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Catastrophic antiphospholipid syndrome presented with coronary thrombosis, renal impairment, and suspected diffuse alveolar hemorrhage treated with rituximab biosimilar (CT-P10)
Catastrophic antiphospholipid syndrome presented with coronary thrombosis, renal impairment, and suspected diffuse alveolar hemorrhage treated with rituximab biosimilar (CT-P10)
Catastrophic antiphospholipid syndrome (CAPS) is a lethal disease that occurs suddenly and progresses to multi-organ failu...
Amelioration of DMH-induced colon cancer by eupafolin through the reprogramming of apoptosis-associated p53/Bcl2/Bax signaling in rats
Amelioration of DMH-induced colon cancer by eupafolin through the reprogramming of apoptosis-associated p53/Bcl2/Bax signaling in rats
Introduction: Colorectal cancer is the third most common malignancy and the second most deadly cancer worldwide. In this p...
Clinical and histological safety assessment of repeated intra-articular sevoflurane injections into knee joints of Sprague-Dawley rats
Clinical and histological safety assessment of repeated intra-articular sevoflurane injections into knee joints of Sprague-Dawley rats
ObjectivesWe investigated the effects of repeated intra-articular injections of liquid sevoflurane to articular structures...
Dysregulation of let-7c-5p/Tyrosyl-DNA phosphodiesterase 1 axis indicates an unfavorable outcome in gastric cancer
Dysregulation of let-7c-5p/Tyrosyl-DNA phosphodiesterase 1 axis indicates an unfavorable outcome in gastric cancer
IntroductionTyrosyl-DNA phosphodiesterase 1 (TDP1) can repair oxidative damage-caused 3′-phosphoglycolates and promote can...
Nitric oxide synthase-2 (CCTTT)n polymorphism is associated with local gene expression and clinical manifestations in patients with chronic rhinosinusitis
Nitric oxide synthase-2 (CCTTT)n polymorphism is associated with local gene expression and clinical manifestations in patients with chronic rhinosinusitis
IntroductionNitric oxide (NO) is synthesized through NO synthase (NOS). The proximal NOS2 gene promoter contains the penta...
The impacts of oxygen and pentoxifylline in hypoxic condition
The impacts of oxygen and pentoxifylline in hypoxic condition
Introduction:Among major trauma patients in the emergency department, the leading cause of morbidity and mortality is a he...
Systemic lupus erythematosus after delivery and myasthenia gravis with COL6A1 gene mutation: A case report
Systemic lupus erythematosus after delivery and myasthenia gravis with COL6A1 gene mutation: A case report
The coexistence of systemic lupus erythematosus (SLE) and myasthenia gravis (MG) is rarely reported, especially the appear...
Clinical characteristics of patients with acquired immunodeficiency syndrome having respiratory symptoms as the initial manifestations: A retrospective study
Clinical characteristics of patients with acquired immunodeficiency syndrome having respiratory symptoms as the initial manifestations: A retrospective study
The aim of the study was to investigate clinical features of patients with AIDS having respiratory symptoms as initial man...
Anti-inflammatory and protective effects of combined treatment with sitagliptin and melatonin in cardiac ischemia reperfusion injury in obese rats: Involvement of TLR-4/NF-κB pathway
Anti-inflammatory and protective effects of combined treatment with sitagliptin and melatonin in cardiac ischemia reperfusion injury in obese rats: Involvement of TLR-4/NF-κB pathway
Background: Obesity is associated with an augmented risk of myocardial ischemia/reperfusion (I/R) injury. Reduction of I/R...
Can chest radiographic findings determine disease severity in Covid-19-positive patients? A single-center study
Can chest radiographic findings determine disease severity in Covid-19-positive patients? A single-center study
ObjectivesThe purpose of this study was to describe the severity of the radiographic findings of COVID-19 over time and to...
Diosmetin attenuate experimental ulcerative colitis in rats via suppression of NF-κB, TNF-α and IL-6 signalling pathways correlated with down-regulation of apoptotic events
Diosmetin attenuate experimental ulcerative colitis in rats via suppression of NF-κB, TNF-α and IL-6 signalling pathways correlated with down-regulation of apoptotic events
IntroductionUlcerative colitis (UC) is a chronic inflammation of colon in which the innermost tissue of colon and rectum d...
Erythema in local and trunk skin caused by intramuscular injection of vitamin K1: A case report and literature review
Erythema in local and trunk skin caused by intramuscular injection of vitamin K1: A case report and literature review
A 52-year-old woman presented with erythema, papules, pain, and itching on the buttocks and trunk that had persisted for 1...
Association between aryl hydrocarbon receptor and 4-hydroxynonenal in oxidative stress-mediated chronic rhinosinusitis with nasal polyps
Association between aryl hydrocarbon receptor and 4-hydroxynonenal in oxidative stress-mediated chronic rhinosinusitis with nasal polyps
ObjectiveСhronic rhinosinusitis with nasal polyps (CRSwNPs) is a distinct entity within the chronic rhinosinusitis group o...
Neutrophil extracellular traps are associated with altered human pulmonary artery endothelial barrier function
Neutrophil extracellular traps are associated with altered human pulmonary artery endothelial barrier function
Introduction: Acute respiratory response syndrome (ARDS) leads to increased permeability of the endothelial-epithelial bar...
