Treadmill exercise activates mechanosensitive Piezo1 to inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction in mice

Aharonov A, Shakked A, Umansky KB, Savidor A, Genzelinakh A, Kain D, Lendengolts D, Revach OY, Morikawa Y, Dong J, Levin Y, Geiger B, Martin JF, Tzahor E (2020) ERBB2 drives YAP activation and EMT-like processes during cardiac regeneration. Nat Cell Biol 22:1346–1356. https://doi.org/10.1038/s41556-020-00588-4

Article  PubMed  CAS  Google Scholar 

An S, Wang X, Shi H, Zhang X, Meng H, Li W, Chen D, Ge J (2020) Apelin protects against ischemia-reperfusion injury in diabetic myocardium via inhibiting apoptosis and oxidative stress through PI3K and p38-MAPK signaling pathways. Aging 12:25120–25137. https://doi.org/10.18632/aging.104106

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ashraf MI, Ebner M, Wallner C, Haller M, Khalid S, Schwelberger H, Koziel K, Enthammer M, Hermann M, Sickinger S, Soleiman A, Steger C, Vallant S, Sucher R, Brandacher G, Santer P, Dragun D, Troppmair J (2014) A p38MAPK/MK2 signaling pathway leading to redox stress, cell death and ischemia/reperfusion injury. Cell Commun Signal 12:6. https://doi.org/10.1186/1478-811X-12-6

Article  PubMed  PubMed Central  CAS  Google Scholar 

Blythe NM, Muraki K, Ludlow MJ, Stylianidis V, Gilbert HTJ, Evans EL, Cuthbertson K, Foster R, Swift J, Li J, Drinkhill MJ, van Nieuwenhoven FA, Porter KE, Beech DJ, Turner NA (2019) Mechanically activated Piezo1 channels of cardiac fibroblasts stimulate p38 mitogen-activated protein kinase activity and interleukin-6 secretion. J Biol Chem 294:17395–17408. https://doi.org/10.1074/jbc.RA119.009167

Article  PubMed  PubMed Central  CAS  Google Scholar 

Botker HE, Hausenloy D, Andreadou I, Antonucci S, Boengler K, Davidson SM, Deshwal S, Devaux Y, Di Lisa F, Di Sante M, Efentakis P, Femmino S, Garcia-Dorado D, Giricz Z, Ibanez B, Iliodromitis E, Kaludercic N, Kleinbongard P, Neuhauser M, Ovize M, Pagliaro P, Rahbek-Schmidt M, Ruiz-Meana M, Schluter KD, Schulz R, Skyschally A, Wilder C, Yellon DM, Ferdinandy P, Heusch G (2018) Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection. Basic Res Cardiol 113:39. https://doi.org/10.1007/s00395-018-0696-8

Article  PubMed  PubMed Central  CAS  Google Scholar 

Braidotti N, Chen SN, Long CS, Cojoc D, Sbaizero O (2022) Piezo1 channel as a potential target for hindering cardiac fibrotic remodeling. Int J Mol Sci. https://doi.org/10.3390/ijms23158065

Article  PubMed  PubMed Central  Google Scholar 

Chen W, Pretorius D, Zhou Y, Nakada Y, Yang J, Zhang J (2021) TT-10-loaded nanoparticles promote cardiomyocyte proliferation and cardiac repair in a mouse model of myocardial infarction. JCI Insight. https://doi.org/10.1172/jci.insight.151987

Article  PubMed  PubMed Central  Google Scholar 

Cinar E, Zhou S, DeCourcey J, Wang Y, Waugh RE, Wan J (2015) Piezo1 regulates mechanotransductive release of ATP from human RBCs. Proc Natl Acad Sci U S A 112:11783–11788. https://doi.org/10.1073/pnas.1507309112

Article  PubMed  PubMed Central  CAS  Google Scholar 

Coste B, Xiao B, Santos JS, Syeda R, Grandl J, Spencer KS, Kim SE, Schmidt M, Mathur J, Dubin AE, Montal M, Patapoutian A (2012) Piezo proteins are pore-forming subunits of mechanically activated channels. Nature 483:176–181. https://doi.org/10.1038/nature10812

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cui X, Dong H, Luo S, Zhuang B, Li Y, Zhong C, Ma Y, Hong L (2024) Long non-coding RNA-cardiac-inducing RNA 6 mediates repair of infarcted hearts by inducing mesenchymal stem cell differentiation into cardiogenic cells through cyclin-dependent kinase 1. Int J Mol Sci. https://doi.org/10.3390/ijms25063466

Article  PubMed  PubMed Central  Google Scholar 

Eisner DA, Caldwell JL, Kistamas K, Trafford AW (2017) Calcium and excitation-contraction coupling in the heart. Circ Res 121:181–195. https://doi.org/10.1161/CIRCRESAHA.117.310230

