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NEJM Endocrinology
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SCI Abstract
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ALL
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Risk of Progression and Costs of Care for Patients with Type 2 Diabetes and Chronic Kidney Disease
Chronic kidney disease (CKD) progression is associated with a significant incremental economic burden. Previous work has d...
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A Pragmatic Approach to Improving Management and Patient Flow for Painful Diabetic Neuropathy in UK Primary Care
Painful diabetic peripheral neuropathy (pDPN) affects approximately 25% of individuals with diabetes in the UK and remains...
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The Mechanisms of Inflammatory Factors and the Total Load of Cerebral Small Vessel Disease in Diabetic Retinopathy and Cognitive Impairment
The purpose of this study was to explore the roles and methods of inflammatory factors and total load of cerebral small ve...
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Effect of Automated Insulin Delivery System Therapy at Diagnosis on Metabolic Control in Children and Adolescents with Type 1 Diabetes
The primary goal of managing type 1 diabetes mellitus (T1D) is to achieve glycemic control and prevent both acute...
Diabetes Therapy
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Pharmacokinetic Characteristics of a Once-Weekly Combination Therapy of Insulin Icodec and Semaglutide Versus Its Separate Components in Chinese Individuals with Type 2 Diabetes
IcoSema is under development as a once-weekly injectable combination therapy of icodec (basal insulin) and semaglutide (gl...
Diabetes Therapy
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Efficacy and Safety of Once-Weekly Insulin Icodec in Indian Participants with Diabetes: Results from ONWARDS 1, 4, and 6 Studies
These analyses explored the efficacy and safety of once-weekly insulin icodec (icodec) in Indian participants with type&am...
Diabetes Therapy
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Real-World Effectiveness of Tirzepatide versus Semaglutide on HbA1c and Weight in Patients with Type 2 Diabetes
To evaluate real-world hemoglobin A1c (HbA1c) and weight change in adults initiating treatment with tirzepatide (dual gluc...
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A Multicenter, Prospective, Observational, and Single-Arm Interventional Study of Mirogabalin in Diabetic Peripheral Neuropathic Pain: Rationale and Design of Dia-NeP
The exact prevalence of and recent changes in diabetic polyneuropathy (DPN) and diabetic peripheral neuropathic pain (DPNP...
Diabetes Therapy
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Tubeless Insulin Pump Combined with a Cloud-Based Data Management Platform: Real-World Evidence from 14,765 French People with Diabetes
This study aimed to examine glucose metrics and insulin delivery patterns in children, adolescents, and adults with type&a...
Diabetes Therapy
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Identifying the Healthcare Burden of Diabetic Ketoacidosis: Economic Analysis and Mitigation Strategies for Adult Patients in the United Arab Emirates
Diabetic ketoacidosis (DKA) is a potentially fatal diabetes complication marked by hyperglycemia, ketonemia, and acidosis ...
Diabetes Therapy
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Protective Role of Serum β-Hydroxybutyrate in Early Diabetic Kidney Disease: A Longitudinal Study
β-Hydroxybutyrate (βHB), the most stable form of ketone bodies, has exhibited protective effects in metabolic an...
Diabetes Therapy
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Insights into the Mechanism of Action of Tirzepatide: A Narrative Review
Tirzepatide is the first dual long-acting glucose-dependent insulinotropic polypeptide receptor and glucagon-like peptide-...
Diabetes Therapy
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Diabetes Educators: Understanding the Role of Finerenone in Chronic Kidney Disease Associated with Type 2 Diabetes Mellitus
People living with type 2 diabetes mellitus (T2DM) are at risk of developing diabetes-related complications such as chroni...
Diabetes Therapy
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A Randomized Phase 3 Study Evaluating the Efficacy and Safety of Alogliptin in Pediatric Participants with Type 2 Diabetes Mellitus
There is an unmet need for pharmacological therapies for children with type 2 diabetes mellitus (T2DM). We assessed the ef...
Diabetes Therapy
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Advances in Imaging Techniques for Assessing Myocardial Microcirculation in People with Diabetes
Microangiopathy is a key complication of diabetes, adversely effecting several organs including the heart, kidneys, eyes, ...
Diabetes Therapy
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The Prevalence of Atherosclerotic Cardiovascular Disease in Patients with Type 2 Diabetes in Jordan: The PACT-MEA Study
This study investigated the prevalence and clinical management of atherosclerotic cardiovascular disease (ASCVD) and ASCVD...
