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Investigating Potential Prescribing Cascades Resulting in Prochlorperazine Prescription: An Exploratory Analysis of Antihypertensives and NSAIDs
Investigating Potential Prescribing Cascades Resulting in Prochlorperazine Prescription: An Exploratory Analysis of Antihypertensives and NSAIDs
A prescribing cascade occurs when medication is used to treat or prevent an adverse drug reaction (ADR) to another medicat...
Managing Acute Severe Ulcerative Colitis in the Older Patient: A Growing Concern
Managing Acute Severe Ulcerative Colitis in the Older Patient: A Growing Concern
Since the prevalence of older patients with ulcerative colitis is increasing, hospitalizations for severe disease in this ...
Prescribing Cascades: An Umbrella Review and Updated Systematic Review
Prescribing Cascades: An Umbrella Review and Updated Systematic Review
Prescribing cascades (PCs) often remain underrecognized, contributing to inappropriate prescribing and increased healthcar...
Propofol Use and Delirium in Patients Aged 80 Years and Over: A Retrospective Cohort Study of 9850 ICU Admissions
Propofol Use and Delirium in Patients Aged 80 Years and Over: A Retrospective Cohort Study of 9850 ICU Admissions
There is inconsistent evidence regarding the relationship between propofol and delirium, and this evidence is predominantl...
Hospitalisation as an Opportunity to Optimise Quality Use of Medicines in Older Adults: A Systematic Review
Hospitalisation as an Opportunity to Optimise Quality Use of Medicines in Older Adults: A Systematic Review
Hospitalisation represents an opportunity to optimise medication therapy in patients at high risk of medication-related ha...
Cardiovascular-Related Polypharmacy and Its Association with Liver and Kidney Function: A Cross-Sectional Study Using Primary Care Data
Cardiovascular-Related Polypharmacy and Its Association with Liver and Kidney Function: A Cross-Sectional Study Using Primary Care Data
Individuals at high risk of cardiovascular disease (CVD) often require multiple concurrent medications, resulting in polyp...
Longitudinal Non-interventional Changes of the FORTA Score are Associated with Changes of Cognitive and Physical Function Tests in Community-Dwelling Older People
Longitudinal Non-interventional Changes of the FORTA Score are Associated with Changes of Cognitive and Physical Function Tests in Community-Dwelling Older People
Listing tools were found to ameliorate drug treatment in older people; the FORTA (Fit-fOR-The-Aged) list is a clinically v...
Efficacy and Safety of Mirabegron in Frail Older Adults with Overactive Bladder
Efficacy and Safety of Mirabegron in Frail Older Adults with Overactive Bladder
Overactive bladder (OAB) is a commonly occurring condition in older adults that has significant consequences on health and...
Guideline-Directed Heart Failure Pharmacotherapy in Adults Aged ≥75 Years: Evidence Gaps, Tolerability, and Implications for Clinical Practice
Guideline-Directed Heart Failure Pharmacotherapy in Adults Aged ≥75 Years: Evidence Gaps, Tolerability, and Implications for Clinical Practice
Heart failure predominantly affects older adults, yet the evidence supporting guideline-directed medical therapy is largel...
Exploring the Link Between Pharmacological Management of Orthostatic Hypotension and Cognitive Performance: A Scoping Review
Exploring the Link Between Pharmacological Management of Orthostatic Hypotension and Cognitive Performance: A Scoping Review
Orthostatic hypotension is recognized as a potential contributor to cognitive impairment in older adults. It is still unkn...
Trends in Multi-dose Drug Dispensing Amongst Older Adults in Sweden: A Nationwide Repeated Cross-Sectional Register Study, 2014–2023
Trends in Multi-dose Drug Dispensing Amongst Older Adults in Sweden: A Nationwide Repeated Cross-Sectional Register Study, 2014–2023
Multi-dose dispensing (MDD) is a medication management system in Sweden that pre-packages regularly used prescription medi...
External Validation of a Community Pharmacy-Based Screening Tool for Frailty That Uses Routinely Collected Data
External Validation of a Community Pharmacy-Based Screening Tool for Frailty That Uses Routinely Collected Data
Frailty increases the risk of medication-related harm in older adults, emphasising the importance of early detection of dr...
Adapting the Geriatric Medicine 5Ms Framework to Geriatric Dermatology
Adapting the Geriatric Medicine 5Ms Framework to Geriatric Dermatology
Older adults represent a growing proportion of dermatology patients, yet their care is complicated by multimorbidity, cogn...
Development and Validation of Prescribing Appropriateness Criteria (PAC) for Sri Lankan Older Adults
Development and Validation of Prescribing Appropriateness Criteria (PAC) for Sri Lankan Older Adults
Inappropriate prescribing in Sri Lankan older adults, contributes to adverse drug events, hospital admissions and increase...
Gabapentinoid Use and Risk of Alzheimer’s Disease-Related Dementias: A Systematic Review and Meta-analysis of Observational Studies
Gabapentinoid Use and Risk of Alzheimer’s Disease-Related Dementias: A Systematic Review and Meta-analysis of Observational Studies
Gabapentinoids, particularly gabapentin and pregabalin, are widely prescribed for neuropathic pain and other chronic condi...
