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CircRNF121 knockdown suppresses the progression of cervical cancer by regulating miR‐153‐3p/ATF2 axis and wnt/β‐catenin pathway
CircRNF121 knockdown suppresses the progression of cervical cancer by regulating miR‐153‐3p/ATF2 axis and wnt/β‐catenin pathway
Abstract Cervical cancer (CC) is a common malignancy in gynecology. Emerging evidence has demonstrated that circular RNAs ...
Road‐map of pre‐clinical treatment for Visceral Leishmaniasis
Road‐map of pre‐clinical treatment for Visceral Leishmaniasis
Abstract Visceral leishmaniasis (VL) or Kala-azar, is the most lethal form of leishmaniasis, is still prevalent in many co...
Schisandrin B ameliorates non‐alcoholic liver disease through anti‐inflammation activation in diabetic mice
Schisandrin B ameliorates non‐alcoholic liver disease through anti‐inflammation activation in diabetic mice
Abstract Type 2 diabetes mellitus (T2DM) is a metabolic risk factor associated with non-alcoholic liver disease (NAFLD). S...
Synthesis of novel hybrid pharmacophore of N‐((4‐sulfamoylphenyl)carbamothioyl)alkanamides as potent carbonic anhydrase‐II and 15‐lipoxygenase inhibitors
Synthesis of novel hybrid pharmacophore of N‐((4‐sulfamoylphenyl)carbamothioyl)alkanamides as potent carbonic anhydrase‐II and 15‐lipoxygenase inhibitors
Abstract A series of N-((4-sulfamoylphenyl)carbamothioyl)alkanamides (5a-j) were synthesized by the reaction of sulphanila...
CircMYBL2 regulates the resistance of cervical cancer cells to paclitaxel via miR‐665‐dependent regulation of EGFR
CircMYBL2 regulates the resistance of cervical cancer cells to paclitaxel via miR‐665‐dependent regulation of EGFR
Abstract Circular RNAs are considered to be associated with cancer resistance. This study aims to investigate the function...
CircFAT1 facilitates cervical cancer malignant progression by regulating ERK1/2 and p38 MAPK pathway through miR‐409‐3p/CDK8 axis
CircFAT1 facilitates cervical cancer malignant progression by regulating ERK1/2 and p38 MAPK pathway through miR‐409‐3p/CDK8 axis
Abstract Circular RNA FAT atypical cadherin 1 (circFAT1) has been reported to play vital roles in the progression of some ...
Investigating function of long noncoding RNA of HOTAIRM1 in progression of SKOV3 ovarian cancer cells
Investigating function of long noncoding RNA of HOTAIRM1 in progression of SKOV3 ovarian cancer cells
Abstract Ovarian cancer is one of the most heterogeneous malignancies in the field of gynecologic oncology. Deregulation o...
Potential antiviral activity of isorhamnetin against SARS‐CoV‐2 spike pseudotyped virus in vitro
Potential antiviral activity of isorhamnetin against SARS‐CoV‐2 spike pseudotyped virus in vitro
Abstract Coronavirus Disease 2019 (COVID-19) cases and deaths are still rising worldwide, there is currently no effective ...
CircMYLK promotes the growth, migration, invasion, and survival of bladder cancer cells by upregulating CCND3 level via competitively binding to miR‐34a
CircMYLK promotes the growth, migration, invasion, and survival of bladder cancer cells by upregulating CCND3 level via competitively binding to miR‐34a
Abstract Bladder cancer is one of the most common types of urothelial carcinoma with a rising incidence rate worldwide. Ci...
CQMUH‐011 mitigates autoimmune hepatitis via inhibiting the function of T lymphocytes
CQMUH‐011 mitigates autoimmune hepatitis via inhibiting the function of T lymphocytes
Abstract CQMUH-011 is a modified adamantane sulfonamide compound, that inhibits macrophage proliferation and possesses ant...
Identification of kinases and kinase inhibitors for the differential targeting of Wnt/β‐catenin signaling in gastric cancer subtypes
Identification of kinases and kinase inhibitors for the differential targeting of Wnt/β‐catenin signaling in gastric cancer subtypes
Abstract The oncogenic signaling pathway Wnt is often activated in many cancers including gastric cancer. Wnt signaling pa...
Repurposing of FDA‐approved drugs as inhibitors of sterol C‐24 methyltransferase of Leishmania donovani to fight against leishmaniasis
Repurposing of FDA‐approved drugs as inhibitors of sterol C‐24 methyltransferase of Leishmania donovani to fight against leishmaniasis
Abstract Leishmaniasis is a vector-borne disease caused by around 20 species of Leishmania. The main clinical forms of lei...
New isolate from Salvinia molesta with antioxidant and urease inhibitory activity
New isolate from Salvinia molesta with antioxidant and urease inhibitory activity
Abstract Urease plays a significant role in the pathogenesis of urolithiasis pyelonephritis, urinary catheter encrustation...
Changes in the proportions of an active pharmaceutical through cocrystals
Changes in the proportions of an active pharmaceutical through cocrystals
Abstract In this study, the modulation of amounts sulfathiazolium cations in different 2,6-pyridinedicarboxylates is demon...
Proteolytic degradation patterns of the receptor for advanced glycation end products peptide fragments correlate with their neuroprotective activity in Alzheimer's disease models
Proteolytic degradation patterns of the receptor for advanced glycation end products peptide fragments correlate with their neuroprotective activity in Alzheimer's disease models
Abstract The receptor for advanced glycation end products (RAGE) plays an essential role in Alzheimer's disease (AD). We p...
