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Integrated Multi-Omics Analyses Identify Acupuncture-Associated Changes in Gut Microbiota, Short-Chain Fatty Acids, and TNC Gene Expression in Chronic Migraine Rats
Integrated Multi-Omics Analyses Identify Acupuncture-Associated Changes in Gut Microbiota, Short-Chain Fatty Acids, and TNC Gene Expression in Chronic Migraine Rats
In NTG-induced CM rats, TA reduced hyperalgesia and neuroinflammation, accompanied by changes in gut microbiota, SCFA prof...
Comparative Analysis of Ferroptosis- and Mitochondria-Related Genes in Ischemic Stroke via Bioinformatics Analysis and Experimental Validation
Comparative Analysis of Ferroptosis- and Mitochondria-Related Genes in Ischemic Stroke via Bioinformatics Analysis and Experimental Validation
Ferroptosis-related gene signatures outperform mitochondria-associated genes in the diagnosis of ischemic stroke. Read more.
Microplastics, Gut Dysbiosis, and Inflammatory Pathways in Ulcerative Colitis
Microplastics, Gut Dysbiosis, and Inflammatory Pathways in Ulcerative Colitis
This review comprehensively reviews the fundamental characteristics of MPs and their interactions with the gut microbiota ...
Isopropyl 3-(3,4-Dihydroxyphenyl)-2-Hydroxypropanoate Attenuates Experimental Renal Ischemia-Reperfusion Injury by Limiting Sterile Inflammation and Preserving Mitochondrial Function: Involvement of an Nrf2-Associated Cytoprotective Response
Isopropyl 3-(3,4-Dihydroxyphenyl)-2-Hydroxypropanoate Attenuates Experimental Renal Ischemia-Reperfusion Injury by Limiting Sterile Inflammation and Preserving Mitochondrial Function: Involvement of an Nrf2-Associated Cytoprotective Response
Isopropyl 3-(3,4-Dihydroxyphenyl)-2-Hydroxypropanoate Attenuates Experimental Renal Ischemia-Reperfusion Injury by Limitin...
Gegen Qinlian Decoction Mitigates DSS-Induced Acute Colitis and Reinstates Gut Barrier Function in Mice, Correlating with Suppressed IL-33/ST2 Signaling
Gegen Qinlian Decoction Mitigates DSS-Induced Acute Colitis and Reinstates Gut Barrier Function in Mice, Correlating with Suppressed IL-33/ST2 Signaling
GGQLD reduces the severity of DSS-induced colitis in mice by inhibiting the IL-33/ST2 signaling pathway and alleviating di...
Genetically Predicted Associations of CX3CL1 and UMOD with Acute Kidney Injury Risk: Evidence from Mendelian Randomization and Clinical Validation
Genetically Predicted Associations of CX3CL1 and UMOD with Acute Kidney Injury Risk: Evidence from Mendelian Randomization and Clinical Validation
The genetic evidence and possible pathogenic mechanisms of CX3CL1 and UMOD as candidate proteins for AKI, CX3CL1 and UMOD....
The Role of Perivascular Stem Cells in Inflammatory Vascular Diseases: From Immunomodulation to Vascular Regeneration
The Role of Perivascular Stem Cells in Inflammatory Vascular Diseases: From Immunomodulation to Vascular Regeneration
Current evidence on three core mechanisms: immunomodulation, vascular repair, and mitochondrial transfer as a recently dis...
Inhibition of VNN1-Induced ROS-Dependent NETs Formation Alleviates Lung Injury and Systemic Inflammation in Sepsis Mice
Inhibition of VNN1-Induced ROS-Dependent NETs Formation Alleviates Lung Injury and Systemic Inflammation in Sepsis Mice
VNN1 inhibition reduces neutrophil extracellular traps formation and alleviates lung injury and systemic inflammation in s...
Targeting Macrophage-Mediated Mechanisms in Sepsis-Induced Cardiomyopathy: From Pathophysiology to Therapeutic Strategies
Targeting Macrophage-Mediated Mechanisms in Sepsis-Induced Cardiomyopathy: From Pathophysiology to Therapeutic Strategies
This review focuses on the key mechanisms by which macrophages contribute to SICM. We discuss macrophage-driven pathogenes...
