Investigating the effect of increased dopamine signaling on cerebral blood flow in Major Depressive Disorder: a double-blind randomized placebo-controlled study

Shankman SA, Katz AC, DeLizza AA, Sarapas C, Gorka SM, Campbell ML. The different facets of anhedonia and their associations with different psychopathologies. In: Ritsner MS, editor. Anhedonia: A Comprehensive Handbook Volume I [Internet]. Dordrecht: Springer Netherlands; 2014 [cited 2021 Aug 20]. p. 3–22. Available from: http://link.springer.com/10.1007/978-94-017-8591-4_1

American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders [Internet]. Fifth Edition. American Psychiatric Association; 2013 [cited 2025 Mar 17]. Available from: https://psychiatryonline.org/doi/book/10.1176/appi.books.9780890425596

Rizvi SJ, Pizzagalli DA, Sproule BA, Kennedy SH. Assessing anhedonia in depression: Potentials and pitfalls. Neurosci Biobehav Rev. 2016;65:21–35.

Article  PubMed  PubMed Central  Google Scholar 

Calabrese JR, Fava M, Garibaldi G, Grunze H, Krystal AD, Laughren T, et al. Methodological approaches and magnitude of the clinical unmet need associated with amotivation in mood disorders. J Affect Disord. 2014;168:439–51.

Article  PubMed  Google Scholar 

McCabe C, Mishor Z, Cowen PJ, Harmer CJ. Diminished neural processing of aversive and rewarding stimuli during selective serotonin reuptake inhibitor treatment. Biol Psychiatry. 2010;67:439–45.

Article  PubMed  CAS  Google Scholar 

Nutt D, Demyttenaere K, Janka Z, Aarre T, Bourin M, Canonico PL, et al. The other face of depression, reduced positive affect: the role of catecholamines in causation and cure. J Psychopharmacol (Oxf). 2007;21:461–71.

Article  CAS  Google Scholar 

Spijker J, Bijl RV, De Graaf R, Nolen WA. Determinants of poor 1-year outcome of DSM-III-R major depression in the general population: results of the Netherlands Mental Health Survey and Incidence Study (NEMESIS): Poor outcome of depression. Acta Psychiatr Scand. 2001;103:122–30.

Article  PubMed  CAS  Google Scholar 

Uher R, Perlis RH, Henigsberg N, Zobel A, Rietschel M, Mors O, et al. Depression symptom dimensions as predictors of antidepressant treatment outcome: replicable evidence for interest-activity symptoms. Psychol Med. 2012;42:967–80.

Article  PubMed  CAS  Google Scholar 

Haber SN, Knutson B. The reward circuit: linking primate anatomy and human imaging. Neuropsychopharmacology. 2010;35:4–26.

Article  PubMed  PubMed Central  Google Scholar 

Sescousse G, Caldú X, Segura B, Dreher JC. Processing of primary and secondary rewards: a quantitative meta-analysis and review of human functional neuroimaging studies. Neurosci Biobehav Rev. 2013;37:681–96.

Article  PubMed  Google Scholar 

Pizzagalli DA. Depression, stress, and anhedonia: toward a synthesis and integrated model. Annu Rev Clin Psychol. 2014;10:393–423.

Article  PubMed  PubMed Central  Google Scholar 

Pizzagalli DA, Berretta S, Wooten D, Goer F, Pilobello KT, Kumar P, et al. Assessment of striatal dopamine transporter binding in individuals with major depressive disorder: in vivo positron emission tomography and postmortem evidence. JAMA Psychiatry. 2019;76:854–61.

Article  PubMed  PubMed Central  Google Scholar 

Borsini A, Wallis ASJ, Zunszain P, Pariante CM, Kempton MJ. Characterizing anhedonia: A systematic review of neuroimaging across the subtypes of reward processing deficits in depression. Cogn Affect Behav Neurosci. 2020;20:816–41.

Article  PubMed  PubMed Central  Google Scholar 

Admon R, Kaiser RH, Dillon DG, Beltzer M, Goer F, Olson DP, et al. Dopaminergic enhancement of striatal response to reward in major depression. Am J Psychiatry. 2017;174:378–86. Apr.

Article  PubMed  Google Scholar 

Liu Y, Admon R, Mellem MS, Belleau EL, Kaiser RH, Clegg R, et al. Machine learning identifies large-scale reward-related activity modulated by dopaminergic enhancement in major depression. Biol Psychiatry Cogn Neurosci Neuroimag. 2020;5:163–72.

Google Scholar 

Freeman HL. Amisulpride compared with standard neuroleptics in acute exacerbations of schizophrenia: three efficacy studies. Int Clin Psychopharmacol. 1997;12:S11–7.

Article  PubMed  Google Scholar 

Montgomery SA. Dopaminergic deficit and the role of amisulpride in the treatment of mood disorders. Int Clin Psychopharmacol. 2002;17:S9–15.

PubMed  Google Scholar 

Racagni G, Canonico PL, Ravizza L, Pani L, Amore M. Consensus on the use of substituted benzamides in psychiatric patients. Neuropsychobiology. 2004;50:134–43.

Article  PubMed  CAS  Google Scholar 

Smeraldi E. Amisulpride versus fluoxetine in patients with dysthymia or major depression in partial remission A double-blind, comparative study. J Affect Disord. 1998;48:47–56.

