Adamo L, Rocha-Resende C, Lin C-Y, Evans S, Williams J, Dun H, Li W, Mpoy C, Andhey PS, Rogers BE, Lavine K, Kreisel D, Artyomov M, Randolph GJ, Mann DL (2020) Myocardial B cells are a subset of circulating lymphocytes with delayed transit through the heart. JCI Insight 5:e134700. https://doi.org/10.1172/jci.insight.134700

Article  PubMed  PubMed Central  Google Scholar 

Ait-Oufella H, Herbin O, Bouaziz J-D, Binder CJ, Uyttenhove C, Laurans L, Taleb S, Van Vré E, Esposito B, Vilar J, Sirvent J, Van Snick J, Tedgui A, Tedder TF, Mallat Z (2010) B cell depletion reduces the development of atherosclerosis in mice. J Exp Med 207:1579–1587. https://doi.org/10.1084/jem.20100155

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alampour-Rajabi S, El Bounkari O, Rot A, Müller-Newen G, Bachelerie F, Gawaz M, Weber C, Schober A, Bernhagen J (2015) MIF interacts with CXCR7 to promote receptor internalization, ERK1/2 and ZAP-70 signaling, and lymphocyte chemotaxis. FASEB J 29:4497–4511. https://doi.org/10.1096/fj.15-273904

Article  CAS  PubMed  Google Scholar 

Alugupalli KR, Leong JM, Woodland RT, Muramatsu M, Honjo T, Gerstein RM (2004) B1b lymphocytes confer T cell-independent long-lasting immunity. Immunity 21:379–390. https://doi.org/10.1016/j.immuni.2004.06.019

Article  CAS  PubMed  Google Scholar 

Andreadou I, Ghigo A, Nikolaou PE, Swirski FK, Thackeray JT, Heusch G, Vilahur G (2025) Immunometabolism in heart failure. Nat Rev Cardiol. https://doi.org/10.1038/s41569-025-01165-8

Article  PubMed  Google Scholar 

Ansel KM, Harris RBS, Cyster JG (2002) CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity. Immunity 16:67–76. https://doi.org/10.1016/S1074-7613(01)00257-6

Article  CAS  PubMed  Google Scholar 

Badolato R, Alsina L, Azar A, Bertrand Y, Bolyard AA, Dale D, Deyà-Martínez À, Dickerson KE, Ezra N, Hasle H, Kang HJ, Kiani-Alikhan S, Kuijpers TW, Kulagin A, Langguth D, Levin C, Neth O, Olbrich P, Peake J, Rodina Y, Rutten CE, Shcherbina A, Tarrant TK, Vossen MG, Wysocki CA, Belschner A, Bridger GJ, Chen K, Dubuc S, Hu Y, Jiang H, Li S, MacLeod R, Stewart M, Taveras AG, Yan T, Donadieu J (2024) A phase 3 randomized trial of mavorixafor, a CXCR4 antagonist, for WHIM syndrome. Blood 144:35–45. https://doi.org/10.1182/blood.2023022658

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barber CL, Montecino-Rodriguez E, Dorshkind K (2011) Reduced production of B-1–specified common lymphoid progenitors results in diminished potential of adult marrow to generate B-1 cells. Proc Natl Acad Sci U S A 108:13700–13704. https://doi.org/10.1073/pnas.1107172108

Article  PubMed  PubMed Central  Google Scholar 

Barr TA, Brown S, Ryan G, Zhao J, Gray D (2007) TLR-mediated stimulation of APC: distinct cytokine responses of B cells and dendritic cells. Eur J Immunol 37:3040–3053. https://doi.org/10.1002/eji.200636483

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bilchick KC, Cochran JD, McSkimming C, Kothari H, Ma Z, Bivona DJ, Bekiranov S, McNamara C (2025) CXC-chemokine-receptor-type-5 expression on circulating naive B cells predicts improvement after cardiac resynchronization therapy. JACC: Basic Transl Sci 10:221–223. https://doi.org/10.1016/j.jacbts.2024.09.011

Article  PubMed  Google Scholar 

Binder CJ (2010) Natural IgM antibodies against oxidation-specific epitopes. J Clin Immunol 30:56–60. https://doi.org/10.1007/s10875-010-9396-3

Article  CAS  Google Scholar 

Bodhankar S, Chen Y, Vandenbark AA, Murphy SJ, Offner H (2014) Treatment of experimental stroke with IL-10-producing B-cells reduces infarct size and peripheral and CNS inflammation in wild-type B-cell-sufficient mice. Metab Brain Dis 29:59–73. https://doi.org/10.1007/s11011-013-9474-3

Article  CAS  PubMed  Google Scholar 

Bonecchi R, Graham GJ (2016) Atypical chemokine receptors and their roles in the resolution of the inflammatory response. Front Immunol. https://doi.org/10.3389/fimmu.2016.00224

