Sun J, Du X, Chen Y. Current progress on postoperative cognitive dysfunction: an update. J Integr Neurosci. 2024;23: 224.

Article  PubMed  Google Scholar 

Olotu C. Postoperative neurocognitive disorders. Curr Opin Anaesthesiol. 2020;33:101–8.

Article  PubMed  Google Scholar 

Lu J, Hou W, Gao S, Zhang Y, Zong Y. The role of gut microbiota-gut-brain axis in perioperative neurocognitive dysfunction. Front Pharmacol. 2022;13:879745.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kong H, Xu LM, Wang DX. Perioperative neurocognitive disorders: a narrative review focusing on diagnosis, prevention, and treatment. CNS Neurosci Ther. 2022;28:1147–67.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dilmen OK, Meco BC, Evered LA, Radtke FM. Postoperative neurocognitive disorders: a clinical guide. J Clin Anesth. 2024;92:111320.

Article  PubMed  Google Scholar 

Evered L, Atkins K, Silbert B, Scott DA. Acute peri-operative neurocognitive disorders: a narrative review. Anaesthesia. 2022;77(Suppl 1):34–42.

Article  PubMed  Google Scholar 

Peden CJ, Miller TR, Deiner SG, Eckenhoff RG, Fleisher LA. Improving perioperative brain health: an expert consensus review of key actions for the perioperative care team. Br J Anaesth. 2021;126:423–32.

Article  PubMed  Google Scholar 

Peng W, Lu W, Jiang X, Xiong C, Chai H, Cai L, Lan Z. Current progress on neuroinflammation-mediated postoperative cognitive dysfunction: an update. Curr Mol Med. 2023;23:1077–86.

Article  CAS  PubMed  Google Scholar 

Rump K, Adamzik M. Epigenetic mechanisms of postoperative cognitive impairment induced by anesthesia and neuroinflammation. Cells. 2022. https://doi.org/10.3390/cells11192954.

Article  PubMed  PubMed Central  Google Scholar 

Song Y, Cao H, Zuo C, Gu Z, Huang Y, Miao J, Fu Y, Guo Y, Jiang Y, Wang F. Mitochondrial dysfunction: a fatal blow in depression. Biomed Pharmacother. 2023;167: 115652.

Article  CAS  PubMed  Google Scholar 

Zhang Z, Yang W, Wang L, Zhu C, Cui S, Wang T, Gu X, Liu Y, Qiu P. Unraveling the role and mechanism of mitochondria in postoperative cognitive dysfunction: a narrative review. J Neuroinflammation. 2024;21:293.

Article  PubMed  PubMed Central  Google Scholar 

Ye F, Wei C, Wu A. The potential mechanism of mitochondrial homeostasis in postoperative neurocognitive disorders: an in-depth review. Ann Med. 2024;56:2411012.

Article  PubMed  PubMed Central  Google Scholar 

Chen M, Yan R, Ding L, Luo J, Ning J, Zhou R. Research advances of mitochondrial dysfunction in perioperative neurocognitive disorders. Neurochem Res. 2023;48:2983–95.

Article  CAS  PubMed  Google Scholar 

Sayehmiri F, Motamedi F, Batool Z, Naderi N, Shaerzadeh F, Zoghi A, Rezaei O, Khodagholi F, Pourbadie HG. Mitochondrial plasticity and synaptic plasticity crosstalk; in health and Alzheimer’s disease. CNS Neurosci Ther. 2024;30: e14897.

Article  CAS  PubMed  PubMed Central  Google Scholar 

He Q, Qu M, Shen T, Su J, Xu Y, Xu C, Barkat MQ, Cai J, Zhu H, Zeng LH, Wu X. Control of mitochondria-associated endoplasmic reticulum membranes by protein S-palmitoylation: novel therapeutic targets for neurodegenerative diseases. Ageing Res Rev. 2023;87:101920.

Article  CAS  PubMed  Google Scholar 

Li YE, Sowers JR, Hetz C, Ren J. Cell death regulation by MAMs: from molecular mechanisms to therapeutic implications in cardiovascular diseases. Cell Death Dis. 2022;13:504.

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Ridder I, Kerkhofs M, Lemos FO, Loncke J, Bultynck G, Parys JB. The ER-mitochondria interface, where Ca(2+) and cell death meet. Cell Calcium. 2023;112: 102743.

