Abad M, Mosteiro L, Pantoja C, Cañamero M, Rayon T, Ors I, Graña O, Megías D, Domínguez O, Martínez D, Manzanares M, Ortega S, Serrano M (2013) Reprogramming in vivo produces teratomas and iPS cells with totipotency features. Nature 502:340–345. https://doi.org/10.1038/nature12586
Article CAS PubMed Google Scholar
Allsopp RC (1996) Models of initiation of replicative senescence by loss of telomeric DNA. Exp Gerontol 31:235–243. https://doi.org/10.1016/0531-5565(95)02008-X
Article CAS PubMed Google Scholar
Ayano G (2016) Bipolar disorders and valproate: pharmacokinetics, pharmacodynamics, therapeutic effects and indications of valproate: review of articles. Bipolar Disorder: Open Access. https://doi.org/10.4172/2472-1077.1000109
Baker DJ, Wijshake T, Tchkonia T, Lebrasseur NK, Childs BG, Van De Sluis B, Kirkland JL, Van Deursen JM (2011) Clearance of p16 Ink4a-positive senescent cells delays ageing-associated disorders. Nature 479:232–236. https://doi.org/10.1038/nature10600
Article CAS PubMed PubMed Central Google Scholar
Becker AB, Chen L, Ning B, Hu S, Hossack JA, Klibanov AL, Annex BH, French BA (2022) Contrast enhanced ultrasound reveals partial perfusion recovery after hindlimb ischemia as opposed to full recovery by laser Doppler perfusion imaging. Ultrasound Med Biol 48:1058. https://doi.org/10.1016/J.ULTRASMEDBIO.2022.02.002
Article PubMed PubMed Central Google Scholar
Bhave VS, Paranjpe S, Bowen WC, Donthamsetty S, Bell AW, Khillan JS, Michalopoulos GK (2011) Genes inducing iPS phenotype play a role in hepatocyte survival and proliferation in vitro and liver regeneration in vivo. Hepatology 54:1360–1370. https://doi.org/10.1002/hep.24507
Article CAS PubMed PubMed Central Google Scholar
Biswas D, Jiang P (2016) Chemically induced reprogramming of somatic cells to pluripotent stem cells and neural cells. Int J Mol Sci. https://doi.org/10.3390/ijms17020226
Article PubMed PubMed Central Google Scholar
Boos F, Oo JA, Warwick T, Günther S, Izquierdo Ponce J, Lopez M, Rafii D, Buchmann G, Pham MD, Msheik ZS, Li T, Seredinski S, Haydar S, Kashefiolasl S, Plate KH, Behr R, Mietsch M, Krishnan J, Pullamsetti SS, Bibli SI, Hinkel R, Baker AH, Boon RA, Schulz MH, Wittig I, Miller FJ, Brandes RP, Leisegang MS (2023) The endothelial-enriched lncRNA LINC00607 mediates angiogenic function. Basic Res Cardiol. https://doi.org/10.1007/S00395-023-00978-3/FIGURES/5
Article PubMed PubMed Central Google Scholar
Brandes R, Fleming I, Busse R (2005) Endothelial aging. Cardiovasc Res 66:286–294. https://doi.org/10.1016/j.cardiores.2004.12.027
Article CAS PubMed Google Scholar
Burton DGA, Krizhanovsky V (2014) Physiological and pathological consequences of cellular senescence. Cell Mol Life Sci 71:4373–4386. https://doi.org/10.1007/s00018-014-1691-3
Article CAS PubMed PubMed Central Google Scholar
Cai H (2005) Hydrogen peroxide regulation of endothelial function: origins, mechanisms, and consequences. Cardiovasc Res 68:26–36. https://doi.org/10.1016/j.cardiores.2005.06.021
Article CAS PubMed Google Scholar
Campisi J (2005) Senescent cells, Tumor suppression, and Organismal aging: good citizens, bad neighbors. Cell 120:513–522. https://doi.org/10.1016/j.cell.2005.02.003
Article CAS PubMed Google Scholar
Campisi J, D’Adda Di Fagagna F (2007) Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 8:729–740. https://doi.org/10.1038/nrm2233
Article CAS PubMed Google Scholar
