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Drug-likeness defects drive carrier-free cyanine–PROTAC self-assembly for tumor-specific protein degradation
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Optimizing the composition and size of perfluorocarbon nanodroplets to balance their acoustic activation and blood circulation time
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Bivalent gambogic acid-functionalized curcumin nanoparticles with insulin modulate the gut-liver-kidney network in type 2 diabetes
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A pH-responsive metal–lignin nanozyme microneedle system for stage-adapted therapy of infected skin wounds
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MβCD@HA-Ad nanoparticles inhibit pancreatic cancer progression by targeting Caveolin-1/Piezo1/PLA2G4A-mediated lipid reprogramming
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Peptide-dendrimer conjugates target and destruct neutrophil extracellular traps to block tumor metastasis
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NanoReady: A ready-made DC-selective delivery platform for personalized mRNA cancer vaccines with strong NHP immunogenicity
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A stimuli-responsive hydrogel that targets myeloid differentiation primary response 88 signaling in the foreign body response
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Oxidized carbon nanohorns-reinforced dual-responsive hydrogel for internal-external synergistic diabetic wound repair
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Off-the-shelf microbrachytherapy using on-site fast radiolabeling for keloid treatment
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Biophysical considerations for designing viruses, lipid nanoparticles and virus-like particles for CRISPR-based genome editing
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The design of activatable photosensitizers and applications in precision immunomodulation
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Next-generation colon-targeted oral delivery for immune modulation in inflammatory bowel diseases
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Injectable and sprayable supramolecular prodrug hydrogel for long-acting chemo-hormonal therapy of prostate cancer
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Glutathione-responsive self-assembling peptide-coated Salmonella for antitumor therapy
Cancer imposes an ever-growing global health challenge, with over 19 million new diagnoses in 2020 and projections exceedi...
Loading of therapeutic cell penetrating peptides into extracellular vesicles for pulmonary fibrosis
Volume 390, 10 February 2026, 114561Author links open overlay panel, , , , , , AbstractExtracellular vesicles (EVs) are he...
Hepatocyte-specific partial cellular reprogramming via selective OSK mRNA lipid nanoparticle attenuates liver fibrosis
The ability to transiently modulate cell identity in vivo using non-integrating mRNA technology presents a transformative ...
Octopus-inspired polymeric nanovaccine enables high antigen loading and robust T cell activation for cancer immunotherapy
Therapeutic vaccines represent a promising strategy for cancer immunotherapy and have garnered considerable attention [[1]...
Engineered nanoparticles for subconjunctival delivery to the retinal pigment epithelium: A multi-target therapy for dry AMD
Dry age-related macular degeneration (dAMD) is a leading cause of irreversible blindness, driven by oxidative stress-induc...
Nanochirality-programmed type-I photosensitizer enables deep-tumor photodynamic therapy by reducing extracellular-matrix adhesion
Tumor hypoxia and poor penetration of therapeutics across tumor-microenvironment barriers remain major obstacles to effect...
Localized inflammasome inhibition mitigates foreign body response to subcutaneous long-acting antiretroviral therapy for HIV
Long-acting antiretroviral therapy (LA-ART) holds promise for improving adherence and viral suppression in human immunodef...