Lipoxin A4 Attenuates E. coli-Induced ARDS-Like Lung Injury in Mice via ALX/FPR2-Dependent Macrophage Reprogramming
Lipoxin A4 Attenuates E. coli-Induced ARDS-Like Lung Injury in Mice via ALX/FPR2-Dependent Macrophage Reprogramming
LXA4 alleviates bacterial ARDS lung injury & promotes pro-resolving macrophages via ALX/FPR2 signaling—a promisi...
Postoperative Abdominal Infectious Complications Promote Colon Cancer Metastasis by Inducing MDSCs to Release Neutrophil Extracellular Traps
Postoperative Abdominal Infectious Complications Promote Colon Cancer Metastasis by Inducing MDSCs to Release Neutrophil Extracellular Traps
Postoperative infection is associated with enhanced colon cancer metastasis, and experimental data indicate that the MDSC-...
Tocilizumab in FIRES: From Treatment Timing to Treat-to-Target Use [Letter]
Tocilizumab in FIRES: From Treatment Timing to Treat-to-Target Use [Letter]
Letter for the article The Clinical Outcomes of Tocilizumab Usage in Cryptogenic Febrile Infection-Related Epilepsy Syndro...
Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Overlapping with IgG4-Related Disease Accompanied by Mesangial Immunoglobulin a Deposition: A Case Report
Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Overlapping with IgG4-Related Disease Accompanied by Mesangial Immunoglobulin a Deposition: A Case Report
Emerging evidence suggests that, in rare instances, AAV and IgG4-RD may coexist in the same patient, constituting an immun...
Therapeutic Efficacy of Sivelestat Sodium in ARDS Following Aortic Dissection: A Pilot Physiological Trial with Exploratory Transcriptomic Analysis
Therapeutic Efficacy of Sivelestat Sodium in ARDS Following Aortic Dissection: A Pilot Physiological Trial with Exploratory Transcriptomic Analysis
Evaluating the physiological and clinical effects of sivelestat in patients with aortic dissection–associated ARDS, ...
A Machine Learning-Based Nomogram for Predicting Overall Survival in BCLC Stage 0–B Hepatocellular Carcinoma Patients with Low HALP Score
A Machine Learning-Based Nomogram for Predicting Overall Survival in BCLC Stage 0–B Hepatocellular Carcinoma Patients with Low HALP Score
A low HALP score defines a subgroup of BCLC stage 0‑B HCC patients with poorer survival. This provides a tool for individu...
SIRT1 as a Key Regulator in Rheumatic Diseases: Integrating Molecular Insights with Traditional Chinese Medicine Approaches
SIRT1 as a Key Regulator in Rheumatic Diseases: Integrating Molecular Insights with Traditional Chinese Medicine Approaches
This review explores the role of SIRT1 as a key regulator in rheumatic diseases and the therapeutic potential of TCM-based...
Biomarkers in Chronic Nonbacterial Osteomyelitis: Bridging Autoinflammation and Classical Inflammatory Diseases
Biomarkers in Chronic Nonbacterial Osteomyelitis: Bridging Autoinflammation and Classical Inflammatory Diseases
This model provides a unifying explanation for the marked clinical and molecular heterogeneity observed in CNO. Read more.
Dynamic Changes in Serum Choline Acetyltransferase and Acetylcholinesterase in Septic versus Non-Septic ICU Patients: A Prospective Exploratory Study
Dynamic Changes in Serum Choline Acetyltransferase and Acetylcholinesterase in Septic versus Non-Septic ICU Patients: A Prospective Exploratory Study
Serum ChAT levels decrease in sepsis and correlate with severity. Age modifies this association. AChE levels lower in non-...
Evaluation of Anxiety and Depression in Patients with Chronic Rhinosinusitis with Nasal Polyps
Evaluation of Anxiety and Depression in Patients with Chronic Rhinosinusitis with Nasal Polyps
Evaluation of Anxiety and Depression in Patients with Chronic Rhinosinusitis with Nasal Polyps
Bibliometric Trends in Inflammasome‑Driven Pyroptosis and Cardiovascular Disease
Bibliometric Trends in Inflammasome‑Driven Pyroptosis and Cardiovascular Disease
This bibliometric study identifies NLRP3 as the central research focus in inflammasome‑driven pyroptosis research, with th...
