Hepatic Hydrothorax: A Contemporary Review for Pleural Physicians

Bai M, Li J, Liu L, et al. Risk factors and clinical features of hepatic hydrothorax: insights from a single-centre cohort. Front Med (Lausanne). 2023;10:1165604.

Article  PubMed  Google Scholar 

Gomez-Herrera J, Carrillo-Bayona JA, Londoño-Burbano A, et al. Hepatic Hydrothorax worsens outcomes in cirrhosis: a retrospective study. J Clin Med. 2023;12(1):212.

Google Scholar 

Wilkins H, Britt E, Bhatnagar M, Pippard B. Hepatic hydrothorax. J Thorac Dis. 2024;16(4):1662–71.

Article  PubMed  PubMed Central  Google Scholar 

Cadranel JF, Ollivier-Hourmand I, Cadranel J, et al. International survey among hepatologists and pulmonologists on the hepatic hydrothorax: plea for recommendations. BMC Gastroenterol. 2023;23(1):305.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Banini BA, Alwatari Y, Stovall M, et al. Multidisciplinary management of hepatic hydrothorax in 2020: an evidence-based review and guidance. Hepatology. 2020;72(5):1851–63.

Article  PubMed  Google Scholar 

Vidyani A, Sibarani CI, Widodo B, et al. Diagnosis and management of hepatic hydrothorax. Korean J Gastroenterol. 2024;83(2):45–53.

Article  PubMed  Google Scholar 

Gao Y, Wang X, Chen L, et al. Spontaneous bacterial empyema in patients with hepatic hydrothorax: incidence, risk factors, and outcomes. Clin Res Hepatol Gastroenterol. 2021;45(3):101503.

Google Scholar 

Hooper C, Lee YCG, Maskell N. Investigation of a unilateral pleural effusion in adults: British thoracic society pleural disease guideline 2010. Thorax. 2010;65(Suppl 2):ii4–17.

Article  PubMed  Google Scholar 

Hallifax RJ, Rahman NM. Modern management of pleural effusions. BMJ. 2017;358:j3440.

Google Scholar 

European Association for the Study of the Liver. EASL clinical practice guidelines for the management of patients with decompensated cirrhosis. J Hepatol. 2018;69(2):406–60.

Article  Google Scholar 

Xiol X, Guardiola J. Hepatic hydrothorax. Curr Opin Pulm Med. 1998;4(4):239–43.

Article  PubMed  CAS  Google Scholar 

Bernardi M, Moreau R, Angeli P, et al. Albumin infusion in patients with cirrhosis: where are we now and what’s next? JHEP Rep. 2023;5(8):100749.

Google Scholar 

Morando F, Rosi S, Gola E, et al. Adherence to a moderate sodium restriction diet in outpatients with cirrhosis and ascites: a real-life cross-sectional study. Liver Int. 2015;35(5):1508–15.

Article  PubMed  CAS  Google Scholar 

Fogel MR, Sawhney VK, Neal EA, et al. Diuresis in the ascitic patient: a randomized controlled trial of three regimens. J Clin Gastroenterol. 1981;3(Suppl 1):73–80.

Article  PubMed  Google Scholar 

Sawhney VK, Gregory PB, Swezey SE, Blaschke TF. Furosemide disposition in cirrhotic patients. Gastroenterology. 1981;81(6):1012–6.

Article  PubMed  CAS  Google Scholar 

Daskalopoulos G, Laffi G, Morgan T, et al. Immediate effects of Furosemide on renal hemodynamics in chronic liver disease with Ascites. Gastroenterology. 1987;92(7):1859–65.

Article  PubMed  CAS  Google Scholar 

Runyon BA, Montano AA, Akriviadis EA, et al. The serum-ascites albumin gradient is superior to the exudate-transudate concept in the differential diagnosis of ascites. Ann Intern Med. 1992;117(3):215–20.

Article  PubMed  CAS  Google Scholar 

Spahr L, Villeneuve JP, Tran HK, Pomier-Layrargues G. Furosemide-induced natriuresis as a test to identify cirrhotic patients with refractory ascites. Hepatology. 2001;33(1):28–32.

Article  PubMed  CAS  Google Scholar 

Pockros PJ, Reynolds TB. Rapid diuresis in patients with ascites from chronic liver disease: the importance of peripheral edema. Gastroenterology. 1986;90(6):1827–33.

Article  PubMed  CAS  Google Scholar 

Pippard B, Britt E, Wilkins H, Bhatnagar M. Hepatic hydrothorax: a narrative review. Pulm Ther. 2022;8(2):241–54.

