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Epigenetic regulation of inflammation by CxxC domain‐containing proteins*
Epigenetic regulation of inflammation by CxxC domain‐containing proteins*
Abstract Epigenetic regulation of gene transcription in the immune system is important for proper control of protective an...
Chromodomain helicase DNA‐binding 4 (CHD4) regulates early B cell identity and V(D)J recombination*
Chromodomain helicase DNA‐binding 4 (CHD4) regulates early B cell identity and V(D)J recombination*
Summary B lymphocytes develop from uncommitted precursors into immunoglobulin (antibody)-producing B cells, a major arm of...
ZAP70, too little, too much can lead to autoimmunity*
ZAP70, too little, too much can lead to autoimmunity*
Abstract Establishing both central and peripheral tolerance requires the appropriate TCR signaling strength to discriminat...
Epigenetics and CD8+ T cell memory*
Epigenetics and CD8+ T cell memory*
Abstract Following antigen recognition, CD8+ T lymphocytes can follow different patterns of differentiation, with the gene...
Understanding immunity in a tissue‐centric context: Combining novel imaging methods and mathematics to extract new insights into function and dysfunction*
Understanding immunity in a tissue‐centric context: Combining novel imaging methods and mathematics to extract new insights into function and dysfunction*
Abstract A central question in immunology is what features allow the immune system to respond in a timely manner to a vari...
Silencing and activating anergic B cells*
Silencing and activating anergic B cells*
Abstract Despite the existence of central tolerance mechanisms, including clonal deletion and receptor editing to eliminat...
Epigenetic regulation of natural killer cell memory*
Epigenetic regulation of natural killer cell memory*
Abstract Immunological memory is the underlying mechanism by which the immune system remembers previous encounters with pa...
Spatial determinates of effector and memory CD8+ T cell fates
Spatial determinates of effector and memory CD8+ T cell fates
Abstract The lymph node plays a critical role in mounting an adaptive immune response to infection, clearance of foreign p...
Imaging dendritic cell functions*
Imaging dendritic cell functions*
Abstract Dendritic cells (DCs) are crucial for the appropriate initiation of adaptive immune responses. During inflammatio...
Visualization and functional characterization of lymphoid organ fibroblasts*
Visualization and functional characterization of lymphoid organ fibroblasts*
Abstract Fibroblastic reticular cells (FRCs) are specialized stromal cells of lymphoid organs that generate the structural...
Skin‐ny deeping: Uncovering immune cell behavior and function through imaging techniques*
Skin‐ny deeping: Uncovering immune cell behavior and function through imaging techniques*
Abstract As the largest organ of the body, the skin is a key barrier tissue with specialized structures where ongoing immu...
T cell activation niches—Optimizing T cell effector function in inflamed and infected tissues*
T cell activation niches—Optimizing T cell effector function in inflamed and infected tissues*
Abstract Successful immunity to infection, malignancy, and tissue damage requires the coordinated recruitment of numerous ...
Information flow in the spatiotemporal organization of immune responses
Information flow in the spatiotemporal organization of immune responses
Abstract Immune responses must be rapid, tightly orchestrated, and tailored to the encountered stimulus. Lymphatic vessels...
Imaging innate immunity*
Imaging innate immunity*
Abstract Innate immunity is the first line of defense against infectious intruders and also plays a major role in the deve...
Imaging the different timescales of germinal center selection*
Imaging the different timescales of germinal center selection*
Abstract Germinal centers (GCs) are the site of antibody affinity maturation, a fundamental immunological process that inc...
Autoimmunity in motion: Mechanisms of immune regulation and destruction revealed by in vivo imaging*
Autoimmunity in motion: Mechanisms of immune regulation and destruction revealed by in vivo imaging*
Abstract Autoimmunity arises when mechanisms of immune tolerance fail. Here we discuss mechanisms of T cell activation and...
Epigenetics and tissue immunity—Translating environmental cues into functional adaptations*
Epigenetics and tissue immunity—Translating environmental cues into functional adaptations*
Abstract There is an increasing appreciation that many innate and adaptive immune cell subsets permanently reside within n...
Micro but mighty—Micronutrients in the epigenetic regulation of adaptive immune responses*
Micro but mighty—Micronutrients in the epigenetic regulation of adaptive immune responses*
Abstract Micronutrients are essential small molecules required by organisms in minute quantity for survival. For instance,...
Emerging roles for endogenous retroviruses in immune epigenetic regulation*
Emerging roles for endogenous retroviruses in immune epigenetic regulation*
Abstract In recent years, there has been significant progress toward understanding the transcriptional networks underlying...
Imaging reveals novel innate immune responses in lung, liver, and beyond*
Imaging reveals novel innate immune responses in lung, liver, and beyond*
Abstract Highly dynamic immune responses are generated toward pathogens or injuries, in vivo. Multiple immune cell types p...
RNA regulation in immunity
RNA regulation in immunity
RNAs scaffold complex molecular machines that regulate their stability, translation, modification, and subcellular localiz...
Heterogeneity in antiviral B cell responses: Lessons from the movies*
Heterogeneity in antiviral B cell responses: Lessons from the movies*
Abstract Humoral and cellular responses to viral infections coexist in a dynamic equilibrium that often results in efficie...
Imaging viral infection in vivo to gain unique perspectives on cellular antiviral immunity*
Imaging viral infection in vivo to gain unique perspectives on cellular antiviral immunity*
Abstract The past decade has seen near continual global public health crises caused by emerging viral infections. Extraord...
Moving beyond velocity: Opportunities and challenges to quantify immune cell behavior
Moving beyond velocity: Opportunities and challenges to quantify immune cell behavior
Abstract The analysis of cellular behavior using intravital multi-photon microscopy has contributed substantially to our u...
What sequencing technologies can teach us about innate immunity*
What sequencing technologies can teach us about innate immunity*
Abstract For years, we have taken a reductionist approach to understanding gene regulation through the study of one gene i...
Transcriptional and epigenetic regulation in thymic epithelial cells
Transcriptional and epigenetic regulation in thymic epithelial cells
Abstract The thymus is required for the development of both adaptive and innate-like T cell subsets. There is keen interes...
Diving into the mechanism of action of tumor immunotherapies with intravital imaging*
Diving into the mechanism of action of tumor immunotherapies with intravital imaging*
Abstract The clinical successes and tremendous hopes raised by tumor immunotherapies such as tumor-targeting monoclonal an...
Imaging leukocyte migration through afferent lymphatics*
Imaging leukocyte migration through afferent lymphatics*
Abstract Afferent lymphatics mediate the transport of antigen and leukocytes, especially of dendritic cells (DCs) and T ce...
Regulation of airway immunity by epithelial miRNAs*
Regulation of airway immunity by epithelial miRNAs*
Abstract The airway epithelium is essential to protect the host from inhaled pathogens and particles. It maintains immune ...
Cell‐intrinsic and ‐extrinsic roles of miRNAs in regulating T cell immunity
Cell‐intrinsic and ‐extrinsic roles of miRNAs in regulating T cell immunity
Summary T cells are crucial to generate an effective response against numerous invading microbial pathogens and play a piv...
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