Drug Utilisation of Fall-Risk-Increasing Drugs (FRIDs) and Risk of Hospitalisation: A Nested Case–Control Study Among Community-Dwelling Older Adults
Drug Utilisation of Fall-Risk-Increasing Drugs (FRIDs) and Risk of Hospitalisation: A Nested Case–Control Study Among Community-Dwelling Older Adults
Falls are a leading cause of hospitalisation among older adults, with substantial impacts on quality of life and healthcar...
Leveraging Real-World Data for Clinical Decision Making in Geriatric Oncology
Leveraging Real-World Data for Clinical Decision Making in Geriatric Oncology
Older adults represent most patients with cancer worldwide, yet they remain substantially underrepresented in randomized c...
Hypoglycaemia in Older Adults with Diabetes: Pathophysiology, Prevention, and Personalized Care in an Aging Population
Hypoglycaemia in Older Adults with Diabetes: Pathophysiology, Prevention, and Personalized Care in an Aging Population
Managing diabetes in older adults requires balancing long-term glycaemic control with the prevention of hypoglycaemia, to ...
Reduced-Dose Edoxaban in Patients Aged ≥ 80 Years: A Single-Center Real-World Analysis
Reduced-Dose Edoxaban in Patients Aged ≥ 80 Years: A Single-Center Real-World Analysis
Optimal anticoagulation strategies in octogenarians remain controversial owing to age-related risks of thromboembolism and...
Characteristics of Late-Onset Systemic Lupus Erythematosus: Clinical Manifestations and Diagnostic and Treatment Challenges
Characteristics of Late-Onset Systemic Lupus Erythematosus: Clinical Manifestations and Diagnostic and Treatment Challenges
Systemic lupus erythematosus (SLE) is widely recognized as a systemic autoimmune disease predominantly affecting young wom...
Anesthesia Considerations in Older Adults Undergoing Emergency Mechanical Thrombectomy for Acute Ischaemic Stroke
Anesthesia Considerations in Older Adults Undergoing Emergency Mechanical Thrombectomy for Acute Ischaemic Stroke
Acute ischemic stroke (AIS) is a significant cause of morbidity and mortality among older adults, with its incidence, seve...
Association of Antipsychotic Dose with Surrogate Efficacy and Safety Outcomes in Hospitalized Older Adults: A Retrospective Cohort Study
Association of Antipsychotic Dose with Surrogate Efficacy and Safety Outcomes in Hospitalized Older Adults: A Retrospective Cohort Study
Antipsychotics are frequently used in hospitalized older adults to manage agitation and delirium, despite limited supporti...
Sarcopenia and Cachexia in Older Patients with Cancer: Pathophysiology, Diagnosis, Impact on Outcomes, and Management Strategies
Sarcopenia and Cachexia in Older Patients with Cancer: Pathophysiology, Diagnosis, Impact on Outcomes, and Management Strategies
Sarcopenia and cachexia are two common and overlapping but distinct muscle wasting syndromes that predict adverse outcomes...
Frailty-Informed Pain Management: A Clinical Imperative Beyond Chronological Age
Frailty-Informed Pain Management: A Clinical Imperative Beyond Chronological Age
Chronic pain is a prevalent and disabling condition whose management becomes increasingly complex with aging and frailty. ...
Anti-hypertensive Drug Classes and Risk of New-Onset Atrial Fibrillation in Healthy Older Adults: A Post Hoc Analysis of ASPREE Trial
Anti-hypertensive Drug Classes and Risk of New-Onset Atrial Fibrillation in Healthy Older Adults: A Post Hoc Analysis of ASPREE Trial
Prior studies have suggested potential benefits of antihypertensive medication (AHM) in preventing atrial fibrillation. It...
Patterns and Characteristics of Gabapentin Use Among Medicare Beneficiaries
Patterns and Characteristics of Gabapentin Use Among Medicare Beneficiaries
Gabapentin is increasingly prescribed to older adults, yet prescribing patterns and characteristics of gabapentin initiato...
Effectiveness of Patient-Directed Education to Sustain Deprescribing: A Pragmatic Trial
Effectiveness of Patient-Directed Education to Sustain Deprescribing: A Pragmatic Trial
More than one in three older adults use potentially inappropriate medications (PIMs), and those with chronic conditions ar...
Trends and Guideline Adherence in Gabapentinoid Use among Geriatric Outpatients: A Retrospective Cross-Sectional Study at a Falls Clinic
Trends and Guideline Adherence in Gabapentinoid Use among Geriatric Outpatients: A Retrospective Cross-Sectional Study at a Falls Clinic
With pain treatment shifting away from opioids, alternative analgesics—such as gabapentinoids—are increasingly...
Inclusion of Older Adults in Early-Phase Cancer Clinical Trials: Safety, Efficacy and a Way Forward
Inclusion of Older Adults in Early-Phase Cancer Clinical Trials: Safety, Efficacy and a Way Forward
Early-phase clinical trials (EPCTs) are critical for evaluating the safety, tolerability, efficacy and pharmacokinetics of...
Initial Real-World Evidence for Lecanemab in the United States
Initial Real-World Evidence for Lecanemab in the United States
Lecanemab is the first anti-amyloid monoclonal antibody with full approval in the US for the treatment of early Alzheimer&...
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