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Top-down control of sustained attention by medial prefrontal cortex—locus coeruleus (mPFC-LC) projection neurons during the rodent continuous performance test (rCPT)
Top-down control of sustained attention by medial prefrontal cortex—locus coeruleus (mPFC-LC) projection neurons during the rodent continuous performance test (rCPT)
The medial prefrontal cortex (mPFC) plays a pivotal role in attention by exerting top-down control to allocate cognitive r...
Investigating the effect of increased dopamine signaling on cerebral blood flow in Major Depressive Disorder: a double-blind randomized placebo-controlled study
Investigating the effect of increased dopamine signaling on cerebral blood flow in Major Depressive Disorder: a double-blind randomized placebo-controlled study
Anhedonia, a core symptom of major depressive disorder (MDD), is linked to dysfunction in reward-related brain regions and...
Altered striatal dopamine regulation in Adgrl3 knockout mice
Altered striatal dopamine regulation in Adgrl3 knockout mice
Dopamine signaling is essential for regulating movement, learning, and reward processing, and its dysregulation has been i...
In memoriam—Shigeto Yamawaki, M.D., Ph.D. (1954–2026)
In memoriam—Shigeto Yamawaki, M.D., Ph.D. (1954–2026)
Professor Shigeto Yamawaki, ACNP Fellow Emeritus, former President of the In...
Chronic ethanol self-administration alters dopamine in the caudate nucleus and putamen of rhesus macaques in a sex-dependent manner
Chronic ethanol self-administration alters dopamine in the caudate nucleus and putamen of rhesus macaques in a sex-dependent manner
Alcohol use disorder (AUD) affects over 28 million people in the U.S and is associated with neurobiological alterations, i...
Kappa opioid receptors mediate aversion—and it matters
Kappa opioid receptors mediate aversion—and it matters
Authors and AffiliationsInstitute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, Hei...
Splice isoforms of the histone variant macroH2A1 differentially regulate hippocampal gene expression and memory formation
Splice isoforms of the histone variant macroH2A1 differentially regulate hippocampal gene expression and memory formation
Histone variants are critical components of neuronal chromatin that are emerging as key regulators of long-term memory for...
Cultural humility in the teaching and practice of clinical care
Cultural humility in the teaching and practice of clinical care
We would like to acknowledge the land in Ontario, Canada, on which the University of Guelph sits, the ancestral lands of t...
Rapid hippocampal synaptic potentiation induced by ketamine metabolite (2R,6R)-hydroxynorketamine persistently primes synaptic plasticity
Rapid hippocampal synaptic potentiation induced by ketamine metabolite (2R,6R)-hydroxynorketamine persistently primes synaptic plasticity
The pharmacologically active (R,S)-ketamine (ketamine) metabolite (2 R,6 R)-hydroxynorketamine (HNK) maintains...
The role of sex in the association between cannabis use disorder and resting-state functional connectivity
The role of sex in the association between cannabis use disorder and resting-state functional connectivity
While Cannabis use disorder (CUD) is twice as prevalent in males, females transition more quickly from heavy use to CUD an...
Correction: Neuropsychopharmacology Volume 50 Issue 1
Correction Published: 19 March 2025 ...
Grey matter morphometry in young adult e-cigarette users, tobacco cigarette users & non-using controls
Grey matter morphometry in young adult e-cigarette users, tobacco cigarette users & non-using controls
Despite the rise in electronic cigarette use in recent years, the neurobiological effects of daily e-cigarette use versus ...
Preregistered multi-site preclinical randomized controlled trials: the beginning of a new day in reverse translational science?
Despite significant developments in basic neuroscience and pharmacology of a...
Central Med23 deficiency leads to malformation of dentate gyrus and ADHD-like behaviors in mice
Central Med23 deficiency leads to malformation of dentate gyrus and ADHD-like behaviors in mice
Attention-deficit hyperactivity disorder (ADHD) is a prevalent psychiatric disorder with high heritability, while its etio...
Early-life adversity alters adult nucleus incertus neurons: implications for neuronal mechanisms of increased stress and compulsive behavior vulnerability
Early-life adversity alters adult nucleus incertus neurons: implications for neuronal mechanisms of increased stress and compulsive behavior vulnerability
Early-life stress (ELS) arising from physical and emotional abuse disrupts normal brain development and impairs hypothalam...
