Sung H, Ferlay J, Siegel RL et al (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209–249. https://doi.org/10.3322/caac.21660

Article  PubMed  Google Scholar 

Ganti AK, Klein AB, Cotarla I, Seal B, Chou E (2021) Update of incidence, prevalence, survival, and initial treatment in patients with non-small cell lung cancer in the US. JAMA Oncol 7(12):1824–1832. https://doi.org/10.1001/jamaoncol.2021.4932

Article  PubMed  Google Scholar 

Reinhardt H, Trittler R, Eggleton AG et al (2017) Paving the way for dose banding of chemotherapy: an analytical approach. J Natl Compr Canc Netw 15(4):484–493. https://doi.org/10.6004/jnccn.2017.0048

Article  PubMed  Google Scholar 

Lyman GH, Dale DC, Crawford J (2003) Incidence and predictors of low dose-intensity in adjuvant breast cancer chemotherapy: a nationwide study of community practices. J Clin Oncol 21(24):4524–4531. https://doi.org/10.1200/JCO.2003.05.002

Article  PubMed  Google Scholar 

Lyman GH, Sparreboom A (2013) Chemotherapy dosing in overweight and obese patients with cancer. Nat Rev Clin Oncol 10(8):451–459. https://doi.org/10.1038/nrclinonc.2013.108

Article  PubMed  Google Scholar 

Wildiers H, Reiser M (2011) Relative dose intensity of chemotherapy and its impact on outcomes in patients with early breast cancer or aggressive lymphoma. Crit Rev Oncol Hematol 77(3):221–240. https://doi.org/10.1016/j.critrevonc.2010.02.002

Article  PubMed  Google Scholar 

Seidel C, Schaefers C, Connolly EA et al (2024) Efficacy and safety of high-dose chemotherapy as the first or subsequent salvage treatment line in patients with relapsed or refractory germ cell cancer: an international multicentric analysis. ESMO Open 9(5):103449. https://doi.org/10.1016/j.esmoop.2024.103449

Article  PubMed  PubMed Central  Google Scholar 

Singh S, Parulekar W, Murray N et al (2005) Influence of sex on toxicity and treatment outcome in small-cell lung cancer. J Clin Oncol 23(4):850–856. https://doi.org/10.1200/JCO.2005.03.171

Article  PubMed  Google Scholar 

Lyman GH (2009) Impact of chemotherapy dose intensity on cancer patient outcomes. J Natl Compr Canc Netw 7(1):99–108. https://doi.org/10.6004/jnccn.2009.0009

Article  PubMed  Google Scholar 

Oun R, Rowan E (2017) Cisplatin induced arrhythmia; electrolyte imbalance or disturbance of the SA node? Eur J Pharmacol 811:125–128. https://doi.org/10.1016/j.ejphar.2017.05.063

Article  PubMed  Google Scholar 

Tjan-Heijnen VC, Wagener DJ, Postmus PE (2002) An analysis of chemotherapy dose and dose-intensity in small-cell lung cancer: lessons to be drawn. Ann Oncol 13(10):1519–1530. https://doi.org/10.1093/annonc/mdf249

Article  PubMed  Google Scholar 

Klasa RJ, Murray N, Coldman AJ (1991) Dose-intensity meta-analysis of chemotherapy regimens in small-cell carcinoma of the lung. J Clin Oncol 9(3):499–508. https://doi.org/10.1200/JCO.1991.9.3.499

Article  PubMed  Google Scholar 

Crawford J (2004) The importance of chemotherapy dose intensity in lung cancer. Semin Oncol 31(6 Suppl 15):25–31. https://doi.org/10.1053/j.seminoncol.2004.11.025

Article  PubMed  Google Scholar 

Souquet PJ, Lombard-Bohas CH, Freyer G, Bombaron P, Geriniere L, Bernard JP (1996) Chemotherapy in elderly patients with bronchogenic cancers. Rev Mal Respir 13(4):327–333

PubMed  Google Scholar 

Sculier JP, Paesmans M, Thiriaux J et al (1999) A comparison of methods of calculation for estimating carboplatin AUC with a retrospective pharmacokinetic-pharmacodynamic analysis in patients with advanced non-small cell lung cancer. European Lung Cancer Working Party. Eur J Cancer 35(9):1314–1319. https://doi.org/10.1016/s0959-8049(99)00029-5

Article  PubMed  Google Scholar 

Brunetto AT, Carden CP, Myerson J et al (2010) Modest reductions in dose intensity and drug-induced neutropenia have no major impact on survival of patients with non-small cell lung cancer treated with platinum-doublet chemotherapy. J Thorac Oncol 5(9):1397–1403. https://doi.org/10.1097/JTO.0b013e3181eba7f9