Diabetes Therapy
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Knowledge, Attitudes, and Practices in Neonatal Diabetes Mellitus Management: the JEnious-NeOnatal-DIabetes (JENODI) Survey
We aimed to explore the knowledge, attitude, and management of neonatal diabetes mellitus (NDM) among members of the Inter...
Diabetes Therapy
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Predictors of Composite Maternal and Fetal Outcomes among Pregnant Women with Early-Onset Type 2 Diabetes: A Cross-Sectional Study
The most common form of pregestational diabetes in pregnancy is type 2 diabetes, requiring strict metabolic monitoring owi...
Diabetes Therapy
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Clinical Profile and Treatment Patterns in Individuals with Type 2 Diabetes and Chronic Kidney Disease Who Initiate a GLP-1 Receptor Agonist: A Multinational Cohort Study
Novel therapies are emerging for the prevention of chronic kidney disease (CKD) progression in patients with type 2 diabet...
Diabetes Therapy
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Long- and Short-Term Cost-Effectiveness of Once-Weekly Semaglutide versus Dulaglutide for the Treatment of Type 2 Diabetes in China: A Hypothetical Modeling Exercise
This study aimed to evaluate the long- and short-term cost-effectiveness of once-weekly semaglutide versus dulaglutide for...
Diabetes Therapy
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Real-World Comparisons Between Glucagon-Like Peptide-1 Receptor Agonists and Other Glucose-Lowering Agents in Type 2 Diabetes: Retrospective Analyses of Cardiovascular and Economic Outcomes in England
Clinical trials have demonstrated that glucagon-like peptide-1 receptor agonists (GLP-1RAs) reduce the risk of major adver...
Diabetes Therapy
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Tirzepatide Was Associated with Improved Health-Related Quality of Life in Adults with Obesity or Overweight and Type 2 Diabetes: Results from the Phase 3 SURMOUNT-2 Trial
In SURMOUNT-2, a phase 3, randomized clinical trial, tirzepatide treatment resulted in clinically meaningful reduction in ...
Diabetes Therapy
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Comparing Efficacy of Chiglitazar, Pioglitazone, and Semaglutide in Type 2 Diabetes: A Retrospective Study
Type 2 diabetes (T2D) is a complex chronic metabolic disease characterized by insulin resistance, dyslipidemia, inflammati...
Diabetes Therapy
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Combining GLP-1 Receptor Agonists and SGLT2 Inhibitors in Type 2 Diabetes Mellitus: A Scoping Review and Expert Insights for Clinical Practice Utilizing the Nominal Group Technique
Treating type 2 diabetes has shifted from a gluco-centric approach to broader cardio-renal-metabolic strategy, dr...
Diabetes Therapy
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Once-Weekly Semaglutide Versus Sodium-Glucose Co-transporter 2 Inhibitors: Real-World Impact on Weight, HbA1c, and Healthcare Resource Utilization in Type 2 Diabetes (PAUSE)
Clinical trials have demonstrated greater glycemic control and weight loss with once-weekly (OW) semaglutide versus other ...
Diabetes Therapy
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The Association Between HbA1c Levels and the Risk of Myocardial Infarction and Stroke in People with Type 2 Diabetes: A Post Hoc Analysis of the REPRESENT Study
The aim of this work was to analyze the association between baseline glycated hemoglobin (HbA1c) levels and other factors ...
Diabetes Therapy
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Systematic Literature Review of the Impact of Type 2 Diabetes and Heart Failure Guideline Adherence on Clinical and Economic Outcomes
Type 2 diabetes mellitus (T2DM) is associated with comorbidities, particularly in the cardiovascular, renal, and metabolic...
Diabetes Therapy
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Association of Blood Heavy Metals with Diabetic Foot Ulcers in U.S. Adults with Diabetes: Insights from the 1999–2004 NHANES Data
Diabetic foot ulcers (DFU) are serious complications of diabetes. These ulcers significantly increase the risk of amputati...
Diabetes Therapy
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Preferences, Expectations and Attitudes on Basal Insulin from Patient–Physician–Payer Perspective: A Multi-stakeholder Survey by the Italian Diabetes Society (ITA4P Study)
Diabetes management often involves complex insulin regimens, posing significant challenges for patients and healthcare sys...
Diabetes Therapy
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Durability of Effectiveness Between Users of Once-Weekly Semaglutide and Dipeptidyl Peptidase 4 Inhibitors (DPP–4i) in US Adults with Type 2 Diabetes
Long-term effectiveness and durability of glucose-lowering medications are important considerations in managing type&n...
Diabetes Therapy
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