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The role of sex differences in cardiovascular, metabolic, and immune functions in health and disease: a review for “Sex Differences in Health Awareness Day”
The role of sex differences in cardiovascular, metabolic, and immune functions in health and disease: a review for “Sex Differences in Health Awareness Day”
Sexual dimorphism is a fundamental characteristic of the anatomy and physiology of animals and humans, yet biomedical rese...
Sex differences in the modulation of anxiety- and depression-like behaviors by matrix metalloproteinase-9 expression levels in mice
Sex differences in the modulation of anxiety- and depression-like behaviors by matrix metalloproteinase-9 expression levels in mice
MMP-9 overexpressing female mice display low anxiety. MMP-9 knockout female mice display low depressive-like behavior. MMP...
Mapping the hippocampal spatial proteomic signature in male and female mice of an early Alzheimer’s disease model
Mapping the hippocampal spatial proteomic signature in male and female mice of an early Alzheimer’s disease model
Hippocampal dysfunction induced by soluble amyloid-β oligomers (oAβ) is an early neuropathological hallmark of A...
Sex-related differences and associated transcriptional signatures in the brain ventricular system and cerebrospinal fluid development in full-term neonates
Sex-related differences and associated transcriptional signatures in the brain ventricular system and cerebrospinal fluid development in full-term neonates
The cerebrospinal fluid (CSF) is known to serve as a unique environment for neurodevelopment, with specific proteins secre...
Sex differences in mouse infralimbic cortex projections to the nucleus accumbens shell
Sex differences in mouse infralimbic cortex projections to the nucleus accumbens shell
The nucleus accumbens (NAc) is an important region in motivation and reward. Glutamatergic inputs from the infralimbic cor...
Sex bias in celiac disease: XWAS and monocyte eQTLs in women identify TMEM187 as a functional candidate gene
Sex bias in celiac disease: XWAS and monocyte eQTLs in women identify TMEM187 as a functional candidate gene
Celiac disease (CeD) is an immune-mediated disorder that develops in genetically predisposed individuals upon gluten consu...
Sex differences in type 2 diabetes: an opportunity for personalized medicine
Sex differences in type 2 diabetes: an opportunity for personalized medicine
Over the past several decades, substantial ground has been gained in understanding the biology of sex differences. With ne...
Univariate and multivariate sex differences and similarities in gray matter volume within essential language-processing areas
Univariate and multivariate sex differences and similarities in gray matter volume within essential language-processing areas
Sex differences in language-related abilities have been reported. It is generally assumed that these differences stem from...
Sex-based differences in natural killer T cell-mediated protection against diet-induced steatohepatitis in Balb/c mice
Sex-based differences in natural killer T cell-mediated protection against diet-induced steatohepatitis in Balb/c mice
Metabolic dysfunction-associated steatotic liver disease (MASLD) is prevalent in Western countries, evolving into metaboli...
Sex differences in the rapid detection of neutral faces associated with emotional value
Sex differences in the rapid detection of neutral faces associated with emotional value
Rapid detection of faces with emotional meaning is essential for understanding the emotions of others, possibly promoting ...
Genetic hypogonadal mouse model reveals niche-specific influence of reproductive axis and sex on intestinal microbial communities
Genetic hypogonadal mouse model reveals niche-specific influence of reproductive axis and sex on intestinal microbial communities
The gut microbiome has been linked to many diseases with sex bias including autoimmune, metabolic, neurological, and repro...
Sex-differences in proteasome-dependent K48-polyubiquitin signaling in the amygdala are developmentally regulated in rats
Sex-differences in proteasome-dependent K48-polyubiquitin signaling in the amygdala are developmentally regulated in rats
Sex differences have been observed in several brain regions for the molecular mechanisms involved in baseline (resting) an...
Sex and age differences in social and cognitive function in offspring exposed to late gestational hypoxia
Sex and age differences in social and cognitive function in offspring exposed to late gestational hypoxia
Gestational sleep apnea is a hypoxic sleep disorder that affects 8–26% of pregnancies and increases the risk for cen...
Sex differences in binge alcohol drinking and the behavioral consequences of protracted abstinence in C57BL/6J mice
Sex differences in binge alcohol drinking and the behavioral consequences of protracted abstinence in C57BL/6J mice
Binge alcohol drinking is a risk factor linked to numerous disease states including alcohol use disorder (AUD). While men ...
Correction: Variability of temperature measurements recorded by a wearable device by biological sex
Correction: Variability of temperature measurements recorded by a wearable device by biological sex
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Regulatory mechanism of LncRNAs in gonadal differentiation of hermaphroditic fish, Monopterus albus
Regulatory mechanism of LncRNAs in gonadal differentiation of hermaphroditic fish, Monopterus albus
Monopterus albus is a hermaphroditic fish with sex reversal from ovaries to testes via the ovotestes in the process of gon...