Chalecka-Franaszek E, Chuang DM (1999) Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons. Proc Natl Acad Sci U S A 96:8745–8750. https://doi.org/10.1073/pnas.96.15.8745
Article CAS PubMed PubMed Central Google Scholar
Cheng L, Hu W, Qiu B, Zhao J, Yu Y, Guan W, Wang M, Yang W, Pei G (2014) Generation of neural progenitor cells by chemical cocktails and hypoxia. Cell Res 24:665–679. https://doi.org/10.1038/cr.2014.32
Article CAS PubMed PubMed Central Google Scholar
Conroy RM, Pyörälä K, Fitzgerald AP, Sans S, Menotti A, De Backer G, De Bacquer D, Ducimetière P, Jousilahti P, Keil U, Njølstad I, Oganov RG, Thomsen T, Tunstall-Pedoe H, Tverdal A, Wedel H, Whincup P, Witheimsen L, Graham IM (2003) Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project. Eur Heart J 24:987–1003. https://doi.org/10.1016/S0195-668X(03)00114-3
Article CAS PubMed Google Scholar
Coppé J-P, Desprez P-Y, Krtolica A, Campisi J (2010) The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol Mech Dis 5:99–118. https://doi.org/10.1146/annurev-pathol-121808-102144
Dalkara T, Østergaard L, Heusch G, Attwell D (2025) Pericytes in the brain and heart: functional roles and response to ischaemia and reperfusion. Cardiovasc Res 120:2336–2348. https://doi.org/10.1093/CVR/CVAE147
Article PubMed PubMed Central Google Scholar
van Deursen JM (2014) The role of senescent cells in ageing. Nature 509:439–446. https://doi.org/10.1038/nature13193
Article CAS PubMed PubMed Central Google Scholar
Donato AJ, Machin DR, Lesniewski LA (2018) Mechanisms of dysfunction in the aging vasculature and role in age-related disease. Circ Res 123:825–848. https://doi.org/10.1161/CIRCRESAHA.118.312563
Article CAS PubMed PubMed Central Google Scholar
Donato AJ, Morgan RG, Walker AE, Lesniewski LA (2015) Cellular and molecular biology of aging endothelial cells. J Mol Cell Cardiol 89:122–135. https://doi.org/10.1016/j.yjmcc.2015.01.021
Article CAS PubMed PubMed Central Google Scholar
Edelberg JM, Tang L, Hattori K, Lyden D, Rafii S (2002) Young adult bone marrow-derived endothelial precursor cells restore aging-impaired cardiac angiogenic function. Circ Res. https://doi.org/10.1161/01.RES.0000020861.20064.7E
Evason K, Collins JJ, Huang C, Hughes S, Kornfeld K (2008) Valproic acid extends Caenorhabditis elegans lifespan. Aging Cell 7:305–317. https://doi.org/10.1111/j.1474-9726.2008.00375.x
Article CAS PubMed PubMed Central Google Scholar
Gevaert AB, Lemmens K, Vrints CJ, Van Craenenbroeck EM (2017) Targeting endothelial function to treat heart failure with preserved ejection fraction: the promise of exercise training. Oxid Med Cell Longev. https://doi.org/10.1155/2017/4865756
Article PubMed PubMed Central Google Scholar
Herbertz S, Sawyer JS, Stauber AJ, Gueorguieva I, Driscoll KE, Estrem ST, Cleverly AL, Desaiah D, Guba SC, Benhadji KA, Slapak CA, Lahn MM (2015) Clinical development of galunisertib (Ly2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway. Drug Des Devel Ther 9:4479–4499. https://doi.org/10.2147/DDDT.S86621
Article CAS PubMed PubMed Central Google Scholar
Jessen KR, Mirsky R, Arthur-Farraj P (2015) The role of cell plasticity in tissue repair: adaptive cellular reprogramming. Dev Cell 34:613–620. https://doi.org/10.1016/j.devcel.2015.09.005
Article CAS PubMed Google Scholar
Kalies K, Knöpp K, Wurmbrand L, Korte L, Dutzmann J, Pilowski C, Koch S, Sedding D (2024) Isolation of circulating endothelial cells provides tool to determine endothelial cell senescence in blood samples. Sci Rep 14:4271. https://doi.org/10.1038/s41598-024-54455-5
Comments (0)