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Short-term stress preconditioning activates sympathetic innervation in the testes to mitigate testicular ischemia-reperfusion injury
Short-term stress preconditioning activates sympathetic innervation in the testes to mitigate testicular ischemia-reperfusion injury
Testicular tissues are highly vulnerable to oxidative stress and external insults due to their unique physiological microe...
The role of maternal infections in neurodevelopmental psychiatric disorders: focus on the P2X7/NLRP3/IL-1β signalling pathway
The role of maternal infections in neurodevelopmental psychiatric disorders: focus on the P2X7/NLRP3/IL-1β signalling pathway
Immune activation in the prenatal and early postnatal periods is increasingly implicated in the aetiology of neurodevelopm...
Comprehensive insight on immune landscape in intracerebral hemorrhage patients with single-cell RNA sequencing: from blood to hematoma
Comprehensive insight on immune landscape in intracerebral hemorrhage patients with single-cell RNA sequencing: from blood to hematoma
As limited medical interventions proved efficacy in intracerebral hemorrhage (ICH), the mechanisms underlying primary and ...
TRPM7 contributes to pyroptosis and its involvement in status epilepticus
TRPM7 contributes to pyroptosis and its involvement in status epilepticus
Pyroptosis, a novel form of programmed cell death, has been implicated in neurodegeneration diseases. However, its role in...
Ketogenic diet modulates immune cell transcriptional landscape and ameliorates experimental autoimmune uveitis in mice
Ketogenic diet modulates immune cell transcriptional landscape and ameliorates experimental autoimmune uveitis in mice
Uveitis manifests as immune-mediated inflammatory disorders within the eye, posing a serious threat to vision. The ketogen...
Metformin attenuates central sensitization by regulating neuroinflammation through the TREM2-SYK signaling pathway in a mouse model of chronic migraine
Metformin attenuates central sensitization by regulating neuroinflammation through the TREM2-SYK signaling pathway in a mouse model of chronic migraine
Chronic migraine (CM) is a serious neurological disorder. Central sensitization is one of the important pathophysiological...
Autoantibody profiles in Alzheimer´s, Parkinson´s, and dementia with Lewy bodies: altered IgG affinity and IgG/IgM/IgA responses to alpha-synuclein, amyloid-beta, and tau in disease-specific pathological patterns
Autoantibody profiles in Alzheimer´s, Parkinson´s, and dementia with Lewy bodies: altered IgG affinity and IgG/IgM/IgA responses to alpha-synuclein, amyloid-beta, and tau in disease-specific pathological patterns
Alzheimer’s disease (AD) and Parkinson’s disease (PD) are leading neurodegenerative disorders marked by protei...
Glyphosate exposure exacerbates neuroinflammation and Alzheimer’s disease-like pathology despite a 6-month recovery period in mice
Glyphosate exposure exacerbates neuroinflammation and Alzheimer’s disease-like pathology despite a 6-month recovery period in mice
Glyphosate use in the United States (US) has increased each year since the introduction of glyphosate-tolerant crops in 19...
Lateralized response of skull bone marrow via osteopontin signaling in mice after ischemia reperfusion
Lateralized response of skull bone marrow via osteopontin signaling in mice after ischemia reperfusion
Skull bone marrow is thought to be an immune tissue closely associated with the central nervous system (CNS). Recent studi...
The hypothalamic steroidogenic pathway mediates susceptibility to inflammation-evoked depression in female mice
The hypothalamic steroidogenic pathway mediates susceptibility to inflammation-evoked depression in female mice
Depression is two-to-three times more frequent among women. The hypothalamus, a sexually dimorphic area, has been implicat...
Design, synthesis, and characterization of novel system xC− transport inhibitors: inhibition of microglial glutamate release and neurotoxicity
Design, synthesis, and characterization of novel system xC− transport inhibitors: inhibition of microglial glutamate release and neurotoxicity
Neuroinflammation appears to involve some degree of excitotoxicity promulgated by microglia, which release glutamate via t...
An engineered Fc fusion protein that targets antigen-specific T cells and autoantibodies mitigates autoimmune disease
An engineered Fc fusion protein that targets antigen-specific T cells and autoantibodies mitigates autoimmune disease
Current effective therapies for autoimmune diseases rely on systemic immunomodulation that broadly affects all T and/or B ...
Astrocyte-specific knockout of YKL-40/Chi3l1 reduces Aβ burden and restores memory functions in 5xFAD mice
Astrocyte-specific knockout of YKL-40/Chi3l1 reduces Aβ burden and restores memory functions in 5xFAD mice
Glial cell-mediated neuroinflammation and neuronal attrition are highly correlated with cognitive impairment in Alzheimer&...
Low-dose PLX5622 treatment prevents neuroinflammatory and neurocognitive sequelae after sepsis
Low-dose PLX5622 treatment prevents neuroinflammatory and neurocognitive sequelae after sepsis
Sepsis-associated encephalopathy (SAE) is characterized by symptoms of delirium including hallucinations, impaired concent...
