(2024) National Diabetes Statistics Report. In:Centers for Disease Control
(2018) Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris. Nature 562:367–372. https://doi.org/10.1038/s41586-018-0590-4
Aasum E, Hafstad AD, Severson DL, Larsen TS (2003) Age-dependent changes in metabolism, contractile function, and ischemic sensitivity in hearts from db/db mice. Diabetes 52:434–441. https://doi.org/10.2337/diabetes.52.2.434
Article CAS PubMed Google Scholar
Anita NZ, Swardfager W (2022) Soluble epoxide hydrolase and diabetes complications. Int J Mol Sci. https://doi.org/10.3390/ijms23116232
Article PubMed PubMed Central Google Scholar
Belke DD, Larsen TS, Gibbs EM, Severson DL (2000) Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db) mice. Am J Physiol Endocrinol Metab 279:E1104-1113. https://doi.org/10.1152/ajpendo.2000.279.5.E1104
Article CAS PubMed Google Scholar
Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Series B Stat Methodol 57:289–300
Browaeys R, Saelens W, Saeys Y (2020) Nichenet: modeling intercellular communication by linking ligands to target genes. Nat Methods 17:159–162. https://doi.org/10.1038/s41592-019-0667-5
Article CAS PubMed Google Scholar
Buse JB, Ginsberg HN, Bakris GL, Clark NG, Costa F, Eckel R, Fonseca V, Gerstein HC, Grundy S, Nesto RW, Pignone MP, Plutzky J, Porte D, Redberg R, Stitzel KF, Stone NJ (2007) Primary prevention of cardiovascular diseases in people with diabetes mellitus: a scientific statement from the American Heart Association and the American Diabetes Association. Circulation 115:114–126. https://doi.org/10.1161/circulationaha.106.179294
Cable DM, Murray E, Shanmugam V, Zhang S, Zou LS, Diao M, Chen H, Macosko EZ, Irizarry RA, Chen F (2022) Cell type-specific inference of differential expression in spatial transcriptomics. Nat Methods 19:1076–1087. https://doi.org/10.1038/s41592-022-01575-3
Article CAS PubMed PubMed Central Google Scholar
Carley AN, Severson DL (2005) Fatty acid metabolism is enhanced in type 2 diabetic hearts. Biochim Biophys Acta 1734:112–126. https://doi.org/10.1016/j.bbalip.2005.03.005
Article CAS PubMed Google Scholar
Castanza AS, Recla JM, Eby D, Thorvaldsdóttir H, Bult CJ, Mesirov JP (2023) Extending support for mouse data in the Molecular Signatures Database (MSigDB). Nat Methods 20:1619–1620. https://doi.org/10.1038/s41592-023-02014-7
Article CAS PubMed PubMed Central Google Scholar
Cheng YJ, Imperatore G, Geiss LS, Saydah SH, Albright AL, Ali MK, Gregg EW (2018) Trends and disparities in cardiovascular mortality among U.S. adults with and without self-reported diabetes, 1988–2015. Diabetes Care 41:2306–2315. https://doi.org/10.2337/dc18-0831
Choudhary S, Satija R (2022) Comparison and evaluation of statistical error models for scRNA-seq. Genome Biol 23:27. https://doi.org/10.1186/s13059-021-02584-9
Article CAS PubMed PubMed Central Google Scholar
Crewe C, Kinter M, Szweda LI (2013) Rapid inhibition of pyruvate dehydrogenase: an initiating event in high dietary fat-induced loss of metabolic flexibility in the heart. PLoS ONE 8:e77280. https://doi.org/10.1371/journal.pone.0077280
Article CAS PubMed PubMed Central Google Scholar
De Jong KA, Lopaschuk GD (2017) Complex energy metabolic changes in heart failure with preserved ejection fraction and heart failure with reduced ejection fraction. Can J Cardiol 33:860–871. https://doi.org/10.1016/j.cjca.2017.03.009
Erhardsson M, Ljung Faxen U, Venkateshvaran A, Svedlund S, Saraste A, Lagerstrom Fermer M, Gan LM, Shah SJ, Tromp J, Sp Lam C, Lund LH, Hage C (2023) Regional differences and coronary microvascular dysfunction in heart failure with preserved ejection fraction. ESC Heart Fail 10:3729–3734. https://doi.org/10.1002/ehf2.14569
