Wang L, Wang F-S, Gershwin, Wang ME, Wang A, Me L. G. Human autoimmune diseases: A comprehensive update. J Intern Med. John Wiley & Sons, Ltd; 2015;278:369–95. https://doi.org/10.1111/joim.12395
Pisetsky DS. Pathogenesis of autoimmune disease. Nat Rev Nephrol Nat Res. 2023;19:1. https://doi.org/10.1038/s41581-023-00720-1.
David M. Introduction to immunity and inflammation. In: Brunton LL, Knollmann BC, editors. Goodman & Gilman’s The Pharmacological Basis of Therapeutics. 14th ed. McGraw Hill; 2023. pp. 749–67.
Warrick KA, Vallez CN, Meibers HE, Pasare C. Bidirectional communication between the innate and adaptive immune systems. Annu Rev Immunol Annual Reviews Inc. 2025;43:489–514. https://doi.org/10.1146/annurev-immunol-083122-040624.
Conrad N, Misra S, Verbakel JY, Verbeke G, Molenberghs G, Taylor PN, et al. Incidence, prevalence, and co-occurrence of autoimmune disorders over time and by age, sex, and socioeconomic status: A population-based cohort study of 22 million individuals in the UK. The Lancet. Elsevier B V. 2023;401:1878–90. https://doi.org/10.1016/S0140-6736(23)00457-9.
Abend AH, He I, Bahroos N, Christianakis S, Crew AB, Wise LM, et al. Estimation of prevalence of autoimmune diseases in the United States using electronic health record data. J Clin Invest Am Soc Clin Invest. 2025;135. https://doi.org/10.1172/JCI178722.
Mohamed-Ahmed O, Shang L, Wang L, Chen Z, Kartsonaki C, Bragg F. Incidence and prevalence of autoimmune diseases in China: A systematic review and meta-analysis of epidemiological studies. Glob Epidemiol Elsevier Inc. 2024;8:100158. https://doi.org/10.1016/j.gloepi.2024.100158.
Lee AY, Jeong J, Heo KN, Park S, Ah YM, Han JM, et al. Complications associated with immunosuppressive agents in solid organ transplant recipients: A nationwide analysis. J Clin Med Multidisciplinary Digit Publishing Inst (MDPI). 2025;14:3602. https://doi.org/10.3390/jcm14103602.
Panche AN, Diwan AD, Chandra SR. Flavonoids: an overview. Volume 5. Cambridge University Press; 2016. p. e47. [cited 2025 Oct 9];. https://doi.org/10.1017/JNS.2016.41. J Nutr Sci [Internet].
Vollmannová A, Bojňanská T, Musilová J, Lidiková J, Cifrová M. Quercetin as one of the most abundant represented biological valuable plant components with remarkable chemoprotective effects - A review. Heliyon [Internet] Elsevier. 2024;10:e33342. https://doi.org/10.1016/J.HELIYON.2024.E33342. [cited 2025 Oct 9];.
Khazdair MR, Anaeigoudari A, Agbor GA. Anti-viral and anti-inflammatory effects of kaempferol and quercetin and COVID-2019: A scoping review. Asian Pac. J. Trop. Biomed. Wolters Kluwer Medknow Publications; 2021. pp. 327–34. https://doi.org/10.4103/2221-1691.319567
Rocha MFG, Sales JA, da Rocha MG, Galdino LM, de Aguiar L, de Pereira-Neto W. Antifungal effects of the flavonoids kaempferol and quercetin: a possible alternative for the control of fungal biofilms. Biofouling Taylor Francis Ltd. 2019;35:320–8. https://doi.org/10.1080/08927014.2019.1604948.
Shrestha R, Mohankumar K, Martin G, Hailemariam A, Lee S, ook, Jin U et al. ho,. Flavonoids kaempferol and quercetin are nuclear receptor 4A1 (NR4A1, Nur77) ligands and inhibit rhabdomyosarcoma cell and tumor growth. Journal of Experimental and Clinical Cancer Research. BioMed Central Ltd; 2021;40. https://doi.org/10.1186/s13046-021-02199-9
Long Z, Xiang W, He Q, Xiao W, Wei H, Li H, et al. Efficacy and safety of dietary polyphenols in rheumatoid arthritis: A systematic review and meta-analysis of 47 randomized controlled trials. Front Immunol Front Immunol. 2023;14. https://doi.org/10.3389/fimmu.2023.1024120.
Gangwar V, Garg A, Lomore K, Korla K, Bhat SS, Rao RP, et al. Immunomodulatory effects of a concoction of natural bioactive compounds-mechanistic insights. Biomedicines Biomedicines. 2021;9. https://doi.org/10.3390/biomedicines9111522.
