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Mechanistic analysis on epigenetic programming of tumor drug resistance
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Therapy-induced microenvironmental senescence in tumor treatment resistance: From mechanism to therapy
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Resensitizing drug-resistant cancers by co-targeting apoptosis and mitochondrial stress pathway
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Effectiveness of Sulbactam/Durlobactam in carbapenem-resistant Acinetobacter baumannii pulmonary infection complicated with carbapenem-resistant Enterobacterales and/or carbapenem-resistant Pseudomonas aeruginosa infection: A prospective, multicenter, cohort study
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Adaptive lineage plasticity drives multidrug resistance to KRAS-EGFR targeted therapy
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Corrigendum to “RNF26 regulating tumor immunogenicity of hepatocellular carcinoma by degrading GRP78 and instigating ER stress” [Drug Resist. Updat. 86 (2026) 101375]
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
ZDHHC16-induced GPX2 S-palmitoylation promotes lenvatinib resistance and inhibits lenvatinib-induced immunogenic cell death in hepatocellular carcinoma
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A multifunctional antimicrobial peptide with cell-penetrating and β-lactam-potentiating activities for combating methicillin-resistant Staphylococcus aureus and carbapenem-resistant Enterobacteriaceae infections
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
MZF1-mediated GAPDH overexpression drives glycolytic reprogramming and neuroendocrine progression in advanced prostate cancer
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Targeting a novel metabolic vulnerability of non-small cell lung cancer to fatty acid oxidation surmounts chemoresistance
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ITPKB suppresses ER calcium release to promote CXCL9 expression and enhance immunotherapy sensitivity in triple-negative breast cancer
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
ZBED6-driven nucleotide metabolic reprogramming improves sensitivity to anti-PD1 therapy in NK/T cell lymphoma
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
OGT-mediated O-GlcNAcylation of BICD2 drives gemcitabine resistance in pancreatic cancer via accelerating G2/M cell cycle progression
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Tumor-intrinsic PHGDH inhibition sensitizes colorectal cancer to PD-1 blockade via α-ketoglutarate–mediated macrophage reprogramming
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Piperidine-derived resensitizers revive aminoglycoside capacity against persister cells of Pseudomonas aeruginosa in vivo
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Resistance to CAR-based cell therapy: Mechanisms and overcoming strategies
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Immunotherapy in cancer: Mechanisms and strategies to overcome resistance
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Biomimetic delivery systems for overcoming drug resistance in gastrointestinal cancers
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Consensus on standardized later-line systemic therapy for hepatocellular carcinoma
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Extracellular matrix stiffness and mechanotransduction in cancer drug resistance
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Metabolic basis of fatty acid oxidation and immunotherapy resistance with clinical perspectives
Volume 84, January 2026, 101317Author links open overlay panel, Section snippetsCRediT authorship contribution statementJu...
Three decades of ESKAPEE antimicrobial resistance: Emerging burdens in working-age individuals and high-income regions
Volume 84, January 2026, 101325Author links open overlay panel, , Section snippetsCRediT authorship contribution statement...
Molecular profiling of chemotherapy-resistant breast cancer reveals DNA methylation remodeling associated with the acquisition of paclitaxel resistance
Available online 2 January 2026, 101350Author links open overlay panel, , , , , , , , , , , , , , , , , , , …Highlights•Ch...
IFNα2b modulates anti-tumor immune responses involving STAT3-associated dendritic cell dysfunction in JAK2v617f-positive myeloproliferative neoplasms
Myeloproliferative neoplasms (MPNs) are clonal hematologic malignancies characterized by excessive proliferation of mature...
Glucocorticoid receptor activated by dexamethasone promotes the chemoresistance and stemness of lung cancer
Siyuan Chen: Writing – review & editing, Formal analysis. Huaicheng Tan: Methodology, Formal analysis, Data curation. ...
Lars2-signaling mediates platinum resistance by accumulating cancer stem cell population and suppressing anti-tumor immunity
Platinum-based chemotherapy remains a cornerstone of cancer treatment; however, its clinical efficacy is frequently compro...
Hyperbaric oxygen targets RCN1 to modulate ER-mitochondria crosstalk and ameliorate sorafenib resistance in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is counted among the top four causes of cancer-associated deaths globally and exhibits a gr...
Entinostat overcomes cisplatin resistance in bladder cancer by promoting H3K18la-mediated DHRS2 expression and nuclear translocation to suppress the AKR1C3-androgen axis
Bladder cancer (BCa) remains a significant cause of cancer-related morbidity and mortality globally (Bray et al., 2024). F...
RCN2 facilitates esophageal squamous cellular carcinoma metastasis and cisplatin resistance through UBR5-mediated PPP2CA ubiquitination and degradation
Esophageal cancer (EC) is the seventh leading cause of cancer-related mortality around the world, with more than 470,000 n...
UBL3 governs VEGFR inhibitor resistance by activating NOTCH signaling in renal cell carcinoma
Volume 85, March 2026, 101332Author links open overlay panel, , , , , , , , , , , , , , , AbstractBackgroundTargeted thera...
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