COVID-19 vaccine and corticosteroids: A challenging issue
COVID-19 vaccine and corticosteroids: A challenging issue
Access to society journal content varies across our titles. If you have access to a journal via a society or association ...
Curcumin suppresses neuroinflammation to protect neurons by preventing NLRP3 inflammasome activation
Curcumin suppresses neuroinflammation to protect neurons by preventing NLRP3 inflammasome activation
IntroductionNucleotide-binding and oligomerization domain like receptors protein 3 (NLRP3) inflammasome-mediated interleuk...
Can the coronavirus disease 2019 (COVID-19) cause choroiditis and optic neuropathy?
Can the coronavirus disease 2019 (COVID-19) cause choroiditis and optic neuropathy?
Objectives: We aim to investigate the involvement of the choroid and retinal nerve fiber layer (RNFL) in COVID-19 patients...
Wnt/β-catenin signaling regulates lipopolysaccharide-altered polarizations of RAW264.7 cells and alveolar macrophages in mouse lungs
Wnt/β-catenin signaling regulates lipopolysaccharide-altered polarizations of RAW264.7 cells and alveolar macrophages in mouse lungs
IntroductionMacrophages are capable of exerting both proinflammatory and anti-inflammatory functions in response to distin...
Optimal timing for laparoscopic cholecystectomy in the treatment of gallbladder calculi incarceration
Optimal timing for laparoscopic cholecystectomy in the treatment of gallbladder calculi incarceration
ObjectiveLaparoscopic cholecystectomy (LC) has become a popular method in the treatment of gallbladder calculi incarcerati...
Identifying mechanisms of Epimedii Folium against Alzheimer’s disease via a network pharmacology approach Epimedii Folium treats Alzheimer’s disease via PI3K-AKT
Identifying mechanisms of Epimedii Folium against Alzheimer’s disease via a network pharmacology approach Epimedii Folium treats Alzheimer’s disease via PI3K-AKT
To elucidate the mechanism of the multi-target action of Epimedii Folium on Alzheimer’s disease, this study focuses on the...
Efficacy, safety, and adherence of tocilizumab therapy in elderly patients with rheumatoid arthritis: A real-world observational study
Efficacy, safety, and adherence of tocilizumab therapy in elderly patients with rheumatoid arthritis: A real-world observational study
Objective: We evaluated the efficacy, safety, and drug survival rate of tocilizumab in the elderly patients with rheumatoi...
Clinicopathological characteristics of mucin phenotype and its relation to the malignant potential in early differentiated gastric adenocarcinoma
Clinicopathological characteristics of mucin phenotype and its relation to the malignant potential in early differentiated gastric adenocarcinoma
ObjectivesMucin phenotype is a tool to classify gastric cancer, but the relationship between mucin phenotype and its malig...
Rapamycin-induced M2 macrophage autophagy promotes the migration and invasion of bladder cancer cells via increased IL-10 secretion
Rapamycin-induced M2 macrophage autophagy promotes the migration and invasion of bladder cancer cells via increased IL-10 secretion
Intrduction:Rapamycin is an mTOR inhibitor and a prominent inducer of autophagy in cancer cells and tumor interstitial cel...
Antitumor activity of flavonoids from Alpinia officinarum hance on gastric cancer
Antitumor activity of flavonoids from Alpinia officinarum hance on gastric cancer
Introduction: To investigate antitumor activity and mechanism of flavonoids from Alpinia officinarum Hance against gastric...
Integrative analyses reveal RNA regulatory network in Ti particles induced inflammation
Integrative analyses reveal RNA regulatory network in Ti particles induced inflammation
Introduction Wear particles induced inflammatory osteolysis is the most important initiating factors in the mechanism of a...
Estradiol attenuates LPS-induced acute lung injury via induction of aquaporins AQP1 and AQP5
Estradiol attenuates LPS-induced acute lung injury via induction of aquaporins AQP1 and AQP5
BackgroundAcute lung injury (ALI) is associated with increased inflammation and oxidative stress. Estradiol is produced by...
Study on the inhibitory effect of ulinastatin on caspase-1-dependent pyroptosis in acinar cells of acute pancreatitis
Study on the inhibitory effect of ulinastatin on caspase-1-dependent pyroptosis in acinar cells of acute pancreatitis
ObjectivesPyroptosis, a special kind of cell death, is generally believed to aggravate the inflammatory response. It has b...
The roles of basophils in mediating the immune responses
The roles of basophils in mediating the immune responses
Basophils are the rarest blood cell population and have not been extensively studied. Our understanding of the functions o...
Patients who are admitted to the Department of Internal Medicine with a very low C-reactive protein concentration
Patients who are admitted to the Department of Internal Medicine with a very low C-reactive protein concentration
IntroductionC-reactive protein (CRP) is a marker commonly used in clinical practice as a reference for the inflammatory ac...
The effects of methylated flavonoids on depression-like activity and pro-inflammatory cytokine thresholds in mice induced by repeated finasteride administration
The effects of methylated flavonoids on depression-like activity and pro-inflammatory cytokine thresholds in mice induced by repeated finasteride administration
The aim of the study was to investigate the influence of naringenin (NGN) and its methylated derivatives (50 or 100 mg kg−...
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