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Pharmacokinetic comparison of cisplatin administration via HIPEC and intravenous infusion in a porcine model
Pharmacokinetic comparison of cisplatin administration via HIPEC and intravenous infusion in a porcine model
Epithelial ovarian cancer (EOC) is associated with high recurrence and poor prognosis. Cytoreductive surgery (CRS) with hy...
A phase 1 study of orally administered 5-fluoro-2’-deoxycytidine with tetrahydrouridine in patients with refractory solid tumors
A phase 1 study of orally administered 5-fluoro-2’-deoxycytidine with tetrahydrouridine in patients with refractory solid tumors
The DNA methyltransferase (DNMT) inhibitor 5-fluoro-2’-deoxycytidine (FdCyd) combined with tetrahydrouridine (THU) y...
Curcumin in colorectal cancer: preventive strategies and therapeutic mechanisms
Curcumin in colorectal cancer: preventive strategies and therapeutic mechanisms
Colorectal cancer (CRC) is a leading global cause of cancer-related deaths, influenced by both genetic predisposition and ...
Prospective monitoring of plasma abemaciclib in breast cancer patients: associations with age and adverse events
Prospective monitoring of plasma abemaciclib in breast cancer patients: associations with age and adverse events
Plasma abemaciclib concentrations vary among individuals, and their association with hematologic toxicity has been reporte...
Association between modifications in intravenous chemotherapy dose and disease-free survival and related influencing factors in lung cancer patients: a retrospective study based on inverse probability weighting
Association between modifications in intravenous chemotherapy dose and disease-free survival and related influencing factors in lung cancer patients: a retrospective study based on inverse probability weighting
Lung cancer treatment options have advanced, chemotherapy continues to play a central role in its management. However, the...
Analysis of intercellular lipids in the stratum corneum of patients with capecitabine-induced hand-foot syndrome: comparison with the stratum corneum of healthy individuals
Analysis of intercellular lipids in the stratum corneum of patients with capecitabine-induced hand-foot syndrome: comparison with the stratum corneum of healthy individuals
Capecitabine (CAP) side effect, a prodrug of 5-fluorouracil (5-FU), is hand-foot syndrome (HFS), a localized skin disorder...
Mapping drug-drug interactions in pharmacokinetic boosting of olaparib
Mapping drug-drug interactions in pharmacokinetic boosting of olaparib
In pharmacokinetic (PK) boosting, an intentional drug-drug interaction (DDI) is used to increase the exposure of another d...
A pharmacokinetic-pharmacodynamic/toxicodynamic model framework for PARP inhibitor combination therapy with DNA-damaging chemotherapeutics
A pharmacokinetic-pharmacodynamic/toxicodynamic model framework for PARP inhibitor combination therapy with DNA-damaging chemotherapeutics
Poly(ADP-ribose) polymerase inhibitors (PARPi) can induce synthetic lethality in cancer cells with defective homologous re...
Post-transplantation gilteritinib maintenance therapy and therapeutic drug monitoring in pediatric acute myeloid leukemia with FLT3–internal tandem duplication
Post-transplantation gilteritinib maintenance therapy and therapeutic drug monitoring in pediatric acute myeloid leukemia with FLT3–internal tandem duplication
FLT3 internal tandem duplication (FLT3-ITD) mutations occur frequently in acute myeloid leukemia (AML) and are associated ...
First-in-class HIF-2α therapy in genitourinary oncology: Belzutifan from von Hippel–Lindau disease to advanced renal cell carcinoma
First-in-class HIF-2α therapy in genitourinary oncology: Belzutifan from von Hippel–Lindau disease to advanced renal cell carcinoma
Hypoxia signaling governs angiogenesis, erythropoiesis, and cellular metabolism; its dysregulation via stabilized hypoxia-...
Drug–drug interactions with pioglitazone, losartan, and midazolam and anti-tumor efficacy and safety study of TAS-115 in patients with solid tumors
Drug–drug interactions with pioglitazone, losartan, and midazolam and anti-tumor efficacy and safety study of TAS-115 in patients with solid tumors
TAS-115 is an oral multi-kinase inhibitor currently under development for the treatment of osteosarcoma and chronic fibros...
Recent advances in bispecific antibody-drug conjugates for breast cancer therapy
Recent advances in bispecific antibody-drug conjugates for breast cancer therapy
Bispecific antibody-drug conjugates (BsADCs) represent a promising strategy to overcome limitations of conventional ADCs i...
Revolutionizing cancer treatment with senotherapeutics: a current perspective
Revolutionizing cancer treatment with senotherapeutics: a current perspective
Cellular senescence is a double-edged sword in cancer biology, initially acting as a tumor-suppressive mechanism but later...
Etoposide dosing challenges in a testicular cancer patient with hepatic impairment and drug-drug interactions–a case report
Etoposide dosing challenges in a testicular cancer patient with hepatic impairment and drug-drug interactions–a case report
Etoposide, together with cisplatin, is a cornerstone in the treatment of metastatic testicular cancer, but dosing can be c...
The potential and promise of natural antioxidants as epigenetic modulators in oral squamous cell carcinoma
The potential and promise of natural antioxidants as epigenetic modulators in oral squamous cell carcinoma
Oral squamous cell carcinoma is the most common oral malignancy and poses a major health challenge because of late-stage d...
Synergistic interactions and optimal sequencing of chemotherapy and immunotherapy in cancer treatment
Synergistic interactions and optimal sequencing of chemotherapy and immunotherapy in cancer treatment
Chemotherapy and immunotherapy are now both crucial methods for combating cancers. However, the interplay between immunoth...
