Machine learning-based identification of basement membrane-related signature to predict recurrence and immunotherapy benefit in bladder cancer

Kaufman DS, Shipley WU, Feldman AS. Bladder cancer. Lancet. 2009;374(9685):239–49. https://doi.org/10.1016/S0140-6736(09)60491-8.

Article  CAS  PubMed  Google Scholar 

Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229–63. https://doi.org/10.3322/caac.21834.

Article  PubMed  Google Scholar 

Kamat AM, Hahn NM, Efstathiou JA, Lerner SP, Malmstrom PU, Choi W, et al. Bladder cancer Lancet. 2016;388(10061):2796–810. https://doi.org/10.1016/S0140-6736(16)30512-8.

Article  PubMed  Google Scholar 

Akhtar M, Al-Bozom IA, Ben Gashir M, Taha NM. Intrinsic Molecular Subclassification of Urothelial Carcinoma of the Bladder: Are We Finally there? Adv Anat Pathol. 2019;26(4):251–6. https://doi.org/10.1097/PAP.0000000000000235.

Article  PubMed  Google Scholar 

Babjuk M, Burger M, Capoun O, Cohen D, Comperat EM, Dominguez Escrig JL, et al. European Association of Urology Guidelines on Non-muscle-invasive Bladder Cancer (Ta, T1, and Carcinoma in Situ). Eur Urol. 2022;81(1):75–94. https://doi.org/10.1016/j.eururo.2021.08.010.

Article  PubMed  Google Scholar 

Yurchenco PD. Basement membranes: cell scaffoldings and signaling platforms. Cold Spring Harb Perspect Biol. 2011;3(2). https://doi.org/10.1101/cshperspect.a004911.

Gatseva A, Sin YY, Brezzo G, Van Agtmael T. Basement membrane collagens and disease mechanisms. Essays Biochem. 2019;63(3):297–312. https://doi.org/10.1042/EBC20180071.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Miller RT. Mechanical properties of basement membrane in health and disease. Matrix Biol. 2017;57–58:366 – 73. https://doi.org/10.1016/j.matbio.2016.07.001

Seyfried TN, Huysentruyt LC. On the origin of cancer metastasis. Crit Rev Oncog. 2013;18(1–2):43–73. https://doi.org/10.1615/critrevoncog.v18.i1-2.40.

Article  PubMed  PubMed Central  Google Scholar 

Guan X. Cancer metastases: challenges and opportunities. Acta Pharm Sin B. 2015;5(5):402–18. https://doi.org/10.1016/j.apsb.2015.07.005.

Article  PubMed  PubMed Central  Google Scholar 

Kluth LA, Black PC, Bochner BH, Catto J, Lerner SP, Stenzl A, et al. Prognostic and Prediction Tools in Bladder Cancer: A Comprehensive Review of the Literature. Eur Urol. 2015;68(2):238–53. https://doi.org/10.1016/j.eururo.2015.01.032.

Article  PubMed  Google Scholar 

Dai H, Zhao K, Zhao Y, Jiang K, Hang Z, Huang X, et al. Machine learning model in multi-omics perspective demystifies the prognostic significance of crotonylation heterogeneity in clear cell renal cell carcinoma. BMC Urol. 2025;25(1):229. https://doi.org/10.1186/s12894-025-01914-4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dai H, Yu Z, Zhao Y, Jiang K, Hang Z, Huang X, et al. Integrating machine learning models with multi-omics analysis to decipher the prognostic significance of mitotic catastrophe heterogeneity in bladder cancer. Biol Direct. 2025;20(1):56. https://doi.org/10.1186/s13062-025-00650-x.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, Zhu H, Ren J, Ren M. Integrative machine learning models predict prostate cancer diagnosis and biochemical recurrence risk: Advancing precision oncology. NPJ Digit Med. 2025;8(1):524. https://doi.org/10.1038/s41746-025-01930-6.

Article  PubMed  PubMed Central  Google Scholar 

Dai H, Zhang X, Yin L, Chen H, Liu K, Li J, et al. Integrating machine learning and multi-omics analysis to explore Treg-associated programmed cell death features in clear cell renal cell carcinoma. Cancer Cell Int. 2026;26(1):15. https://doi.org/10.1186/s12935-025-04133-x.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Charoentong P, Finotello F, Angelova M, Mayer C, Efremova M, Rieder D, et al. Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade. Cell Rep. 2017;18(1):248–62. https://doi.org/10.1016/j.celrep.2016.12.019.

