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Dosing and Discontinuation of Methylphenidate Medication in Relation to Weight Status in Children and Adolescents
Dosing and Discontinuation of Methylphenidate Medication in Relation to Weight Status in Children and Adolescents
Evidence and clinical guidelines on methylphenidate dosing in different weight status groups are limited. This study aimed...
Advances in Pharmacotherapy for Congenital Hyperinsulinism
Advances in Pharmacotherapy for Congenital Hyperinsulinism
Congenital hyperinsulinism (CHI) is a rare disorder causing persistent hypoglycaemia in infants due to excessive insulin s...
Neurological Adverse Effects of Antipsychotic Medication in Children and Young People
Neurological Adverse Effects of Antipsychotic Medication in Children and Young People
Neurological adverse effects (NAEs) are commonly reported in individuals treated with antipsychotic medications. Children ...
Toward Optimal Treatment Outcomes in New-Onset Polyarticular-Course Juvenile Idiopathic Arthritis
Toward Optimal Treatment Outcomes in New-Onset Polyarticular-Course Juvenile Idiopathic Arthritis
Polyarticular-course juvenile idiopathic arthritis (polyJIA) is a chronic inflammatory arthritis involving > 4 dist...
Doxecitine and Doxribtimine: First Approval
Doxecitine and Doxribtimine: First Approval
Doxecitine and doxribtimine (KYGEVVI®) are pyrimidine nucleosides developed by UCB for the treatment of thymidine kin...
Pediatric Myocarditis: Challenges in Diagnosis and Treatment
Pediatric Myocarditis: Challenges in Diagnosis and Treatment
Pediatric myocarditis is a clinically diverse and often under-recognized inflammatory condition of the myocardium, with pr...
Impact of β-Blockers on the Risk of Low-Birth-Weight Infants in Women with Long QT Syndrome or Marfan Syndrome: A Single-Center Retrospective Study from 2008 to 2022 in a Tertiary Care Center
Impact of β-Blockers on the Risk of Low-Birth-Weight Infants in Women with Long QT Syndrome or Marfan Syndrome: A Single-Center Retrospective Study from 2008 to 2022 in a Tertiary Care Center
β-Blockers are an essential treatment for cardiovascular disease, the incidence of which is rising among women of chi...
Acute Phase Reaction After First Neridronate Infusion in Children with Osteogenesis Imperfecta: An Analysis Based on Questionnaire Data from 65 Patients
Acute Phase Reaction After First Neridronate Infusion in Children with Osteogenesis Imperfecta: An Analysis Based on Questionnaire Data from 65 Patients
Bisphosphonates represent the current standard of care for the pharmacological treatment of pediatric patients with osteog...
Guselkumab: Pediatric First Approval
Guselkumab: Pediatric First Approval
Guselkumab (TREMFYA®) is a fully human IgG1λ monoclonal antibody developed by Johnson & Johnson to selec...
Puzolcabtagene Autoleucel: Pediatric First Approval
Puzolcabtagene Autoleucel: Pediatric First Approval
Puzolcabtagene autoleucel [普利得凯®] is an autologous, humanized anti-CD19 chimeric antigen ...
Therapeutic Role of Neostigmine and Pyridostigmine in Pediatric Chronic Intestinal Pseudo-Obstruction: A Systematic Review
Therapeutic Role of Neostigmine and Pyridostigmine in Pediatric Chronic Intestinal Pseudo-Obstruction: A Systematic Review
Chronic intestinal pseudo-obstruction (CIPO) is a rare and severe disorder presenting with the clinical and radiological f...
Established and Emerging Therapies for High-Risk Neuroblastoma
Established and Emerging Therapies for High-Risk Neuroblastoma
High-risk neuroblastoma (HRNB) accounts for a disproportionately high percentage of cancer-related deaths among pediatric ...
Advances in Management of Eosinophilic Esophagitis in Pediatrics
Advances in Management of Eosinophilic Esophagitis in Pediatrics
Eosinophilic esophagitis is a chronic immune-mediated inflammatory disorder of the esophagus comprising symptoms of esopha...
Oral Lamivudine for Extended HIV Postnatal Prophylaxis
Oral Lamivudine for Extended HIV Postnatal Prophylaxis
Despite considerable progress in preventing mother-to-child transmission (PMTCT) of human immunodeficiency virus (HIV), el...
Effect of Lactoferrin in Obese Children and Adolescents with Metabolic Dysfunction-Associated Steatotic Disease: A Randomized Controlled Study
Effect of Lactoferrin in Obese Children and Adolescents with Metabolic Dysfunction-Associated Steatotic Disease: A Randomized Controlled Study
Lactoferrin is an iron-binding glycoprotein existing in mammalian milk. It has immunomodulatory, antioxidant, and anti-inf...
