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Mitochondrial creatine sensitivity is lost in the D2.mdx model of Duchenne muscular dystrophy and rescued by the mitochondrial-enhancing compound Olesoxime
Mitochondrial creatine sensitivity is lost in the D2.mdx model of Duchenne muscular dystrophy and rescued by the mitochondrial-enhancing compound Olesoxime
Duchenne muscular dystrophy (DMD) is associated with distinct mitochondrial stress responses. Here, we aimed to determine ...
Ion dynamics and the regulation of circadian cellular physiology
Ion dynamics and the regulation of circadian cellular physiology
Circadian rhythms in physiology and behaviour allow organisms to anticipate the daily environmental changes imposed by the...
The role of intracellular calcium and Rho kinase pathways in G protein-coupled receptor-mediated contractions of urinary bladder urothelium and lamina propria.
The role of intracellular calcium and Rho kinase pathways in G protein-coupled receptor-mediated contractions of urinary bladder urothelium and lamina propria.
The influence of extracellular and intracellular calcium (Ca2+) on smooth muscle contractile activity varies between organ...
Editorial: Special section on inward rectifier potassium channels
Editorial: Special section on inward rectifier potassium channels
* Corresponding Author; email: [email protected]1Anesthesiology, Department of Pharmacology, Vanderbilt University, Nashvi...
Circulating microRNAs associated with non-alcoholic fatty liver disease
Circulating microRNAs associated with non-alcoholic fatty liver disease
MicroRNAs (miRNAs) are secreted from cells as either protein bound or enclosed in extracellular vesicles. Circulating live...
Glycolytic side pathways regulating macrophage inflammatory phenotypes and functions
Glycolytic side pathways regulating macrophage inflammatory phenotypes and functions
Macrophages are crucial effector cells of the innate immune system and have important roles in the initiation and resoluti...
Molecular and cellular basis of praziquantel action in the cardiovascular system
Molecular and cellular basis of praziquantel action in the cardiovascular system
The anthelmintic drug praziquantel (PZQ) causes contraction of parasitic schistosomes, as well as constriction of blood ve...
Resident muscle stem myogenic characteristics in postnatal muscle growth impairments in children with cerebral palsy
Resident muscle stem myogenic characteristics in postnatal muscle growth impairments in children with cerebral palsy
Children with cerebral palsy (CP), have impaired postnatal muscle growth, with some muscles developing contractures. Funct...
The lactate receptor GPR81 is predominantly expressed in type II human skeletal muscle fibers: potential for lactate autocrine signaling
The lactate receptor GPR81 is predominantly expressed in type II human skeletal muscle fibers: potential for lactate autocrine signaling
GPR81 was first identified in adipocytes as a receptor for L-lactate, which upon binding inhibits cAMP-PKA-CREB signaling....
MicroRNA-30e-3p reduces coronary microembolism-induced cardiomyocyte pyroptosis and inflammation by sequestering HDAC2 from the SMAD7 promoter
MicroRNA-30e-3p reduces coronary microembolism-induced cardiomyocyte pyroptosis and inflammation by sequestering HDAC2 from the SMAD7 promoter
Objective: This study investigates the mechanism by which microRNA (miR)-30e-3p reduces coronary microembolism (CME)-induc...
Cellularity in bone marrow autografts for bone and fracture healing
Cellularity in bone marrow autografts for bone and fracture healing
The use of autografts, as primary cell and tissue source is the current gold standard approach to treat critical size bone...
Non-steroidal anti-inflammatory drugs and implications for the cyclooxygenase pathway in embryonic development
Non-steroidal anti-inflammatory drugs and implications for the cyclooxygenase pathway in embryonic development
Non-steroidal anti-inflammatory drugs (NSAIDs) are a class of analgesics that inhibit the activity of cyclooxygenase isoen...
Succinate-SUCNR1 induces renal tubular cell apoptosis
Succinate-SUCNR1 induces renal tubular cell apoptosis
Succinate has long been known to be only an intermediate product of the tricarboxylic acid cycle until identified as a nat...
Evolving roles of activins and inhibins in ovarian cancer pathophysiology
Evolving roles of activins and inhibins in ovarian cancer pathophysiology
Activins and Inhibins are unique members of the Transforming Growth Factor-b (TGFb) family of growth factors, with the abi...
