Early-life adversity alters adult nucleus incertus neurons: implications for neuronal mechanisms of increased stress and compulsive behavior vulnerability

Leroux PA, Dissaux N, Le Reste JY, Bronsard G, Lavenne-Collot N. Association between HPA axis functioning and mental health in maltreated children and adolescents: A systematic literature review. Children 2023;10:1344.

Article  PubMed  PubMed Central  Google Scholar 

Heim C, Newport DJ, Mletzko T, Miller AH, Nemeroff CB. The link between childhood trauma and depression: Insights from HPA axis studies in humans. Psychoneuroendocrinology 2008;33:693–710.

Article  PubMed  CAS  Google Scholar 

Seidenfaden D, Knorr U, Soendergaard MG, Poulsen HE, Fink-Jensen A, Jorgensen MB, et al. The relationship between self-reported childhood adversities, adulthood psychopathology and psychological stress markers in patients with schizophrenia. Compr Psychiatry. 2017;72:48–55.

Article  PubMed  Google Scholar 

Andersen SL. Stress, sensitive periods, and substance abuse. Neurobiol Stress. 2019;10:100140.

Article  PubMed  Google Scholar 

Sinha R. How does stress increase risk of drug abuse and relapse? Psychopharmacol (Berl). 2001;158:343–59.

Article  CAS  Google Scholar 

Moustafa AA, Parkes D, Fitzgerald L, Underhill D, Garami J, Levy-Gigi E, et al. The relationship between childhood trauma, early-life stress, and alcohol and drug use, abuse, and addiction: An integrative review. Curr Psychol. 2021;40:579–84.

Article  Google Scholar 

Rousson AN, Fleming CB, Herrenkohl TI. Childhood maltreatment and later stressful life events as predictors of depression: A test of the stress sensitization hypothesis. Psychol Violence. 2020;10:493.

Article  PubMed  PubMed Central  Google Scholar 

Seo D, Rabinowitz AG, Douglas RJ, Sinha R. Limbic response to stress linking life trauma and hypothalamus-pituitary-adrenal axis function. Psychoneuroendocrinology 2019;99:38–46.

Article  PubMed  CAS  Google Scholar 

Pruessner JC, Champagne F, Meaney MJ, Dagher A. Dopamine release in response to a psychological stress in humans and its relationship to early life maternal care: A positron emission tomography study using [11C] raclopride. J Neurosci. 2004;24:2825–31.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Marusak HA, Martin KR, Etkin A, Thomason ME. Childhood trauma exposure disrupts the automatic regulation of emotional processing. Neuropsychopharmacology 2015;40:1250–8.

Article  PubMed  PubMed Central  Google Scholar 

Kim JH, Martins SS, Shmulewitz D, Santaella J, Wall MM, Keyes KM, et al. Childhood maltreatment, stressful life events, and alcohol craving in adult drinkers. Alcohol Clin Exp Res. 2014;38:2048–55.

Article  PubMed  PubMed Central  Google Scholar 

Ramkumar R, Edge-Partington M, Terstege DJ, Adigun K, Ren Y, Khan NS, et al. Long-term impact of early-life stress on serotonin connectivity. Biol Psychiatry. 2024;96:287–99.

Article  PubMed  CAS  Google Scholar 

Streeter GL. Anatomy of the floor of the fourth ventricle. (The relations between the surface markings and the underlying structures.). Am J Anat. 1903;2:299–313.

Article  Google Scholar 

Ma S, Sang Q, Lanciego JL, Gundlach AL. Localization of relaxin-3 in brain of Macaca fascicularis: Identification of a nucleus incertus in primate. J Comp Neurol. 2009;517:856–72.

Article  PubMed  CAS  Google Scholar 

Szlaga A, Sambak P, Trenk A, Gugula A, Singleton CE, Drwiega G, et al. Functional neuroanatomy of the rat nucleus incertus–medial septum tract: implications for the cell-specific control of the septohippocampal pathway. Front Cell Neurosci. 2022;16:57.

Article  Google Scholar 

Smith CM, Shen PJ, Banerjee A, Bonaventure P, Ma S, Bathgate RAD, et al. Distribution of relaxin-3 and RXFP3 within arousal, stress, affective, and cognitive circuits of mouse brain. J Comp Neurol. 2010;518:4016–45.

