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Exosomal heterogeneity and functional zonation in cancer drug resistance
The emergence of drug resistance remains one of the most formidable challenges in the effective treatment of solid tumors....
Piezo1 as a therapeutic target in kidney disease: emerging mechanistic insights and translational potential
Prof. Anil Bhanudas Gaikwad is Professor at the Department of Pharmacy, Birla Institute of Technology and Science Pilani (...
Plasmodium falciparum falcilysin as an emerging potential drug target for antimalarial drug discovery
Malaria remains a significant global health challenge, with rising drug resistance highlighting the urgent need for new th...
Advances and challenges in Toll-like receptor-targeted therapy for rheumatoid arthritis
Figure 1 TLR-targeted genetic polymorphisms, mechanism and drug application in three RA pathological manifestations. SNPs ...
Integrating herbgenomics with systems biology approaches for sustainable utilization of medicinal plant resources
Herbal medicines, originating from plants or fungi, have been utilized for over 5000 years and remain a vital and indispen...
Decoding protein kinases in autophagy with small-molecule modulators for cancer therapy
Autophagy is an intracellular degradation and recycling mechanism that preserves cellular homeostasis by breaking down dam...
Circadian disruption in hepatocellular carcinoma: Current findings and future directions of molecular mechanisms
Hepatocellular carcinoma (HCC) is a lethal malignancy with approximately 860 000 new cases and 750 000 deaths annually wor...
PolyBodies for the Treatment of Respiratory Syncytial Virus Infection
Respiratory viruses continue to be a major cause of mortality and pose a significant risk to human health worldwide, espec...
Biotechnology-based therapies for mitigation of pulmonary fibrosis: an update
Pulmonary fibrosis (PF) is a chronic interstitial lung disease that causes inflammation and scarring around the alveoli of...
The role of seaweed-derived natural components in obesity: A systematic review
Advancements in technology have significantly altered people’s lifestyles, leading to extended periods of sitting and redu...
Gallium-based antimicrobials: mechanisms of action, resistance outlook, and translational potential for next-generation anti-infective therapies
Antimicrobial resistance has escalated into one of the gravest public-health crises of the 21st century.(p1) Multidrug-res...
Evaluating the potential of mRNA technology for cytokine production and delivery in antitumor therapy
Cytokines are the master communicators of the immune system, acting as potent signaling proteins that direct cellular traf...
Corrigendum to “Reimagining medical affairs through strategic leadership in patient partnering healthcare” [Drug Discov. Today 31(1) (2026) 104558]
Volume 31, Issue 1, January 2026, 104594Author links open overlay panelSébastien Reig 1, Christel Becker 2Show morePreviou...
Spatiotemporal control of prodrug activation through external stimuli for effective and safe on-site release in solid tumors: From current advances to future perspectives
Achieving precise control over anticancer drug activity remains a key challenge in prodrug design. Stimuli-responsive syst...
Trait-based ViTAP assessment of pandemic potential for US avian influenza A (H5N1) clade 2.3.4.4b
Influenza pandemics rank among the most devastating infectious disease events in human history, with the ‘Spanish flu’ of ...
Insights into the cell type-specific susceptibility of kidney cells to ferroptosis
Ferroptosis is a regulated form of cell death driven by iron-dependent lipid peroxidation. Emerging evidence implicates fe...
Gaining regulatory acceptance for novel technologies in nonclinical drug development: A scoping review of its conceptualization in scientific literature
Although integrating novel technologies into nonclinical drug development can counteract declining R&D success, their ...
Mapping ligands for MT1/MT2 and 5-HT2C receptors: Chemotypes, SAR, and polypharmacology
Alban Lepailleur is an Associate Professor at the University of Caen Normandy. His research lies at the interface of medic...
Next-generation drug conjugates for breast cancer: Clinical prospects and mechanism-based strategies to overcome resistance
BC is one of the most common malignant tumors among women worldwide, with characteristics of high molecular heterogeneity ...
Generative AI in pharmaceutical R&D: From large language models to AI agents to regulation
Generative AI (GenAI) is reshaping pharmaceutical R&D, offering transformative potential across research and developme...
Computational methods for modeling protein–protein interactions in the AI era: Current status and future directions
Proteins carry out nearly all life processes by interacting with other molecules, particularly other proteins, through pro...
A review of the efficacy of prostate cancer therapies against castration-resistant prostate cancer
Tao Zhang is a lecturer at the School of Food Science and Environmental Health, Technological University Dublin, and progr...
Effectiveness of histamine receptor antagonists in the treatment of histamine-driven clinical symptoms: do we have a histamine or, better, an anti-histamine problem?
Thomas Boehm studied medicine at the Medical University of Vienna and worked for several years in basic science laboratori...
Building a human genetic data lake to scale up insights for drug discovery
Genome-wide association studies (GWAS) have identified numerous disease-associated variants, yet efficient storage and ana...
Fexaramine as the intestine-specific farnesoid X receptor agonist: A promising agent to treat obesity and metabolic disorders
Fexaramine, a gut-restricted farnesoid X receptor (FXR) agonist, promotes glucose and lipid homeostasis, improves insulin ...
Insights from the European Medicines Agency on digital health technology derived endpoints
This study evaluates the use of digital health technologies (DHTs) for endpoint measurement in clinical trials, as documen...
Navigating the complexities of spinal cord injury: an overview of pathology, treatment strategies and clinical trials
Spinal cord injury (SCI) is a catastrophic condition resulting in significant sensory and motor neurological deficits. It ...
The main aspects of non-clinical studies required for obtaining marketing authorisation for small molecules and biologics/biopharmaceuticals in the European Union and the United States
Drug development is a challenging, long, expensive, and risky process. However, it is crucial to bring new medicines to th...
Advancing atherosclerosis treatment: Drug encapsulation nanosystems and synthetic HDL nanoparticles
Ana Figueiras is a researcher and assistant professor at the Faculty of Pharmacy, University of Coimbra and a member of RE...
The role of cyclic adenosine monophosphate (cAMP) in pathophysiology of fibrosis
Sophie L. Harding-Fox obtained her BSc in Biological Sciences from the University of East Anglia in 2016. After graduating...
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