Gender Differences in GRK2 in Cardiovascular Diseases and its Interactions with Estrogen
Gender Differences in GRK2 in Cardiovascular Diseases and its Interactions with Estrogen
G protein-coupled receptor kinase 2 (GRK2) is a multifunctional protein involved in regulating G protein-coupled receptor ...
miR-542-5p Targets c-myc and Negates the Cell Proliferation Effect of SphK1 in Intestinal Epithelial Cells
miR-542-5p Targets c-myc and Negates the Cell Proliferation Effect of SphK1 in Intestinal Epithelial Cells
Intestinal epithelial barrier defects occur commonly during a variety of pathological conditions, though their underlying ...
Physiology of chemokines in the cancer microenvironment
Physiology of chemokines in the cancer microenvironment
Chemokines are chemotactic cytokines whose canonical functions govern movement of receptor-expressing cells along chemical...
Improving Physiological Relevance of Cell Culture: The Possibilities, Considerations and Future Directions of the Ex Vivo Co-Culture Model
Improving Physiological Relevance of Cell Culture: The Possibilities, Considerations and Future Directions of the Ex Vivo Co-Culture Model
In vitro models provide an important platform for the investigation of cellular growth and atrophy to inform, or extend me...
The impact of high fat feeding and Parkin overexpression on skeletal muscle mass, mitochondrial respiration and H2O2 emission
The impact of high fat feeding and Parkin overexpression on skeletal muscle mass, mitochondrial respiration and H2O2 emission
Obesity is a major risk factor for developing various health problems, including insulin resistance and type 2 diabetes. A...
An Overview of Alamadine/MrgD Signaling and Its Role in Cardiomyocytes
An Overview of Alamadine/MrgD Signaling and Its Role in Cardiomyocytes
The renin-angiotensin system (RAS) is a classical hormonal system involved in a myriad of cardiovascular functions. This s...
Lymphangioleiomyomatosis, a metastatic lung disease
Lymphangioleiomyomatosis, a metastatic lung disease
Lymphangioleiomyomatosis (LAM) is a rare disease affecting women, caused by somatic mutations in the TSC1 or TSC2 genes, a...
Cartilage Extracellular Matrix-derived Matrikines in Osteoarthritis
Cartilage Extracellular Matrix-derived Matrikines in Osteoarthritis
Osteoarthritis (OA) is among the most frequent diseases of the musculoskeletal system. Degradation of cartilage extracellu...
Sex differences in cardiovasculasr response to sepsis
Sex differences in cardiovasculasr response to sepsis
Recently, there has been increased recognition of the importance of sex as a biological factor affecting disease and healt...
Barriers and Opportunities for Gemcitabine in Pancreatic Cancer Therapy
Barriers and Opportunities for Gemcitabine in Pancreatic Cancer Therapy
Pancreatic ductal adenocarcinoma (PDA) has become one of the leading causes of cancer-related deaths across the world. A l...
Protein disulfide isomerase A3 activity promotes extracellular accumulation of proteins relevant to basal breast cancer outcomes in human MDA-MB-A231 breast cancer cells
Protein disulfide isomerase A3 activity promotes extracellular accumulation of proteins relevant to basal breast cancer outcomes in human MDA-MB-A231 breast cancer cells
Metastasis and recurrence of breast cancer remain major causes of patient mortality, and there is an ongoing need to ident...
PCM1 labeling reveals myonuclear and nuclear dynamics in skeletal muscle across species
PCM1 labeling reveals myonuclear and nuclear dynamics in skeletal muscle across species
Myonuclei transcriptionally regulate muscle fibers during homeostasis and adaptation to exercise. Their subcellular locati...
Bidirectional sensitivity of CALHM1 channel to protons from both sides of plasma membrane
Bidirectional sensitivity of CALHM1 channel to protons from both sides of plasma membrane
Calcium homeostasis modulator 1 (CALHM1), a newly discovered voltage-dependent nonselective ion channel, has drawn attenti...
Sulforaphane attenuates cancer cell-induced atrophy of C2C12 myotubes
Sulforaphane attenuates cancer cell-induced atrophy of C2C12 myotubes
Cancer cachexia is common in many cancers and the loss of skeletal muscle mass compromises the response to therapies and q...
Endothelial miR-196b-5p regulates angiogenesis via the hypoxia/miR-196b-5p/HMGA2/HIF1α loop
Endothelial miR-196b-5p regulates angiogenesis via the hypoxia/miR-196b-5p/HMGA2/HIF1α loop
Angiogenesis is involved in development, reproduction, wound healing, homeostasis and other pathophysiological events. Imb...
Diverse Functions of Apolipoprotein A-I in Lung Fibrosis
Diverse Functions of Apolipoprotein A-I in Lung Fibrosis
Apolipoprotein A-I (apoA-I) mediates reverse cholesterol transport (RCT) out of cells. In addition to its important role i...
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