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Characterization of metabolic activity, isozyme contribution and species differences of bavachin, and identification of efflux transporters for bavachin‐O‐glucuronide in HeLa1A1 cells
Characterization of metabolic activity, isozyme contribution and species differences of bavachin, and identification of efflux transporters for bavachin‐O‐glucuronide in HeLa1A1 cells
Abstract Objectives Bavachin is a bioactive natural flavonoid with oestrogen-like activity. Here, we aimed to investigate ...
The hepatoprotective effect and mechanism of lotus leaf on liver injury induced by Genkwa Flos
The hepatoprotective effect and mechanism of lotus leaf on liver injury induced by Genkwa Flos
Abstract Objectives As a traditional Chinese medicine, lotus leaf was reported to have significant hepatoprotective effect...
Preclinical studies indicate that INFLATIV, an herbal medicine cream containing Pereskia aculeata, presents potential to be marketed as a topical anti‐inflammatory agent and as adjuvant in psoriasis therapy
Preclinical studies indicate that INFLATIV, an herbal medicine cream containing Pereskia aculeata, presents potential to be marketed as a topical anti‐inflammatory agent and as adjuvant in psoriasis therapy
Abstract Objectives A previous study reported that the hexane fraction (HF) obtained from Pereskia aculeata leaves showed ...
Population pharmacokinetics of micafungin over repeated doses in critically ill patients: a need for a loading dose?
Population pharmacokinetics of micafungin over repeated doses in critically ill patients: a need for a loading dose?
Abstract Objectives To study the population pharmacokinetics of micafungin in critically ill patients, evaluate and optimi...
Catechol protects against iron‐mediated oxidative brain injury by restoring antioxidative metabolic pathways; and modulation of purinergic and cholinergic enzymes activities
Catechol protects against iron‐mediated oxidative brain injury by restoring antioxidative metabolic pathways; and modulation of purinergic and cholinergic enzymes activities
Abstract Objectives This study was aimed at investigating neuroprotective effect of catechol on redox imbalance, cholinerg...
Geniposide in Gardenia jasminoides var. radicans Makino modulates blood pressure via inhibiting WNK pathway mediated by the estrogen receptors
Geniposide in Gardenia jasminoides var. radicans Makino modulates blood pressure via inhibiting WNK pathway mediated by the estrogen receptors
Abstract Objectives To investigate the effects of geniposide in an iridoid found in Gardenia jasminoides var. radicans Mak...
Losartan and azelastine either alone or in combination as modulators for endothelial dysfunction and platelets activation in diabetic hyperlipidemic rats
Losartan and azelastine either alone or in combination as modulators for endothelial dysfunction and platelets activation in diabetic hyperlipidemic rats
Abstract Aim The present study aimed mainly to demonstrate the effect of the antihistamine azelastine (AZ) and Angiotensin...
Shikonin ameliorates experimental autoimmune encephalomyelitis (EAE) via immunomodulatory, anti‐apoptotic and antioxidative activity
Shikonin ameliorates experimental autoimmune encephalomyelitis (EAE) via immunomodulatory, anti‐apoptotic and antioxidative activity
Abstract Objectives Multiple sclerosis is a common autoimmune inflammatory disease of the central nervous system. There ar...
Umbelliprenin relieves paclitaxel‐induced neuropathy
Umbelliprenin relieves paclitaxel‐induced neuropathy
Abstract Objectives Umbelliprenin (UMB) is a prenylated coumarin that acts as an in vitro antioxidant and inhibits lipoxyg...
Glucuronidation and its effect on the bioactivity of amentoflavone, a biflavonoid from Ginkgo biloba leaves
Glucuronidation and its effect on the bioactivity of amentoflavone, a biflavonoid from Ginkgo biloba leaves
Abstract Objectives Ginkgo biloba leaves contain amentoflavone (AMF), a dietary flavonoid that possesses antioxidant and a...
Therapeutic effects of açaí seed extract on hepatic steatosis in high‐fat diet‐induced obesity in male mice: a comparative effect with rosuvastatin
Therapeutic effects of açaí seed extract on hepatic steatosis in high‐fat diet‐induced obesity in male mice: a comparative effect with rosuvastatin
Abstract Objectives Obesity is considered a risk factor for the development of non-alcoholic fatty liver disease (NAFLD). ...
Berberine, a natural alkaloid sensitizes human hepatocarcinoma to ionizing radiation by blocking autophagy and cell cycle arrest resulting in senescence
Berberine, a natural alkaloid sensitizes human hepatocarcinoma to ionizing radiation by blocking autophagy and cell cycle arrest resulting in senescence
Abstract Objective To study the radiosensitizing potential of Berberine and the underlying mechanism in human hepatocarcin...
Pinoresinol‐4‐O‐β‐D‐glucopyranoside: a lignan from prunes (Prunus domestica) attenuates oxidative stress, hyperglycaemia and hepatic toxicity in vitro and in vivo
Pinoresinol‐4‐O‐β‐D‐glucopyranoside: a lignan from prunes (Prunus domestica) attenuates oxidative stress, hyperglycaemia and hepatic toxicity in vitro and in vivo
Abstract Objectives This study aimed to explore the pharmacological properties of pinoresinol-4-O-β-D-glucopyranosid...
Carissa carandas L. – phyto‐pharmacological review
Carissa carandas L. – phyto‐pharmacological review
Abstract Objectives Carissa carandas is an evergreen thorny shrub (Apocynaceae family), commonly, known as karonda. It has...
Recent trends in targeting miRNAs for cancer therapy
Recent trends in targeting miRNAs for cancer therapy
Abstract Objectives MicroRNAs (miRNAs) are a type of small noncoding RNA employed by the cells for gene regulation. A sing...
Recombinant ling zhi‐8 enhances Tregs function to restore glycemic control in streptozocin‐induced diabetic rats
Recombinant ling zhi‐8 enhances Tregs function to restore glycemic control in streptozocin‐induced diabetic rats
Abstract Objectives To explore the effect of recombinant LZ-8 (rLZ-8) on streptozocin (STZ)-induced diabetic rats and furt...
Investigation on the metabolic characteristics of isobavachin in Psoralea corylifolia L. (Bu‐gu‐zhi) and its potential inhibition against human cytochrome P450s and UDP‐glucuronosyltransferases
Investigation on the metabolic characteristics of isobavachin in Psoralea corylifolia L. (Bu‐gu‐zhi) and its potential inhibition against human cytochrome P450s and UDP‐glucuronosyltransferases
Abstract Objectives Isobavachin is a phenolic with anti-osteoporosis activity. This study aimed to explore its metabolic f...
A comparative study on pharmacokinetics and tissue distribution of 5‐hydroxy‐4‐methoxycanthin‐6‐one and its metabolite in normal and dextran sodium sulfate‐induced colitis rats by HPLC‐MS/MS
A comparative study on pharmacokinetics and tissue distribution of 5‐hydroxy‐4‐methoxycanthin‐6‐one and its metabolite in normal and dextran sodium sulfate‐induced colitis rats by HPLC‐MS/MS
Abstract Objectives This study aimed to investigate the existing form of 5-hydroxy-4-methoxycanthin-6-one (PQ-A) in vivo a...
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