Nisar A, Jagtap S, Vyavahare S, Deshpande M, Harsulkar A, Ranjekar P, et al. Phytochemicals in the treatment of inflammation-associated diseases: The journey from preclinical trials to clinical practice. Front Pharmacol Front Media S A. 2023;14:1177050. https://doi.org/10.3389/fphar.2023.1177050.
Samadi F, Kahrizi MS, Heydari F, Arefnezhad R, Roghani-Shahraki H, Mokhtari Ardekani A, Karger AG et al. 2022;107:464–71. https://doi.org/10.1159/000525494.
Shen P, Lin W, Deng X, Ba X, Han L, Chen Z, et al. Potential implications of quercetin in autoimmune diseases. Front Immunol Front Media S A. 2021;12:689044. https://doi.org/10.3389/fimmu.2021.689044.
Guan F, Wang Q, Bao Y, Chao Y. Anti-rheumatic effect of quercetin and recent developments in nano formulation. RSC Adv Royal Soc Chem. 2021;11:7280. https://doi.org/10.1039/d0ra08817j.
Liu X, Tao T, Yao H, Zheng H, Wang F, Gao Y. Mechanism of action of quercetin in rheumatoid arthritis models: Meta-analysis and systematic review of animal studies. Inflammopharmacology Inflammopharmacology. 2023;31:1629–45. https://doi.org/10.1007/s10787-023-01196-y.
Article CAS PubMed Google Scholar
Atta A, Salem MM, El-Said KS, Mohamed TM. Mechanistic role of quercetin as inhibitor for adenosine deaminase enzyme in rheumatoid arthritis: Systematic review. Cell Mol Biol Lett Cell Mol Biol Lett. 2024;29. https://doi.org/10.1186/s11658-024-00531-7.
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ BMJ. 2021;372. https://doi.org/10.1136/bmj.n71.
Richardson WS, Wilson MC, Nishikawa J, Hayward RS. The well-built clinical question: A key to evidence-based decisions. ACP J Club. 1995;123:A12–3.
Article CAS PubMed Google Scholar
Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan-a web and mobile app for systematic reviews. Syst Rev BioMed Cent Ltd. 2016;5:1–10. https://doi.org/10.1186/s13643-016-0384-4.
Sterne JAC, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ [Internet]. British Medical Journal Publishing Group; 2019 [cited 2026 Jan 26];366. https://doi.org/10.1136/BMJ.L4898
Javadi F, Eghtesadi S, Ahmadzadeh A, Aryaeian N, Zabihiyeganeh M, Foroushani AR, et al. The effect of quercetin on plasma oxidative status, C-reactive protein and blood pressure in women with rheumatoid arthritis. Int J Prev Med. 2014;5:239–301.
Javadi F, Ahmadzadeh A, Eghtesadi S, Aryaeian N, Zabihiyeganeh M, Rahimi Foroushani A, et al. The effect of quercetin on inflammatory factors and clinical symptoms in women with rheumatoid arthritis: A double-blind, randomized controlled trial. J Am Coll Nutr Routledge. 2017;36:9–15. https://doi.org/10.1080/07315724.2016.1140093.
Li C, Pan J, Xu C, Jin Z, Chen X. A preliminary inquiry into the potential mechanism of huang-lian-jie-du decoction in treating rheumatoid arthritis via network pharmacology and molecular docking. Front Cell Dev Biol Front Media S A. 2022;9. https://doi.org/10.3389/fcell.2021.740266.
Pan F, Zhu L, Lv H, Pei C. Quercetin promotes the apoptosis of fibroblast-like synoviocytes in rheumatoid arthritis by upregulating lncRNA MALAT1. Int J Mol Med Spandidos Publications. 2016;38:1507–14. https://doi.org/10.3892/ijmm.2016.2755.
Zhao J, Chen B, Peng X, Wang C, Wang K, Han F, et al. Quercetin suppresses migration and invasion by targeting miR-146a/GATA6 axis in fibroblast-like synoviocytes of rheumatoid arthritis. Immunopharmacol Immunotoxicol Taylor Francis Ltd. 2020;42:221–7. https://doi.org/10.1080/08923973.2020.1742732.
Sun H-T, Li J-P, Qian W-Q, Yin M-F, Yin H, Huang G-C. Quercetin suppresses inflammatory cytokine production in rheumatoid arthritis fibroblast-like synoviocytes. Exp Ther Med Spandidos Publications. 2021;22. https://doi.org/10.3892/etm.2021.10695.
Chen G, Ye Y, Cheng M, Tao Y, Zhang K, Huang Q, et al. Quercetin combined with human umbilical cord mesenchymal stem cells regulated tumour necrosis factor-α/interferon-γ-stimulated peripheral blood mononuclear cells via activation of toll-like receptor 3 signalling. Front Pharmacol Front Media S A. 2020;11. https://doi.org/10.3389/fphar.2020.00499.
