Temporal trends in gabapentinoid use for the acute management of spinal cord injury: a retrospective cohort study

Rosner J, Negraeff M, Bélanger LM, Tsang A, Ritchie L, Mac-Thiong JM, et al. Characterization of hyperacute neuropathic pain after spinal cord injury: a prospective study. The journal of pain : official journal of the American Pain Society. 2022;23:89–97. https://doi.org/10.1016/j.jpain.2021.06.013

Article  Google Scholar 

Felix ER, Cardenas DD, Bryce TN, Charlifue S, Lee TK, MacIntyre B, et al. Prevalence and impact of neuropathic and nonneuropathic pain in chronic spinal cord injury. Arch Phys Med Rehabil. 2022;103:729–37. https://doi.org/10.1016/j.apmr.2021.06.022

Article  PubMed  Google Scholar 

Burke D, Fullen BM, Stokes D, Lennon O. Neuropathic pain prevalence following spinal cord injury: A systematic review and meta-analysis. Eur J Pain. 2017;21:29–44. https://doi.org/10.1002/EJP.905

Article  CAS  PubMed  Google Scholar 

Hunt C, Moman R, Peterson A, Wilson R, Covington S, Mustafa R, et al. Prevalence of chronic pain after spinal cord injury: a systematic review and meta-analysis. Reg Anesth Pain Med. 2021;46:328–36. https://doi.org/10.1136/RAPM-2020-101960

Article  PubMed  Google Scholar 

Finnerup NB, Norrbrink C, Trok K, Piehl F, Johannesen IL, Sørensen JC, et al. Phenotypes and predictors of pain following traumatic spinal cord injury: A prospective study. The journal of pain : official journal of the American Pain Society. 2014;15:40–8. https://doi.org/10.1016/j.jpain.2013.09.008

Article  Google Scholar 

Crul TC, Post MWM, Visser-Meily JMA, Stolwijk-Swüste JM. Prevalence and determinants of pain in spinal cord injury during initial inpatient rehabilitation: data from the dutch spinal cord injury database. Arch Phys Med Rehabil. 2023;104:74–82. https://doi.org/10.1016/j.apmr.2022.07.005

Article  PubMed  Google Scholar 

Varghese J, Anderson KD, Widerström-Noga E, Mehan U. A primary care provider’s guide to pain after spinal cord injury: screening and management. Top Spinal Cord Inj Rehabil. 2020;26:133 https://doi.org/10.46292/SCI2603-133

Article  PubMed  PubMed Central  Google Scholar 

Widerström-Noga E. Neuropathic pain and spinal cord injury: management, phenotypes, and biomarkers. Drugs. 2023;83:1001–25. https://doi.org/10.1007/S40265-023-01903-7

Article  PubMed  Google Scholar 

Saita K, Sumitani M, Koyama Y, Sugita S, Matsubayashi Y, Ogata T, et al. Neuropathic pain development and maintenance and its association with motor recovery after cervical spinal cord injury. J Spinal Cord Med. 2024;48:585–92. https://doi.org/10.1080/10790268.2024.2309421

Article  PubMed  PubMed Central  Google Scholar 

Kukkar A, Bali A, Singh N, Jaggi AS. Implications and mechanism of action of gabapentin in neuropathic pain. Arch Pharm Res. 2013;36:237–51. https://doi.org/10.1007/s12272-013-0057-y

Article  CAS  PubMed  Google Scholar 

Chincholkar M. Analgesic mechanisms of gabapentinoids and effects in experimental pain models: a narrative review. Br J Anaesth. 2018;120:1315–34. https://doi.org/10.1016/J.BJA.2018.02.066

Article  CAS  PubMed  Google Scholar 

Derry S, Bell RF, Straube S, Wiffen PJ, Aldington D, Moore RA. Pregabalin for neuropathic pain in adults. Cochrane Database Syst Rev. 2019;1:CD007076 https://doi.org/10.1002/14651858.CD007076.PUB3

Article  PubMed  Google Scholar 

Wiffen PJ, Derry S, Bell RF, Rice ASC, Tölle TR, Phillips T, et al. Gabapentin for chronic neuropathic pain in adults. Cochrane Database Syst Rev. 2017;6:CD007938 https://doi.org/10.1002/14651858.CD007938.PUB4

Article  PubMed  Google Scholar 

Hong JSW, Atkinson LZ, Al-Juffali N, Awad A, Geddes JR, Tunbridge EM, et al. Gabapentin and pregabalin in bipolar disorder, anxiety states, and insomnia: Systematic review, meta-analysis, and rationale. Mol Psychiatry. 2021;27:1339–49. https://doi.org/10.1038/s41380-021-01386-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang LL, Wright JA, Fischer KM, Croghan IT, Nanda S, Schroeder DR, et al. Gabapentinoid prescribing practices at a large academic medical center. Mayo Clin. Proc. Innov. Qual. Outcomes. 2023;7:58–68. https://doi.org/10.1016/j.mayocpiqo.2022.12.002

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mack A. Examination of the evidence for off-label use of gabapentin. Journal of managed care pharmacy : JMCP. 2015;9:559–68. https://doi.org/10.18553/JMCP.2003.9.6.559

Article  Google Scholar 

Chan AYL, Yuen ASC, Tsai DHT, Lau WCY, Jani YH, Hsia Y, et al. Gabapentinoid consumption in 65 countries and regions from 2008 to 2018: a longitudinal trend study. Nat Commun. 2023;14:1–11.