Silver(I)‐N‐heterocyclic carbene complexes challenge cancer; evaluation of their anticancer properties and in silico studies
Silver(I)‐N‐heterocyclic carbene complexes challenge cancer; evaluation of their anticancer properties and in silico studies
Abstract Because of the continuous need for efficient therapeutic agents against various kinds of cancers and infectious d...
Design, synthesis, and biological evaluation of 3′,4′,5′‐trimethoxy evodiamine derivatives as potential antitumor agents
Design, synthesis, and biological evaluation of 3′,4′,5′‐trimethoxy evodiamine derivatives as potential antitumor agents
Abstract A series of compounds bearing 3′,4′,5′-trimethoxy module into the core structure of evodiami...
Neobavaisoflavone protects osteoblasts from dexamethasone‐induced oxidative stress by upregulating the CRNDE‐mediated Nrf2/HO‐1 signaling pathway
Neobavaisoflavone protects osteoblasts from dexamethasone‐induced oxidative stress by upregulating the CRNDE‐mediated Nrf2/HO‐1 signaling pathway
Abstract Neobavaisoflavone (NBIF) is a flavonoid, which has a variety of pharmacological activities. However, the mechanis...
Challenges of peptide and protein drug delivery by oral route: Current strategies to improve the bioavailability
Challenges of peptide and protein drug delivery by oral route: Current strategies to improve the bioavailability
Abstract Advancement in biotechnology provided a notable expansion of peptide and protein therapeutics, used as antigens, ...
Beyond its anti‐migraine properties, sumatriptan is an anti‐inflammatory agent: A systematic review
Beyond its anti‐migraine properties, sumatriptan is an anti‐inflammatory agent: A systematic review
Abstract Sumatriptan is the first available medication from triptans family that was approved by the U.S. Food and Drug Ad...
Synthesis of benzimidazole based hydrazones as non‐sugar based α‐glucosidase inhibitors: Structure activity relation and molecular docking
Synthesis of benzimidazole based hydrazones as non‐sugar based α‐glucosidase inhibitors: Structure activity relation and molecular docking
Abstract In search for α-glucosidase inhibitors used in the treatment of diabetes mellitus, a series of unique benzi...
Synthesis and characterization of new pyrazole–tetrazole derivatives as new vasorelaxant agents
Synthesis and characterization of new pyrazole–tetrazole derivatives as new vasorelaxant agents
Abstract The synthesis of new functionalized tetrazole–pyrazole compounds is reported. They were fully characterize...
Discovery of novel indole‐1,2,4‐triazole derivatives as tubulin polymerization inhibitors
Discovery of novel indole‐1,2,4‐triazole derivatives as tubulin polymerization inhibitors
Abstract A series of novel indole-1,2,4-triazole derivatives have been designed, synthesized, and evaluated as potential t...
Platycodin D inhibits the malignant progression of papillary thyroid carcinoma by NF‐κB and enhances the therapeutic efficacy of pembrolizumab
Platycodin D inhibits the malignant progression of papillary thyroid carcinoma by NF‐κB and enhances the therapeutic efficacy of pembrolizumab
Abstract Papillary thyroid carcinoma (PTC) is the most common pathological type of thyroid cancer. Studies have shown that...
Sinapic acid inhibits pancreatic cancer proliferation, migration, and invasion via downregulation of the AKT/Gsk‐3β signal pathway
Sinapic acid inhibits pancreatic cancer proliferation, migration, and invasion via downregulation of the AKT/Gsk‐3β signal pathway
Abstract Among digestive system cancers, the extremely poor prognosis of pancreatic cancer (PC) is a pressing concern. Non...
Novel strategies to oral delivery of insulin: Current progress of nanocarriers for diabetes management
Novel strategies to oral delivery of insulin: Current progress of nanocarriers for diabetes management
Abstract Diabetes mellitus is one of the most serious public health problems in the world. Repeated daily injections of su...
Terbutaline attenuates LPS‐induced injury of pulmonary microvascular endothelial cells by cAMP/Epac signaling
Terbutaline attenuates LPS‐induced injury of pulmonary microvascular endothelial cells by cAMP/Epac signaling
Abstract Acute lung injury (ALI), characterized by an acute onset of severe hypoxemia, is a common and devastating syndrom...
Sodium tanshinone IIA sulfonate promotes spinal cord injury repair by inhibiting blood spinal cord barrier disruption in vitro and in vivo
Sodium tanshinone IIA sulfonate promotes spinal cord injury repair by inhibiting blood spinal cord barrier disruption in vitro and in vivo
Abstract Spinal cord injury (SCI) leads to microvascular damage and the destruction of the blood spinal cord barrier (BSCB...
Antiproliferative, antimigratory, and prooxidative potential of novel platinum(IV) complexes and resveratrol on breast cancer (MDA‐MB‐231) and choriocarcinoma (JEG‐3) cell lines
Antiproliferative, antimigratory, and prooxidative potential of novel platinum(IV) complexes and resveratrol on breast cancer (MDA‐MB‐231) and choriocarcinoma (JEG‐3) cell lines
Abstract Platinum(IV) complexes offer the potential to overcome cisplatin resistance of cancer cells, with possible improv...
Oleanolic acid reduces oxidative stress and neuronal apoptosis after experimental subarachnoid hemorrhage by regulating Nrf2/HO‐1 pathway
Oleanolic acid reduces oxidative stress and neuronal apoptosis after experimental subarachnoid hemorrhage by regulating Nrf2/HO‐1 pathway
Abstract Oxidative stress is an early major pathological feature after subarachnoid hemorrhage (SAH) and involves in the d...
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