Antenatal Diagnosis and Management of Congenital Pulmonary Airway Malformation: Current Perspectives

Sileo FG, Alameddine S, Iaccarino DA, Mascio DD, Giuliani GA, Bertucci E, et al. Outcome of fetal congenital pulmonary malformations: a systematic review and meta-analysis. J Perinat Med. 2024;52:457–66.

Article  PubMed  Google Scholar 

Thakkar HS, Durell J, Chakraborty S, Tingle B-L, Choi A, Fowler DJ, et al. Antenatally detected congenital pulmonary airway malformations: the Oxford experience. Eur J Pediatr Surg. 2016;27:324–9.

Article  PubMed  Google Scholar 

Pederiva F, Rothenberg SS, Hall N, Ijsselstijn H, Wong KKY, Von Der Thüsen J, Ciet P, Achiron R, Pio d’Adamo A, Schnater JM. Congenital lung malformations. Nat Rev Dis Primers. 2023;9:60.

Article  PubMed  Google Scholar 

Kurjak A, Medjedović E. Congenital pulmonary airway malformation. Donald School J Ultrasound Obstet Gynecol. 2024;18:85–8.

Article  Google Scholar 

Stocker J, Madewell J, Drake R. Congenital cystic Adenomatoid malformation of the lung. Classification and morphologic Spectrum. In: In: 50 landmark papers every pediatric surgeon should know. 1st ed. Boca Raton: CRC Press; 2023. p. 95–7.

Chapter  Google Scholar 

Adzick NS. Management of fetal lung lesions. Clin Perinatol. 2003;30:481–92.

Article  PubMed  Google Scholar 

Wong KKY, Flake AW, Tibboel D, Rottier RJ, Tam PKH. Congenital pulmonary airway malformation: advances and controversies. Lancet Child Adolesc Health. 2018;2:290–7.

Article  PubMed  Google Scholar 

King A, Lee TC, Steen E, Olutoye OO, Belfort MA, Cassady CI, et al. Prenatal imaging to predict need for urgent perinatal surgery in congenital lung lesions. J Surg Res. 2020;255:463–8.

Article  PubMed  Google Scholar 

Stocker JT. Symposium 24: non-neoplastic lung disease. Histopathology. 2002;41(S2):424–31. https://doi.org/10.1046/j.1365-2559.41.s2.58.x.

Article  Google Scholar 

Aryal K, Regmi PR, Adhikari G, Bhhattarai U, Sedhain SP. Congenital pulmonary airway malformation (CPAM): a case report and review of the literature. Radiol Case Rep. 2023;18:3483–6.

Article  PubMed  PubMed Central  Google Scholar 

Kunisaki SM. Narrative review of congenital lung lesions. Transl Pediatr. 2021;10:1418431–1431.

Article  Google Scholar 

David M, Lamas-Pinheiro R, Henriques-Coelho T. Prenatal and postnatal management of congenital pulmonary airway malformation. Neonatology. 2016;110:101–15.

Article  PubMed  CAS  Google Scholar 

Seear M, Townsend J, Hoepker A, Jamieson D, McFadden D, Daigneault P, Glomb W. A review of congenital lung malformations with a simplified classification system for clinical and research use. Pediatr Surg Int. 2017;33(6):657–64.

Article  PubMed  Google Scholar 

Pederiva F, Rothenberg SS, Hall N, Ijsselstijn H, Wong KKY, von der Thüsen J, Ciet P, Achiron R, Pio d'Adamo A, Schnater JM. Congenital lung malformations. Nat Rev Dis Primers. 2023;9(1):60. https://doi.org/10.1038/s41572-023-00470-1.

Article  PubMed  Google Scholar 

Biyyam DR, Chapman T, Ferguson MR, Deutsch G, Dighe MK. Congenital lung abnormalities: embryologic features, prenatal diagnosis, and postnatal radiologic-pathologic correlation. Radiographics. 2010;30:1721–38.

Article  PubMed  Google Scholar 

Bunduki V, Ruano R, Marques da Silva M, Miguelez J, Miyadahira S, Gilberto Maksoud J, Zugaib M. Prognostic factors associated with congenital cystic adenomatoid malformation of the lung. Prenat Diagn. 2000;20:459–64.

Article  PubMed  CAS  Google Scholar 

Cavoretto P, Molina F, Poggi S, Davenport M, Nicolaides KH. Prenatal diagnosis and outcome of echogenic fetal lung lesions. Ultrasound Obstet Gynecol. 2008;32:769–83.

Article  PubMed  CAS  Google Scholar 

Cai C, Tian M, Liu C, Zhang G, Li X, Zhou B, Sun Y, Yu G. Clinical perinatal Management of High-Risk Fetal Congenital Pulmonary Airway Malformation. 2024; https://doi.org/10.21203/rs.3.rs-4550511/v1.

