Gauthier S, Rosa-Neto P, Morais JA, Webster C. World Alzheimer Report 2021: Journey through the diagnosis of dementia. In.; 2021.

Selkoe DJ, Hardy J. The amyloid hypothesis of Alzheimer’s disease at 25 years. EMBO Mol Med. 2016;8(6):595–608.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jeremic D, Jiménez-Díaz L, Navarro-López JD. Past, present and future of therapeutic strategies against amyloid-β peptides in Alzheimer’s disease: a systematic review. Ageing Res Rev. 2021;72:101496.

Article  CAS  PubMed  Google Scholar 

Vyas Y, Montgomery JM, Cheyne JE. Hippocampal deficits in Amyloid-β-Related rodent models of Alzheimer’s Disease. Front Neurosci. 2020;14:266.

Article  PubMed  PubMed Central  Google Scholar 

Palop JJ, Mucke L. Amyloid-beta-induced neuronal dysfunction in Alzheimer’s disease: from synapses toward neural networks. Nat Neurosci. 2010;13(7):812–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lührs T, Ritter C, Adrian M, Riek-Loher D, Bohrmann B, Döbeli H, Schubert D, Riek R. 3D structure of Alzheimer’s amyloid-β(1–42) fibrils. Proc Natl Acad Sci U S A. 2005;102(48):17342–7.

Article  PubMed  PubMed Central  Google Scholar 

Sanchez-Varo R, Mejias-Ortega M, Fernandez-Valenzuela JJ, Nuñez-Diaz C, Caceres-Palomo L, Vegas-Gomez L, Sanchez-Mejias E, Trujillo-Estrada L, Garcia-Leon JA, Moreno-Gonzalez I et al. Transgenic Mouse Models of Alzheimer’s Disease: An Integrative Analysis. Int J Mol Sci 2022, 23(10).

Braak H, Thal DR, Ghebremedhin E, Del Tredici K. Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years. J Neuropathol Exp Neurol. 2011;70(11):960–9.

Article  CAS  PubMed  Google Scholar 

Michno W, Wehrli P, Meier SR, Sehlin D, Syvänen S, Zetterberg H, Blennow K, Hanrieder J. Chemical imaging of evolving amyloid plaque pathology and associated Aβ peptide aggregation in a transgenic mouse model of Alzheimer’s disease. J Neurochem. 2020;152(5):602–16.

Article  CAS  PubMed  Google Scholar 

Tamagno E, Guglielmotto M, Monteleone D, Manassero G, Vasciaveo V, Tabaton M. The unexpected role of Aβ1–42 monomers in the pathogenesis of Alzheimer’s Disease. J Alzheimers Dis. 2018;62(3):1241–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mucke L, Selkoe DJ. Neurotoxicity of amyloid β-protein: synaptic and network dysfunction. Cold Spring Harb Perspect Med. 2012;2(7):a006338.

Article  PubMed  PubMed Central  Google Scholar 

Kent SA, Spires-Jones TL, Durrant CS. The physiological roles of tau and Aβ: implications for Alzheimer’s disease pathology and therapeutics. Acta Neuropathol. 2020;140(4):417–47.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li S, Selkoe DJ. A mechanistic hypothesis for the impairment of synaptic plasticity by soluble Abeta oligomers from Alzheimer’s brain. J Neurochem. 2020;154(6):583–97.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sanchez-Rodriguez I, Djebari S, Temprano-Carazo S, Vega-Avelaira D, Jimenez-Herrera R, Iborra-Lazaro G, Yajeya J, Jimenez-Diaz L, Navarro-Lopez JD. Hippocampal long-term synaptic depression and memory deficits induced in early amyloidopathy are prevented by enhancing G-protein-gated inwardly rectifying potassium channel activity. J Neurochem. 2020;153(3):362–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sanchez-Rodriguez I, Gruart A, Delgado-Garcia JM, Jimenez-Diaz L, Navarro-Lopez JD. Role of GirK channels in long-term potentiation of synaptic inhibition in an in vivo mouse model of early amyloid-beta Pathology. Int J Mol Sci 2019, 20(5).

Sánchez-Rodríguez I, Temprano-Carazo S, Nájera A, Djebari S, Yajeya J, Gruart A, Delgado-García JM, Jiménez-Díaz L, Navarro-López JD. Activation of G-protein-gated inwardly rectifying potassium (Kir3/GirK) channels rescues hippocampal functions in a mouse model of early amyloid-β pathology. Sci Rep. 2017;7(1):14658.

Article  PubMed  PubMed Central  Google Scholar 

Morroni F, Sita G, Tarozzi A, Rimondini R, Hrelia P. Early effects of Aβ1–42 oligomers injection in mice: involvement of PI3K/Akt/GSK3 and MAPK/ERK1/2 pathways. Behav Brain Res. 2016;314:106–15.