Article  PubMed  PubMed Central  Google Scholar 

Gilbert CR, Shojaee S, Maldonado F, et al. Pleural interventions in the management of hepatic hydrothorax. Chest. 2022;161(1):276–83.

Article  PubMed  Google Scholar 

Gordon CE, Feller-Kopman D, Balk EM, Smetana GW. Pneumothorax following thoracentesis: a systematic review and meta-analysis. Arch Intern Med. 2010;170(4):332–9.

Article  PubMed  Google Scholar 

McVay PA, Toy PT. Lack of increased bleeding after paracentesis and thoracentesis in patients with mild coagulation abnormalities. Transfusion. 1991;31(2):164–71.

Article  PubMed  CAS  Google Scholar 

Badillo R, Rockey DC. Hepatic hydrothorax: clinical features, management, and outcomes in 77 patients and review of the literature. Medicine (Baltimore). 2014;93(3):135–42.

Article  PubMed  Google Scholar 

Sobotka LA, Spitzer C, Hinton A, et al. Management of hepatic hydrothorax and effect on length of stay, mortality, cost, and 30-day hospital readmission. J Gastroenterol Hepatol. 2020;35(4):641–7.

Article  PubMed  Google Scholar 

Chin A, Bastaich DR, Dahman B, et al. Refractory hepatic hydrothorax is associated with increased mortality with death occurring at lower MELD-Na compared to cirrhosis and refractory ascites. Hepatology. 2024;79:844–56.

Article  PubMed  Google Scholar 

Gou X, Jia W, He C, et al. Hepatic hydrothorax does not increase the risk of death after transjugular intrahepatic portosystemic shunt in cirrhosis patients. Eur Radiol. 2023;33:3407–15.

Article  PubMed  Google Scholar 

Osman KT, Naritsin A, Amuchi B, Qamar AA. Liver transplantation for refractory hepatic hydrothorax is associated with a greater survival benefit compared to other complications of cirrhosis. Liver Transpl. 2024;30:142–50.

Article  PubMed  Google Scholar 

Thevenot T, Raevens S, Aujayeb A, et al. Pulmonary complications of advanced chronic liver diseases: an updated review. Explor Dig Dis. 2024;3:301–25.

Article  Google Scholar 

Chen A, Shojaee S, Ost D, Christophi C, Musto P, Eapen GA. Use of indwelling tunneled pleural catheters for the management of hepatic hydrothorax. Chest. 2016;149(2):R3867.

Google Scholar 

Wang Z, Xu L, Wang W, et al. Indwelling pleural catheter for hepatic hydrothorax: a systematic review. Clin Respir J. 2018;12(10):2670–8.

Google Scholar 

Kniese C, Boffa DJ, Rickert A, Arnaoutakis G, Kim AW, Detterbeck FC. Indwelling pleural catheters in the management of hepatic hydrothorax: a 10-year single-centre experience. J Surg Res. 2019;234:8–13.

Google Scholar 

Avula A, Parasa S, Gaddam S, et al. Indwelling pleural catheter (IPC) for the management of hepatic hydrothorax: a systematic review and meta-analysis. J Bronchol Interv Pulmonol. 2022;29(3):194–202.

Article  Google Scholar 

Walker SP, Bintcliffe O, Keenan E, et al. Randomised trial of indwelling pleural catheters for refractory transudative pleural effusions. Eur Respir J. 2022;59(2):2201276.

Article  Google Scholar 

Thøgersen A, Kristiansen B, Løkke A, Hilberg O, Borg M. Indwelling peritoneal and pleural catheters in the management of malignant and non-malignant ascites and pleural effusion: experiences from a Danish tertiary center. Eur Clin Respir J. 2025;12(1):2529053. https://doi.org/10.1080/20018525.2025.2529053.

Article  PubMed  PubMed Central  Google Scholar 

Strauss RM, Boyer TD. The use of chemical pleurodesis in the management of hepatic hydrothorax: a pilot study. Am J Gastroenterol. 1994;89(8):1520–2.

PubMed  CAS  Google Scholar 

Kalomenidis I, Milionis H, Dimopoulou I, et al. Talc pleurodesis in hepatic hydrothorax: efficacy and safety. Respiration. 2006;73(6):801–5.

Google Scholar 

Kim Y, Kim HJ, Lee HJ, et al. Management of hepatic Hydrothorax using video-assisted thoracoscopic surgery and pleurodesis: a single-centre experience. Clin Mol Hepatol. 2012;18(3):258–64.

Article  Google Scholar 

Lee HJ, Kim Y, Lee YS, et al. Outcomes of Talc pleurodesis for hepatic Hydrothorax in cirrhotic patients undergoing thoracoscopy. Clin Mol Hepatol. 2012;18(3):258–64.

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