Fixed Dosing of Leuprolide Acetate, a GnRH Agonist, in Children with Central Precocious Puberty: A Population Pharmacokinetic Justification
Fixed Dosing of Leuprolide Acetate, a GnRH Agonist, in Children with Central Precocious Puberty: A Population Pharmacokinetic Justification
Central precocious puberty is the early onset of puberty due to premature activation of the hypothalamic-pituitary-gonadal...
Targeted Treatments for Myasthenia Gravis in Children and Adolescents
Targeted Treatments for Myasthenia Gravis in Children and Adolescents
Myasthenia gravis (MG) is an antibody-mediated disorder of the neuromuscular junction affecting children and adults. MG is...
Apremilast: First Pediatric Approval
Apremilast: First Pediatric Approval
Apremilast (Otezla®) is an inhibitor of phosphodiesterase-4 (PDE-4) being developed by Amgen. It is approved in multi...
Dexmedetomidine for Less Invasive Surfactant Administration: A Pilot Study
Dexmedetomidine for Less Invasive Surfactant Administration: A Pilot Study
Less invasive surfactant administration (LISA) involves delivering surfactant to a spontaneously breathing infant by passi...
High-Fidelity Clinical Simulation to Improve a Pediatric Clinical Trial Design: Lessons Learned and Conceptualization of the Return on Investment (ROI) and Return on Engagement (ROE) Analysis
High-Fidelity Clinical Simulation to Improve a Pediatric Clinical Trial Design: Lessons Learned and Conceptualization of the Return on Investment (ROI) and Return on Engagement (ROE) Analysis
Clinical trials entail complex processes that are more challenging when they are addressed to pediatric patients and inclu...
Population Pharmacokinetics and Dose Optimization of Piperacillin in Infants and Children with Pneumonia
Population Pharmacokinetics and Dose Optimization of Piperacillin in Infants and Children with Pneumonia
We aimed to determine the piperacillin disposition and optimize the dosing regimens for infants and children with pneumoni...
How Consistent are Anti-Infective Drug Dosing Recommendations Across Three European Paediatric Formularies?
How Consistent are Anti-Infective Drug Dosing Recommendations Across Three European Paediatric Formularies?
Drug dosing recommendations in paediatrics are mainly based on the age and bodyweight of the child. Because of the limited...
A New Perspective on Drugs for Duchenne Muscular Dystrophy: Proposals for Better Respiratory Outcomes and Improved Regulatory Pathways
A New Perspective on Drugs for Duchenne Muscular Dystrophy: Proposals for Better Respiratory Outcomes and Improved Regulatory Pathways
New drugs for Duchenne muscular dystrophy (DMD) are emerging rapidly. However, we and others believe these drugs are achie...
Optimizing Drug Selection in Children with Multiple Sclerosis: What Do We Know and What Remains Unanswered?
Optimizing Drug Selection in Children with Multiple Sclerosis: What Do We Know and What Remains Unanswered?
Pediatric-onset multiple sclerosis (POMS) refers to multiple sclerosis with onset before 18 years of age. It is characteri...
Visceral Pain in Preterm Infants with Necrotizing Enterocolitis: Underlying Mechanisms and Implications for Treatment
Visceral Pain in Preterm Infants with Necrotizing Enterocolitis: Underlying Mechanisms and Implications for Treatment
Necrotizing enterocolitis (NEC) is a relatively rare but very severe gastrointestinal disease primarily affecting very pre...
Off-Label Use of Anakinra in Inflammatory Conditions in Neonates and Infants Up to 3 Months of Age: A Case Series and a Review of the Literature
Off-Label Use of Anakinra in Inflammatory Conditions in Neonates and Infants Up to 3 Months of Age: A Case Series and a Review of the Literature
Anakinra is an interleukin-1 receptor antagonist (IL-1Ra). Since IL-1 has been shown to play a key role in the etiology of...
Prevalence and Temporal Trends of Attention Deficit Hyperactivity Disorder Medication Fills During Pregnancy and Breastfeeding in Denmark
Prevalence and Temporal Trends of Attention Deficit Hyperactivity Disorder Medication Fills During Pregnancy and Breastfeeding in Denmark
Females of reproductive age are increasingly using attention deficit hyperactivity disorder (ADHD) medication, but its use...
Bosutinib: Pediatric First Approval
Bosutinib: Pediatric First Approval
Bosutinib (BOSULIF®), an orally administered BCR–ABL tyrosine kinase inhibitor (TKI) developed by Pfizer Inc., ...
Approaches to the Prevention and Treatment of Respiratory Syncytial Virus Infection in Children: Rationale and Progress to Date
Approaches to the Prevention and Treatment of Respiratory Syncytial Virus Infection in Children: Rationale and Progress to Date
Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infection (LRTI) in children, and is...
Cantharidin Topical Solution 0.7%: First Approval
Cantharidin Topical Solution 0.7%: First Approval
Cantharidin (YCANTH™) is a proprietary drug-device combination product containing a formulation of cantharidin 0.7% ...
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