Aharonov A, Shakked A, Umansky KB, Savidor A, Genzelinakh A, Kain D, Lendengolts D, Revach OY, Morikawa Y, Dong J, Levin Y, Geiger B, Martin JF, Tzahor E (2020) ERBB2 drives YAP activation and EMT-like processes during cardiac regeneration. Nat Cell Biol 22:1346–1356. https://doi.org/10.1038/s41556-020-00588-4
Article PubMed CAS Google Scholar
An S, Wang X, Shi H, Zhang X, Meng H, Li W, Chen D, Ge J (2020) Apelin protects against ischemia-reperfusion injury in diabetic myocardium via inhibiting apoptosis and oxidative stress through PI3K and p38-MAPK signaling pathways. Aging 12:25120–25137. https://doi.org/10.18632/aging.104106
Article PubMed PubMed Central CAS Google Scholar
Ashraf MI, Ebner M, Wallner C, Haller M, Khalid S, Schwelberger H, Koziel K, Enthammer M, Hermann M, Sickinger S, Soleiman A, Steger C, Vallant S, Sucher R, Brandacher G, Santer P, Dragun D, Troppmair J (2014) A p38MAPK/MK2 signaling pathway leading to redox stress, cell death and ischemia/reperfusion injury. Cell Commun Signal 12:6. https://doi.org/10.1186/1478-811X-12-6
Article PubMed PubMed Central CAS Google Scholar
Blythe NM, Muraki K, Ludlow MJ, Stylianidis V, Gilbert HTJ, Evans EL, Cuthbertson K, Foster R, Swift J, Li J, Drinkhill MJ, van Nieuwenhoven FA, Porter KE, Beech DJ, Turner NA (2019) Mechanically activated Piezo1 channels of cardiac fibroblasts stimulate p38 mitogen-activated protein kinase activity and interleukin-6 secretion. J Biol Chem 294:17395–17408. https://doi.org/10.1074/jbc.RA119.009167
Article PubMed PubMed Central CAS Google Scholar
Botker HE, Hausenloy D, Andreadou I, Antonucci S, Boengler K, Davidson SM, Deshwal S, Devaux Y, Di Lisa F, Di Sante M, Efentakis P, Femmino S, Garcia-Dorado D, Giricz Z, Ibanez B, Iliodromitis E, Kaludercic N, Kleinbongard P, Neuhauser M, Ovize M, Pagliaro P, Rahbek-Schmidt M, Ruiz-Meana M, Schluter KD, Schulz R, Skyschally A, Wilder C, Yellon DM, Ferdinandy P, Heusch G (2018) Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection. Basic Res Cardiol 113:39. https://doi.org/10.1007/s00395-018-0696-8
Article PubMed PubMed Central CAS Google Scholar
Braidotti N, Chen SN, Long CS, Cojoc D, Sbaizero O (2022) Piezo1 channel as a potential target for hindering cardiac fibrotic remodeling. Int J Mol Sci. https://doi.org/10.3390/ijms23158065
Article PubMed PubMed Central Google Scholar
Chen W, Pretorius D, Zhou Y, Nakada Y, Yang J, Zhang J (2021) TT-10-loaded nanoparticles promote cardiomyocyte proliferation and cardiac repair in a mouse model of myocardial infarction. JCI Insight. https://doi.org/10.1172/jci.insight.151987
Article PubMed PubMed Central Google Scholar
Cinar E, Zhou S, DeCourcey J, Wang Y, Waugh RE, Wan J (2015) Piezo1 regulates mechanotransductive release of ATP from human RBCs. Proc Natl Acad Sci U S A 112:11783–11788. https://doi.org/10.1073/pnas.1507309112
Article PubMed PubMed Central CAS Google Scholar
Coste B, Xiao B, Santos JS, Syeda R, Grandl J, Spencer KS, Kim SE, Schmidt M, Mathur J, Dubin AE, Montal M, Patapoutian A (2012) Piezo proteins are pore-forming subunits of mechanically activated channels. Nature 483:176–181. https://doi.org/10.1038/nature10812
Article PubMed PubMed Central CAS Google Scholar
Cui X, Dong H, Luo S, Zhuang B, Li Y, Zhong C, Ma Y, Hong L (2024) Long non-coding RNA-cardiac-inducing RNA 6 mediates repair of infarcted hearts by inducing mesenchymal stem cell differentiation into cardiogenic cells through cyclin-dependent kinase 1. Int J Mol Sci. https://doi.org/10.3390/ijms25063466
Article PubMed PubMed Central Google Scholar
Eisner DA, Caldwell JL, Kistamas K, Trafford AW (2017) Calcium and excitation-contraction coupling in the heart. Circ Res 121:181–195. https://doi.org/10.1161/CIRCRESAHA.117.310230
Article PubMed PubMed Central CAS Google Scholar
