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Periodontal ligament stem cells promote polarization of M2 macrophages
Periodontal ligament stem cells promote polarization of M2 macrophages
Abstract Macrophages are widely distributed in a variety of tissues, and the different state of macrophages polarization i...
Crosstalk between R848 and abortive HIV‐1 RNA‐induced signaling enhances antiviral immunity
Crosstalk between R848 and abortive HIV‐1 RNA‐induced signaling enhances antiviral immunity
Abstract Pathogens trigger multiple pattern recognition receptors (PRRs) that together dictate innate and adaptive immune ...
T cell counts and IL‐6 concentration in blood of North African COVID‐19 patients are two independent prognostic factors for severe disease and death
T cell counts and IL‐6 concentration in blood of North African COVID‐19 patients are two independent prognostic factors for severe disease and death
Abstract The immune system plays a crucial role in the response against severe acute respiratory syndrome coronavirus 2 wi...
Hspa8 and ICAM‐1 as damage‐induced mediators of γδ T cell activation
Hspa8 and ICAM‐1 as damage‐induced mediators of γδ T cell activation
Abstract Tissue-resident γδ T cells form the first line of defense at barrier surfaces where they survey host ...
K27‐linked noncanonic ubiquitination in immune regulation
K27‐linked noncanonic ubiquitination in immune regulation
Abstract Ubiquitination is a common form of posttranslational modification that has been implicated in regulating consider...
Cellular immune responses in the pathophysiology of preeclampsia
Cellular immune responses in the pathophysiology of preeclampsia
Abstract Preeclampsia, defined as new-onset hypertension accompanied by proteinuria occurring at 20 weeks of gestatio...
A review of signaling and transcriptional control in T follicular helper cell differentiation
A review of signaling and transcriptional control in T follicular helper cell differentiation
Abstract T follicular helper (Tfh) cells are a critical component of adaptive immunity and assist in optimal Ab-mediated d...
Neuroimmune regulatory networks of the airway mucosa in allergic inflammatory disease
Neuroimmune regulatory networks of the airway mucosa in allergic inflammatory disease
Abstract Communication between the nervous and immune systems serves a key role in host-protective immunity at mucosal bar...
Metallothioneins alter macrophage phenotype and represent novel therapeutic targets for acetaminophen‐induced liver injury
Metallothioneins alter macrophage phenotype and represent novel therapeutic targets for acetaminophen‐induced liver injury
Abstract Acetaminophen (APAP) intoxication is the foremost cause of drug-induced liver failure in developed countries. The...
TRB sequences targeting ORF1a/b are associated with disease severity in hospitalized COVID‐19 patients
TRB sequences targeting ORF1a/b are associated with disease severity in hospitalized COVID‐19 patients
Abstract The potential protective or pathogenic role of the adaptive immune response to SARS-CoV-2 infection has been vigo...
Innate lymphoid cell recovery and occurrence of GvHD after hematopoietic stem cell transplantation
Innate lymphoid cell recovery and occurrence of GvHD after hematopoietic stem cell transplantation
Abstract Lymphocytes are essential for microbial immunity, tumor surveillance, and tissue homeostasis. However, the in viv...
Monoclonal antibodies capable of binding SARS‐CoV‐2 spike protein receptor‐binding motif specifically prevent GM‐CSF induction
Monoclonal antibodies capable of binding SARS‐CoV‐2 spike protein receptor‐binding motif specifically prevent GM‐CSF induction
Abstract A severe acute respiratory syndrome (SARS)-like coronavirus 2 (SARS-CoV-2) has recently caused a pandemic COVID-1...
More than neutrophils: Lin(+)Ly6G(+)IL‐5Rα(+) multipotent myeloid cells (MMCs) are dominant in normal murine bone marrow and retain capacity to differentiate into eosinophils and monocytes
More than neutrophils: Lin(+)Ly6G(+)IL‐5Rα(+) multipotent myeloid cells (MMCs) are dominant in normal murine bone marrow and retain capacity to differentiate into eosinophils and monocytes
Abstract Bone marrow is a hematopoietic site harboring multiple populations of myeloid cells in different stages of differ...
Metabolic and functional impairment of CD8+ T cells from the lungs of influenza‐infected obese mice
Metabolic and functional impairment of CD8+ T cells from the lungs of influenza‐infected obese mice
Abstract Obesity is an independent risk factor for morbidity and mortality in response to influenza infection. However, th...
The anti‐inflammatory peptide Catestatin blocks chemotaxis
The anti‐inflammatory peptide Catestatin blocks chemotaxis
Abstract Increased levels of the anti-inflammatory peptide Catestatin (CST), a cleavage product of the pro-hormone chromog...