Article  PubMed  PubMed Central  Google Scholar 

Bonnavion R, Liu S, Kawase H, Roquid KA, Offermanns S (2023) Large chemokine binding spectrum of human and mouse atypical chemokine receptor GPR182 (ACKR5). Front Pharmacol 14:1297596. https://doi.org/10.3389/fphar.2023.1297596

Article  CAS  PubMed  PubMed Central  Google Scholar 

Boring L, Gosling J, Cleary M, Charo IF (1998) Decreased lesion formation in CCR2−/− mice reveals a role for chemokines in the initiation of atherosclerosis. Nature 394:894–897. https://doi.org/10.1038/29788

Article  CAS  PubMed  Google Scholar 

Bot I, Ortiz Zacarías NV, De Witte WEA, De Vries H, Van Santbrink PJ, Van Der Velden D, Kröner MJ, Van Der Berg D-J, Stamos D, De Lange ECM, Kuiper J, Ijzerman AP, Heitman LH (2017) A novel CCR2 antagonist inhibits atherogenesis in apoE deficient mice by achieving high receptor occupancy. Sci Rep 7:52. https://doi.org/10.1038/s41598-017-00104-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Burger JA, Kipps TJ (2006) CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment. Blood 107:1761–1767. https://doi.org/10.1182/blood-2005-08-3182

Article  CAS  PubMed  Google Scholar 

Casarotti ACA, Teixeira D, Longo-Maugeri IM, Ishimura ME, Coste MER, Bianco HT, Moreira FT, Bacchin AF, Izar MC, Gonçalves I, Caixeta A, Szarf G, Pinto IM, Fonseca FA (2021) Role of B lymphocytes in the infarcted mass in patients with acute myocardial infarction. Biosci Rep 41:BSR20203413. https://doi.org/10.1042/BSR20203413

Article  CAS  PubMed  PubMed Central  Google Scholar 

Centa M, Jin H, Hofste L, Hellberg S, Busch A, Baumgartner R, Verzaal NJ, Lind Enoksson S, Perisic Matic L, Boddul SV, Atzler D, Li DY, Sun C, Hansson GK, Ketelhuth DFJ, Hedin U, Wermeling F, Lutgens E, Binder CJ, Maegdesfessel L, Malin SG (2019) Germinal center-derived antibodies promote atherosclerosis plaque size and stability. Circulation 139:2466–2482. https://doi.org/10.1161/CIRCULATIONAHA.118.038534

Article  PubMed  Google Scholar 

Cerutti A, Cols M, Puga I (2013) Marginal zone B cells: virtues of innate-like antibody-producing lymphocytes. Nat Rev Immunol 13:118–132. https://doi.org/10.1038/nri3383

Article  CAS  PubMed  PubMed Central  Google Scholar 

Choi YS, Dieter JA, Rothaeusler K, Luo Z, Baumgarth N (2012) B-1 cells in the bone marrow are a significant source of natural IgM. Eur J Immunol 42:120–129. https://doi.org/10.1002/eji.201141890

Article  CAS  PubMed  Google Scholar 

Cinamon G, Zachariah MA, Lam OM, Foss FW, Cyster JG (2008) Follicular shuttling of marginal zone B cells facilitates antigen transport. Nat Immunol 9:54–62. https://doi.org/10.1038/ni1542

Article  CAS  PubMed  Google Scholar 

Cipriani S, Francisci D, Mencarelli A, Renga B, Schiaroli E, D’Amore C, Baldelli F, Fiorucci S (2013) Efficacy of the CCR5 antagonist maraviroc in reducing early, ritonavir-induced atherogenesis and advanced plaque progression in mice. Circulation 127:2114–2124. https://doi.org/10.1161/CIRCULATIONAHA.113.001278

Article  CAS  PubMed  Google Scholar 

Clarke AJ, Riffelmacher T, Braas D, Cornall RJ, Simon AK (2018) B1a B cells require autophagy for metabolic homeostasis and self-renewal. J Exp Med 215:399–413. https://doi.org/10.1084/jem.20170771

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cohen S, Beebe JS, Chindalore V, Guan S, Hassan-Zahraee M, Saxena M, Xi L, Hyde C, Koride S, Levin R, Lubaczewski S, Salganik M, Sloan A, Stevens E, Peeva E, Vincent MS, Martin DA, Chu M (2024) A phase 1, randomized, double-blind, placebo-controlled, single- and multiple-dose escalation study to evaluate the safety and pharmacokinetics/pharmacodynamics of PF-06835375, a C-X-C chemokine receptor type 5 directed antibody, in patients with systemic lupus erythematosus or rheumatoid arthritis. Arthritis Res Ther 26:117. https://doi.org/10.1186/s13075-024-03337-2

Article  CAS  PubMed  PubMed Central  Google Scholar 

De Silva NS, Klein U (2015) Dynamics of B cells in germinal centres. Nat Rev Immunol 15:137–148. https://doi.org/10.1038/nri3804