Article  CAS  PubMed  Google Scholar 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209–49. https://doi.org/10.3322/caac.21660.

Article  CAS  PubMed  Google Scholar 

Wronski P, Wronski S, Kurant M, Malinowski B, Wicinski M. Curcumin may prevent basement membrane disassembly by matrix metalloproteinases and progression of the bladder cancer. Nutrients. 2021;14(1). https://doi.org/10.3390/nu14010032.

Kang SG, Ha YR, Ko YH, Kang SH, Joo KJ, Cho HY, et al. Effect of laminin 332 on motility and invasion in bladder cancer. Kaohsiung J Med Sci. 2013;29(8):422–9. https://doi.org/10.1016/j.kjms.2012.12.003.

Article  PubMed  PubMed Central  Google Scholar 

Kamada M, Koshikawa N, Minegishi T, Kawada C, Karashima T, Shuin T, et al. Urinary laminin-gamma2 is a novel biomarker of non-muscle invasive urothelial carcinoma. Cancer Sci. 2015;106(12):1730–7. https://doi.org/10.1111/cas.12832.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao L, Ren R, Shen J, Hou J, Ning J, Feng Y, et al. Values of OAS gene family in the expression signature, immune cell infiltration and prognosis of human bladder cancer. BMC Cancer. 2022;22(1):1016. https://doi.org/10.1186/s12885-022-10102-8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang W, Chen L, Lu X, Dong X, Feng M, Tu Y, et al. EFHD2 regulates T cell receptor signaling and modulates T helper cell activation in early sepsis. Int Immunopharmacol. 2024;133:112087. https://doi.org/10.1016/j.intimp.2024.112087.

Article  CAS  PubMed  Google Scholar 

Muraoka D, Seo N, Hayashi T, Hyuga-Amaike C, Okamori K, Tawara I, et al. Signal-transducing adaptor protein-2 promotes generation of functional long-term memory CD8 + T cells by preventing terminal effector differentiation. Oncotarget. 2017;8(19):30766–80. https://doi.org/10.18632/oncotarget.15403.

Article  PubMed  PubMed Central  Google Scholar 

He K, Lin C, Wang H, Wu H, Yin S, Tao C, et al. The circ-GLG1/miR-346/KCNJ9 axis drives malignant progression of bladder cancer by modulating KCNJ9 expression. Exp Cell Res. 2026;455(2):114885. https://doi.org/10.1016/j.yexcr.2026.114885.

Article  CAS  PubMed  Google Scholar 

Chen F, Lin J, Kang R, Tang D, Liu J. Alkaliptosis induction counteracts paclitaxel-resistant ovarian cancer cells via ATP6V0D1-mediated ABCB1 inhibition. Mol Carcinog. 2024;63(8):1515–27. https://doi.org/10.1002/mc.23741.

Article  CAS  PubMed  Google Scholar 

Chang CF, Chen LC, Chen YT, Huang CY, Yu CC, Lin VC, et al. Unveiling DENND2D as a novel prognostic biomarker for prostate cancer recurrence: from gene to prognosis. Biomedicines. 2024;13(1). https://doi.org/10.3390/biomedicines13010025.

Salazar C, Yanez O, Elorza AA, Cortes N, Garcia-Beltran O, Tiznado W, et al. Biosystem analysis of the hypoxia inducible domain family member 2a: implications in cancer biology. Genes (Basel). 2020;11(2). https://doi.org/10.3390/genes11020206.

Zhu H, Zhao Y, Wang Y, Wei G, Liu J. Understanding the relationship between cuproptosis and the development of hepatocellular carcinoma: implications for targeted therapies. Front Immunol. 2025;16:1557223. https://doi.org/10.3389/fimmu.2025.1557223.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun J, Ren S, Zhao Q, He J, Wang Y, Ren M. Endostatin-based anti-angiogenic therapy and immune modulation: mechanisms and synergistic potential in cancer treatment. Front Immunol. 2025;16:1623859. https://doi.org/10.3389/fimmu.2025.1623859.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bozyk A, Wojas-Krawczyk K, Krawczyk P, Milanowski J. Tumor microenvironment-a short review of cellular and interaction diversity. Biology (Basel). 2022;11(6). https://doi.org/10.3390/biology11060929.

van Dorp J, van der Heijden MS. The bladder cancer immune micro-environment in the context of response to immune checkpoint inhibition. Front Immunol. 2023;14:1235884. https://doi.org/10.3389/fimmu.2023.1235884.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Comments (0)

No login
gif