Article  CAS  Google Scholar 

Encinosa W, Bernard D, Selden TM. Opioid and non-opioid analgesic prescribing before and after the CDC’s 2016 opioid guideline. Int. J. Health Econ. Manag. 2022;22:1–52. https://doi.org/10.1007/s10754-021-09307-4

Article  PubMed  Google Scholar 

Bélanger LMA, Umedaly HS, Noonan VK, Park SE, Prince J, Thorogood NP, et al. Evaluation of a clinical protocol to assess and diagnose neuropathic pain during acute hospital admission results from traumatic spinal cord injury. Clin J Pain. 2018;34:104–12. https://doi.org/10.1097/AJP.0000000000000523

Article  PubMed  Google Scholar 

Warner FM, Cragg JJ, Jutzeler CR, Grassner L, MacH O, Maier DD, et al. Association of timing of gabapentinoid use with motor recovery after spinal cord injury. Neurology. 2020;95:E3412–9. https://doi.org/10.1212/WNL.0000000000010950

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cragg JJ, Jutzeler CR, Grassner L, Ramer M, Bradke F, Kramer JLK. Beneficial “pharmaceutical pleiotropy” of gabapentinoids in spinal cord injury: a case for refining standard-of-care. Neurorehabil Neural Repair. 2020;34:686–9. https://doi.org/10.1177/1545968320931516

Article  PubMed  Google Scholar 

Tedeschi A, Dupraz S, Laskowski CJ, Xue J, Ulas T, Beyer M, et al. The calcium channel subunit Alpha2delta2 suppresses axon regeneration in the adult CNS. Neuron. 2016;92:419–34. https://doi.org/10.1016/J.NEURON.2016.09.026/ATTACHMENT/D5BB7F7E-B452-419A-ADAD-6393BC2C4AFF/MMC4.PDF

Article  CAS  PubMed  Google Scholar 

Warner FM, Cragg JJ, Jutzeler CR, Röhrich F, Weidner N, Saur M, et al. Early administration of gabapentinoids improves motor recovery after human spinal cord injury. Cell Rep. 2017;18:1614–8. https://doi.org/10.1016/J.CELREP.2017.01.048

Article  CAS  PubMed  Google Scholar 

Sun W, Larson MJE, Kiyoshi CM, Annett AJ, Stalker WA, Peng J, et al. Gabapentinoid treatment promotes corticospinal plasticity and regeneration following murine spinal cord injury. J Clin Invest. 2020;130:345–58. https://doi.org/10.1172/JCI130391

Article  CAS  PubMed  Google Scholar 

Wilson JR, Doty S, Petitt JC, El-Abtah M, Francis JJ, Sharpe MG, et al. Feasibility of gabapentin as an intervention for neurorecovery after an acute spinal cord injury: Protocol. Front Neurol. 2022;13:1033386. 10.3389/FNEUR.2022.1033386.

Article  PubMed  PubMed Central  Google Scholar 

Mehta S, McIntyre A, Dijkers M, Loh E, Teasell RW. Gabapentinoids are effective in decreasing neuropathic pain and other secondary outcomes after spinal cord injury: a meta-analysis. Arch Phys Med Rehabil. 2014;95:2180–6. https://doi.org/10.1016/J.APMR.2014.06.010

Article  PubMed  Google Scholar 

Noonan VK, Kwon BK, Soril L, Fehlings MG, Hurlbert RJ, Townson A, et al. The rick hansen spinal cord injury registry (RHSCIR): a national patient-registry. Spinal Cord. 2012;50:22–7. https://doi.org/10.1038/SC.2011.109

Article  CAS  PubMed  Google Scholar 

Rupp R, Biering-Sørensen F, Burns SP, Graves DE, Guest J, Jones L, et al. International standards for neurological classification of spinal cord injuryrevised 2019. Top Spinal Cord Inj Rehabil. 2021;27:1–22. https://doi.org/10.46292/SCI2702-1

Article  PubMed  PubMed Central  Google Scholar 

von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet. 2007;370:1453–7. https://doi.org/10.1016/S0140-6736(07)61602-X

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