CCAAT/enhancer binding protein (C/EBP) delta promotes the expression of PTX3 and macrophage phagocytosis during A. fumigatus infection
CCAAT/enhancer binding protein (C/EBP) delta promotes the expression of PTX3 and macrophage phagocytosis during A. fumigatus infection
Abstract Given the increasing incidence of pulmonary aspergillosis, it is important to understand the natural defense mech...
Bone marrow microenvironment drives AML cell OXPHOS addiction and AMPK inhibition to resist chemotherapy
Bone marrow microenvironment drives AML cell OXPHOS addiction and AMPK inhibition to resist chemotherapy
Abstract The stromal niche plays a pivotal role in AML chemoresistance and energy metabolism reprogramming is a hallmark o...
Kindlin‐3 maintains marginal zone B cells but confines follicular B cell activation and differentiation
Kindlin‐3 maintains marginal zone B cells but confines follicular B cell activation and differentiation
Abstract Integrin-mediated interactions between hematopoietic cells and their microenvironment are important for the devel...
Differential expression of maturation and activation markers on NK cells in patients with active and latent tuberculosis
Differential expression of maturation and activation markers on NK cells in patients with active and latent tuberculosis
Abstract NK cells were recently suggested to be important for the initial control of M. tuberculosis infection. The phenot...
Dickkopf proteins in pathological inflammatory diseases
Dickkopf proteins in pathological inflammatory diseases
Abstract The human body encounters various challenges. Tissue repair and regeneration processes are augmented after tissue...
Specific innate immune cells uptake fetal antigen and display homeostatic phenotypes in the maternal circulation
Specific innate immune cells uptake fetal antigen and display homeostatic phenotypes in the maternal circulation
Abstract Pregnancy represents a period when the mother undergoes significant immunological changes to promote tolerance of...
Dynamic changes in human single‐cell transcriptional signatures during fatal sepsis
Dynamic changes in human single‐cell transcriptional signatures during fatal sepsis
Abstract Systemic infections, especially in patients with chronic diseases, may result in sepsis: an explosive, uncoordina...
ATR kinase activity promotes antibody class switch recombination in B cells through cell cycle regulation without suppressing DSB resection and microhomology usage
ATR kinase activity promotes antibody class switch recombination in B cells through cell cycle regulation without suppressing DSB resection and microhomology usage
Abstract Class switch recombination (CSR) changes the effector functions of antibodies and is carried out by classical and...
Poly(I:C) enhances the efficacy of phagocytosis checkpoint blockade immunotherapy by inducing IL‐6 production
Poly(I:C) enhances the efficacy of phagocytosis checkpoint blockade immunotherapy by inducing IL‐6 production
Abstract Macrophage phagocytosis plays essential roles in antitumor immunity. CD47/SIRPα phagocytosis checkpoint blo...
Structural characteristics of coiled‐coil regions in AF10‐DOT1L and AF10‐inhibitory peptide complex
Structural characteristics of coiled‐coil regions in AF10‐DOT1L and AF10‐inhibitory peptide complex
Abstract The interaction of the solo H3K79 methyltransferase DOT1-like (DOT1L) and its regulatory factor ALL1-fused gene f...
IRF3 inhibits IFN‐γ‐mediated restriction of intracellular pathogens in macrophages independently of IFNAR
IRF3 inhibits IFN‐γ‐mediated restriction of intracellular pathogens in macrophages independently of IFNAR
Abstract Macrophages use an array of innate immune sensors to detect intracellular pathogens and to tailor effective antim...
ADAM17/MMP inhibition prevents neutrophilia and lung injury in a mouse model of COVID‐19
ADAM17/MMP inhibition prevents neutrophilia and lung injury in a mouse model of COVID‐19
Abstract Severe coronavirus disease 2019 (COVID-19) is characterized by lung injury, cytokine storm, and increased neutrop...
Human macrophage polarization shapes B. pertussis intracellular persistence
Human macrophage polarization shapes B. pertussis intracellular persistence
Abstract We previously demonstrated that Bordetella pertussis, the etiologic agent of whooping cough, is able to survive i...
The histone deacetylase Hdac7 supports LPS‐inducible glycolysis and Il‐1β production in murine macrophages via distinct mechanisms
The histone deacetylase Hdac7 supports LPS‐inducible glycolysis and Il‐1β production in murine macrophages via distinct mechanisms
Abstract TLRs reprogram macrophage metabolism, enhancing glycolysis and promoting flux through the tricarboxylic acid cycl...
CCR7+ dendritic cells sorted by binding of CCL19 show enhanced Ag‐presenting capacity and antitumor potency
CCR7+ dendritic cells sorted by binding of CCL19 show enhanced Ag‐presenting capacity and antitumor potency
Abstract Dendritic cell therapy has been a promising addition to the current armory of therapeutic options in cancer for m...
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