Gutterman DD, Chabowski DS, Kadlec AO, et al. The human microcirculation: regulation of flow and beyond. Circ Res. 2016;118(1):157–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Salvatore T, Galiero R, Caturano A, et al. Coronary microvascular dysfunction in diabetes mellitus: pathogenetic mechanisms and potential therapeutic options. Biomedicines. 2022;10(9):2274.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chareonthaitawee P, Kaufmann PA, Rimoldi O, Camici PG. Heterogeneity of resting and hyperemic myocardial blood flow in healthy humans. Cardiovasc Res. 2001;50(1):151–61.

Article  CAS  PubMed  Google Scholar 

Crea F, Camici PG, Bairey Merz CN. Coronary microvascular dysfunction: an update. Eur Heart J. 2014;35(17):1101–11.

Article  PubMed  Google Scholar 

Cortigiani L, Rigo F, Gherardi S, Galderisi M, Bovenzi F, Sicari R. Prognostic meaning of coronary microvascular disease in type 2 diabetes mellitus: a transthoracic Doppler echocardiographic study. J Am Soc Echocardiogr. 2014;27(7):742–8.

Article  PubMed  Google Scholar 

Nitenberg A, Valensi P, Sachs R, Cosson E, Attali JR, Antony I. Prognostic value of epicardial coronary artery constriction to the cold pressor test in type 2 diabetic patients with angiographically normal coronary arteries and no other major coronary risk factors. Diabetes Care. 2004;27(1):208–15.

Article  PubMed  Google Scholar 

Murthy VL, Naya M, Foster CR, et al. Association between coronary vascular dysfunction and cardiac mortality in patients with and without diabetes mellitus. Circulation. 2012;126(15):1858–68.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ramesh P, Yeo JL, Brady EM, McCann GP. Role of inflammation in diabetic cardiomyopathy. Ther Adv Endocrinol Metab. 2022;13:20420188221083530.

Article  PubMed  PubMed Central  Google Scholar 

Ammirati E, Moroni F, Pedrotti P, et al. Non-invasive imaging of vascular inflammation. Front Immunol. 2014;5:399.

Article  PubMed  PubMed Central  Google Scholar 

Murthy VL, Naya M, Foster CR, et al. Improved cardiac risk assessment with noninvasive measures of coronary flow reserve. Circulation. 2011;124(20):2215–24.

Article  PubMed  PubMed Central  Google Scholar 

Ahmed AI, Saad JM, Alahdab F, et al. Prognostic value of positron emission tomography derived myocardial flow reserve: a systematic review and meta-analysis. Atherosclerosis. 2023;382:117280.

Article  CAS  PubMed  Google Scholar 

Aljizeeri A, Ahmed AI, Suliman I, Alfaris MA, Elneama A, Al-Mallah MH. Incremental prognostic value of positron emission tomography-derived myocardial flow reserve in patients with and without diabetes mellitus. Eur Heart J Cardiovasc Imaging. 2023;24(5):563–71.

Article  PubMed  Google Scholar 

Slomka P, Berman DS, Alexanderson E, Germano G. The role of PET quantification in cardiovascular imaging. Clin Transl Imaging. 2014;2(4):343–58.

Article  PubMed  PubMed Central  Google Scholar 

von Scholten BJ, Hasbak P, Christensen TE, et al. Cardiac (82)Rb PET/CT for fast and non-invasive assessment of microvascular function and structure in asymptomatic patients with type 2 diabetes. Diabetologia. 2016;59(2):371–8.

Article  Google Scholar 

Zobel EH, Winther SA, Hasbak P, et al. Myocardial flow reserve assessed by cardiac 82Rb positron emission tomography/computed tomography is associated with albumin excretion in patients with Type 1 diabetes. Eur Heart J Cardiovasc Imaging. 2019;20(7):796–803.

Article  PubMed  Google Scholar 

de Souza A, Harms HJ, Martell L, et al. Accuracy and reproducibility of myocardial blood flow quantification by single photon emission computed tomography imaging in patients with known or suspected coronary artery disease. Circ Cardiovasc Imaging. 2022;15(6):e013987.

Article  PubMed  PubMed Central  Google Scholar 

Vandenberghe S, Moskal P, Karp JS. State of the art in total body PET. EJNMMI Phys. 2020;7(1):35.