Kim HR, Kim BM, Won JY, Lee KA, Ko HM, Kang YS, et al. Quercetin, a plant polyphenol, has potential for the prevention of bone destruction in rheumatoid arthritis. J Med Food Mary Ann Liebert Inc. 2019;22:152–61. https://doi.org/10.1089/jmf.2018.4259.
Zheng Q, Wang D, Lin R, Chen Y, Xu Z, Xu W. Quercetin is a potential therapy for rheumatoid arthritis via targeting Caspase-8 through ferroptosis and pyroptosis. J Inflamm Res Dove Med Press Ltd. 2023;16:5729–54. https://doi.org/10.2147/JIR.S439494.
Amirchaghmaghi M, Delavarian Z, Iranshahi M, Shakeri MT, Mosannen Mozafari P, Mohammadpour AH, et al. A randomized placebo-controlled double blind clinical trial of quercetin for treatment of oral lichen planus. J Dent Res Dent Clin Dent Prospects. Maad Rayan Publishing Co. 2015;9:23–8. https://doi.org/10.15171/joddd.2015.005.
Zhao Z, Wang L, Zhang M, Zhou C, Wang Y, Ma J, et al. Reveals of quercetin’s therapeutic effects on oral lichen planus based on network pharmacology approach and experimental validation. Sci Rep Nat Res. 2022;12. https://doi.org/10.1038/s41598-022-04769-z.
Liu Y, Yu C, Ji K, Wang X, Li X, Xie H, et al. Quercetin reduces TNF-α-induced mesangial cell proliferation and inhibits PTX3 production: Involvement of NF-κB signaling pathway. Phytotherapy Res John Wiley Sons Ltd. 2019;33:2401–8. https://doi.org/10.1002/ptr.6430.
Luo X, Bao X, Weng X, Bai X, Feng Y, Huang J, et al. The protective effect of quercetin on macrophage pyroptosis via TLR2/Myd88/NF-κB and ROS/AMPK pathway. Life Sci. Elsevier Inc.; 2022. p. 291. https://doi.org/10.1016/j.lfs.2021.120064.
Li Y, Yao J, Han C, Yang J, Chaudhry MT, Wang S, et al. Quercetin, inflammation and immunity. Nutrients MDPI AG. 2016;8:167. https://doi.org/10.3390/nu8030167.
Chen HY, Chiang YF, Hong YH, Shieh TM, Huang TC, Ali M, et al. Quercetin ameliorates renal injury and pyroptosis in lupus nephritis through inhibiting IL-33/ST2 pathway in vitro and in vivo. Antioxid MDPI. 2022;11:2238. https://doi.org/10.3390/antiox11112238.
Yang Y, Zhang X, Xu M, Wu X, Zhao F, Zhao C. Quercetin attenuates collagen-induced arthritis by restoration of Th17/Treg balance and activation of Heme Oxygenase 1-mediated anti-inflammatory effect. Int Immunopharmacol [Internet] Elsevier. 2018;54:153–62. https://doi.org/10.1016/j.intimp.2017.11.013. [cited 2025 Oct 15];. B.V.
Feng L, Yang Z, Hou N, Wang M, Lu X, Li Y, et al. Long non-coding RNA Malat1 increases the rescuing effect of quercetin on TNFα-impaired bone marrow stem cell osteogenesis and ovariectomy-induced osteoporosis. Int J Mol Sci Int J Mol Sci. 2023;24. https://doi.org/10.3390/ijms24065965.
O’Brien J, Hayder H, Zayed Y, Peng C. Overview of microRNA biogenesis, mechanisms of actions, and circulation. Front Endocrinol (Lausanne) Front Media S A. 2018;9:402. https://doi.org/10.3389/fendo.2018.00402.
Ke X, Chen Z, Wang X, Kang H, Hong S. Quercetin improves the imbalance of Th1/Th2 cells and Treg/Th17 cells to attenuate allergic rhinitis. Autoimmun Autoimmun. 2023;56. https://doi.org/10.1080/08916934.2023.2189133.
Lin J, Li F, Jiao J, Qian Y, Xu M, Wang F, et al. Quercetin, a natural flavonoid, protects against hepatic ischemia–reperfusion injury via inhibiting Caspase-8/ASC dependent macrophage pyroptosis. J Adv Res Elsevier B V. 2025;70:555–69. https://doi.org/10.1016/j.jare.2024.05.010.
Sul OJ, Ra SW. Quercetin prevents LPS-induced oxidative stress and inflammation by modulating NOX2/ROS/NF-kB in lung epithelial cells. Molecules [Internet] Molecules. 2021. https://doi.org/10.3390/molecules26226949. [cited 2025 Oct 15];26.
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