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IL-6R-CD3–engineered regulatory T cells alleviate neuropathic pain by remodeling the neuroimmune microenvironment
IL-6R-CD3–engineered regulatory T cells alleviate neuropathic pain by remodeling the neuroimmune microenvironment
Chronic neurological condition Neuropathic pain is marked by sustained neuronal sensitization. Regulatory T cells are cruc...
Machine learning-based identification of basement membrane-related signature to predict recurrence and immunotherapy benefit in bladder cancer
Machine learning-based identification of basement membrane-related signature to predict recurrence and immunotherapy benefit in bladder cancer
The basement membrane (BM) plays a critical role in regulating bladder cancer (BC) progression. However, a BM-related sign...
Moxibustion combined with anti-PD-1 antibodies improves immunosuppression in septic mice potentially through the PD-1/PD-L1 pathway
Moxibustion combined with anti-PD-1 antibodies improves immunosuppression in septic mice potentially through the PD-1/PD-L1 pathway
This study was to investigate the therapeutic effects of moxibustion (Mox) combined with anti-PD-1 antibody on septic mice...
Association between COVID-19 booster vaccination and influenza mortality: a nationwide retrospective cohort study using the SIVEP-Gripe database in Brazil
Association between COVID-19 booster vaccination and influenza mortality: a nationwide retrospective cohort study using the SIVEP-Gripe database in Brazil
To identify clinical and epidemiological predictors of mortality among patients hospitalized with laboratory-confirmed inf...
Decoding PANoptosis: Crosstalk of cell death pathways in immunity and inflammation
Decoding PANoptosis: Crosstalk of cell death pathways in immunity and inflammation
PANoptosis is an emerging regulated cell death that integrates the molecular machinery of apoptosis, necroptosis, and pyro...
TRIM28 and TRIM32: multifaceted regulators of innate immunity and antiviral defence
TRIM28 and TRIM32: multifaceted regulators of innate immunity and antiviral defence
As versatile E3 ubiquitin ligases, Tripartite Motif (TRIM) proteins are essential elements of the innate immune response. ...
Immune checkpoint inhibitor-induced myasthenia gravis and myocarditis: a fatal immune-related adverse event
Immune checkpoint inhibitor-induced myasthenia gravis and myocarditis: a fatal immune-related adverse event
Checkpoint inhibitors, a class of immunotherapeutic agents, have transformed the oncology landscape by targeting immune ch...
Microbiome immune crosstalk in Sjögren’s syndrome: mechanistic insights and translational perspectives
Microbiome immune crosstalk in Sjögren’s syndrome: mechanistic insights and translational perspectives
Sjögren’s syndrome (SS) is a systemic autoimmune disorder driven by interactions among genetic susceptibility, ...
Emapalumab plus conventional therapy with or without ruxolitinib for pediatric hemophagocytic lymphohistiocytosis: a single center retrospective study
Emapalumab plus conventional therapy with or without ruxolitinib for pediatric hemophagocytic lymphohistiocytosis: a single center retrospective study
Background. Hemophagocytic lymphohistiocytosis (HLH) is a rare, highly fatal hyperinflammatory syndrome characterized by a...
Emerging target antigen landscape for CAR T-cell therapy in solid tumors: current advances and future directions
Emerging target antigen landscape for CAR T-cell therapy in solid tumors: current advances and future directions
Chimeric antigen receptor (CAR) T-cell therapy has achieved remarkable clinical success in hematologic malignancies but re...
Transcriptomic analysis of lncRNA-miRNA-mRNA competing endogenous RNA regulatory networks in radiation-induced mouse thymic degeneration
Transcriptomic analysis of lncRNA-miRNA-mRNA competing endogenous RNA regulatory networks in radiation-induced mouse thymic degeneration
Excessive or inappropriate radiation can seriously harm organisms. Radiation-induced thymus injury (RITI) is a severe comp...
Decoding the PI3K/Akt/mTOR–JAK/STAT signaling axis in multiple sclerosis: mechanistic crosstalk and therapeutic opportunities
Decoding the PI3K/Akt/mTOR–JAK/STAT signaling axis in multiple sclerosis: mechanistic crosstalk and therapeutic opportunities
Multiple Sclerosis (MS) is a chronic immune-mediated neurodegenerative disorder characterized by demyelination, axonal inj...
Therapeutic and pharmacological effects of quercetin in autoimmune diseases: a systematic review of preclinical and clinical evidence
Therapeutic and pharmacological effects of quercetin in autoimmune diseases: a systematic review of preclinical and clinical evidence
Autoimmune diseases are chronic conditions that arise from the loss of immune tolerance toward the body’s own tissue...
Integrated transcriptomic analysis of peripheral blood CD4 + T cells identifies immune-associated hub genes in rheumatoid arthritis: discovery and external validation
Integrated transcriptomic analysis of peripheral blood CD4 + T cells identifies immune-associated hub genes in rheumatoid arthritis: discovery and external validation
Rheumatoid arthritis (RA) is a chronic autoimmune disease driven by dysregulated immune responses, particularly involving ...