Correction: miR155, TREM2, INPP5D: Disease stage and cell-type are essential considerations when targeting clinical interventions based on mouse models of Alzheimer’s amyloidopathy
Correction: miR155, TREM2, INPP5D: Disease stage and cell-type are essential considerations when targeting clinical interventions based on mouse models of Alzheimer’s amyloidopathy
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease
Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease
Alterations in progranulin (PGRN) expression are associated with multiple neurodegenerative diseases (NDs), including fron...
Correction : IL-1R1 signaling in TBI: assessing chronic impacts and neuroinflammatory dynamics in a mouse model of mild closed-head injury
Correction : IL-1R1 signaling in TBI: assessing chronic impacts and neuroinflammatory dynamics in a mouse model of mild closed-head injury
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Single-cell RNA sequencing unveils Lrg1's role in cerebral ischemia‒reperfusion injury by modulating various cells
Single-cell RNA sequencing unveils Lrg1's role in cerebral ischemia‒reperfusion injury by modulating various cells
Cerebral ischemia‒reperfusion injury causes significant harm to human health and is a major contributor to stroke-re...
TRIM45 aggravates microglia pyroptosis via Atg5/NLRP3 axis in septic encephalopathy
TRIM45 aggravates microglia pyroptosis via Atg5/NLRP3 axis in septic encephalopathy
Neuroinflammation mediated by microglial pyroptosis is an important pathogenic mechanism of septic encephalopathy (SAE). I...
Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis
Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis
As one of most common and severe mental disorders, major depressive disorder (MDD) significantly increases the risks of pr...
OTUD1 ameliorates cerebral ischemic injury through inhibiting inflammation by disrupting K63-linked deubiquitination of RIP2
OTUD1 ameliorates cerebral ischemic injury through inhibiting inflammation by disrupting K63-linked deubiquitination of RIP2
Inflammatory response triggered by innate immunity plays a pivotal element in the progress of ischemic stroke. Receptor-in...
Hypothermia combined with extracellular vesicles from clonally expanded immortalized mesenchymal stromal cells improves neurodevelopmental impairment in neonatal hypoxic-ischemic brain injury
Hypothermia combined with extracellular vesicles from clonally expanded immortalized mesenchymal stromal cells improves neurodevelopmental impairment in neonatal hypoxic-ischemic brain injury
Neonatal encephalopathy following hypoxia–ischemia (HI) is a leading cause of childhood death and morbidity. Hypothe...
Naïve Huntington’s disease microglia mount a normal response to inflammatory stimuli but display a partially impaired development of innate immune tolerance that can be counteracted by ganglioside GM1
Naïve Huntington’s disease microglia mount a normal response to inflammatory stimuli but display a partially impaired development of innate immune tolerance that can be counteracted by ganglioside GM1
Chronic activation and dysfunction of microglia have been implicated in the pathogenesis and progression of many neurodege...
Temporal changes in regulatory T cell subsets defined by the transcription factor Helios in stroke and their potential role in stroke-associated infection: a prospective case–control study
Temporal changes in regulatory T cell subsets defined by the transcription factor Helios in stroke and their potential role in stroke-associated infection: a prospective case–control study
Regulatory T cells (Tregs) are involved in the systemic immune response after ischemic stroke. However, their role remains...
14-3-3 \(\upzeta /\updelta\)-reported early synaptic injury in Alzheimer’s disease is independently mediated by sTREM2
14-3-3 \(\upzeta /\updelta\)-reported early synaptic injury in Alzheimer’s disease is independently mediated by sTREM2
Synaptic loss is closely associated with tau aggregation and microglia activation in later stages of Alzheimer’s dis...
PSMC5 regulates microglial polarization and activation in LPS-induced cognitive deficits and motor impairments by interacting with TLR4
PSMC5 regulates microglial polarization and activation in LPS-induced cognitive deficits and motor impairments by interacting with TLR4
Luteolin is a flavonoid found in high concentrations in celery and green pepper, and acts as a neuroprotectant. PSMC5 (pro...
Protective role of IL-17-producing γδ T cells in a laser-induced choroidal neovascularization mouse model
Protective role of IL-17-producing γδ T cells in a laser-induced choroidal neovascularization mouse model
Vision loss in patients with wet/exudative age-related macular degeneration (AMD) is associated with choroidal neovascular...
Ly6C-high monocytes alleviate brain injury in experimental subarachnoid hemorrhage in mice
Ly6C-high monocytes alleviate brain injury in experimental subarachnoid hemorrhage in mice
Subarachnoid hemorrhage (SAH) is an uncommon type of potentially fatal stroke. The pathophysiological mechanisms of brain ...
Cyanidin-3-O-glucoside protects the brain and improves cognitive function in APPswe/PS1ΔE9 transgenic mice model
Cyanidin-3-O-glucoside protects the brain and improves cognitive function in APPswe/PS1ΔE9 transgenic mice model
Cyanidin-3-O-glucoside (C3G) is a natural anthocyanin with antioxidant, anti-inflammatory, and antitumor properties. Howev...
Cytokine enrichment in deep cerebellar nuclei is contributed by multiple glial populations and linked to reduced amyloid plaque pathology
Cytokine enrichment in deep cerebellar nuclei is contributed by multiple glial populations and linked to reduced amyloid plaque pathology
Alzheimer’s disease (AD) pathology and amyloid-beta (Aβ) plaque deposition progress slowly in the cerebellum co...
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