Available online 11 February 2026, 151588

Surgical site infection (SSI) is one of the most common nosocomial infections that occur in pediatric patients in the United States, with colorectal procedures consistently demonstrating the highest rates of SSI. Strategies to reduce SSI in colorectal surgery include standardized perioperative colorectal care bundles, which commonly incorporate preoperative bowel preparation. Robust adult literature exists supporting the use of mechanical bowel preparation in combination with oral antibiotics to mitigate SSI; however, pediatric evidence remains less definitive. Current pediatric literature shows heterogeneity of bowel preparation use amongst surgeons, with existing literature consisting primarily of small retrospective studies. A well-designed pediatric randomized controlled trial comparing the four available bowel preparation strategies would provide much needed evidence to define best practice for preoperative colorectal surgery care amid current variations in clinical practice.

Surgical site infections

Colorectal surgery

Pediatric bowel preparation

© 2026 The Author(s). Published by Elsevier Inc.