Article  PubMed  Google Scholar 

Goldstraw P, Chansky K, Crowley J et al (2016) The IASLC Lung Cancer Staging Project: proposals for revision of the TNM stage groupings in the forthcoming (eighth) edition of the TNM Classification for Lung Cancer. J Thorac Oncol 11(1):39–51. https://doi.org/10.1016/j.jtho.2015.09.009

Article  PubMed  Google Scholar 

Li X, Pan Y, Han Y et al (2022) Chinese food image database for eating and appetite studies. Nutrients 14(14):2916. https://doi.org/10.3390/nu14142916

Article  PubMed  PubMed Central  Google Scholar 

Oken MM, Creech RH, Tormey DC et al (1982) Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol 5(6):649–655

Article  PubMed  Google Scholar 

Schober P, Mascha EJ, Vetter TR (2021) Statistics from A (agreement) to Z (z score): a guide to interpreting common measures of association, agreement, diagnostic accuracy, effect size, heterogeneity, and reliability in medical research. Anesth Analg 133(6):1633–1641. https://doi.org/10.1213/ANE.0000000000005773

Article  PubMed  Google Scholar 

Crivellari G, Monfardini S, Stragliotto S, Marino D, Aversa SM (2007) Increasing chemotherapy in small-cell lung cancer: from dose intensity and density to megadoses. Oncologist 12(1):79–89. https://doi.org/10.1634/theoncologist.12-1-79

Article  PubMed  Google Scholar 

Griggs JJ, Bohlke K, Balaban EP et al (2021) Appropriate systemic therapy dosing for obese adult patients with cancer: ASCO guideline update. J Clin Oncol 39(18):2037–2048. https://doi.org/10.1200/JCO.21.00471

Article  PubMed  Google Scholar 

Rindi G, Klimstra DS, Abedi-Ardekani B et al (2018) A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal. Mod Pathol 31(12):1770–1786. https://doi.org/10.1038/s41379-018-0110-y

Article  PubMed  PubMed Central  Google Scholar 

Dasari A, Mehta K, Byers LA, Sorbye H, Yao JC (2018) Comparative study of lung and extrapulmonary poorly differentiated neuroendocrine carcinomas: a SEER database analysis of 162,983 cases. Cancer 124(4):807–815. https://doi.org/10.1002/cncr.31124

Article  PubMed  Google Scholar 

Sherman S, Rotem O, Shochat T, Zer A, Moore A, Dudnik E (2020) Efficacy of immune check-point inhibitors (ICPi) in large cell neuroendocrine tumors of lung (LCNEC). Lung Cancer 143:40–46. https://doi.org/10.1016/j.lungcan.2020.03.008

Article  PubMed  Google Scholar 

Chen P, Liu Y, Wen Y, Zhou C (2022) Non-small cell lung cancer in China. Cancer Commun 42(10):937–970. https://doi.org/10.1002/cac2.12359

Article  Google Scholar 

Peterson LM, O’Sullivan J, Wu QV et al (2018) Prospective study of serial (18)F-FDG PET and (18)F-Fluoride PET to predict time to skeletal-related events, time to progression, and survival in patients with bone-dominant metastatic breast cancer. J Nucl Med 59(12):1823–1830. https://doi.org/10.2967/jnumed.118.211102

Article  PubMed  PubMed Central  Google Scholar 

Kim ES, Baran AM, Mondo EL et al (2017) Risk of thromboembolism in cisplatin versus carboplatin-treated patients with lung cancer. PLoS ONE 12(12):e0189410. https://doi.org/10.1371/journal.pone.0189410

Article  PubMed  PubMed Central  Google Scholar 

Moik F, van Es N, Posch F et al (2020) Gemcitabine and platinum-based agents for the prediction of cancer-associated venous thromboembolism: results from the Vienna Cancer and Thrombosis Study. Cancers (Basel). https://doi.org/10.3390/cancers12092493

Article  PubMed  Google Scholar 

Seng S, Liu Z, Chiu SK et al (2012) Risk of venous thromboembolism in patients with cancer treated with Cisplatin: a systematic review and meta-analysis. J Clin Oncol 30(35):4416–4426. https://doi.org/10.1200/JCO.2012.42.4358

Article  PubMed  Google Scholar 

LoPiccolo J, Gusev A, Christiani DC, Janne PA (2024) Lung cancer in patients who have never smoked - an emerging disease. Nat Rev Clin Oncol 21(2):121–146. https://doi.org/10.1038/s41571-023-00844-0

Article  PubMed  PubMed Central