidemiology, pathogenesis and management of atypical femur fractures (AFF...
The Role of Osteoporosis in Spine Surgery and Current Management Strategies: A Review
The Role of Osteoporosis in Spine Surgery and Current Management Strategies: A Review
Osteoporosis is a systemic skeletal disease that presents unique challenges in spine surgery due to decreased bone mass, p...
Leveraging Proteomics and Proteogenomics for Understanding Osteoporosis and Other Musculoskeletal Diseases
Leveraging Proteomics and Proteogenomics for Understanding Osteoporosis and Other Musculoskeletal Diseases
Osteoporosis and musculoskeletal diseases, including osteoarthritis and sarcopenia, contribute substantially to global mor...
New Aspects of the Pathophysiology of Diabetic Bone Fragility – Type 2 Diabetes Mellitus as a Disease of Accelerated Aging
New Aspects of the Pathophysiology of Diabetic Bone Fragility – Type 2 Diabetes Mellitus as a Disease of Accelerated Aging
This review summarizes recent findings of the pathophysiology of bone fragility with a particular focus on type 2 diabetes...
The Periosteum in Health and Disease
The Periosteum in Health and Disease
The periosteum has long been recognized as being essential for bone growth and repair. More recently, its involvement has ...
Cancer Cell Dormancy in the Bone Microenvironment
Cancer Cell Dormancy in the Bone Microenvironment
Cancer cell dormancy in the bone microenvironment presents a major obstacle to curative therapy across multiple cancer typ...
Efficacy of Osteoanabolic Agents in Type 2 Diabetes Mellitus: a Meta-analysis and Review of the Literature
Efficacy of Osteoanabolic Agents in Type 2 Diabetes Mellitus: a Meta-analysis and Review of the Literature
To synthesize evidence on the efficacy of osteoanabolic therapies (teriparatide, abaloparatide, romosozumab) in adults wit...
Management of Geriatric Ankle Fractures
Management of Geriatric Ankle Fractures
This review evaluates current management options for managing ankle fractures in geriatric patients with osteoporosis. It ...
Inequities Across the Spectrum of Osteoporosis Care and Post-Fracture Management in Men
Inequities Across the Spectrum of Osteoporosis Care and Post-Fracture Management in Men
Sex specific differences in the determinants, occurrence, and distribution of osteoporosis and osteoporotic fractures play...
Intravital Microscopy of Osteocytes: A New Era in Bone Cell Biology
Intravital Microscopy of Osteocytes: A New Era in Bone Cell Biology
Intravital imaging technologies have significantly transformed our understanding of osteocyte biology by enabling real-tim...
Osteoporotic Fractures of the Proximal Humerus: an In-Depth Review of Current Management Options
Osteoporotic Fractures of the Proximal Humerus: an In-Depth Review of Current Management Options
Proximal humerus fractures are common osteoporosis-related fractures in the elderly population. Due to these fractures, th...
Correction: Fracture Risk in Type 2 Diabetes: Systematic Review of Cardiovascular Outcome Trials with Glucagon Like Peptide Receptor Agonists
Correction: Fracture Risk in Type 2 Diabetes: Systematic Review of Cardiovascular Outcome Trials with Glucagon Like Peptide Receptor Agonists
Cite this articleMahalingasivam, A.A., Rasmussen, N.HH. Correction: Fracture Risk in Type 2 Diabetes: Systematic Review of...
Role of Chemokines and Cytokines in Prostate Cancer Skeletal Metastasis
Role of Chemokines and Cytokines in Prostate Cancer Skeletal Metastasis
Once prostate cancer (PCa) bone metastases develop, the prognosis dramatically declines. The precise mechanisms regulating...
Associations Among Estrogens, the Gut Microbiome and Osteoporosis
Associations Among Estrogens, the Gut Microbiome and Osteoporosis
The purpose of this Review was to summarize the evidence on the associations among estrogen status, cellular senescence, t...
Association Between Air Pollution and Osteoporosis with High-Risk Populations: A Narrative Review
Association Between Air Pollution and Osteoporosis with High-Risk Populations: A Narrative Review
Air pollution has been raised as a novel risk factor for osteoporosis, which impose a huge burden on both individuals and ...
DAMPs, PAMPs, NLRs, RIGs, CLRs and TLRs – Understanding the Alphabet Soup in the Context of Bone Biology
DAMPs, PAMPs, NLRs, RIGs, CLRs and TLRs – Understanding the Alphabet Soup in the Context of Bone Biology
The purpose of this review is to summarize the current understanding of cell-autonomous innate immune pathways that contri...
Calcium Supplementation- Efficacy and Safety
Calcium Supplementation- Efficacy and Safety
To assess the efficacy of calcium supplements in preventing fractures, and to review their adverse effects, particularly o...
Congenital Bone Disorders Associated with ERI1-Mediated RNA Metabolism Dysfunction: Spondylo-Epi-Metaphyseal Dysplasia Guo-Campeau Type and Beyond
Congenital Bone Disorders Associated with ERI1-Mediated RNA Metabolism Dysfunction: Spondylo-Epi-Metaphyseal Dysplasia Guo-Campeau Type and Beyond
The purpose of this review is to explore the multifaceted roles of the ERI1 exoribonuclease, particularly in RNA metabolis...
Management of Bone Health in Adult Mastocytosis
Management of Bone Health in Adult Mastocytosis
The present review will examine bone disease in mastocytosis, analyze the existing literature on its management, and propo...
PTH Substitution Therapy for Chronic Hypoparathyroidism: PTH 1–84 and Palopegteriparatide
PTH Substitution Therapy for Chronic Hypoparathyroidism: PTH 1–84 and Palopegteriparatide
to describe and compare the efficacy and safety of the main PTH treatments, namely PTH(1–84) and palopegteriparatide...
Medical Management of Hypophosphatasia: Review of Data on Asfotase Alfa
Medical Management of Hypophosphatasia: Review of Data on Asfotase Alfa
Hypophosphatasia (HPP) is a rare, dento-osseous disorder caused by impaired activity of tissue non-specific alkaline phosp...
Chronic Kidney Disease-Mineral and Bone Disorder Management in 4D: The Case for Dynamic Treatment Regime Methods to Optimize Care
Chronic Kidney Disease-Mineral and Bone Disorder Management in 4D: The Case for Dynamic Treatment Regime Methods to Optimize Care
Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) is a complex condition impacting patients with kidney failure a...
Emerging Roles of Eosinophils in Bone
Emerging Roles of Eosinophils in Bone
Eosinophils are traditionally known for their role in immune defense against parasites and their involvement in various im...
Potential of Kefir-Derived Peptides, Probiotics, and Exopolysaccharides for Osteoporosis Management
Potential of Kefir-Derived Peptides, Probiotics, and Exopolysaccharides for Osteoporosis Management
Osteoporosis is a prevalent skeletal disorder in postmenopausal women and older adults. Kefir has gained attention for its...
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