Article  CAS  PubMed  Google Scholar 

Jiménez-Herrera R, Contreras A, Djebari S, Mulero-Franco J, Iborra-Lázaro G, Jeremic D, Navarro-López J, Jiménez-Díaz L. Systematic characterization of a non-transgenic Aβ(1–42) amyloidosis model: synaptic plasticity and memory deficits in female and male mice. Biol Sex Differ. 2023;14(1):59.

Article  PubMed  PubMed Central  Google Scholar 

Takousis P, Sadlon A, Schulz J, Wohlers I, Dobricic V, Middleton L, Lill CM, Perneczky R, Bertram L. Differential expression of microRNAs in Alzheimer’s disease brain, blood, and cerebrospinal fluid. Alzheimers Dement. 2019;15(11):1468–77.

Article  PubMed  Google Scholar 

Bai B, Vanderwall D, Li Y, Wang X, Poudel S, Wang H, Dey KK, Chen PC, Yang K, Peng J. Proteomic landscape of Alzheimer’s Disease: novel insights into pathogenesis and biomarker discovery. Mol Neurodegener. 2021;16(1):55.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zakharova NV, Bugrova AE, Indeykina MI, Fedorova YB, Kolykhalov IV, Gavrilova SI, Nikolaev EN, Kononikhin AS. Proteomic markers and early prediction of Alzheimer’s Disease. Biochem (Mosc). 2022;87(8):762–76.

Article  CAS  Google Scholar 

Horgusluoglu E, Neff R, Song WM, Wang M, Wang Q, Arnold M, Krumsiek J, Galindo-Prieto B, Ming C, Nho K, et al. Integrative metabolomics-genomics approach reveals key metabolic pathways and regulators of Alzheimer’s disease. Alzheimers Dement. 2022;18(6):1260–78.

Article  CAS  PubMed  Google Scholar 

Jiang Y, Zhou X, Ip FC, Chan P, Chen Y, Lai NCH, Cheung K, Lo RMN, Tong EPS, Wong BWY, et al. Large-scale plasma proteomic profiling identifies a high-performance biomarker panel for Alzheimer’s disease screening and staging. Alzheimers Dement. 2022;18(1):88–102.

Article  CAS  PubMed  Google Scholar 

Oláh Z, Kálmán J, Tóth ME, Zvara Á, Sántha M, Ivitz E, Janka Z, Pákáski M. Proteomic analysis of cerebrospinal fluid in Alzheimer’s disease: wanted dead or alive. J Alzheimers Dis. 2015;44(4):1303–12.

Article  PubMed  Google Scholar 

Manavalan A, Mishra M, Feng L, Sze SK, Akatsu H, Heese K. Brain site-specific proteome changes in aging-related dementia. Exp Mol Med. 2013;45(9):e39.

Article  PubMed  PubMed Central  Google Scholar 

Andreev VP, Petyuk VA, Brewer HM, Karpievitch YV, Xie F, Clarke J, Camp D, Smith RD, Lieberman AP, Albin RL, et al. Label-free quantitative LC-MS proteomics of Alzheimer’s disease and normally aged human brains. J Proteome Res. 2012;11(6):3053–67.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang H, Wittnam JL, Zubarev RA, Bayer TA. Shotgun brain proteomics reveals early molecular signature in presymptomatic mouse model of Alzheimer’s disease. J Alzheimers Dis. 2013;37(2):297–308.

Article  CAS  PubMed  Google Scholar 

Gurel B, Cansev M, Koc C, Ocalan B, Cakir A, Aydin S, Kahveci N, Ulus IH, Sahin B, Basar MK, et al. Proteomics analysis of CA1 region of the Hippocampus in Pre-, progression and pathological stages in a mouse model of the Alzheimer’s Disease. Curr Alzheimer Res. 2019;16(7):613–21.

Article  CAS  PubMed  Google Scholar 

Ismail R, Parbo P, Madsen LS, Hansen AK, Hansen KV, Schaldemose JL, Kjeldsen PL, Stokholm MG, Gottrup H, Eskildsen SF, et al. The relationships between neuroinflammation, beta-amyloid and tau deposition in Alzheimer’s disease: a longitudinal PET study. J Neuroinflammation. 2020;17(1):151.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Su L, Surendranathan A, Huang Y, Bevan-Jones WR, Passamonti L, Hong YT, Arnold R, Rodríguez PV, Wang Y, Mak E, et al. Relationship between tau, neuroinflammation and atrophy in Alzheimer’s disease: the NIMROD study. Inform Fusion. 2021;67:116–24.

Article  Google Scholar 

Ikegawa M, Kakuda N, Miyasaka T, Toyama Y, Nirasawa T, Minta K, Hanrieder J. Mass Spectrometry Imaging in Alzheimer’s Disease. Brain Connect. 2023;13(6):319–33.

Kim C-M, Diez I, Bueichekú E, Ahn S, Montal V, Sepulcre J. Spatiotemporal correlation between amyloid and tau accumulations underlies cognitive changes in aging. J Neurosci. 2024;44(7):e0488232023.

Article  CAS  PubMed