Clear cell renal cell carcinoma (ccRCC) is the most prevalent primary kidney cancer. Although its relevant capability to disseminate, long-term brain metastasis is very unusual. The present paper describes two cases of delayed brain metastasis: one occipital that occurred 20 years after a radical nephrectomy, and one thalamic after 11 years. An extensive literature review was also carried out, and only 31 cases of delayed brain metastasis from ccRCC were found. The authors provide an analysis of all 33 cases, focusing on clinical, radiological, and histological features, along with current treatment recommendations.

O carcinoma de células renais claras (ccRCC) é o câncer renal primário mais prevalente. Embora tenha uma capacidade relevante de disseminação, a metástase cerebral de longo prazo é muito incomum. O presente artigo descreve dois casos de metástase cerebral tardia: uma occipital, ocorrida 20 anos após uma nefrectomia radical, e uma talâmica após 11 anos. Uma extensa revisão da literatura também foi realizada, e apenas 31 casos de metástase cerebral tardia de ccRCC foram encontrados. Os autores fornecem uma análise de todos os 33 casos, com foco em características clínicas, radiológicas e histológicas, além das recomendações de tratamento atuais.

GFSQ: data extraction, data synthesis, and writing — original draft; BF: ensured coherence and clarity of the manuscript. All authors contributed to the review of the text and approved the final version of the manuscript.

Received: 08 October 2024

Accepted: 20 March 2025

Article published online:
08 October 2025

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