KM de Winter-de Groot (2025) Natural course of CPAM and pulmonary sequestration: to operate or not to operate, this is the question. Pediatr Pulmonol 60:S64–S65.

Article  PubMed  Google Scholar 

Nelson ND, Xu F, Chandrasekaran P, Litzky LA, Peranteau WH, Frank DB, et al. Defining the spatial landscape of KRAS mutated congenital pulmonary airway malformations: a distinct entity with a spectrum of histopathologic features. Mod Pathol. 2022;35:1870–81.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Brcic L, Fakler F, Eidenhammer S, Thueringer A, Kashofer K, Kulka J, et al. Pleuropulmonary blastoma type I might arise in congenital pulmonary airway malformation type 4 by acquiring a Dicer 1 mutation. Virchows Arch. 2020;477:375–82.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Doss JD, Odibo AO, Jackson S, Vrecenak J, Bligard KH. 754 ultrasound and clinical characteristics of congenital pulmonary airway malformations (CPAM) and neonatal care needs. Am J Obstet Gynecol. 2024;230:S402.

Yousef N, Mokhtari M, Durand P, Raimondi F, Migliaro F, Letourneau A, Tissières P, De Luca D. Lung ultrasound findings in congenital pulmonary airway malformation. Amer J Perinatol. 2018;35:1222–7.

Article  Google Scholar 

An P, Xiao X, Zhao Y, Zhou J, Li X, Xiong Y. Prenatal ultrasound measurements of mild congenital pulmonary airway malformation and long-term prognosis: a retrospective cohort study. Int J Gynaecol Obstet. 2022;157:327–32.

Article  PubMed  CAS  Google Scholar 

Usui N. Surgical treatment for and prognosis of congenital pulmonary airway malformation. In: Sago H, Okuyama H, Kanamori Y, editors. Congenital cystic lung disease: comprehensive understanding of its diagnosis and treatment from fetus to childhood. Singapore: Springer; 2020. p. 63–71.

Chapter  Google Scholar 

Adams NC, Victoria T, Oliver ER, Moldenhauer JS, Adzick NS, Colleran GC. Fetal ultrasound and magnetic resonance imaging: a primer on how to interpret prenatal lung lesions. Pediatr Radiol. 2020;50:1839–54.

Article  PubMed  Google Scholar 

Pogoriler J, Vargas SO. Cystic masses of the pediatric lung: update on congenital pulmonary airway malformation and its differential diagnosis. Virchows Arch. 2025;486:177–88.

Article  PubMed  Google Scholar 

Perea L, Blinman T, Piccione J, Laje P. Bilateral congenital lobar emphysema: staged management. J Pediatr Surg. 2017;52(9):1442.

Article  PubMed  Google Scholar 

Sintim-Damoa A, Cohen HL. Fetal imaging of congenital lung lesions with postnatal correlation. Pediatr Radiol. 2022;52:1921–34.

Article  PubMed  Google Scholar 

Newman B. Magnetic resonance imaging for congenital lung malformations. Pediatr Radiol. 2022;52:312–22.

Article  PubMed  Google Scholar 

Ehrenberg-Buchner S, Stapf AM, Berman DR, Drongowski RA, Mychaliska GB, Treadwell MC. Kunisaki SM fetal lung lesions: can we start to breathe easier? Am J Obstet Gynecol. 2013;208(2):151.e1–7.

Article  PubMed  Google Scholar 

Kunisaki SM, Saito JM, Fallat ME, et al. Development of a multi-institutional registry for children with operative congenital lung malformations. J Pediatr Surg. 2020;55(7):1313–8.

Article  PubMed  Google Scholar 

Crombleholme TM, Coleman B, Hedrick H, Liechty K, Howell L, Flake AW, et al. Cystic adenomatoid malformation volume ratio predicts outcome in prenatally diagnosed cystic adenomatoid malformation of the lung. J Pediatr Surg. 2002;37:331–8.

Article  PubMed  Google Scholar 

Griggs C, Schmaedick M, Gerall C, et al. Vanishing congenital lung malformations: what is the incidence of true regression? Journal of Neonatal-Perinatal Medicine. 2022;15:105–11.

Article  PubMed  CAS  Google Scholar 

Zhu P, Cheng K, He M, Wang Y, Shen P, He K, et al. Diagnostic value of congenital pulmonary airway malformation volume ratio for fetal hydrops due to congenital lung malformations: a systematic review and meta-analysis. Orphanet J Rare Dis. 2022;17:213.

Article  PubMed  PubMed Central  Google Scholar 

Kane SC, Ancona E, Reidy KL, Palma-Dias R. The utility of the congenital pulmonary airway malformation-volume ratio in the assessment of fetal echogenic lung lesions: a systematic review. Fetal Diagn Ther. 2019;47:171–81.

Article  PubMed 

Comments (0)

No login
gif