Article  PubMed  PubMed Central  Google Scholar 

Slart R, Bengel FM, Akincioglu C, et al. Total-body PET/CT applications in cardiovascular diseases: a perspective document of the SNMMI cardiovascular council. J Nucl Med. 2024;65(4):607–17.

Article  CAS  Google Scholar 

Kjaerulff MLG, Nielsen EN, Gormsen LC, Dias AH. First-in-human whole-body PET/CT imaging with the optimized ketone tracer [(11)C]beta-hydroxybutyrate using a long axial field-of-view scanner. Eur J Nucl Med Mol Imaging. 2024;51(12):3802–4.

Article  CAS  PubMed  Google Scholar 

Rasmussen LD, Winther S, Eftekhari A, et al. Second-line myocardial perfusion imaging to detect obstructive stenosis: head-to-head comparison of CMR and PET. JACC Cardiovasc Imaging. 2023;16(5):642–55.

Article  PubMed  Google Scholar 

Loft M, Clemmensen A, Christensen EN, et al. First-in-human: simultaneous hyperpolarized 1–13C-pyruvate magnetic resonance spectroscopy and 18F-FDG PET (hyperPET) imaging of a patient with lymphoma. Clin Nucl Med. 2024. https://doi.org/10.1097/RLU.0000000000005534.

Article  PubMed  Google Scholar 

Danad I, Szymonifka J, Schulman-Marcus J, Min JK. Static and dynamic assessment of myocardial perfusion by computed tomography. Eur Heart J Cardiovasc Imaging. 2016;17(8):836–44.

Article  PubMed  PubMed Central  Google Scholar 

Dantas RN Jr, Assuncao AN Jr, Marques IA, et al. Myocardial perfusion in patients with suspected coronary artery disease: comparison between 320-MDCT and rubidium-82 PET. Eur Radiol. 2018;28(6):2665–74.

Article  PubMed  Google Scholar 

Xue R, Ren Z, Zhao H, et al. Prognostic value of coronary CT angiography and CT myocardial perfusion imaging among patients with and without diabetes. Eur J Radiol. 2023;167:111063.

Article  PubMed  Google Scholar 

Yang W, Ding X, Yu Y, et al. Long-term prognostic value of CT-based high-risk coronary lesion attributes and radiomic features of pericoronary adipose tissue in diabetic patients. Clin Radiol. 2024. https://doi.org/10.1016/j.crad.2024.08.018.

Article  PubMed  Google Scholar 

Michelsen MM, Pena A, Mygind ND, et al. Coronary flow velocity reserve assessed by transthoracic Doppler: the iPOWER study: factors influencing feasibility and quality. J Am Soc Echocardiogr. 2016;29(7):709–16.

Article  PubMed  Google Scholar 

Caiati C, Montaldo C, Zedda N, et al. Validation of a new noninvasive method (contrast-enhanced transthoracic second harmonic echo Doppler) for the evaluation of coronary flow reserve: comparison with intracoronary Doppler flow wire. J Am Coll Cardiol. 1999;34(4):1193–200.

Article  CAS  PubMed  Google Scholar 

Michelsen MM, Mygind ND, Pena A, et al. Transthoracic Doppler echocardiography compared with positron emission tomography for assessment of coronary microvascular dysfunction: the iPOWER study. Int J Cardiol. 2017;228:435–43.

Article  PubMed  Google Scholar 

Ismayl M, Raphael CE, Prasad A, Chareonthaitawee P, Bois JP. Agreement of Doppler flow velocity reserve with PET flow reserve in patients with angina without obstructive coronary arteries. Mayo Clin Proc. 2024. https://doi.org/10.1161/circ.150.suppl_1.4147752.

Article  PubMed  Google Scholar 

Abdelmoneim SS, Dhoble A, Bernier M, et al. Absolute myocardial blood flow determination using real-time myocardial contrast echocardiography during adenosine stress: comparison with single-photon emission computed tomography. Heart. 2009;95(20):1662–8.

Article  CAS  PubMed  Google Scholar 

Vogel R, Indermuhle A, Reinhardt J, et al. The quantification of absolute myocardial perfusion in humans by contrast echocardiography: algorithm and validation. J Am Coll Cardiol. 2005;45(5):754–62.

Article  PubMed  Google Scholar 

Montone RA, Meucci MC, De Vita A, Lanza GA, Niccoli G. Coronary provocative tests in the catheterization laboratory: pathophysiological bases, methodological considerations and clinical implications. Atherosclerosis. 2021;318:14–21.

Article  CAS