Article  PubMed  Google Scholar 

Xu A, Wang Y, Luo D, Xia Y, Xue H, Yao H, Li S. By regulating the IP3R/GRP75/VDAC1 complex to restore mitochondrial dynamic balance, selenomethionine reduces lipopolysaccharide-induced neuronal apoptosis. J Cell Physiol. 2024;239:e31190.

Article  CAS  PubMed  Google Scholar 

Liu J, Yang J. Mitochondria-associated membranes: a hub for neurodegenerative diseases. Biomed Pharmacother. 2022;149:112890.

Article  CAS  PubMed  Google Scholar 

Chang Y, Wang C, Zhu J, Zheng S, Sun S, Wu Y, Jiang X, Li L, Ma R, Li G. SIRT3 ameliorates diabetes-associated cognitive dysfunction via regulating mitochondria-associated ER membranes. J Transl Med. 2023;21:494.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Portelli K, Kandraju H, Ryu M, Shah PS. Efficacy and safety of dexmedetomidine for analgesia and sedation in neonates: a systematic review. J Perinatol. 2024;44:164–72.

Article  PubMed  Google Scholar 

Li J, Wang K, Liu M, He J, Zhang H, Liu H. Dexmedetomidine alleviates cerebral ischemia-reperfusion injury via inhibiting autophagy through PI3K/Akt/mTOR pathway. J Mol Histol. 2023;54:173–81.

Article  PubMed  Google Scholar 

Feng X, Ma W, Zhu J, Jiao W, Wang Y. Dexmedetomidine alleviates early brain injury following traumatic brain injury by inhibiting autophagy and neuroinflammation through the ROS/Nrf2 signaling pathway. Mol Med Rep. 2021. https://doi.org/10.3892/mmr.2021.12300.

Article  PubMed  PubMed Central  Google Scholar 

Hu Y, Zhou H, Zhang H, Sui Y, Zhang Z, Zou Y, Li K, Zhao Y, Xie J, Zhang L. The neuroprotective effect of dexmedetomidine and its mechanism. Front Pharmacol. 2022;13: 965661.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tao Z, Li P, Zhao X. Progress on the mechanisms and neuroprotective benefits of dexmedetomidine in brain diseases. Brain Behav. 2024;14: e70116.

Article  PubMed  PubMed Central  Google Scholar 

Li S, Li R, Li M, Cui Q, Zhang X, Ma T, Wang D, Zeng M, Li H, Bao Z, Peng Y, Sessler DI. Dexmedetomidine administration during brain tumour resection for prevention of postoperative delirium: a randomised trial. Br J Anaesth. 2023;130:e307–16.

Article  CAS  PubMed  Google Scholar 

Shin HJ, Woo Nam S, Kim H, Yim S, Han SH, Hwang JW, Do SH, Na HS. Postoperative delirium after dexmedetomidine versus propofol sedation in healthy older adults undergoing orthopedic lower limb surgery with spinal anesthesia: a randomized controlled trial. Anesthesiology. 2023;138:164–71.

Article  CAS  PubMed  Google Scholar 

Bi X, Wei J, Zhang X. Effects of dexmedetomidine on neurocognitive disturbance after elective non-cardiac surgery in senile patients: a systematic review and meta-analysis. J Int Med Res. 2021;49: 3000605211014294.

Article  CAS  PubMed  Google Scholar 

Yu H, Kang H, Fan J, Cao G, Liu B. Influence of dexmedetomidine on postoperative cognitive dysfunction in the elderly: a meta-analysis of randomized controlled trials. Brain Behav. 2022;12:e2665.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huet O, Gargadennec T, Oilleau JF, Rozec B, Nesseler N, Bouglé A, Kerforne T, Lasocki S, Eljezi V, Dessertaine G, Amour J, Chapalain X. Prevention of post-operative delirium using an overnight infusion of dexmedetomidine in patients undergoing cardiac surgery: a pragmatic, randomized, double-blind, placebo-controlled trial. Crit Care. 2024;28:64.

Article  PubMed  PubMed Central  Google Scholar 

Xiong X, Chen D, Shi J. Is perioperative dexmedetomi