Aromatase inhibition and ketamine in rats: sex-differences in antidepressant-like efficacy
Aromatase inhibition and ketamine in rats: sex-differences in antidepressant-like efficacy
Ketamine has been recently approved to treat resistant depression; however preclinical studies showed sex differences in i...
Sex-specific role of galectin-3 in aortic stenosis
Sex-specific role of galectin-3 in aortic stenosis
Aortic stenosis (AS) is characterized by inflammation, fibrosis, osteogenesis and angiogenesis. Men and women develop thes...
Spatial transcriptomics reveal basal sex differences in supraoptic nucleus gene expression of adult rats related to cell signaling and ribosomal pathways
Spatial transcriptomics reveal basal sex differences in supraoptic nucleus gene expression of adult rats related to cell signaling and ribosomal pathways
The supraoptic nucleus (SON) of the hypothalamus contains magnocellular neurosecretory cells that secrete the hormones vas...
Sex differences in the association between adipose insulin resistance and non-alcoholic fatty liver disease in Chinese adults
Sex differences in the association between adipose insulin resistance and non-alcoholic fatty liver disease in Chinese adults
Adipose insulin resistance (Adipo-IR) is associated with multiple metabolic diseases, including non-alcoholic fatty liver ...
Endothelin mediates sex-differences in acclimation to high salt diet in rats
Endothelin mediates sex-differences in acclimation to high salt diet in rats
Current understanding of sodium (Na+) handling is based on studies done primarily in males. Contrary to the gradual increa...
Two genetic variants in the SRD5A2 gene are found to be associated with sex differences in the disease characteristics of patients with chronic hepatitis B virus infection
Two genetic variants in the SRD5A2 gene are found to be associated with sex differences in the disease characteristics of patients with chronic hepatitis B virus infection
To examine the expression characteristics of single nucleotide polymorphisms (SNPs) in the SRD5A2 gene and investigate the...
Fetal sex differences in placental LCPUFA ether and plasmalogen phosphatidylethanolamine and phosphatidylcholine contents in pregnancies complicated by obesity
Fetal sex differences in placental LCPUFA ether and plasmalogen phosphatidylethanolamine and phosphatidylcholine contents in pregnancies complicated by obesity
We have previously reported that maternal obesity reduces placental transport capacity for lysophosphatidylcholine-docosah...
Age-associated sex difference in the expression of mitochondria-based redox sensitive proteins and effect of pioglitazone in nonhuman primate brain
Age-associated sex difference in the expression of mitochondria-based redox sensitive proteins and effect of pioglitazone in nonhuman primate brain
Paraoxonase 2 (PON2) and neuronal uncoupling proteins (UCP4 and UCP5) possess antioxidant, anti-apoptotic activit...
Sexual differences in locus coeruleus neurons and related behavior in C57BL/6J mice
Sexual differences in locus coeruleus neurons and related behavior in C57BL/6J mice
In addition to social and cultural factors, sex differences in the central nervous system have a critical influence on beh...
Sex differences in obesity-induced renal lipid accumulation revealed by lipidomics: a role of adiponectin/AMPK axis
Sex differences in obesity-induced renal lipid accumulation revealed by lipidomics: a role of adiponectin/AMPK axis
Sex differences have been observed in the development of obesity-related complications in patients, as well as in animal m...
Comparing the antidepressant-like effects of electroconvulsive seizures in adolescent and adult female rats: an intensity dose–response study
Comparing the antidepressant-like effects of electroconvulsive seizures in adolescent and adult female rats: an intensity dose–response study
The induction of electroconvulsive seizures (ECS) in rodents induces sex- and age-specific disparities in antidepressant-l...
TLR8 escapes X chromosome inactivation in human monocytes and CD4+ T cells
TLR8 escapes X chromosome inactivation in human monocytes and CD4+ T cells
Human endosomal Toll-like receptors TLR7 and TLR8 recognize self and non-self RNA ligands, and are important mediators of ...
Sex hormones and the risk of myocardial infarction in women and men: a prospective cohort study in the UK Biobank
Sex hormones and the risk of myocardial infarction in women and men: a prospective cohort study in the UK Biobank
There is conflicting evidence around the role of sex hormones with cardiovascular outcomes. The aim of this study was to e...
Serum metabolomics profiling by proton nuclear magnetic resonance spectrometry of the response to single oral macronutrient challenges in women with polycystic ovary syndrome (PCOS) compared with male and female controls
Serum metabolomics profiling by proton nuclear magnetic resonance spectrometry of the response to single oral macronutrient challenges in women with polycystic ovary syndrome (PCOS) compared with male and female controls
The polycystic ovary syndrome (PCOS) is associated with insulin resistance, obesity and cardiometabolic comorbidities. We ...
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