Article  PubMed  CAS  Google Scholar 

Blasiak A, Gugula A, Gundlach AL, Olucha-Bordonau FE, Aniello F, Donizetti A. Relaxin ligand/receptor systems in the developing teleost fish brain: Conserved features with mammals and a platform to address neuropeptide system functions. Front Mol Neurosci. 2022;15:984524.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sabetghadam A, Grabowiecka-Nowak A, Kania A, Gugula A, Blasiak E, Blasiak T, et al. Melanin-concentrating hormone and orexin systems in rat nucleus incertus: Dual innervation, bidirectional effects on neuron activity, and differential influences on arousal and feeding. Neuropharmacology 2018;139:238–56.

Article  PubMed  CAS  Google Scholar 

Blasiak A, Siwiec M, Grabowiecka A, Blasiak T, Czerw A, Blasiak E, et al. Excitatory orexinergic innervation of rat nucleus incertus - Implications for ascending arousal, motivation and feeding control. Neuropharmacology 2015;99:432–47.

Article  PubMed  CAS  Google Scholar 

Trenk A, Walczak M, Szlaga A, Pradel K, Blasiak A, Blasiak T. Bidirectional communication between the pontine nucleus incertus and the medial septum is carried out by electrophysiologically-distinct neuronal populations. J Neurosci. 2022;42:2234–52.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Nardone S, De Luca R, Zito A, Klymko N, Nicoloutsopoulos D, Amsalem O, et al. A spatially-resolved transcriptional atlas of the murine dorsal pons at single-cell resolution. Nat Commun. 2024;15:1966.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Szőnyi A, Sos KE, Nyilas R, Schlingloff D, Domonkos A, Takács VT, et al. Brainstem nucleus incertus controls contextual memory formation. Science 2019;364:eaaw0445.

Article  PubMed  PubMed Central  Google Scholar 

Lu L, Ren Y, Yu T, Liu Z, Wang S, Tan L, et al. Control of locomotor speed, arousal, and hippocampal theta rhythms by the nucleus incertus. Nat Commun. 2020;11:262.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Rajkumar R, Wu Y, Farooq U, Tan WH, Dawe GS. Stress activates the nucleus incertus and modulates plasticity in the hippocampo-medial prefrontal cortical pathway. Brain Res Bull. 2016;120:83–9.

Article  PubMed  CAS  Google Scholar 

Pereira CW, Santos FN, Sánchez-Pérez AM, Otero-García M, Marchioro M, Ma S, et al. Electrolytic lesion of the nucleus incertus retards extinction of auditory conditioned fear. Behav Brain Res. 2013;247:201–10.

Article  PubMed  CAS  Google Scholar 

Kumar JR, Rajkumar R, Jayakody T, Marwari S, Hong JM, Ma S, et al. Relaxin’ the brain: a case for targeting the nucleus incertus network and relaxin-3/RXFP3 system in neuropsychiatric disorders. Br J Pharm. 2017;174:1061–76.

Article  CAS  Google Scholar 

Ma S, Blasiak A, Olucha-Bordonau FE, Verberne AJM, Gundlach AL. Heterogeneous responses of nucleus incertus neurons to corticotrophin-releasing factor and coherent activity with hippocampal theta rhythm in the rat. J Physiol. 2013;591:3981–4001.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Wang Q, Sun RY, Hu JX, Sun YH, Li CY, Huang H, et al. Hypothalamic-hindbrain circuit for consumption-induced fear regulation. Nat Commun. 2024;15:1–14.

PubMed  PubMed Central  Google Scholar 

Liang J, Zhou Y, Feng Q, Zhou Y, Jiang T, Ren M, et al. A brainstem circuit amplifies aversion. Neuron 2024;112:3634–3650.e5.

Article  PubMed  CAS  Google Scholar 

Lenglos C, Mitra A, Guèvremont G, Timofeeva E. Sex differences in the effects of chronic stress and food restriction on body weight gain and brain expression of CRF and relaxin-3 in rats. Genes Brain Behav. 2013;12:370–87.

Article  PubMed  CAS  Google Scholar 

Blasiak A, Gundlach AL, Hess G, Lewandowski MH. Interactions of circadian rhythmicity, stress and orexigenic neuropeptide systems: Implications for food intake control. Front Neurosci. 2017;11:127.

Article  PubMed  P

Comments (0)

No login
gif