Emig R, Knodt W, Krussig MJ, Zgierski-Johnston CM, Gorka O, Gross O, Kohl P, Ravens U, Peyronnet R (2021) Piezo1 channels contribute to the regulation of human atrial fibroblast mechanical properties and matrix stiffness sensing. Cells. https://doi.org/10.3390/cells10030663
Article PubMed PubMed Central Google Scholar
Heusch G (2024) Myocardial ischemia/reperfusion: translational pathophysiology of ischemic heart disease. Med 5:10–31. https://doi.org/10.1016/j.medj.2023.12.007
Article PubMed CAS Google Scholar
Heusch G, Andreadou I, Bell R, Bertero E, Botker HE, Davidson SM, Downey J, Eaton P, Ferdinandy P, Gersh BJ, Giacca M, Hausenloy DJ, Ibanez B, Krieg T, Maack C, Schulz R, Sellke F, Shah AM, Thiele H, Yellon DM, Di Lisa F (2023) Health position paper and redox perspectives on reactive oxygen species as signals and targets of cardioprotection. Redox Biol 67:102894. https://doi.org/10.1016/j.redox.2023.102894
Article PubMed PubMed Central CAS Google Scholar
Jiang F, Yin K, Wu K, Zhang M, Wang S, Cheng H, Zhou Z, Xiao B (2021) The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction. Nat Commun 12:869. https://doi.org/10.1038/s41467-021-21178-4
Article PubMed PubMed Central CAS Google Scholar
Kanter M, Aksu F, Takir M, Kostek O, Kanter B, Oymagil A (2017) Effects of low intensity exercise against apoptosis and oxidative stress in streptozotocin-induced diabetic rat heart. Exp Clin Endocrinol Diabetes 125:583–591. https://doi.org/10.1055/s-0035-1569332
Article PubMed CAS Google Scholar
Kefauver JM, Ward AB, Patapoutian A (2020) Discoveries in structure and physiology of mechanically activated ion channels. Nature 587:567–576. https://doi.org/10.1038/s41586-020-2933-1
Article PubMed PubMed Central CAS Google Scholar
Khalil NN, Rexius-Hall ML, Gupta D, McCarthy L, Verma R, Kellogg AC, Takamoto K, Xu M, Nejatpoor T, Parker SJ, McCain ML (2024) Hypoxic-normoxic crosstalk activates pro-inflammatory signaling in human cardiac fibroblasts and myocytes in a post-infarct myocardium on a chip. Adv Healthc Mater 13:e2401478. https://doi.org/10.1002/adhm.202401478
Article PubMed PubMed Central CAS Google Scholar
Li X, Wu F, Gunther S, Looso M, Kuenne C, Zhang T, Wiesnet M, Klatt S, Zukunft S, Fleming I, Poschet G, Wietelmann A, Atzberger A, Potente M, Yuan X, Braun T (2023) Inhibition of fatty acid oxidation enables heart regeneration in adult mice. Nature 622:619–626. https://doi.org/10.1038/s41586-023-06585-5
Article PubMed PubMed Central CAS Google Scholar
Liang J, Huang B, Yuan G, Chen Y, Liang F, Zeng H, Zheng S, Cao L, Geng D, Zhou S (2017) Stretch-activated channel Piezo1 is up-regulated in failure heart and cardiomyocyte stimulated by AngII. Am J Transl Res 9:2945–2955
PubMed PubMed Central CAS Google Scholar
Lin Z, Zhou P, von Gise A, Gu F, Ma Q, Chen J, Guo H, van Gorp PR, Wang DZ, Pu WT (2015) Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival. Circ Res 116:35–45. https://doi.org/10.1161/CIRCRESAHA.115.304457
Article PubMed CAS Google Scholar
Liu D, Xing R, Zhang Q, Tian X, Qi Y, Song H, Liu Y, Yu H, Zhang X, Jing Q, Yan C, Han Y (2023) The CREG1-FBXO27-LAMP2 axis alleviates diabetic cardiomyopathy by promoting autophagy in cardiomyocytes. Exp Mol Med 55:2025–2038. https://doi.org/10.1038/s12276-023-01081-2
Article PubMed PubMed Central CAS Google Scholar
Michel MC, Li Y, Heusch G (2001) Mitogen-activated protein kinases in the heart. Naunyn Schmiedebergs Arch Pharmacol 363:245–266. https://doi.org/10.1007/s002100000363
Article PubMed CAS Google Scholar
Molkentin JD, Bugg D, Ghearing N, Dorn LE, Kim P, Sargent MA, Gunaje J, Otsu K, Davis J (2017) Fibroblast-specific genetic manipulation of p38 mitogen-activated protein kinase in vivo reveals its central regulatory role in fibrosis. Circulation 136:549–561. https://doi.org/10.1161/CIRCULATIONAHA.116.026238
Comments (0)