Factors influencing JUUL e-cigarette nicotine vapour-induced reward, withdrawal, pharmacokinetics and brain connectivity in rats: sex matters
Factors influencing JUUL e-cigarette nicotine vapour-induced reward, withdrawal, pharmacokinetics and brain connectivity in rats: sex matters
Though vaping likely represents a safer alternative to smoking, it is not without risks, many of which are not well unders...
Activation of prefrontal parvalbumin interneurons ameliorates working memory deficit even under clinically comparable antipsychotic treatment in a mouse model of schizophrenia
Activation of prefrontal parvalbumin interneurons ameliorates working memory deficit even under clinically comparable antipsychotic treatment in a mouse model of schizophrenia
One of the critical unmet medical needs in schizophrenia is the treatment for cognitive deficits. However, the neural circ...
Targeting SIK3 to modulate hippocampal synaptic plasticity and cognitive function by regulating the transcription of HDAC4 in a mouse model of Alzheimer’s disease
Targeting SIK3 to modulate hippocampal synaptic plasticity and cognitive function by regulating the transcription of HDAC4 in a mouse model of Alzheimer’s disease
Cognitive deterioration and memory decline associated with the progression of Alzheimer’s disease (AD) primarily res...
Greater subjective effects of a low dose of LSD in participants with depressed mood
Greater subjective effects of a low dose of LSD in participants with depressed mood
Recent studies and anecdotal reports suggest that psychedelics can improve mood states, even at low doses. However, few pl...
Correction: Voltage-gated potassium channels control extended access cocaine seeking: a role for nucleus accumbens astrocytes
Authors and AffiliationsDepartment of Neuroscience, University of Kentucky, Lexington, KY, USAMengfan Xia, Tanner L. Ander...
ACNP 62nd Annual Meeting: Poster Abstracts P1 – P250
Sanjay Mathew*, Andrew J. Cutler, Nicole C. Visitacion, Michael Gold, Jason Yuan, Bill AuroraBaylor College of Medicine, H...
ACNP 62nd Annual Meeting: Author Index
First Name Last Name Submission Number(s)Scott Aaronson P249, P323, P327Mahmood Y. Abdelkader P186She...
ACNP 62nd Annual Meeting: Poster Abstracts P251 – P500
Aki Tsuchiyagaito, Rayus Kuplicki, Ryan Smith, Masaya Misaki, Noah Philip, Martin Paulus, Salvador Guinjoan*Laureate Insti...
ACNP 62nd Annual Meeting: Keyword Index
Key Word Submission Number(s)(2R,6R)-hydroxynorketamine P354(R,S)-ketamine P250, P354, P365, P726(R,S...
ACNP 62nd Annual Meeting: Poster Abstracts P501 – P753
Johanna Seitz-Holland*, Cornelius Berberich, Nora Penzel, Kevin Cho Kang-Ik, Ofer Pasternak, Suheyla Cetin-Karayumak, Yoge...
ACNP 62nd Annual Meeting: Panels, Mini-Panels and Study Groups
Dong-Jing FuJanssen Research and Development, LLC, Titusville, New Jersey, United StatesBackground: Regulatory agency appr...
Inhibition of asparagine endopeptidase (AEP) effectively treats sporadic Alzheimer’s disease in mice
Inhibition of asparagine endopeptidase (AEP) effectively treats sporadic Alzheimer’s disease in mice
Alzheimer’s disease (AD) is a progressive neurodegenerative disease with cognitive dysfunction as its major clinical...
Correction: Neutralization of tumor necrosis factor-related apoptosis-inducing ligand reduces spinal cord injury damage in mice
Correction: Neutralization of tumor necrosis factor-related apoptosis-inducing ligand reduces spinal cord injury damage in mice
Authors and AffiliationsDepartment of Experimental and Clinical Pharmacology, University of Catania School of Medicine, Ca...
To lump or to split: cognitive impairment across mood and psychotic disorders
Wenzel J, Badde L, Haas SS, Bonivento C, Van Rheenen TE, Antonucci LA, et al. Transdiagnostic subgroups of cognitive impai...
Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods
Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods
Posttraumatic stress disorder (PTSD) is associated with lower cortical thickness (CT) in prefrontal, cingulate, and insula...
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