Bone marrow SUVmax on F-FDG PET / CT reflects disease burden and immunosuppressive microenvironment in newly diagnosed multiple myeloma
Bone marrow SUVmax on F-FDG PET / CT reflects disease burden and immunosuppressive microenvironment in newly diagnosed multiple myeloma
Disorder of the immune microenvironment plays an important role in the occurrence and development of multiple myeloma in p...
Immune cells in liver transplantation: Dual roles, mechanistic insights, and targeted therapeutic strategies
Immune cells in liver transplantation: Dual roles, mechanistic insights, and targeted therapeutic strategies
Liver transplantation is the most effective treatment for end-stage liver disease and acute liver failure; however, organ ...
Past achievements and future perspectives of personalized vaccines and the role of dendritic cells
Past achievements and future perspectives of personalized vaccines and the role of dendritic cells
Personalized vaccines provide the advantage of patient-specific antigen selection to optimize immune responses, a strategy...
Seasonal pattern, global search trend, and public interest in arthritis from 2004 to 2022: an infodemiology study
Seasonal pattern, global search trend, and public interest in arthritis from 2004 to 2022: an infodemiology study
Arthritis is a common condition that causes articular cartilage damage, joint tissue destruction, and ligament involvement...
Disease activity and immune disbalance are key drivers of infections in patients with idiopathic inflammatory myopathies: results from the MYOTReCSZ cohort
Disease activity and immune disbalance are key drivers of infections in patients with idiopathic inflammatory myopathies: results from the MYOTReCSZ cohort
Patients with idiopathic inflammatory myopathies (IIM) are at increased risk for infections. Identifying clinical and immu...
Characterization of the neuromuscular manifestations in patients with IgG4-related disease: a systematic review
Characterization of the neuromuscular manifestations in patients with IgG4-related disease: a systematic review
Immunoglobulin G4-related disease (IgG4-RD) neurological involvement typically presents as pachymeningitis. However, there...
Dexmedetomidine protects against postoperative neurocognitive disorder by mitigating mitochondrial dysfunction through regulating the IP3R-GRP75-VDAC1 complex-mediated calcium transport
Dexmedetomidine protects against postoperative neurocognitive disorder by mitigating mitochondrial dysfunction through regulating the IP3R-GRP75-VDAC1 complex-mediated calcium transport
Dexmedetomidine (Dex), an α2 adrenergic receptor agonist, has been shown to exert protective effects against postoper...
History of cold urticaria research: from systematic studies of the 19th century to modern prospective strategies in clinical practice
History of cold urticaria research: from systematic studies of the 19th century to modern prospective strategies in clinical practice
This study aimed to determine the current prospective strategies for diagnosing and treating cold urticaria based on the h...
STAT6 inhibition stabilizes induced regulatory T cells and enhances their therapeutic potential in inflammatory bowel disease
STAT6 inhibition stabilizes induced regulatory T cells and enhances their therapeutic potential in inflammatory bowel disease
The development and stability of induced regulatory T cells (iTregs) are essential for their immunosuppressive function an...
Lactylation-related multigene signature in multiple myeloma: integrated prognostic stratification, immune landscape profiling, and therapeutic guidance
Lactylation-related multigene signature in multiple myeloma: integrated prognostic stratification, immune landscape profiling, and therapeutic guidance
Multiple myeloma (MM) is an incurable hematologic malignancy with high heterogeneity and poor prognosis. Lactylation, a no...
Macrophage migration inhibitory factor (MIF): a Janus-faced cytokine in viral pathogenesis and host defense
Macrophage migration inhibitory factor (MIF): a Janus-faced cytokine in viral pathogenesis and host defense
Macrophage migration inhibitory factor (MIF) is one of several pivotal cytokines that contribute to orchestrate immune reg...
Regulatory dynamics of Th17 lymphocytes in oral squamous cell carcinoma: immune modulation and emerging immunotherapies
Regulatory dynamics of Th17 lymphocytes in oral squamous cell carcinoma: immune modulation and emerging immunotherapies
With the rapid increase in the severity and mortality of OSCC, the potential for new and effective therapies has increased...
Polymorphisms in and genes in rheumatoid arthritis: a Brazilian study and meta-analysis of susceptibility and TNFi response
Polymorphisms in and genes in rheumatoid arthritis: a Brazilian study and meta-analysis of susceptibility and TNFi response
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and progressiv...
BECN1 activator peptide Tat-beclin 1 promotes ferroptosis via the BECN1-SLC7A11 axis to inhibit NSCLC progression
BECN1 activator peptide Tat-beclin 1 promotes ferroptosis via the BECN1-SLC7A11 axis to inhibit NSCLC progression
Non-small-cell lung cancer (NSCLC) is associated with high mortality. Beclin 1 (BECN1), an autophagy regulator, and ferrop...
Deciphering macrophage dynamics and immune evasion strategies by the intracellular bacteria
Deciphering macrophage dynamics and immune evasion strategies by the intracellular bacteria
Macrophages are the constituents of the innate immune system that play an important role in the control of infections, pha...
MYC affects mitochondrial function in IgA nephropathy by promoting the degradation of MFN1 through HRD1
MYC affects mitochondrial function in IgA nephropathy by promoting the degradation of MFN1 through HRD1
IgA nephropathy is characterized by the deposition of IgA and complement C3 in the glomerular mesangial region. Recent res...
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