Multi-Omics Association Analysis of Mitochondrial Genes in Hypertrophic Scars: Application of Mendelian Randomization
Multi-Omics Association Analysis of Mitochondrial Genes in Hypertrophic Scars: Application of Mendelian Randomization
Providing multi-omics insight into mitochondrial genes associated with Hypertrophic Scars (HS) through Mendelian randomiza...
Utility of Machine Learning to Characterize Gut Microbiota Dysbiosis and Its Clinical Implications in Inflammatory Bowel Disease
Utility of Machine Learning to Characterize Gut Microbiota Dysbiosis and Its Clinical Implications in Inflammatory Bowel Disease
ML and DL hold considerable promise for translating microbiome research into diagnostic and prognostic tools for IBD. Read...
Association of the Cumulative Inflammatory Index and Long-Term Mortality in Stroke-Associated Pneumonia
Association of the Cumulative Inflammatory Index and Long-Term Mortality in Stroke-Associated Pneumonia
The IIC can serve as a feasible and trustworthy biomarker for predicting mortality in SAP cases, enabling the detection of...
Peripheral Levels of Selected Biomarkers in Patients with Post-Sarcoidosis Chronic Fatigue Syndrome
Peripheral Levels of Selected Biomarkers in Patients with Post-Sarcoidosis Chronic Fatigue Syndrome
Examining whether fatigue and depressive symptoms in sarcoidosis remission relate to residual inflammation or oxidative st...
Preliminary Retrospective Analysis of X-Ray, CT, and MRI Imaging Features of Brucellar Spondylodiscitis Diagnosis
Preliminary Retrospective Analysis of X-Ray, CT, and MRI Imaging Features of Brucellar Spondylodiscitis Diagnosis
Exploring the X-ray, CT, and MRI imaging features of Brucellar spondylodiscitis (BS) across different stages and evaluate ...
Integration of Delta-Radiomics Features and Inflammatory Biomarkers for Neoadjuvant Chemo-Immunotherapy Efficacy in Locally Advanced Esophageal Squamous Cell Carcinoma
Integration of Delta-Radiomics Features and Inflammatory Biomarkers for Neoadjuvant Chemo-Immunotherapy Efficacy in Locally Advanced Esophageal Squamous Cell Carcinoma
Constructing a multi-omics model for predicting efficacy of NACI in LA-ESCC patients by integrating delta-radiomics featur...
Predictive Value of Traditional and Novel Composite Inflammatory Indicators for Severe and Refractory Mycoplasma pneumoniae Pneumonia in Children
Predictive Value of Traditional and Novel Composite Inflammatory Indicators for Severe and Refractory Mycoplasma pneumoniae Pneumonia in Children
Evaluating the predictive efficacy of single inflammatory indicators and novel composite inflammatory indicators for sever...
Platelet Indices and ApoA1 as Predictive Markers in Neoadjuvant Immunochemotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma: A Retrospective Study
Platelet Indices and ApoA1 as Predictive Markers in Neoadjuvant Immunochemotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma: A Retrospective Study
Baseline and preoperative blood parameters (MPV, PDW, P-LCR) and preoperative ApoA1 are valuable predictors of treatment r...
Elevated Serum HMGB1 Levels and Their Association with Stroke Risk of Paroxysmal Atrial Fibrillation
Elevated Serum HMGB1 Levels and Their Association with Stroke Risk of Paroxysmal Atrial Fibrillation
Investigating the association between serum HMGB1 levels and stroke through the long-term follow-up of patients with parox...
Single-Cell RNA Sequencing Reveals Microglial Heterogeneity and Functional States After Cerebral Ischemia-Reperfusion Injury
Single-Cell RNA Sequencing Reveals Microglial Heterogeneity and Functional States After Cerebral Ischemia-Reperfusion Injury
Analyzing the heterogeneity, activation trajectories, and metabolic states of microglia in ischemic stroke to identify the...
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