SCI Abstract

search
+
Functional selectivity of cannabinoids at CB1 receptors: Comprehensive analysis of G proteins, β-arrestin and cAMP signalling dynamics in HEK293T cells
Therapeutic targeting of CB1 has been limited by adverse effects of orthosteric ligands. Allosteric modulation and biased ...
Paeonol ameliorates postmenopausal hyperlipidemia by inhibiting COX-2 to suppress GRP78-mediated endoplasmic reticulum stress
Hyperlipidemia and associated cardiovascular diseases (CVDs) represent a substantial and escalating global health burden, ...
Heat stroke-induced structural and functional impairments of cognition-relevant brain areas in mice is associated with alpha-7 nicotinic acetylcholine receptors downregulation
Classic heat stroke (CHS) occurs due to prolonged exposure to high environmental temperatures without physical exertion. I...
Chronic co-treatment with geniposide and shanzhiside methyl ester elicits antidepressant effects via PACAP signaling in stressed male mice
Depression is a prevalent and debilitating mental health disorder (Monroe and Harkness, 2022). Current antidepressants oft...
Blockade of KCa3.1 ameliorates rheumatoid arthritis by suppressing macrophage M1 polarization via the NLRP3 inflammasome signaling pathway
Rheumatoid arthritis (RA) is a systemic autoimmune disorder, clinically presenting as symmetric polyarthritis mainly affec...
Perineuronal nets and parvalbumin interneurons in the prelimbic cortex contribute to the acquisition of methamphetamine-induced conditioned place preference in female mice
Methamphetamine (MA) is a powerful psychostimulant characterized by significant reinforcing and abuse potential, with its ...
A multi-target combinatorial therapy of MDBA alleviates atopic dermatitis via synchronized immunosuppression and barrier repair
Atopic dermatitis (AD) is a chronic, recurrent inflammatory skin disease that imposes a significant global health burden, ...
Effect of DL0410 and tetrahydrocurcumin (LG0367) alone and in combination on learning and memory in vascular dementia
Amid accelerating population aging in both developed and developing countries, the incidence of Vascular dementia (VaD) ha...
Gut microbiota-derived eicosapentaenoic acid alleviates kidney fibrosis in diabetic nephropathy following acute kidney injury
Diabetes mellitus (DM) and chronic kidney disease (CKD) are highly prevalent in world populations, and recent reports reve...
Perfluorocarbon ameliorates high-altitude pulmonary edema and blood–gas barrier dysfunction in a canine model and a lung-on-chip model by suppressing the HIF-1α/HO-1 pathway
High-altitude pulmonary edema (HAPE) is an increasing problem with high morbidity and mortality due to its rapid onset and...
Exploring the role of cathelicidin LL-37 and ceragenins in wound healing processes
Wound healing and tissue regeneration are essential for maintaining skin integrity in the face of mechanical, chemical, or...
Effect of vitamin D combined with methyldopa and labetalol on hemodynamics and pregnancy outcomes in patients with severe preeclampsia
Preeclampsia, a hypertensive disorder that occurs during pregnancy, presents a significant threat to maternal and fetal he...
Bridging protein quality control and epigenetic dysregulation: The HDAC6 paradox in neurological disorders and therapeutic targeting
Acetylation, a key post-translational modification (PTM), plays a vital role in modulating cellular functions and response...
Sex and pain modality differentially modulate alcohol consumption in mice
Chronic pain and alcohol consumption are strongly associated, but the directionality of this relationship remains unclear,...
Rosmarinic acid ameliorates cognitive impairment in sepsis-associated encephalopathy by preserving blood-brain barrier integrity and suppressing pyroptosis of brain endothelial cells
Sepsis, a life-threatening syndrome triggered by infections, leads to profound physiological, pathophysiological, and bioc...
Identification and validation of ferroptosis-related genes for diabetic nephropathy
With the rising prevalence of diabetes and increasing life expectancy, diabetic nephropathy (DN) has become a leading caus...
Mitochondria-derived peptide MOTS-c alleviates hyperoxia-induced bronchopulmonary dysplasia in neonatal mice by activating Nrf2 pathway
Bronchopulmonary dysplasia (BPD) is a chronic lung disease that commonly occurs in preterm infants, often necessitating me...
Effect of ASP5633, a novel peripherally restricted MT1/MT2 receptor agonist, on urethral function in female rats
The functions of melatonin, a hormone that regulates sleep and various physiological processes, are primarily mediated via...
Mechanistic insights into the neuroprotective effect of syringic acid on methotrexate-induced neurotoxicity in rats via Sirt1/AKT/HO-1 pathway
Methotrexate (MTX) is from the antimetabolite group of anti-cancer drugs that is extensively utilized in the treatment of ...
S-nitrosylation of AMP-activated protein kinase beta 1 drives atherosclerotic calcification in diabetes
Diabetes is not only a major independent risk factor for atherosclerosis (Geng, 2023) but is also associated with increase...
Systemic administration of Neochamaejasmin B inhibits mast cell activation to reduce inflammation in a rosacea mouse model by targeting MRGPRX2
Rosacea is a chronic inflammatory skin disorder that affects approximately 5.5 % of the adult population worldwide(Dirr et...
Impact of semaglutide on lipid profiles in overweight and obese non-diabetic adults: A systematic review and meta-analysis of randomized controlled trials
Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of anti-diabetic medications initially approved for the mana...
Kinetics of thymic regeneration in female mice following short-term rapamycin administration
Rapamycin(RAPA) is a macrolide antibiotic and is widely used in clinical practice(Choudhury et al., 2024; Kraaijeveld et a...
Nasal nanotherapeutics for central nervous system disorders: Bridging the translational gap in central nervous system drug delivery
The central nervous system (brain and spinal cord) regulates essential physiological processes from sensory processing to ...
Concentration-dependent cellular effects of VU0364572 on medium spiny neurons in the nucleus accumbens of male and female mice
Selective targeting of M1 receptors (M1R) presents a promising therapeutic approach for managing cocaine use disorder. In ...
Chicoric acid ameliorates rat salpingitis by inhibiting the Nrf2/Notch1 signaling pathway
The fallopian tube is an essential component of the mammalian reproductive system, serving a vital function in the transpo...
Repositioning drugs for autism spectrum disorder: An integrated network analysis of blood and brain tissue key driver genes
BackgroundAutism spectrum disorder (ASD) is a complex neurological condition marked by social, communication, and behavior...
Valvular interstitial cells as a novel therapeutic target for preventing calcific aortic valve disease
Calcific aortic valve disease (CAVD) is a common heart valve disease among elderly individuals, and despite its prevalence...
METTL3 suppresses inflammatory responses by regulating SIRT1-mediated HMGB1 release in sepsis
Sepsis, characterized by organ failure resulting from an aberrant host response to infection, is commonly observed in pati...
A novel therapeutic prospect: a dual-acting tirzepatide for Alzheimer's disease
Alzheimer's disease (AD), the leading cause of dementia, involves microglial activation, pro-inflammatory cytokine release...
Load More
format_indent_increase