Neurofilament light chain as a marker for neuronal damage: integrating in vitro studies and clinical findings in patients with oxaliplatin-induced neuropathy
Neurofilament light chain as a marker for neuronal damage: integrating in vitro studies and clinical findings in patients with oxaliplatin-induced neuropathy
Oxaliplatin-induced peripheral neuropathy (OIPN) is a chronic, debilitating late effect following oxaliplatin treatment. N...
Potential role of endothelial dysfunction in hypertension and proteinuria in patients with hepatocellular carcinoma receiving atezolizumab plus bevacizumab: a pilot prospective observational study
Potential role of endothelial dysfunction in hypertension and proteinuria in patients with hepatocellular carcinoma receiving atezolizumab plus bevacizumab: a pilot prospective observational study
Bevacizumab, a monoclonal antibody targeting vascular endothelial growth factor (VEGF), is the first-line treatment for pa...
Pharmacokinetic profile of novel reduced-dose Danziten (nilotinib tablets) versus Tasigna (nilotinib capsules): in vivo bioequivalence and population pharmacokinetic analysis
Pharmacokinetic profile of novel reduced-dose Danziten (nilotinib tablets) versus Tasigna (nilotinib capsules): in vivo bioequivalence and population pharmacokinetic analysis
To evaluate single dose pharmacokinetics (PK) of novel reduced-dose film coated Danziten™ (nilotinib tablet...
Pharmacokinetics, mass balance, and metabolism of [C]FCN-437c, a selective and potent CDK4/6 inhibitor in humans
Pharmacokinetics, mass balance, and metabolism of [C]FCN-437c, a selective and potent CDK4/6 inhibitor in humans
This study investigated the pharmacokinetics, mass balance, and metabolism of [14C]FCN-437c, a selective and potent CDK4/6...
Phase 1 studies of the indenoisoquinolines LMP776 and LMP744 in patients with solid tumors and lymphomas
Phase 1 studies of the indenoisoquinolines LMP776 and LMP744 in patients with solid tumors and lymphomas
Indenoisoquinolines are a class of topoisomerase I (TOP1) inhibitors designed to overcome clinical limitations of camptoth...
Effect of Metformin on vascular endothelial injury in patients with non-small cell lung cancer treated with chemotherapy combined with bevacizumab
Effect of Metformin on vascular endothelial injury in patients with non-small cell lung cancer treated with chemotherapy combined with bevacizumab
This paper aimed to unravel the effect of metformin on vascular endothelial injury in patients with non-small cell lung ca...
From predictive biomarker to therapeutic target: the dual role of SLFN11 in chemotherapy sensitivity
From predictive biomarker to therapeutic target: the dual role of SLFN11 in chemotherapy sensitivity
SLFN11, a DNA/RNA helicase implicated in replication stress response, has recently emerged as a pivotal determinant of che...
Novel desensitization protocol utilizing conventional formulations to mitigate Temozolomide-Related skin hypersensitivity
Novel desensitization protocol utilizing conventional formulations to mitigate Temozolomide-Related skin hypersensitivity
Temozolomide (TMZ) is an oral alkylating agent used in the first-line treatment regimen for glioblastoma (GBM) and other h...
Clinical relevance of Nectin-4 downregulation and biological changes caused by cytotoxic chemotherapy in bladder cancer
Clinical relevance of Nectin-4 downregulation and biological changes caused by cytotoxic chemotherapy in bladder cancer
Mechanism underlying resistance to enfortumab vedotin (EV) and prognostication of Nectin-4 expression in muscle-invasive b...
Potential anticancer effects of sodium-glucose cotransporter protein 2 (SGLT2) inhibitors Canagliflozin and Dapagliflozin
Potential anticancer effects of sodium-glucose cotransporter protein 2 (SGLT2) inhibitors Canagliflozin and Dapagliflozin
The use of sodium-glucose cotransporter protein 2 (SGLT2) inhibitors, specifically canagliflozin and dapagliflozin, has ex...
Targeting insulin-like growth factor-1 (IGF-1) by using metformin in non-diabetic metastatic breast cancer female patients: a randomized controlled trial
Targeting insulin-like growth factor-1 (IGF-1) by using metformin in non-diabetic metastatic breast cancer female patients: a randomized controlled trial
Insulin-like growth factor-1 (IGF-1) may play a role in breast cancer (BC) development. Metformin was found to exert anti-...
Peptides derived from the POU domain of BRN2 show antitumor activity against murine melanoma model cells in vitro and in vivo
Peptides derived from the POU domain of BRN2 show antitumor activity against murine melanoma model cells in vitro and in vivo
The BRN2 transcription factor controls the protein expression involved in cell motility and is overexpressed in melanoma. ...
genetic polymorphisms as a candidate prognosis biomarker of Gastrointestinal stromal tumor
genetic polymorphisms as a candidate prognosis biomarker of Gastrointestinal stromal tumor
While imatinib is effective for treating Gastrointestinal Stromal Tumors (GISTs), significant variability in patient outco...
Trends in renal function following vascular endothelial growth factor inhibitor administration in patients with cancer and diabetes mellitus
Trends in renal function following vascular endothelial growth factor inhibitor administration in patients with cancer and diabetes mellitus
Vascular endothelial growth factor (VEGF) inhibitors are associated with a high incidence of proteinuria. In patients with...
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