Article PubMed PubMed Central Google Scholar
Fujita M, Momose A, Ohtomo T, Nishinosono A, Tanonaka K, Toyoda H, Morikawa M, Yamada J (2011) Upregulation of fatty acyl-CoA thioesterases in the heart and skeletal muscle of rats fed a high-fat diet. Biol Pharm Bull 34:87–91. https://doi.org/10.1248/bpb.34.87
Article CAS PubMed Google Scholar
Galow AM, Kussauer S, Wolfien M, Brunner RM, Goldammer T, David R, Hoeflich A (2021) Quality control in scrna-seq can discriminate pacemaker cells: the mtrna bias. Cell Mol Life Sci 78:6585–6592. https://doi.org/10.1007/s00018-021-03916-5
Article CAS PubMed PubMed Central Google Scholar
Gizak A, McCubrey JA, Rakus D (2020) Cell-to-cell lactate shuttle operates in heart and is important in age-related heart failure. Aging (Albany NY) 12:3388–3406. https://doi.org/10.18632/aging.102818
Article CAS PubMed Google Scholar
Guglielmino K, Jackson K, Harris TR, Vu V, Dong H, Dutrow G, Evans JE, Graham J, Cummings BP, Havel PJ, Chiamvimonvat N, Despa S, Hammock BD, Despa F (2012) Pharmacological inhibition of soluble epoxide hydrolase provides cardioprotection in hyperglycemic rats. Am J Physiol Heart Circ Physiol 303:H853-862. https://doi.org/10.1152/ajpheart.00154.2012
Article CAS PubMed PubMed Central Google Scholar
Hao Y, Hao S, Andersen-Nissen E, Mauck WM 3rd, Zheng S, Butler A, Lee MJ, Wilk AJ, Darby C, Zager M, Hoffman P, Stoeckius M, Papalexi E, Mimitou EP, Jain J, Srivastava A, Stuart T, Fleming LM, Yeung B, Rogers AJ, McElrath JM, Blish CA, Gottardo R, Smibert P, Satija R (2021) Integrated analysis of multimodal single-cell data. Cell 184:3573-3587.e3529. https://doi.org/10.1016/j.cell.2021.04.048
Article CAS PubMed PubMed Central Google Scholar
Harris TR, Hammock BD (2013) Soluble epoxide hydrolase: gene structure, expression and deletion. Gene 526:61–74. https://doi.org/10.1016/j.gene.2013.05.008
Article CAS PubMed PubMed Central Google Scholar
Heusch G (2022) Coronary blood flow in heart failure: cause, consequence and bystander. Basic Res Cardiol 117:1. https://doi.org/10.1007/s00395-022-00909-8
Article PubMed PubMed Central Google Scholar
Heusch G, Kleinbongard P (2025) It takes more than omics to identify a cardioprotective mechanism. Cardiovasc Res 121:839–840. https://doi.org/10.1093/cvr/cvaf052
Article CAS PubMed Google Scholar
Hezarkhani S, Hajighaderi A, Hosseinzadeh S, Behnampour N, Veghari G, Fathabadi F, Hesari Z, Joshaghani HR (2024) The serum levels of angiopoietin-like protein 3 and 4 in type 2 diabetic patients with and without metabolic syndrome compared to the control group. Endocrinol Diabetes Metab 7:e466. https://doi.org/10.1002/edm2.466
Article CAS PubMed Google Scholar
Imig JD, Hammock BD (2009) Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases. Nat Rev Drug Discov 8:794–805. https://doi.org/10.1038/nrd2875
Article CAS PubMed PubMed Central Google Scholar
Jeong JY, Jeoung NH, Park KG, Lee IK (2012) Transcriptional regulation of pyruvate dehydrogenase kinase. Diabetes Metab J 36:328–335. https://doi.org/10.4093/dmj.2012.36.5.328
Article PubMed PubMed Central Google Scholar
Joseph LC, Shi J, Nguyen QN, Pensiero V, Goulbourne C, Bauer RC, Zhang H, Morrow JP (2022) Combined metabolomic and transcriptomic profiling approaches reveal the cardiac response to high-fat diet. iScience 25:104184. https://doi.org/10.1016/j.isci.2022.104184
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