Article  PubMed  CAS  Google Scholar 

Schoemaker H, Claustre Y, Fage D, Rouquier L, Chergui K, Curet O, et al. Neurochemical characteristics of amisulpride, an atypical dopamine D2/D3 receptor antagonist with both presynaptic and limbic selectivity. J Pharm Exp Ther. 1997;280:83–97.

Article  CAS  Google Scholar 

Jocham G, Klein TA, Ullsperger M. Differential modulation of reinforcement learning by D2 dopamine and NMDA glutamate receptor antagonism. J Neurosci. 2014;34:13151–62.

Article  PubMed  PubMed Central  Google Scholar 

Grimm O, Nägele M, Küpper-Tetzel L, de Greck M, Plichta M, Reif A. No effect of a dopaminergic modulation fMRI task by amisulpride and L-DOPA on reward anticipation in healthy volunteers. Psychopharmacol (Berl). 2021;238:1333–42.

Article  CAS  Google Scholar 

Detre JA, Wang J. Technical aspects and utility of fMRI using BOLD and ASL. Clin Neurophysiol J Int Fed Clin Neurophysiol. 2002;113:621–34.

Article  Google Scholar 

Ogawa S, Menon RS, Tank DW, Kim SG, Merkle H, Ellermann JM, et al. Functional brain mapping by blood oxygenation level-dependent contrast magnetic resonance imaging. A comparison of signal characteristics with a biophysical model. Biophys J. 1993;64:803–12.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Stewart SB, Koller JM, Campbell MC, Black KJ. Arterial spin labeling versus BOLD in direct challenge and drug-task interaction pharmacological fMRI. PeerJ. 2014;2:e687.

Article  PubMed  PubMed Central  Google Scholar 

Detre JA, Rao H, Wang DJ, Chen YF, Wang Z. Applications of arterial spin labeled MRI in the brain Abstract Journal of Magnetic Resonance Imaging 2012;35:1026–37.

Fan AP, Khalighi MM, Guo J, Ishii Y, Rosenberg J, Wardak M, et al. Identifying Hypoperfusion in Moyamoya Disease With Arterial Spin Labeling and an [15O]-Water Positron Emission Tomography/Magnetic Resonance Imaging Normative DatabaseStroke 2019;50:373–80.

Dolui S, Fan AP, Zhao MY, Nasrallah IM, Zaharchuk G, Detre JA. Reliability of arterial spin labeling derived cerebral blood flow in periventricular white matter Neuroimage: Reports 2021;1:100063.

Narjes, Jaafar N, Alsop DC. Alsop Arterial Spin Labeling: Key Concepts and Progress Towards Use as a Clinical Tool Magnetic Resonance in Medical Sciences 2024;23:352–66.

Cooper CM, Chin Fatt CR, Jha M, Fonzo GA, Grannemann BD, Carmody T, et al. Cerebral blood perfusion predicts response to sertraline versus placebo for major depressive disorder in the EMBARC trial. EClinicalMedicine. 2019;10:32–41.

Article  PubMed  PubMed Central  Google Scholar 

Bracht T, Mertse N, Breit S, Federspiel A, Wiest R, Soravia LM, et al. Alterations of perfusion and functional connectivity of the cingulate motor area are associated with psychomotor retardation in major depressive disorder. Eur Arch Psychiatry Clin Neurosci. 2025;275:1131–39.

Chen G, Bian H, Jiang D, Cui M, Ji S, Liu M, et al. Pseudo-continuous arterial spin labeling imaging of cerebral blood perfusion asymmetry in drug-naïve patients with first-episode major depression. Biomed Rep. 2016;5:675–80.

Article  PubMed  PubMed Central  Google Scholar 

Cooper CM, Chin Fatt CR, Liu P, Grannemann BD, Carmody T, Almeida JRC, et al. Discovery and replication of cerebral blood flow differences in major depressive disorder. Mol Psychiatry. 2020;25:1500–10.

Article  PubMed  Google Scholar 

Duhameau B, Ferré JC, Jannin P, Gauvrit JY, Vérin M, Millet B, et al. Chronic and treatment-resistant depression: a study using arterial spin labeling perfusion MRI at 3Tesla. Psychiatry Res. 2010;182:111–6.

Article  PubMed  Google Scholar 

Fu C, Shi D, Gao Y, Xu J. Functional assessment of prefrontal lobes in patients with major depression disorder using a dual-mode technique of 3D-arterial spin labeling and 18F-fluorodeoxyglucose positron emission tomography/computed tomography. Exp Ther Med. 2017;14:1058–64.

Article  PubMed  PubMed Central  CAS  Google Scholar 

He Z, Zhang D, Muhlert N, Elliott R. Neural substrates for anticipation and consumption of social and monetary incentives in depression. Soc Cogn Affect Neurosci. 2019;14:815–26.

Article  PubMed  PubMed Central  Google Scholar 

Järnum H, Eskildsen SF, Steffensen EG, Lundbye-Christensen S, Simonsen CW, Thomsen IS, et al. Longitudinal MRI study of cortical thickness, perfusion, and metabolite levels in major depressive disorder. Acta Psychiatr Scand. 2011;124:435–46.

Article  PubMed  Google Scholar 

Kaichi Y, Okada G, Takamura M, Toki S, Akiyama Y, Higaki T, et al. Changes in the regional cerebral blood flow detected by arterial spin labeling after 6-week escitalopram treatment for major depressive disorder. J Affect Disord. 2016;194:135–43.

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