Article  PubMed  PubMed Central  CAS  Google Scholar 

Emig R, Knodt W, Krussig MJ, Zgierski-Johnston CM, Gorka O, Gross O, Kohl P, Ravens U, Peyronnet R (2021) Piezo1 channels contribute to the regulation of human atrial fibroblast mechanical properties and matrix stiffness sensing. Cells. https://doi.org/10.3390/cells10030663

Article  PubMed  PubMed Central  Google Scholar 

Heusch G (2024) Myocardial ischemia/reperfusion: translational pathophysiology of ischemic heart disease. Med 5:10–31. https://doi.org/10.1016/j.medj.2023.12.007

Article  PubMed  CAS  Google Scholar 

Heusch G, Andreadou I, Bell R, Bertero E, Botker HE, Davidson SM, Downey J, Eaton P, Ferdinandy P, Gersh BJ, Giacca M, Hausenloy DJ, Ibanez B, Krieg T, Maack C, Schulz R, Sellke F, Shah AM, Thiele H, Yellon DM, Di Lisa F (2023) Health position paper and redox perspectives on reactive oxygen species as signals and targets of cardioprotection. Redox Biol 67:102894. https://doi.org/10.1016/j.redox.2023.102894

Article  PubMed  PubMed Central  CAS  Google Scholar 

Jiang F, Yin K, Wu K, Zhang M, Wang S, Cheng H, Zhou Z, Xiao B (2021) The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction. Nat Commun 12:869. https://doi.org/10.1038/s41467-021-21178-4

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kanter M, Aksu F, Takir M, Kostek O, Kanter B, Oymagil A (2017) Effects of low intensity exercise against apoptosis and oxidative stress in streptozotocin-induced diabetic rat heart. Exp Clin Endocrinol Diabetes 125:583–591. https://doi.org/10.1055/s-0035-1569332

Article  PubMed  CAS  Google Scholar 

Kefauver JM, Ward AB, Patapoutian A (2020) Discoveries in structure and physiology of mechanically activated ion channels. Nature 587:567–576. https://doi.org/10.1038/s41586-020-2933-1

Article  PubMed  PubMed Central  CAS  Google Scholar 

Khalil NN, Rexius-Hall ML, Gupta D, McCarthy L, Verma R, Kellogg AC, Takamoto K, Xu M, Nejatpoor T, Parker SJ, McCain ML (2024) Hypoxic-normoxic crosstalk activates pro-inflammatory signaling in human cardiac fibroblasts and myocytes in a post-infarct myocardium on a chip. Adv Healthc Mater 13:e2401478. https://doi.org/10.1002/adhm.202401478

Article  PubMed  PubMed Central  CAS  Google Scholar 

Li X, Wu F, Gunther S, Looso M, Kuenne C, Zhang T, Wiesnet M, Klatt S, Zukunft S, Fleming I, Poschet G, Wietelmann A, Atzberger A, Potente M, Yuan X, Braun T (2023) Inhibition of fatty acid oxidation enables heart regeneration in adult mice. Nature 622:619–626. https://doi.org/10.1038/s41586-023-06585-5

Article  PubMed  PubMed Central  CAS  Google Scholar 

Liang J, Huang B, Yuan G, Chen Y, Liang F, Zeng H, Zheng S, Cao L, Geng D, Zhou S (2017) Stretch-activated channel Piezo1 is up-regulated in failure heart and cardiomyocyte stimulated by AngII. Am J Transl Res 9:2945–2955

PubMed  PubMed Central  CAS  Google Scholar 

Lin Z, Zhou P, von Gise A, Gu F, Ma Q, Chen J, Guo H, van Gorp PR, Wang DZ, Pu WT (2015) Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival. Circ Res 116:35–45. https://doi.org/10.1161/CIRCRESAHA.115.304457

Article  PubMed  CAS  Google Scholar 

Liu D, Xing R, Zhang Q, Tian X, Qi Y, Song H, Liu Y, Yu H, Zhang X, Jing Q, Yan C, Han Y (2023) The CREG1-FBXO27-LAMP2 axis alleviates diabetic cardiomyopathy by promoting autophagy in cardiomyocytes. Exp Mol Med 55:2025–2038. https://doi.org/10.1038/s12276-023-01081-2

Article  PubMed  PubMed Central  CAS  Google Scholar 

Michel MC, Li Y, Heusch G (2001) Mitogen-activated protein kinases in the heart. Naunyn Schmiedebergs Arch Pharmacol 363:245–266. https://doi.org/10.1007/s002100000363

Article  PubMed  CAS  Google Scholar 

Molkentin JD, Bugg D, Ghearing N, Dorn LE, Kim P, Sargent MA, Gunaje J, Otsu K, Davis J (2017) Fibroblast-specific genetic manipulation of p38 mitogen-activated protein kinase in vivo reveals its central regulatory role in fibrosis. Circulation 136:549–561. https://doi.org/10.1161/CIRCULATIONAHA.116.026238

Article  PubMed  PubMed Central  CAS 

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